Article
Biochemistry & Molecular Biology
Bahareh Nazemi Salman, Shayan Darvish, Ancuta Goriuc, Saeideh Mazloomzadeh, Maryam Hossein Poor Tehrani, Ionut Luchian
Summary: Salivary markers of oxidative stress are associated with clinical disease indices such as gingival bleeding and dental caries. The total antioxidant capacity (TAC) increased in patients with more gingival bleeding and decreased in adolescents with caries. Antioxidants could potentially be used as a preventive and therapeutic measure against oral diseases in the future.
Article
Cell Biology
Riccardo Goldoni, Carolina Dolci, Elisa Boccalari, Francesco Inchingolo, Alessandro Paghi, Lucanos Strambini, Daniela Galimberti, Gianluca Martino Tartaglia
Summary: Salivary analysis is a novel and promising field of research for the diagnosis of neurodegenerative and demyelinating diseases related to aging. Collection of saliva is noninvasive, stress-free, and repeatable, offering advantages for early diagnosis and timely treatment. Advanced biosensors have been proposed for detecting salivary biomarkers associated with various neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Yago Gecy de Sousa Ne, Weslley Ferreira Lima, Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Leonardo Oliveira Bittencourt, Priscila Cunha Nascimento, Renata Duarte de Souza-Rodrigues, Luiz Renato Paranhos, Paulo Antonio Martins-Junior, Rafael Rodrigues Lima
Summary: This study aimed to analyze the research trends on salivary oxidative stress associated with dental caries and to perform bibliometric approaches for existing publications on this association. The findings show that India and Asia have the highest number of publications on this topic, non-stimulated total saliva is the most commonly collected sample, and total antioxidant capacity is the most frequently evaluated parameter. Cross-sectional studies are the most common study design, and articles published from 2017 to 2022 are the most frequent.
Review
Biochemistry & Molecular Biology
Raphael Charchar Campos Alves, Railson Oliveira Ferreira, Deborah Ribeiro Frazao, Yago Gecy de Souza Ne, Paulo Fernando Santos Mendes, Guido Maranon-Vasquez, Luiz Fernando Freire Royes, Nathalia Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues Lima
Summary: This systematic review evaluated the effects of physical exercise on oxidative stress in saliva. The findings suggest that exercise may increase oxidative stress and antioxidant activity in saliva, but there is heterogeneity and inconsistency among studies.
Review
Biochemistry & Molecular Biology
Katarina Jansakova, Klaudia Kyselicova, Daniela Ostatnikova, Gabriela Repiska
Summary: Saliva, as a potential alternative to other body fluids, offers a complex view on the current state of the individual with its sources of nucleic acid of both human and microbial origin, protein, and non-protein molecules. Using salivary markers may simplify ASD screening and potentially reveal the etiopathogenesis of ASD, with the advantage of easier recruitment of neurotypical counterparts for studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Patrycja Pawlik, Katarzyna Blochowiak
Summary: Neurodegenerative diseases result in progressive neuronal degeneration, emphasizing the need for early screening and diagnosis. Biomarkers show promise for early detection, with saliva being explored as a potential non-invasive diagnostic tool. Research on salivary biomarkers for Alzheimer's and Parkinson's diseases continues, aiming to identify correlations between specific biomarkers and early clinical symptoms for improved treatment strategies.
Review
Biochemistry & Molecular Biology
Eelis Hyvarinen, Eino Solje, Jouko Vepsalainen, Arja Kullaa, Tuulia Tynkkynen
Summary: This study reviews the applications of salivary metabolomics in the diagnosis and treatment monitoring of neurodegenerative diseases. Spectroscopic methods, such as NMR spectroscopy and mass spectrometry, provide insights into changes in salivary metabolites in these diseases. The role of different salivary metabolites in brain function is also discussed. Further studies with larger patient cohorts are needed to investigate the association between salivary metabolites and brain function, and to gain a better understanding of the complex pathways in the human body.
Article
Veterinary Sciences
Takanori Kooriyama, Niwako Ogata
Summary: Research on salivary biomarkers of stress responses in dogs is important for advancing studies and improving treatment methods.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Geriatrics & Gerontology
Mingkai Lin, Hongwen Yu, Qiuyan Xie, Zhiyun Xu, Pei Shang
Summary: Microglia, as key immune cells in the CNS, respond to damage, regulate inflammation, and engulf specific segments. Microglia autophagy participates in subcellular regulation and maintains neuronal homeostasis and neuroinflammation.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Tanya Deneva, Youri Ianakiev, Oliana Boykinova
Summary: The study aims to analyze salivary mental stress biomarkers in hospitalized patients with COVID-19 and determine their potential relationship with stress symptoms.
FRONTIERS IN MEDICINE
(2022)
Review
Food Science & Technology
Xinxin Chang, Yudan Wang, Bing Zheng, Yi Chen, Jianhua Xie, Yiming Song, Xiaomeng Ding, Xiaoyi Hu, Xiaobo Hu, Qiang Yu
Summary: Neurodegenerative diseases involve the loss of specific neurons, which is often caused by environmental pollutants like acrolein. Acrolein is highly active and contributes to oxidative stress, polyamine metabolism, and neuronal damage, thereby impacting the progression of neurodegenerative diseases.
