Article
Microbiology
Weiwei Ni, Xinwei Jiao, Huihuang Zou, Mengjuan Jing, Ming Xia, Shichao Zhu, Liming Li
Summary: This study aimed to explore the characteristics of gut microbiota changes in patients with Enteral Nutrition-related Diarrhea (END). The results showed that END patients had lower bacterial richness and diversity compared to patients without END. Additionally, END caused significant changes in bacterial composition.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mariya V. Gryaznova, Yuliya D. Dvoretskaya, Mikhail Y. Syromyatnikov, Sergey V. Shabunin, Pavel A. Parshin, Evgeniy V. Mikhaylov, Nikolay A. Strelnikov, Vasily N. Popov
Summary: This study investigated the microbiome composition of different sections of the piglet intestine and found that Lactobacillus was the most common genus in the ileum, while Fusobacterium and Bacteroides dominated in the rectum. Comparing the microbiome composition of healthy and diarrheal piglets revealed a decrease in Lactobacillus and an increase in Escherichia-Shigella, Enterococcus, and a decrease in Bacteroides in diarrheal piglets, indicating their contribution to the development of diarrhea.
Article
Food Science & Technology
Marek Aljewicz, Beata Nalepa, Slawomir Ciesielski
Summary: This study investigated the impact of different β-glucans on the gut microbiome in rats and found that oat β-glucan and curdlan increased the abundance of specific bacterial genera, while a positive correlation was observed between Streptococcus bacteria and the growth rate of rats. Consuming β-glucans at the recommended dose by EFSA did not significantly alter the structure of the gut microbiome in rats.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Veterinary Sciences
Li Xi, Yumin Song, Xinxi Qin, Jincheng Han, Yung-Fu Chang
Summary: By comparing the gut microbial composition of healthy and diarrheic giraffes, this study found that diarrhea significantly impacts the diversity and composition of the gut microbiota by increasing the proportion of pathogenic bacteria and decreasing beneficial bacteria. It also identified specific changes in bacterial phyla and genera, providing insights for establishing prevention and treatment strategies for diarrhea in giraffes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Zhou-Lin Wu, Ranlei Wei, Xueqin Tan, Danjiao Yang, Dayu Liu, Jiamin Zhangl, Wei Wangl
Summary: The gut microbial community of diarrheic yaks showed a decrease in alpha diversity and changes in beta diversity compared to healthy yaks. Bacterial taxonomic analysis revealed differences in the relative abundance of certain phyla and genera between the two groups. These findings provide a theoretical basis for the prevention and treatment of yak diarrhea.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Xiaolin Liu, Nina van Beek, Aleksa Cepic, Nadia A. Andreani, Cecilia J. Chung, Britt M. Hermes, Kaan Yilmaz, Sandrine Benoit, Kossara Drenovska, Sascha Gerdes, Regine Glaeser, Matthias Goebeler, Claudia Guenther, Anabelle von Georg, Christoph M. Hammers, Maike M. Holtsche, Franziska Huebner, Dimitra Kiritsi, Franziska Schauer, Beke Linnenmann, Laura Huilaja, Kaisa Tasanen-Maatta, Snejina Vassileva, Detlef Zillikens, Christian D. Sadik, Enno Schmidt, Saleh Ibrahim, John F. Baines
Summary: Bullous pemphigoid patients have altered gut microbiota composition and function, with decreased microbial diversity and overall changed microbial community. Disease-associated gut microbial features, including reduced Faecalibacterium prausnitzii and increased pathways related to gamma-aminobutyric acid metabolism, are observed in BP patients. These findings suggest that gut microbiota alterations may play a role in the development of bullous pemphigoid.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Zhimin Su, Linbin Lu, Fuyu Chen, Jianhui Chen, Xiong Chen
Summary: This study identified a relationship between gut microbiota and sunitinib-induced diarrhea, with higher abundance of mucus degrading bacteria and lower abundance of butyrate-producing bacteria in patients with diarrhea. Additionally, Actinobacteria abundance was decreased in patients receiving sunitinib with severe diarrhea.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Fisheries
Olga Burtseva, Anna Kublanovskaya, Tatiana Fedorenko, Elena Lobakova, Konstantin Chekanov
Summary: This study revealed the previously undescribed bacterial diversity in the White Sea fish gut microbiota using 16S rRNA metabarcoding, showing specific patterns of bacteria common in the water of this region.
Article
Biochemistry & Molecular Biology
Casey T. Finnicum, Zahraa Rahal, Maya Hassane, Warapen Treekitkarnmongkol, Ansam Sinjab, Rhiannon Morris, Yuejiang Liu, Elizabeth L. Tang, Sarah Viet, Jason L. Petersen, Philip L. Lorenzi, Lin Tan, Joseph Petrosino, Kristi L. Hoffman, Junya Fujimoto, Seyed Javad Moghaddam, Humam Kadara
Summary: Research has shown that exposure to tobacco carcinogens leads to significant changes in the gut and lung microbiomes, which are associated with the development of lung adenocarcinoma (LUAD) and immunotherapeutic response in human lung cancer patients. Loss of the bacterial growth inhibitor Lcn2 also results in widespread changes in the gut and lung microbiomes. These findings shed light on the role of microbial phenotypes in the development of tobacco-associated LUAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Kang Xiao, Zhengyu Chen, Qin Long
Summary: Microbial communities on the ocular surface are important for maintaining homeostasis. This study investigated the changes in conjunctival microbiota associated with myopia. Swab specimens were collected from low myopia (LM) and high myopia (HM) patients. Analysis revealed distinct microbiome composition between the two groups, with higher abundances of Proteobacteria and lower abundances of Actinobacteria in the HM group. The levels of Acinetobacter were significantly higher in the HM group compared to the LM group. These findings suggest a bacterial microbiota imbalance in the conjunctival sac of HM patients.
JOURNAL OF MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Stefanie Brezina, Martin Borkovec, Andreas Baierl, Fabienne Bastian, Andreas Futschik, Nikolaus Gasche, Thomas Gruenberger, Michael Hallas, Christian Jannsen, Gernot Leeb, Rebecca Lutz, Barbara Sladek, Andrea Gsur
Summary: The study evaluated the usability of FIT cartridges for microbiome analysis and compared it to Stool Collection and Preservation Tubes. The FIT and Preservation Tube samples had highly similar microbiome profiles, with minor differences between abundances of some bacterial taxa. The results indicate that FIT cartridges are suitable for gut microbiome analysis within CRC screening programs.
Article
Gastroenterology & Hepatology
Zijie Jin, Andy Ng, Corinne F. Maurice, David Juncker
Summary: MiCoMo is a low-cost, benchtop multi-bioreactor system that simulates the human colon environment, allowing for the study of gut microbial communities with high throughput and multiplexing capabilities.
Article
Microbiology
Jyoti Chhimwal, Prince Anand, Priyanka Mehta, Mohit Kumar Swarnkar, Vikram Patial, Rajesh Pandey, Yogendra Padwad
Summary: The importance of the gut-liver axis in the pathophysiology of metabolic dysfunction-associated fatty liver disease (MAFLD) is being investigated more closely in recent times. This study assesses the time-dependent gut dysbiosis in MAFLD, its implications in disease progression, and the role of plant-derived prebiotics in its attenuation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Damian Muszynski, Anna Kudra, Bartosz Kamil Sobocki, Marcin Folwarski, Ermanno Vitale, Veronica Filetti, Wojciech Dudzic, Karolina Kazmierczak-Siedlecka, Karol Polom
Summary: There is an urgent need to find new screening methods for the early detection of esophageal cancer, as this can lead to better clinical outcomes. The dysbiosis of the esophageal microbiome, as well as the oral microbiome, has been found to be associated with the development of esophageal cancer. Therefore, studying the changes in the oral microbiome can help identify markers for early detection of this cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Khui Hung Lee, Jing Guo, Yong Song, Amir Ariff, Michael O'Sullivan, Belinda Hales, Benjamin J. Mullins, Guicheng Zhang
Summary: This study identified Ruminococcaceae UCG-002 as potentially associated with IgE-mediated food allergy using 16S rRNA gene sequencing and network analysis. Functional pathway analysis revealed enrichment of methane metabolism and glycerolipid metabolism in the gut microbiome of food-allergic children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Navin Suthahar, Kan Wang, Victor W. Zwartkruis, Stephan J. L. Bakker, Silvio E. Inzucchi, Tim R. Eijgenraam, Fariba Ahmadizar, Eric G. Sijbrands, Ron T. Gansevoort, Lyanne M. Kieneker, Dirk J. van Veldhuisen, Maryam Kavousi, Rudolf A. de Boer
Summary: Relative fat mass (RFM), a novel anthropometric equation based on height and waist measurements, is strongly associated with incident type-2 diabetes (T2D) and shows potential as a predictor of future diabetes risk in the general population, outperforming BMI, waist circumference, and waist-to-hip ratio.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Elze R. Timmers, J. Casper Swarte, Ranko Gacesa, Johannes R. Bjoerk, Rinse K. Weersma, Marina A. Tijssen, Tom J. de Koning, Hermie J. M. Harmsen, Klary E. Niezen-Koning
Summary: This study investigates the relationship between gut microbiome and (non-)motor symptoms in dystonia, and finds differences in abundance of certain bacteria and alterations in related neuro-active metabolic pathways. It suggests the involvement of the gut-brain axis in the pathophysiology of dystonia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Tim J. Knobbe, Daan Kremer, Rianne M. Douwes, Michele F. Eisenga, Antonio W. Gomes-Neto, Coby Annema, J. Casper Swarte, Frank Klont, Gerjan Navis, Stefan P. Berger, Stephan J. L. Bakker
Summary: Prior studies have shown that the use of proton pump inhibitors (PPIs) can negatively impact gut microbiota and the absorption of micronutrients, such as iron and magnesium. This study aims to investigate the association between PPI use and fatigue and health-related quality of life (HRQoL) in kidney transplant recipients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Gastroenterology & Hepatology
Arnau Vich Vila, Shixian Hu, Sergio Andreu-Sanchez, Valerie Collij, Bernadien H. Jansen, Hannah E. Augustijn, Laura A. Bolte, Renate A. A. A. Ruigrok, Galeb Abu-Ali, Cosmas Giallourakis, Jessica Schneider, John Parkinson, Amal Al-Garawi, Alexandra Zhernakova, Ranko Gacesa, Jingyuan Fu, Rinse K. Weersma
Summary: By analyzing the metabolites in fecal samples of patients with inflammatory bowel disease (IBD) and non-IBD controls, along with fecal metagenomics, host genetics, and clinical characteristics, we aimed to reveal metabolic alterations in IBD. The study identified over 300 molecules that were differentially abundant in the feces of patients with IBD, and a specific ratio between a sphingolipid and L-urobilin could distinguish between IBD and non-IBD samples. Additionally, strong associations were found between gut microbiota and fecal metabolome, paving the way for future interventions targeting intestinal inflammation.
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Amaal E. Abdulle, Martin F. Bourgonje, Lyanne M. Kieneker, Sacha la Bastide-van Gemert, Sanne J. Gordijn, Clara Hidden, Tom Nilsen, Ron T. Gansevoort, Douwe J. Mulder, Robin P. F. Dullaart, Martin H. de Borst, Stephan J. L. Bakker, Harry van Goor
Summary: Circulating levels of NGAL are associated with acute kidney injury, severity and progression of CKD. This study investigated NGAL as a potential biomarker for new-onset CKD and found that higher plasma NGAL concentrations are associated with an increased risk of developing CKD in the general population, mainly driven by renal function decline.
Article
Biochemistry & Molecular Biology
Maria Camila Trillos-Almanza, Hanna Wessel, Magnolia Martinez-Aguilar, Eline H. van den Berg, Rianne M. Douwes, Han Moshage, Margery A. Connelly, Stephan J. L. Bakker, Vincent E. de Meijer, Robin P. F. Dullaart, Hans Blokzijl
Summary: Decreased circulating BCAA levels in end-stage liver disease (ESLD) patients are associated with disease severity and impaired muscle function. These findings suggest that BCAA may serve as a useful prognostic marker for assessing liver disease severity.
Article
Biochemistry & Molecular Biology
Manuela Yepes-Calderon, Daan Kremer, Adrian Post, Camilo G. G. Sotomayor, Ulrike Seidel, Patricia Huebbe, Tim J. J. Knobbe, Kai Lueersen, Michele F. F. Eisenga, Eva Corpeleijn, Martin H. H. De Borst, Gerjan J. J. Navis, Gerald Rimbach, Stephan J. L. Bakker
Summary: A study found that kidney transplant recipients have an increased risk of cardiovascular mortality. It also revealed an association between post-transplantation copper status and the risk of cardiovascular mortality, with a potential effect modification by sex. Among male recipients, higher plasma copper concentration was independently associated with a higher risk of cardiovascular mortality, while this association was absent among female recipients.
