Article
Biochemical Research Methods
Malvindar K. Singh-Bains, Nasim F. Mehrabi, Adelie Y. S. Tan, Richard L. M. Faull, Mike Dragunow
Summary: Using HBTMA technology can improve the efficiency of discovering and validating drug targets for neurodegenerative disorders by reducing tissue and reagent usage. It allows for simultaneous detection of protein and mRNA locations in a large number of samples.
Review
Biochemistry & Molecular Biology
Kazuki Kodera, Hideaki Matsui
Summary: In recent years, small fishes such as zebrafish, medaka, and turquoise killifish have been recognized as excellent model animals for studying human neurological disorders. These fishes have high genetic and tissue structure homology with humans, as well as unique features that make them suitable for experiments and analysis. They have been extensively used in neurology research, particularly in uncovering the mechanisms of neurodegenerative diseases and neurodevelopmental disorders. Zebrafish and medaka, in particular, have played a significant role in understanding diseases like Parkinson's and Autism Spectrum Disorder. Turquoise killifish has emerged as a unique model animal for aging research and age-related neurological diseases. These small fishes have great potential in improving our understanding of neurological disorders in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Abbas Jalaiei, Mohammad Reza Asadi, Hani Sabaie, Hossein Dehghani, Jalal Gharesouran, Bashdar Mahmud Hussen, Mohammad Taheri, Soudeh Ghafouri-Fard, Maryam Rezazadeh
Summary: Multiple sclerosis (MS) is a common neurodegenerative disease, with lncRNAs playing a crucial role. Studies have shown the significant involvement of lncRNAs in MS, with most lncRNAs exhibiting abnormal expression in MS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Hye-Ji Woo, Mi-Yoon Chang, Jinil Kim, Eun-Jin Bae, Woong Sun, Ju-Hyun Lee, Il-Joo Cho, Hyogeun Shin, Seung-Jae Lee, Sang-Hun Lee
Summary: Loss-of-function mutations of DNAJC6 have been found to cause key pathologic features of Parkinson's disease in human midbrain-like organoids, including mDA neuron degeneration, alpha-synuclein aggregation, increased neuronal firing frequency, and mitochondrial and lysosomal dysfunctions. The defects in DNAJC6-mediated endocytosis impair the WNT-LMX1A signal during mDA neuron development, leading to the generation of vulnerable neurons with pathologic manifestations. These findings provide insights into disease mechanisms and potential therapeutic interventions for DNAJC6-PD.
Review
Biochemistry & Molecular Biology
Panka Pinter, Alan Alpar
Summary: The focus of this study is on changes in the extracellular matrix in neurodegenerative disorders. The composition of the extracellular matrix is critical for neuronal function, and changes in its assembly can trigger or reflect dysfunction in the brain/spinal cord. The study summarizes the phenotypic appearance, biochemical characteristics, and major enzymes involved in regulating and remodeling the extracellular matrix in disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lukasz Brylinski, Katarzyna Kostelecka, Filip Wolinski, Piotr Duda, Joanna Gora, Michal Granat, Jolanta Flieger, Grzegorz Teresinski, Grzegorz Buszewicz, Ryszard Sitarz, Jacek Baj
Summary: Aluminium (Al) is widely present in the Earth's crust and its role in the pathogenesis of neurological diseases is still debated. This review examines Al toxicokinetics and its involvement in several diseases, including Alzheimer's disease, autism spectrum disorder, alcohol use disorder, multiple sclerosis, Parkinson's disease, and dialysis encephalopathy. The literature suggests excessive Al accumulation in the central nervous system in these diseases, as well as epidemiological links between Al exposure and increased disease prevalence. Al also shows potential as a disease marker and the use of Al chelators has beneficial effects in some cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ramin Lotfi, Rasoul Nasiri Kalmarzi, Misagh Rajabinejad, Sabah Hasani, Fatemeh Zamani
Summary: The semaphorins play important roles in both the nervous system and the immune system, participating in various physiological and pathological immune responses, particularly in immunological disorders. They transduce signals by connecting to their receptors, with some molecules promoting remyelination while others inhibiting this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sajad Najafi, Seyed Mohsen Aghaei Zarch, Jamal Majidpoor, Safoora Pordel, Shahin Aghamiri, Mohammed Fatih Rasul, Yahya Asemani, Omid Vakili, Vida Mohammadi, Ahmad Movahedpour, Nahid Arghiani
Summary: Circular RNAs (circRNAs) are a new class of non-coding RNAs with a closed loop structure, resistant to degrading enzymes, and suggested to have regulatory roles in gene expression. In the human brain, circRNAs show abundance, dynamic expression, and regulation, and are believed to be involved in brain functions and related diseases. They have demonstrated differential expression in brain compartments and contribute to CNS development. Additionally, circRNAs are associated with key pathways involved in brain development, such as axon guidance and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Shichen Wu, Junkai Xie, Han Zhao, Oscar Sanchez, Xihui Zhao, Jennifer L. Freeman, Chongli Yuan
Summary: GenX, a safer alternative to PFOA, has raised safety concerns due to its association with various organ damages. This study systematically assessed the molecular neurotoxicity of low-dose GenX exposure, revealing persistent changes in nuclear morphology, chromatin arrangements, and neuronal characteristics, suggesting GenX as a potential neurotoxin and risk factor for Parkinson's disease.
Article
Environmental Sciences
Haneen Khreis, Christiaan Bredell, Kwan Wai Fung, Lucy Hong, Magdalena Szybka, Veronica Phillips, Ali Abbas, Youn-Hee Lim, Zorana Jovanovic Andersen, James Woodcock, Carol Brayne
Summary: The study aims to investigate whether long-term exposure to ambient air pollution increases the risk of neurodegenerative diseases in adults and to perform a meta-analysis on this association. Current evidence in this field remains inconsistent and limited, highlighting the need for further comprehensive synthesis and analysis.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Soo-hyun Kim, Mi-Yoon Chang
Summary: Brain organoids derived from human pluripotent stem cells provide an accurate representation of human brain development and function, making them suitable models for neurodevelopmental diseases. Studies have focused on overcoming the limitations of these organoids, such as cellular stress and limited maturation, to enhance their usefulness. Additionally, brain organoid-derived cells show potential for cell replacement therapy in disease treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Dimitrios Tsitsipatis, Krystyna Mazan-Mamczarz, Ying Si, Allison B. Herman, Jen-Hao Yang, Abhishek Guha, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Rachel Munk, Xiaoling Yang, Supriyo De, Brijesh K. Singh, Ritchie Ho, Myriam Gorospe, Peter H. King
Summary: This study identified differentially abundant circRNAs in ALS-relevant tissues, such as muscle and spinal cord, and revealed the expression patterns of these circRNAs in different stages of the disease. These findings help understand the neuromuscular molecular programs in ALS and could potentially guide the development of therapies.
Review
Medicine, General & Internal
Alessia Ciancio, Maria Claudia Moretti, Antimo Natale, Alessandro Rodolico, Maria Salvina Signorelli, Antonino Petralia, Mario Altamura, Antonello Bellomo, Aurora Zanghi, Emanuele D'Amico, Carlo Avolio, Carmen Concerto
Summary: This study investigated the relationship between personality traits and fatigue in patients with multiple sclerosis (MS). The findings suggest a correlation between neuroticism and fatigue, but there is inconsistency in the assessment of fatigue, personality, and covariates. Further homogeneous and longitudinal studies are needed to draw firm conclusions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Delsuz Rezaee, Fatemeh Saadatpour, Nayyereh Akbari, Anahita Zoghi, Sajad Najafi, Parisa Beyranvand, Fahimeh Zamani-Rarani, Mohammad Amin Rashidi, Saeid Bagheri-Mohammadi, Mohammad Bakhtiari
Summary: MicroRNAs (miRNAs) have been found to play significant roles in regulating the development and functions of the central nervous system (CNS). Dysregulation of miRNAs has been associated with various neurodegenerative diseases and CNS tumors. They affect the expression of key genes and proteins involved in the pathogenesis of these diseases.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Jana Lizrova Preiningerova, Zuzana Jiraskova Zakostelska, Adhish Srinivasan, Veronika Ticha, Ivana Kovarova, Pavlina Kleinova, Helena Tlaskalova-Hogenova, Eva Kubala Havrdova
Summary: This article discusses the relationship between gut microbiota and the pathophysiology of multiple sclerosis (MS), emphasizing the importance of further research and understanding of the role of microbiota in MS treatment.
