DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

DNA replication stress: Causes, resolution and disease

(2014) Abdelghani Mazouzi et al.   EXPERIMENTAL CELL RESEARCH

A hypomorphic recombination-activating gene 1 ( RAG1 ) mutation resulting in a phenotype resembling common variable immunodeficiency

(2014) Hassan Abolhassani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Essential Function of the MRN Complex in the Resolution of Endogenous Replication Intermediates

(2014) Christopher Bruhn et al.   Cell Reports

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

(2013) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

(2013) Anja M. Duursma et al.   MOLECULAR CELL

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

(2013) Bunsyo Shiotani et al.   Cell Reports

DNA repair: the link between primary immunodeficiency and cancer

(2012) Noel FCC de Miranda et al.   Annals of the New York Academy of Sciences

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

(2012) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

(2012) Kenta Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Loss of ATM kinase activity leads to embryonic lethality in mice

(2012) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim

(2012) Sabine Jurado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice

(2012) Tianyi Zhang et al.   Cell Reports

ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma

(2011) Joanna I. Loizou et al.   CANCER CELL

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atm-Deficient Mice Exhibit Increased Sensitivity to Dextran Sulfate Sodium-Induced Colitis Characterized by Elevated DNA Damage and Persistent Immune Activation

(2010) A. M. Westbrook et al.   CANCER RESEARCH

More than just SCID—The phenotypic range of combined immunodeficiencies associated with mutations in the recombinase activating genes (RAG) 1 and 2

(2010) Tim Niehues et al.   CLINICAL IMMUNOLOGY

The Fission Yeast Rad32(Mre11)-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint

(2010) N. Willis et al.   GENETICS

Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease

(2010) Shradha Agarwal et al.   INFLAMMATORY BOWEL DISEASES

The ATM Cofactor ATMIN Protects against Oxidative Stress and Accumulation of DNA Damage in the Aging Brain

(2010) Nnennaya Kanu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM-deficient thymic lymphoma is associated with aberranttcrdrearrangement and gene amplification

(2010) Shan Zha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dual Functions of Nbs1 in the Repair of DNA Breaks and Proliferation Ensure Proper V(D)J Recombination and T-Cell Development

(2010) A. Saidi et al.   MOLECULAR AND CELLULAR BIOLOGY

Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients

(2009) N. Takahashi et al.   JOURNAL OF IMMUNOLOGY

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

(2009) Omar Nyabi et al.   NUCLEIC ACIDS RESEARCH

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE