Article
Cell Biology
Liu Hong, Chao Yang
Summary: This study found that Eupatilin attenuates postmenopausal osteoporosis through elevating miR-211-5p and repressing the JAK2/STAT3 pathway. The experimental results suggest that Eupatilin promotes the proliferation and mineralization of osteoblasts, improving the pathological conditions of osteoporotic rats.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Matheus Pereira de Brito Mateus, Renan Francisco Rimoldi Tavanti, Tauan Rimoldi Tavanti, Elcio Ferreira Santos, Arshad Jalal, Andre Rodrigues dos Reis
Summary: Selenium deficiency in Brazilian soils and foods has been confirmed, and foliar application of selenium can increase photosynthetic pigment concentration, decrease lipid peroxidation, and enhance antioxidative enzyme activity in coffee plants, leading to higher yield and quality of grains.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chih-Yu Peng, Che-Yi Lin, Szu-Han Chen, Yi-Wen Liao, Cheng-Chia Yu, Shiao-Pieng Lee
Summary: The study revealed that miR-1266-5p is significantly overexpressed in oral cancer cells and its downregulation can inhibit the proliferation, migration, and invasion abilities of oral cancer cells, while also reducing the oncogenic and metastatic potential of oral cancer by targeting DAB2IP.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Food Science & Technology
Yunika Mayangsari, Mayu Okudaira, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Research showed that DMF can enhance intestinal TJ barrier integrity by increasing the expression of occludin and claudin-1, while reducing the expression of claudin-2. This regulation involves the induction of occludin protein translation via mTOR and silencing Cldn2 mRNA via miR-16-5p.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hanyu Xie, Ziyue Qin, Ziji Ling, Xiao Ge, Hang Zhang, Shuyu Guo, Laikui Liu, Kai Zheng, Hongbing Jiang, Rongyao Xu
Summary: Periodontitis increases the risk of atherosclerotic cardiovascular diseases by causing immune dysfunction through apoptosis induction by Porphyromonas gingivalis (P. gingivalis). It remains unclear whether the accumulation of apoptotic cells during P. gingivalis-accelerated plaque formation is associated with impaired macrophage clearance. This study reveals that smooth muscle cells (SMCs) are more susceptible to P. gingivalis-induced apoptosis than endothelial cells through TLR2 pathway activation. Additionally, large amounts of miR-143/145 released from P. gingivalis-infected SMCs are captured by macrophages and promote Siglec-G transcription, which impairs macrophage efferocytosis. This research provides insights into the mechanism and potential therapeutic strategy for oral pathogen-associated systemic diseases.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Plant Sciences
Maycon Anderson de Araujo, Andressa Aparecida Rodrigues de Melo, Vinicius Martins Silva, Andre Rodrigues dos Reis
Summary: The beneficial effect of selenium on sugarcane includes increased nitrogen assimilation, enhanced antioxidant metabolism, and improved growth and sugar accumulation. Leaf selenium concentration increased under selenium application, leading to increased activities of SOD and APX enzymes. Nitrate reductase activity also increased, resulting in higher total amino acids concentration and improved chlorophyll and carotenoid levels. Selenium positively influenced CO2 assimilation rate, stomatal conductance, and internal CO2 concentration. The optimal selenium application rate for sugarcane growth and sugar concentration was determined to be 10 μmol L-1.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Mamdooh Ghoneum, Shaymaa Abdulmalek
Summary: The study demonstrated that KDP, a lactic acid bacterial strain of Lactobacillus sakei, can significantly enhance mucosal immunity in mice by increasing the production of mucosal-specific immunoglobulin A (IgA). Additionally, KDP showed potent antioxidant and antimicrobial activity. These findings suggest that orally administered KDP may be considered for clinical trials focusing on antigen-specific IgA production.
Article
Biochemistry & Molecular Biology
Chie Nakashima, Rina Fujiwara-Tani, Shiori Mori, Shingo Kishi, Hitoshi Ohmori, Kiyomu Fujii, Takuya Mori, Yoshihiro Miyagawa, Kazuhiko Yamamoto, Tadaaki Kirita, Yi Luo, Hiroki Kuniyasu
Summary: In this study, the researchers identified the role and mechanism of action of HOXA11-AS in human oral squamous cell carcinoma (OSCC). They found that HOXA11-AS promotes NQO1 expression by sponging microRNA-494, while suppressing NQO2 expression via recruitment of EZH2 to the NQO2 promoter. These changes in enzyme activities affect cellular metabolism, glycolysis, and metastatic potential. Targeting HOXA11-AS may be a potential therapeutic strategy for high-grade OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Chuang Li, Ning Chen, Xingxing Zhang, Khuram Shahzad, Ruxin Qi, Zhenbin Zhang, Zhiqi Lu, Yue Lu, Xiang Yu, Muhammad Hammad Zafar, Mengzhi Wang, Wujun Liu
Summary: The mixed silage had positive effects on the growth performance and antioxidant properties of Hu sheep, while also altering the bacterial composition of rumen microbes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tingting Cheng, Cheng Wang, Qianqian Lu, Yuru Cao, Weiwei Yu, Wenzhen Li, Ben Liu, Xue Gao, Junhong Lu, Xiaohong Pan
Summary: This study investigated the mechanism and therapeutic effect of resveratrol in Triple-negative breast cancer (TNBC) under a hypoxic tumor microenvironment. The results showed that low concentrations of resveratrol promoted cell proliferation and migration, while high concentrations inhibited cell growth and induced autophagy and apoptosis. Combining metformin with resveratrol enhanced its antioxidant activity and had a synergistic therapeutic effect on TNBC.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Cho-Yi Chen, Masaoki Kawasumi, Tien-Yun Lan, Chi-Lam Poon, Yi-Sian Lin, Pin-Jou Wu, Yao-Chung Chen, Bing-Hong Chen, Cheng-Hsien Wu, Jeng-Fan Lo, Rueyhung Roc Weng, Yi-Chen Sun, Kai-Feng Hung
Summary: Adaptation to ER stress enhances DNA repair and damage tolerance in cancer cells, leading to resistance to chemotherapeutics such as cisplatin. This is mainly achieved by promoting mesenchymal-epithelial transition, slowing cell-cycle progression, and reducing cisplatin-induced apoptosis, with molecular mechanisms involving up-regulation of PCNA ubiquitination and polymerase eta expression. Resistance to cisplatin was found to be correlated with nuclear translocation of p53 and increased expression of GRP78.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Juliang He, Jian Guan, Shian Liao, Zhenjie Wu, Bin Liu, Hao Mo, Zhenchao Yuan
Summary: The study revealed that CCDC144NL-AS1 plays an oncogenic role in osteosarcoma by binding with miR-490-3p and increasing HMGA2 expression. Suppression of CCDC144NL-AS1 expression can inhibit proliferation, migration, and invasion of osteosarcoma cells, while promoting apoptosis.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Jianqing Zhao, Yijing Zhang, Yixi Chen, Juntao Zhang, Jie Pei, Min Cui, Zhen F. Fu, Ling Zhao, Ming Zhou
Summary: Rabies is a global public health threat with dogs and wild animals as main sources. Oral vaccination is a common method for rabies control, with the challenge being the hostile environment and large quantity of proteases in the gastrointestinal tract. Developing adjuvants with protease inhibitory activity is crucial for improving oral rabies vaccines.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Oncology
Tian Chen, Qibing Chen, Fen Li, Manli Zeng, Bingru Wang, Shiyong Huang, Shiming Chen, Zezhang Tao
Summary: This study investigated the effects of MIF knockdown or overexpression combined with UVB irradiation on the proliferation and apoptosis of OSCC cells. The results showed that MIF expression was significantly higher in OSCC tissues and cell lines. MIF knockdown combined with UVB irradiation inhibited OSCC cell proliferation and induced apoptosis through the mitochondrial pathway and MAPK activation. MIF-targeted therapy combined with UVB irradiation may be a promising approach for treating OSCC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Obstetrics & Gynecology
Sule Yildirim Kopuk, Nida Ozer, Yasemin Cekmez, Asli Cakir, Kiran Gurkan
Summary: This study found that apixaban enhances endometrial receptivity by increasing the expression of integrin beta 3 in rats. This finding provides important guidance for future research.
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2022)
Article
Oncology
Ronald Tutrone, Michael J. Donovan, Phillipp Torkler, Vasisht Tadigotla, Tom McLain, Mikkel Noerholm, Johan Skog, James McKiernan
PROSTATE CANCER AND PROSTATIC DISEASES
(2020)
Article
Urology & Nephrology
James McKiernan, Mikkel Noerholm, Vasisht Tadigotla, Sonia Kumar, Phillipp Torkler, Grannum Sant, Jason Alter, Michael J. Donovan, Johan Skog
Review
Oncology
W. Yu, J. Hurley, D. Roberts, S. K. Chakrabortty, D. Enderle, M. Noerholm, X. O. Breakefield, J. K. Skog
Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.
ANNALS OF ONCOLOGY
(2021)
Article
Urology & Nephrology
Rania El Fekih, James Hurley, Vasisht Tadigotla, Areej Alghamdi, Anand Srivastava, Christine Coticchia, John Choi, Hazim Allos, Karim Yatim, Juliano Alhaddad, Siawosh Eskandari, Philip Chu, Albana B. Mihali, Isadora T. Lape, Mauricio P. Lima Filho, Bruno T. Aoyama, Anil Chandraker, Kassem Safa, James F. Markmann, Leonardo V. Riella, Richard N. Formica, Johan Skog, Jamil R. Azzi
Summary: The study demonstrates that urinary exosomal mRNA signatures are a powerful and noninvasive tool for screening kidney allograft rejection, with high predictive performance. The signatures can differentiate between different types of rejection and assist clinicians in therapeutic decision making.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Oncology
Erik Margolis, Gordon Brown, Alan Partin, Ballentine Carter, James McKiernan, Ronald Tutrone, Phillipp Torkler, Christian Fischer, Vasisht Tadigotla, Mikkel Noerholm, Michael J. Donovan, Johan Skog
Summary: The EPI test is a reliable noninvasive method that can discriminate between high-grade prostate cancer, low-grade cancer, and benign diseases. By pooling data from three independent studies, it was found that the EPI test performs better in distinguishing between prostate cancer pathologies (GG1 and GG2 and above).
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Urology & Nephrology
Alexander Kretschmer, Ronald Tutrone, Jason Alter, Elena Berg, Christian Fischer, Sonia Kumar, Phillipp Torkler, Vasisht Tadigotla, Michael Donovan, Grannum Sant, Johan Skog, Mikkel Noerholm
Summary: The study found that the EPI urine biomarker outperformed multivariate risk calculators in a group of pre-biopsy men. The EPI score was associated with low-risk pathology post-RP, with potential implications on AS decisions.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Multidisciplinary Sciences
Erica Frew, Douglas Roberts, Shelly Barry, Matthew Holden, Amanda Restell Mand, Emily Mitsock, Enqing Tan, Wei Yu, Johan Skog
Summary: To address the challenges posed by the novel coronavirus, a cost-effective and rapid SARS-CoV-2 antigen test has been developed, capable of identifying the presence of the virus in patient anterior nares swab samples with high sensitivity and no requirement for equipment or laboratory infrastructure.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Alexander Kretschmer, Holger Kajau, Eric Margolis, Ronald Tutrone, Tobias Grimm, Matthias Trottmann, Christian Stief, Georg Stoll, Christian A. Fischer, Claudia Flinspach, Anja Albrecht, Lisa Meyer, Tina Priewasser, Daniel Enderle, Romy Mueller, Phillipp Torkler, Jason Alter, Johan Skog, Mikkel Noerholm
Summary: Improved risk stratification of patients suspected of prostate cancer prior to biopsy is a clinical need. The non-invasive urine test EPI-CE utilizes RNA from exosomes to provide a risk score for high grade prostate cancer. In a clinical validation study, EPI-CE demonstrated superior performance compared to commonly used risk calculators, providing better risk assessment for patients suspected of prostate cancer.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Sudipto K. Chakrabortty, Yevgenia L. Khodor, Robert R. Kitchen, Dulaney L. Miller, Kailey M. Babcock, Kyle S. Manning, Steven P. Lang, Vasisht Tadigotla, Wei Yu, Eric Bershad, Johan Skog, Susana Zanello
Summary: Molecular profiling is important in space exploration for understanding the effects of environmental exposures on human health and performance. A novel exosome-based platform has been developed for profiling biological processes in body fluids, which has diagnostic applications and can be used to study Space Associated Neuro-Ocular Syndrome and monitor patients with impaired cerebrospinal fluid drainage or elevated intracranial pressure.
