Journal
COATINGS
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/coatings10010023
Keywords
CAUTI; antimicrobial compounds; coatings; urinary catheters; microbial; surface modifications; biofilm
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Funding
- Catalyst Seed Grant from the University of Notre Dame
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Urinary catheters are common medical devices, whose main function is to drain the bladder. Although they improve patients' quality of life, catheter placement predisposes the patient to develop a catheter-associated urinary tract infection (CAUTI). The catheter is used by pathogens as a platform for colonization and biofilm formation, leading to bacteriuria and increasing the risk of developing secondary bloodstream infections. In an effort to prevent microbial colonization, several catheter modifications have been made ranging from introduction of antimicrobial compounds to antifouling coatings. In this review, we discuss the effectiveness of different coatings in preventing catheter colonization in vitro and in vivo, the challenges in fighting CAUTIs, and novel approaches targeting host-catheter-microbe interactions.
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