Article
Biochemistry & Molecular Biology
Martin F. F. Bourgonje, Amaal E. E. Abdulle, Lyanne M. M. Kieneker, Sacha la Bastide-van Gemert, Stephan J. L. Bakker, Ron T. T. Gansevoort, Sanne J. J. Gordijn, Harry van Goor, Arno R. R. Bourgonje
Summary: Oxidative stress is important in cardiovascular disease, and current biomarkers are insufficient for predicting cardiovascular events. This study assessed the utility of redox-related biomarkers in predicting cardiovascular events and all-cause mortality in a population-based cohort. The levels of homocysteine, gamma-GT, HDL cholesterol, bilirubin, and protein-adjusted free thiol were analyzed, and lower levels of protein-adjusted R-SH were associated with an increased risk of cardiovascular events and all-cause mortality in men. The study highlights the value of R-SH levels in cardiovascular risk assessment and the importance of other oxidative stress-related biomarkers.
Article
Medicine, General & Internal
Evelien E. Quint, Avril J. Haanstra, Yvonne van der Veen, Heleen Maring, Stefan P. Berger, Adelita Ranchor, Stephan J. L. Bakker, Evelyn Finnema, Robert A. Pol, Coby Annema, PreCareTx Investigators
Summary: The study aims to examine the effectiveness of a multimodal prehabilitation programme on the health status of kidney transplant candidates, and to explore the potential of implementing prehabilitation in daily clinical practice. The study will be conducted as a randomized controlled trial, with participants assigned to either a prehabilitation group or a care as usual group. The results of the study will be disseminated at international conferences and in peer-reviewed journals.
Letter
Cardiac & Cardiovascular Systems
Tamas Szili-Torok, Yuanxin Xu, Martin H. H. de Borst, Stephan J. L. Bakker, Uwe J. F. Tietge
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Francesco Merlo, Dion Groothof, Farnaz Khatami, Noushin Sadat Ahanchi, Faina Wehrli, Stephan J. L. Bakker, Michele F. Eisenga, Taulant Muka
Summary: The risk of chronic diseases increases with age and after menopause, potentially due to an increase in bodily iron. This study investigated how iron biomarkers change with age, sex, and menopausal status. The results showed that iron accumulates differently depending on sex, age, and menopausal status, with women, especially those in menopause, showing higher iron levels compared to men and premenopausal women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sabrina Pagano, Stephan J. L. Bakker, Catherine Juillard, Robin P. F. Dullaart, Nicolas Vuilleumier
Summary: Alterations in circulating Cytokeratin 18 (CK18) are involved in the progression of NAFLD to NASH and atherogenesis. This study aimed to explore the accuracy of CK18 for identifying NAFLD and CVD risk. Results showed intricate associations between CK18, FLI, and CVD risk scores. M30 was an independent predictor of FLI ≥ 60, while M65 best discriminated NAFLD individuals at very-high 10-year CVD risk. CK18 M65 may represent a candidate biomarker to identify NAFLD individuals at low CVD risk.
Article
Multidisciplinary Sciences
J. Casper Swarte, Tim J. Knobbe, Johannes R. Bjork, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Summary: This study investigates the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients. The results show that multiple bacterial species are associated with lower HRQoL in this population, and physical and mental HRQoL explain a significant part of the variance in the gut microbiome. Additionally, metabolic and neuroactive pathways are also associated with lower HRQoL, suggesting potential modifiable factors to improve HRQoL.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Sara Sokooti, Tamas Szili-Torok, Hiddo J. L. Heerspink, Robin P. F. Dullaart, Stephan J. L. Bakker
Summary: This study found that indirect measures of insulin resistance can predict the development of post-transplantation diabetes mellitus (PTDM) in kidney transplant recipients (KTRs). In addition to the commonly used homeostasis model assessment-insulin resistance (HOMA-IR), insulin-free surrogates of insulin resistance can also be useful in identifying KTRs at risk of PTDM, thereby avoiding the need for measuring insulin.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
S. Brushett, R. Gacesa, A. Vich Vila, M. F. Brandao Gois, S. Andreu-Sanchez, J. C. Swarte, M. A. Y. Klaassen, V. Collij, T. Sinha, L. A. Bolte, J. Wu, M. Swertz, M. L. A. de Kroon, S. A. Reijneveld, C. Wijmenga, R. K. Weersma, J. Fu, H. M. van Loo, A. Kurilshikov, A. Zhernakova
Summary: The gut microbiome is associated with internalizing disorders, independent of psychotropic drug use.