Letter
Dermatology
Susana Garcia-Silva, Cristina Vico-Alonso, Lisa Meyer, Daniel Enderle, J. Aquiles Sanchez, Maria del Mar Onteniente, Mikkel Noerholm, Johan Skog, Jose-Luis Rodriguez-Peralto, Pablo-Luis Ortiz-Romero, Hector Peinado
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Oncology
Ronald Tutrone, Ben Lowentritt, Brian Neuman, Michael J. J. Donovan, Elliot Hallmark, T. Jeffrey Cole, Yiyuan Yao, Claire Biesecker, Sonia Kumar, Vinita Verma, Grannum R. R. Sant, Jason Alter, Johan Skog
Summary: In the 5-year follow-up of the prostate biopsy Decision Impact Trial, patient outcomes were assessed based on a pre-biopsy ExoDx Prostate (EPI) score at 2.5 years. The results showed that patients with low-risk EPI scores had lower biopsy rates compared to those with high-risk EPI scores, while patients receiving standard of care had the same biopsy rates regardless of EPI score. Additionally, in the EPI arm, the time to first biopsy was longer for patients with low-risk EPI scores. This study demonstrates that the EPI test risk stratification identifies low-risk patients that are not found with the standard of care.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Georgios Tsakonas, Vasisht Tadigotla, Sudipto K. Chakrabortty, Giuseppe Stragliotto, Dalin Chan, Rolf Lewensohn, Wei Yu, Johan K. Skog, Per Hydbring, Simon Ekman
Summary: In this study, the genetic analysis of cerebrospinal fluid (CSF) and its correlation to associated tumor compartments in non-small cell lung cancer (NSCLC) patients with brain metastases (BM) was investigated. The study found specific variants that could serve as targets for individually tailored therapies in NSCLC patients with BM.
Meeting Abstract
Oncology
B. Spieler, Y. Khodor, S. Chakrabortty, C. Fischer, V. Tadigotla, R. Stoyanova, M. Abramowtiz, S. Punnen, A. Pollack, S. Yu, J. K. Skog, A. Dal Pra, S. M. Gaston
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Meeting Abstract
Oncology
Douglas Roberts, Emily Mitsock, Olubode Ogunlusi, Seth Yu, Johan Skog
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Andrew S. Chi, Daniel P. Cahill, David A. Reardon, Patrick Y. Wen, Tom Mikkelsen, David M. Peereboom, Eric T. Wong, Elizabeth R. Gerstner, Jorg Dietrich, Scott R. Plotkin, Andrew D. Norden, Eudocia Q. Lee, Lakshmi Nayak, Shota Tanaka, Hiroaki Wakimoto, Nina Lelic, Mara V. Koerner, Lindsay K. Klofas, Mia S. Bertalan, Isabel C. Arrillaga-Romany, Rebecca A. Betensky, William T. Curry, Darrel R. Borger, Leonora Balaj, Robert R. Kitchen, Sudipto K. Chakrabortty, Michael D. Valentino, Johan Skog, Xandra O. Breakefield, A. John Iafrate, Tracy T. Batchelor
JCO PRECISION ONCOLOGY
(2020)