Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies

Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice

(2020) Lucia Moreno-Lama et al.   ONCOGENE

Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models

(2019) Zebin Wang et al.   Scientific Reports

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

(2019) Triparna Sen et al.   Cancer Discovery

PARG regulates the proliferation and differentiation of DCs and T�cells via PARP/NF‑κB in tumour metastases of colon carcinoma

(2019) Jie‑Qiong Wang et al.   ONCOLOGY REPORTS

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

ARTD1 in Myeloid Cells Controls the IL-12/18–IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer

(2019) Friedrich A. Kunze et al.   JOURNAL OF IMMUNOLOGY

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

(2019) Miguel A. Galindo-Campos et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of natural killer cell‐mediated cellular cytotoxicity

(2019) Isabel Prager et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Durvalumab in Combination with Olaparib in Patients with Relapsed Small Cell Lung Cancer: Results from a Phase II Study

(2019) Anish Thomas et al.   Journal of Thoracic Oncology

PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function

(2019) Laura C. Echeverri Tirado et al.   MEDIATORS OF INFLAMMATION

Restriction of AID activity and somatic hypermutation by PARP-1

(2019) Sandra Tepper et al.   NUCLEIC ACIDS RESEARCH

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

(2019) Constantia Pantelidou et al.   Cancer Discovery

A decade of clinical development of PARP inhibitors in perspective

(2019) J Mateo et al.   ANNALS OF ONCOLOGY

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

(2019) Timo Reisländer et al.   Nature Communications

Prospects for combining immune checkpoint blockade with PARP inhibition

(2019) Anping Li et al.   Journal of Hematology & Oncology

Combining PARP inhibition with PD-1 inhibitors

(2019) Ulrik Lassen   LANCET ONCOLOGY

Transcriptional Regulation of Differentiation and Functions of Effector T Regulatory Cells

(2019) Shin-ichi Koizumi et al.   Cells

To PARP or not to PARP?—Toward sensitizing acute myeloid leukemia stem cells to immunotherapy

(2019) Benjamin Heyman et al.   EMBO JOURNAL

PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice

(2018) Vivek Dharwal et al.   BIOCHEMICAL PHARMACOLOGY

Generation of memory B cells and their reactivation

(2018) Takeshi Inoue et al.   IMMUNOLOGICAL REVIEWS

Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

(2018) Alan Ashworth et al.   Nature Reviews Clinical Oncology

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

(2018) George E. Ronson et al.   Nature Communications

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

Development of PARP and Immune-Checkpoint Inhibitor Combinations

(2018) Ross A Stewart et al.   CANCER RESEARCH

PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

(2018) Jianfeng Shen et al.   CANCER RESEARCH

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

(2018) Liya Ding et al.   Cell Reports

Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition

(2018) Kathleen E. Fenerty et al.   Journal for ImmunoTherapy of Cancer

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer

(2018) Roman M. Chabanon et al.   JOURNAL OF CLINICAL INVESTIGATION

PARP1-LSD1 functional interplay controls transcription of SOD2 that protects human pro-inflammatory macrophages from death under an oxidative condition

(2018) Paulina Tokarz et al.   FREE RADICAL BIOLOGY AND MEDICINE

PARP-1 promotes tumor recurrence after warm ischemic liver graft transplantation via neutrophil recruitment and polarization

(2017) Shuai Wang et al.   Oncotarget

The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy?

(2017) Christine Böger et al.   OncoImmunology

PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

(2017) Judith Navarro et al.   Scientific Reports

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Transcriptional Control of Dendritic Cell Development

(2016) Theresa L. Murphy et al.   Annual Review of Immunology

Visualizing antibody affinity maturation in germinal centers

(2016) J. M. J. Tas et al.   SCIENCE

Dynamic Tuning of Lymphocytes: Physiological Basis, Mechanisms, and Function

(2015) Zvi Grossman et al.   Annual Review of Immunology

MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1−/− and Parp-2−/− mice with lung cancer cachexia

(2015) Alba Chacon-Cabrera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells

(2015) Xuerui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function

(2015) Mohamed A Ghonim et al.   Journal of Translational Medicine

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

(2015) Peter Bai   MOLECULAR CELL

The Promise of Proteomics for the Study of ADP-Ribosylation

(2015) Casey M. Daniels et al.   MOLECULAR CELL

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation

(2015) Jana Prochazkova et al.   PLoS Genetics

CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer

(2015) T. Higuchi et al.   Cancer Immunology Research

Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors

(2015) José Yélamos et al.   OncoImmunology

Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression

(2014) X. Wei Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

PARP-1 regulates expression of TGF-  receptors in T cells

(2013) P. Zhang et al.   BLOOD

Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation

(2013) M. Sambucci et al.   TheScientificWorldJOURNAL

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

(2012) Suzanne L Topalian et al.   CURRENT OPINION IN IMMUNOLOGY

Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes

(2012) Johan Aurelius et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity

(2011) Leonardo Cavone et al.   Multiple Sclerosis Journal

Innate immune cells in motion

(2011) Elizabeth C. Thompson   TRENDS IN IMMUNOLOGY

Increased Foxp3+ Regulatory T Cells in Poly(ADP-Ribose) Polymerase-1 Deficiency

(2010) F. Nasta et al.   JOURNAL OF IMMUNOLOGY

Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice

(2010) L Nicolás et al.   ONCOGENE

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

(2009) Isabelle Robert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines

(2009) Mourad Zerfaoui et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activation

(2008) Luis Saenz et al.   BMC GENOMICS

Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses

(2008) Helen E. Ambrose et al.   IMMUNOLOGY

Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells

(2008) Rut Valdor et al.   MOLECULAR IMMUNOLOGY