Article
Biochemistry & Molecular Biology
Emma Shardlow, Cassandra Rao, Roman Sattarov, Ling Wu, Paul E. Fraser, Christopher Exley
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Article
Neurosciences
Matthew Mold, Caroline Linhart, Johana Gomez-Ramirez, Andres Villegas-Lanau, Christopher Exley
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Letter
Biochemistry & Molecular Biology
Christopher Exley
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Chemistry, Physical
Christopher Exley, Gea Guerriero, Xabier Lopez
Review
Cell Biology
Gea Guerriero, Ian Stokes, Nathalie Valle, Jean-Francois Hausman, Christopher Exley
Article
Environmental Sciences
Caroline Linhart, Simona Panzacchi, Fiorella Belpoggi, Peter Clausing, Johann G. Zaller, Koen Hertoge
Summary: This study confirms widespread pesticide contamination of public sites within intensively managed agricultural areas. Pesticide residues were also found in periods with little or no pesticide application in the field (autumn and winter).
ENVIRONMENTAL SCIENCES EUROPE
(2021)
Correction
Environmental Sciences
Caroline Linhart, Simona Panzacchi, Fiorella Belpoggi, Peter Clausing, Johann G. Zaller, Koen Hertoge
ENVIRONMENTAL SCIENCES EUROPE
(2021)
Article
Biochemistry & Molecular Biology
Emma Shardlow, Caroline Linhart, Sameerah Connor, Erin Softely, Christopher Exley
Summary: The study measured the aluminium content of thirteen infant vaccines, finding that only three vaccines contained the amount indicated by the manufacturer. Six vaccines had a greater quantity of aluminium, while four vaccines had a lower quantity. The data raised questions about the significance of aluminium content in vaccines and highlighted areas of limited information. Monitoring the aluminium content in vaccines is crucial for ensuring both efficacy and safety, given the known toxicity of aluminium in humans.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emma Shardlow, Bakhtbilland Khan, Christopher Exley
Summary: This study investigated the impact of different metal ions on the aggregatory behavior and size of A beta(1-42) under simulated physiological conditions. The results showed that Al3+ ions stabilized smaller, toxic intermediates while excess Cu2+ facilitated the formation of larger, more inert species. This suggests a complex relationship between metal ions and the toxicity of A beta(1-42).
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Environmental Sciences
Ramona Cech, Johann G. Zaller, Angeliki Lyssimachou, Peter Clausing, Koen Hertoge, Caroline Linhart
Summary: This study analyzed data on pesticide residues in grass samples collected over six years in the Autonomous Province of Bolzano-South Tyrol, Italy. The results indicate that measures to reduce pesticide drift have not been sufficient to eliminate substantial risks to human health and the environment in nontarget areas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Caroline Silveira Martinez, Jose Antonio Uranga-Ocio, Franck Maciel Pecanha, Dalton Valentim Vassallo, Christopher Exley, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can protect rats from the effects of long-term exposure to high and low levels of aluminum in the diet on reproductive function. The supplementation of EWH can reduce inflammation and oxidative stress in the reproductive organs, and maintain normal sperm production and quality.
Article
Multidisciplinary Sciences
Christopher Exley, Matthew J. Mold