The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Reduces Oxidative and Mechanical Stress-Evoked Matrix Degradation in Chondrifying Cell Cultures

(2019) Eszter Szentléleky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age-related alterations of articular cartilage in pituitary adenylate cyclase–activating polypeptide (PACAP) gene–deficient mice

(2019) Vince Szegeczki et al.   GeroScience

Postmenopausal osteoporosis is associated with the regulation of SP, CGRP, VIP, and NPY

(2018) Xiaoguang Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Do Neuroendocrine Peptides and Their Receptors Qualify as Novel Therapeutic Targets in Osteoarthritis?

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of water extract from epimedium on neuropeptide signaling in an ovariectomized osteoporosis rat model

(2018) Hengrui Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts

(2018) Tanja Niedermair et al.   Scientific Reports

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene

(2017) S.C. Warner et al.   EUROPEAN JOURNAL OF PAIN

Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model

(2016) Sang Jun Kim et al.   BIOMATERIALS

Gelatin microspheres containing calcitonin gene-related peptide or substance P repair bone defects in osteoporotic rabbits

(2016) Jianghao Chen et al.   BIOTECHNOLOGY LETTERS

Substance P Promotes the Proliferation, but Inhibits Differentiation and Mineralization of Osteoblasts from Rats with Spinal Cord Injury via RANKL/OPG System

(2016) Hai-Juan Liu et al.   PLoS One

Inhibition of substance P signaling aggravates the bone loss in ovariectomy-induced osteoporosis

(2016) Xin-Feng Zheng et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue

(2015) Barbara Lisowska et al.   PLoS One

Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification

(2014) Tanja Niedermair et al.   MATRIX BIOLOGY

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Signalling Exerts Chondrogenesis Promoting and Protecting Effects: Implication of Calcineurin as a Downstream Target

(2014) Tamás Juhász et al.   PLoS One

NK1 Receptor Blockade Is Ineffective in Improving Outcome following a Balloon Compression Model of Spinal Cord Injury

(2014) Anna Victoria Leonard et al.   PLoS One

The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology

(2014) Susanne Grässel   ARTHRITIS RESEARCH & THERAPY

Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12

(2013) B. M. Janelsins et al.   BLOOD

Substance P Signaling Controls Mast Cell Activation, Degranulation, and Nociceptive Sensitization in a Rat Fracture Model of Complex Regional Pain Syndrome

(2012) Wen-Wu Li et al.   ANESTHESIOLOGY

Control of Arthritis Pain with Anti–Nerve-Growth Factor: Risk and Benefit

(2012) Matthias F. Seidel et al.   Current Rheumatology Reports

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis

(2011) Alfred Opolka et al.   ARTHRITIS AND RHEUMATISM

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Substance P–Neurokinin-1 receptor interaction upregulates monocyte tissue factor

(2011) Mohammad M. Khan et al.   JOURNAL OF NEUROIMMUNOLOGY

Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats

(2010) Francis FY Lam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro

(2009) Liping Wang et al.   BONE

Changes of substance P during fracture healing in ovariectomized mice

(2009) Wen-Ge Ding et al.   REGULATORY PEPTIDES

Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc

(2009) Stephen M Richardson et al.   ARTHRITIS RESEARCH & THERAPY

Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption

(2008) Masaru Yamaguchi et al.   AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factor

(2008) M.R. Howard et al.   NEUROPEPTIDES

Interleukin (IL)-1 regulates ozone-enhanced tracheal smooth muscle responsiveness by increasing substance P (SP) production in intrinsic airway neurons of ferret

(2008) Z.-X. Wu et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

(2008) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY