Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin

Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-231 Human Breast Cancer Cells through Up-Regulation of IFIT2

(2019) So Koh et al.   Nutrients

Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROS/Stat3 Signaling Pathway

(2019) Su-Lim Kim et al.   Oxidative Medicine and Cellular Longevity

Activation of EMT in colorectal cancer by MTDH/NF-κB p65 pathway

(2019) Nahla E. El-Ashmawy et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway

(2019) Yuexiang Qin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phenethyl Isothiocyanate Exposure Promotes Oxidative Stress and Suppresses Sp1 Transcription Factor in Cancer Stem Cells

(2019) Bijaya Upadhyaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of modification of MTDH gene expression on colorectal cancer aggressiveness

(2019) Nahla E. El-Ashmawy et al.   GENE

ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals

(2019) Saranya NavaneethaKrishnan et al.   Oxidative Medicine and Cellular Longevity

Metadherin–PRMT5 complex enhances the metastasis of hepatocellular carcinoma through the WNT–β-catenin signaling pathway

(2019) Kai Zhu et al.   CARCINOGENESIS

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment

(2019) Ada Koschorke et al.   CELLULAR ONCOLOGY

Role of Phytochemicals in Cancer Prevention

(2019) Alok Ranjan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Huaier Granule extract inhibit the proliferation and metastasis of lung cancer cells through down-regulation of MTDH, JAK2/STAT3 and MAPK signaling pathways

(2018) Yang Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

(2018) Shireen Chikara et al.   CANCER LETTERS

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

(2018) Ming Luo et al.   Cell Metabolism

Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells

(2018) Zainab Sabry Othman Ahmed et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Isothiocyanates: Translating the Power of Plants to People

(2018) Dushani L. Palliyaguru et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells

(2018) Ho Hyun et al.   MOLECULES

LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer

(2018) Liyun Luo et al.   ONCOGENE

Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer

(2018) Jian‑Wang Li et al.   ONCOLOGY REPORTS

Metadherin is an apoptotic modulator in prostate cancer through miR-342-3p regulation

(2018) Kebang Hu et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation

(2018) Natasa S. Giallourou et al.   EUROPEAN JOURNAL OF NUTRITION

Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway

(2018) Yue Chen et al.   PHYTOTHERAPY RESEARCH

Breast cancer stem cells: Biology and therapeutic implications

(2018) Ramesh Butti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Radio resistance in breast cancer cells is mediated through TGF-β signalling, hybrid epithelial-mesenchymal phenotype and cancer stem cells

(2018) Poonam Yadav et al.   BIOMEDICINE & PHARMACOTHERAPY

Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer

(2017) Kensuke Suzuki et al.   Oncotarget

Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry

(2017) Ann P. Lawson et al.   Oncotarget

Astrocyte Elevated Gene-1 Regulates β-Catenin Signaling to Maintain Glioma Stem-like Stemness and Self-Renewal

(2016) Bin Hu et al.   MOLECULAR CANCER RESEARCH

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat

(2016) Marisela Agudelo et al.   PLoS One

Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy

(2015) L. L. Atwell et al.   Cancer Prevention Research

Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer

(2015) Y. Liang et al.   CANCER RESEARCH

PEITC induces apoptosis of Human Brain Glioblastoma GBM8401 Cells through the extrinsic- and intrinsic -signaling pathways

(2015) Yu-Cheng Chou et al.   NEUROCHEMISTRY INTERNATIONAL

Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate

(2015) Ramesh K. Krishnan et al.   Nature Communications

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway

(2014) Cheng Du et al.   BMC CANCER

Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells

(2014) Dan Wang et al.   BMC CANCER

Mechanism of Action of Phenethylisothiocyanate and Other Reactive Oxygen Species-Inducing Anticancer Agents

(2014) I. Jutooru et al.   MOLECULAR AND CELLULAR BIOLOGY

Breast cancer subtypes: response to radiotherapy and potential radiosensitisation

(2013) F E Langlands et al.   BRITISH JOURNAL OF RADIOLOGY

AEG-1 participates in TGF-beta1-induced EMT through p38 MAPK activation

(2013) Jiali Wei et al.   CELL BIOLOGY INTERNATIONAL

Discovery of the cancer stem cell related determinants of radioresistance

(2013) Claudia Peitzsch et al.   RADIOTHERAPY AND ONCOLOGY

Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models

(2012) Parul Gupta et al.   BMC Medicine

Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells throughG0/G1Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death

(2012) Po-Yuan Chen et al.   Evidence-based Complementary and Alternative Medicine

Targeting Protein Kinase C (PKC) and Telomerase by Phenethyl Isothiocyanate (PEITC) Sensitizes PC-3 Cells Towards Chemotherapeutic Drug-Induced Apoptosis

(2012) Sutapa Mukherjee et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Inhibition of Mitochondrial Respiration and Rapid Depletion of Mitochondrial Glutathione by β-Phenethyl Isothiocyanate: Mechanisms for Anti-Leukemia Activity

(2011) Gang Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma

(2011) Evan Noch et al.   CANCER BIOLOGY & THERAPY

Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition

(2011) Xiaoyan Li et al.   CANCER SCIENCE

N-acetylcysteine, reactive oxygen species and beyond

(2010) Shi-Yong Sun   CANCER BIOLOGY & THERAPY

Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung

(2010) A. Izzotti et al.   CARCINOGENESIS

Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells

(2010) Young Jin Moon et al.   Evidence-based Complementary and Alternative Medicine

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

LYRIC/AEG-1 Is Targeted to Different Subcellular Compartments by Ubiquitinylation and Intrinsic Nuclear Localization Signals

(2009) H. J. Thirkettle et al.   CLINICAL CANCER RESEARCH

Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-α36

(2009) Lianguo Kang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

PEITC Induces G1 Cell Cycle Arrest on HT-29 Cells Through the Activation of p38 MAPK Signaling Pathway

(2008) Ka Lung Cheung et al.   AAPS Journal

Multilevel Regulation of Gene Expression by MicroRNAs

(2008) E. V. Makeyev et al.   SCIENCE

Chemoprevention of familial adenomatous polyposis inApcMin/+ mice by phenethyl isothiocyanate (PEITC)

(2007) Tin Oo Khor et al.   MOLECULAR CARCINOGENESIS