Article
Endocrinology & Metabolism
Yeon-Hee Lee, Chon Suk, Seung-Il Shin, Ji-Youn Hong
Summary: This study aimed to investigate the neuroendocrine responses based on cortisol, dehydroepiandrosterone (DHEA), cortisol/DHEA ratio, and chromogranin A levels, which reflect the activity of the hypothalamic-pituitary-adrenal axis, according to the presence or absence of psychological stress in patients with gingivitis and periodontitis compared to that in healthy controls. The results showed that salivary cortisol and chromogranin A levels increased with the severity of periodontal disease; their levels were the highest in the periodontitis group and were significantly higher in the following descending order: periodontitis, gingivitis, and healthy control groups. Periodontitis and psychological stress were significant and strong predictors of above-average cortisol levels and cortisol/DHEA ratios.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Biochemistry & Molecular Biology
Nikolay Mehterov, Boyan Vladimirov, Andrea Sacconi, Claudio Pulito, Marcin Rucinski, Giovanni Blandino, Victoria Sarafian
Summary: miR-30c-5p, when downregulated in saliva, shows potential as a novel non-invasive biomarker for early detection of oral squamous cell carcinoma (OSCC).
Review
Pharmacology & Pharmacy
Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Guo, Jiayin Lv, Zhihui Sun, Wei Yang, Bingjin Li, Xin Li, Ranji Cui
Summary: Berberine, a natural alkaloid compound, has been studied for its effects on neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Current evidence shows that it can inhibit neuroinflammation, oxidative stress, and endoplasmic reticulum stress, reducing neuron damage and apoptosis. Further research is needed to fully understand the specific mechanisms involved.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Radoslaw Motkowski, Mateusz Maciejczyk, Marta Hryniewicka, Joanna Karpinska, Bozena Mikoluc
Summary: This study found that statin treatment in children with familial hypercholesterolemia does not significantly affect the concentration of antioxidant vitamins, and there is no risk of adverse effects associated with increased vitamin concentration. Therefore, additional supplementation of antioxidant vitamins or modification of low-fat and low-cholesterol diet is not necessary for pediatric patients treated with statins.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Milosz Nesterowicz, Malgorzata Zendzian-Piotrowska, Jerzy Robert Ladny, Anna Zalewska, Mateusz Maciejczyk
Summary: Amantadine does not significantly affect protein glycoxidation, lacks antioxidant and antiglycation effects, and may even have some glycoxidant, proglycation, and prooxidant properties.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Aleksander Nobis, Daniel Zalewski, Eliza Samaryn, Mateusz Maciejczyk, Anna Zalewska, Napoleon Waszkiewicz
Summary: Depression is a prevalent psychiatric disorder that significantly impacts individuals and public health worldwide. Recent research has focused on identifying biological markers to better understand the underlying mechanisms of depression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Joanna Kaminska, Mateusz Maciejczyk, Agnieszka Cwiklinska, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Summary: This study evaluated the concentration of pro-inflammatory and anti-inflammatory cytokines in CSF and serum of UIA patients, finding that in CSF, most proteins showed significantly higher concentration in UIA patients compared to the control group, while no significant difference was observed in serum. Furthermore, some inflammatory factors were positively or negatively correlated with the size and number of aneurysms.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Nutrition & Dietetics
Elzbieta Supruniuk, Ewa Zebrowska, Mateusz Maciejczyk, Anna Zalewska, Adrian Chabowski
Summary: This study examined the effects of high-protein diets on lipid peroxidation and sphingolipid metabolism in rats. The results showed that high-protein diets significantly impacted hypothalamic metabolic pathways, leading to increased lipid peroxidation, ceramide accumulation, and changes in sphingolipid metabolism.
Article
Immunology
Julita Szulimowska, Anna Zalewska, Katarzyna Taranta-Janusz, Grazyna Marczuk-Kolada, Malgorzata Zendzian-Piotrowska, Mateusz Maciejczyk
Summary: Chronic kidney disease (CKD) is a systemic inflammatory disease that affects multiple organs, including the kidneys, cardiovascular system, and oral cavity. Children with CKD experience reduced saliva secretion (hyposalivation), leading to increased dental caries and impaired quality of life. This study evaluated the inflammatory and anti-inflammatory profile in the saliva of CKD children at different stages of renal failure. The results showed significant changes in salivary cytokines, chemokines, and growth factors in CKD children compared to healthy controls.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Health Care Sciences & Services
Karolina Szuflak, Roksana Malak, Brittany Fechner, Dorota Sikorska, Wlodzimierz Samborski, Ewa Mojs, Karolina Gerreth
Summary: This study investigates the relationship between muscle tightness and drooling during feeding in individuals with cerebral palsy. The results show that the tightness of certain muscles in the head area is correlated with drooling behavior. After a three-month therapeutic intervention, the frequency of drooling during feeding decreased.
Article
Medicine, General & Internal
Justyna Dorf, Konrad Zareba, Anna Pryczynicz, Joanna Matowicka-Karna, Boguslaw Kedra, Piotr Zukowski, Anna Zalewska, Mateusz Maciejczyk
Summary: Gastric cancer is associated with redox imbalance and increased oxidative damage to proteins, lipids, and DNA. Histopathological parameters of the tumor are associated with the level of antioxidants and oxidative damage products. Determination of redox parameters may be useful in the assessment of the tumor progression.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anna Zalewska, Bozena Antonowicz, Julita Szulimowska, Izabela Zieniewska-Siemienczuk, Barbara Lesniewska, Jan Borys, Sara Zieba, Paula Kostecka-Sochon, Malgorzata Zendzian-Piotrowska, Roberto Lo Giudice, Giusseppe Lo Giudice, Piotr Zukowski, Mateusz Maciejczyk
Summary: Although titanium and its alloys have high biocompatibility, there is a growing debate regarding the removal of titanium implants due to potential long-term adverse effects. To enhance the biocompatibility of titanium implants, increasing the thickness of the titanium dioxide passive layer is being explored. In this study, we compared the cytotoxicity, mitochondrial function, and redox balance of fibroblast mitochondria between hard-anodized (type II), standard-anodized (type III), and non-anodized titanium discs. The results showed oxidative stress in fibroblast mitochondria regardless of anodization, but type II anodization prevented changes in complex II activity, had the lowest citrate synthase inhibition, and reduced cytochrome c oxidase inhibition, potentially preventing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dariusz Juchnowicz, Michal Dzikowski, Joanna Rog, Napoleon Waszkiewicz, Kaja Hanna Karakula, Anna Zalewska, Mateusz Maciejczyk, Hanna Karakula-Juchnowicz
Summary: This study assessed the utility of complete blood count (CBC) in the prediction of schizophrenia diagnosis and its relationship with oxidative stress (OS). The findings showed that certain CBC parameters were altered in patients with the first episode of psychosis compared to healthy individuals, and there were various associations between OS and CBC. The study also proposed promising CBC models for distinguishing different patient groups.
Article
Medicine, General & Internal
Monika Kamianowska, Aleksandra Kamianowska, Mateusz Maciejczyk, Anna Kurowska, Bozena Blazewicz, Agnieszka Maria Rogowska, Anna Wasilewska
Summary: This study analyzed the concentrations of renal biomarkers (osteopontin, cystatin C, and NGAL) in neonates and found that prematurity may lead to increased excretion of osteopontin and cystatin C, but not NGAL. The excretion of NGAL and cystatin C may change during the first weeks of a premature neonate's life, but osteopontin does not.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Monika Kamianowska, Agnieszka Rybi-Szuminska, Aleksandra Kamianowska, Mateusz Maciejczyk, Katarzyna Solomianko, Alicja Koput, Anna Wasilewska
Summary: This study aimed to assess the urinary concentration of trefoil factor 3 (TFF3) in healthy term and stable preterm neonates. The results showed higher TFF3/cr. values in preterm neonates compared to term neonates, and male term neonates had increased urinary TFF3 excretion. These findings have important implications for the diagnosis in neonatology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf, Daniel Michalak, Malgorzata Zendzian-Piotrowska, Anna Zalewska, Mateusz Maciejczyk
Summary: This study compares the antioxidant and antiglycation potentials of popular H2 antagonists (ranitidine, cimetidine, and famotidine) on protein glycoxidation. The results show that ranitidine is the only H2 blocker that significantly inhibits protein glycation and has antioxidant properties. It can compete with proteins for the addition of carbonyl groups.
Article
Chemistry, Medicinal
Emilia Szymanska, Joanna Potas, Mateusz Maciejczyk, Magdalena Ewa Sulewska, Malgorzata Pietruska, Anna Zalewska, Aleksandra Pietruska, Katarzyna Winnicka
Summary: This study tested different emulgel compositions for the delivery of delta-aminolevulinic acid and investigated the impact of the drug on the behavior of gelling agents. The results showed that a combination of xanthan and gellan gum enhanced the retention of the emulgels in oral mucosal tissue. In addition, the incorporation of delta-aminolevulinic acid promoted interactions with mucosal tissue. Cytotoxicity studies demonstrated that emulgels based on tragacanth and gellan/xanthan may have a protective effect on the metabolic activity of human gingival fibroblasts and keratinocytes.
Article
Dentistry, Oral Surgery & Medicine
Joanna Toczewska, Dagmara Baczynska, Anna Zalewska, Mateusz Maciejczyk, Tomasz Konopka
Summary: This study evaluated the expression of genes encoding antioxidant enzymes in the saliva and gingival tissue of patients with periodontitis. The results showed that the expression of GPX1 and TXN1 genes in saliva was significantly higher, while the expression of SOD1, GPX1, and TXN1 genes in gingival tissue was significantly lower in periodontitis patients compared to healthy individuals. Additionally, the activity of GPX1 in unstimulated saliva, SOD1 in stimulated saliva, and both antioxidant enzymes in gingival crevicular fluid were lower in periodontitis patients.
DENTAL AND MEDICAL PROBLEMS
(2023)
