TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation

NLRC5 negatively regulates LTA‐induced inflammation via TLR2/NF‐κB and participates in TLR2‐mediated allergic airway inflammation

(2019) Muzi Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation through toll‐like receptor 2 on group 2 innate lymphoid cells can induce asthmatic characteristics

(2019) Takashi Ishii et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Airway epithelial TSLP production of TLR2 drives type 2 immunity in allergic airway inflammation

(2018) Jiajia Lv et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Melatonin suppresses TLR9-triggered proinflammatory cytokine production in macrophages by inhibiting ERK1/2 and AKT activation

(2018) Xiongfei Xu et al.   Scientific Reports

Sodium Phenylbutyrate Ameliorates Inflammatory Response Induced by Staphylococcus aureus Lipoteichoic Acid via Suppressing TLR2/NF-κB/NLRP3 Pathways in MAC-T Cells

(2018) Xin Wang et al.   MOLECULES

TLR9-based immunotherapy for the treatment of allergic diseases

(2017) Shokrollah Farrokhi et al.   Immunotherapy

Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome

(2017) Zhengwang Cao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease

(2016) Seonmin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

JNK-TLR9 signal pathway mediates allergic airway inflammation through suppressing melatonin biosynthesis

(2016) Hui-Mei Wu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma

(2016) Zhiyong Dong et al.   MEDIATORS OF INFLAMMATION

Toll-like receptors as targets for allergen immunotherapy

(2015) Zahra Aryan et al.   Current Opinion in Allergy and Clinical Immunology

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

(2015) Hideaki Morita et al.   IMMUNITY

Lipoteichoic acid modulates inflammatory response in macrophages after phagocytosis of titanium particles through Toll-like receptor 2 cascade and inflammasomes

(2015) Yasushi Naganuma et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Helicobacter urease–induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma

(2015) Katrin N. Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

Ovalbumin-induced experimental allergic asthma is Toll-like receptor 2 dependent

(2014) Xiaodi Li et al.   ALLERGY AND ASTHMA PROCEEDINGS

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Inflammasomes in Respiratory Disease

(2014) Guy G. Brusselle et al.   CHEST

Melatonin reduces airway inflammation in ovalbumin-induced asthma

(2014) In-Sik Shin et al.   IMMUNOBIOLOGY

TLR Expression on Neutrophils at the Pulmonary Site of Infection: TLR1/TLR2-Mediated Up-Regulation of TLR5 Expression in Cystic Fibrosis Lung Disease

(2014) B. Koller et al.   JOURNAL OF IMMUNOLOGY

Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells

(2014) In-Sik Shin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling

(2014) In-Sik Shin et al.   JOURNAL OF PINEAL RESEARCH

Regulation of TLR2 and NLRP3 in Primary Murine Renal Tubular Epithelial Cells

(2014) Sashi G. Kasimsetty et al.   NEPHRON CLINICAL PRACTICE

The NLRP3 inflammasome: role in airway inflammation

(2013) H. Im et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation

(2013) Ourania Koltsida et al.   EMBO Molecular Medicine

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

(2013) J. L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammasome-Mediated Secretion of IL-1  in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids

(2013) R. G. Snodgrass et al.   JOURNAL OF IMMUNOLOGY

The role of melatonin in the cells of the innate immunity: a review

(2013) Juan R. Calvo et al.   JOURNAL OF PINEAL RESEARCH

Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma

(2012) D. S. Ferreira et al.   CLINICAL AND EXPERIMENTAL ALLERGY

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages

(2012) Yu Qiao et al.   FEBS LETTERS

Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice

(2012) I. C. Allen et al.   JOURNAL OF IMMUNOLOGY

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

(2012) Mi-Zhen Xia et al.   JOURNAL OF PINEAL RESEARCH

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant

(2011) A.-G. Besnard et al.   ALLERGY

Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway

(2011) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Evidence of immune system melatonin production by two pineal melatonin deficient mice, C57BL/6 and Swiss strains

(2009) Araceli Gómez-Corvera et al.   JOURNAL OF PINEAL RESEARCH

Melatonin levels and enzymatic antioxidant defense system decrease in blood of patients with bronchial asthma

(2009) N Gumral et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-B activation in respiratory syncytial virus-infected RAW264.7 macrophages

(2008) Sheng-Hai Huang et al.   JOURNAL OF PINEAL RESEARCH

Division of labor between dendritic cell subsets of the lung

(2008) C H GeurtsvanKessel et al.   Mucosal Immunology