Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect

(2019) Yuxiao Lai et al.   BIOMATERIALS

A Magnesium‐Enriched 3D Culture System that Mimics the Bone Development Microenvironment for Vascularized Bone Regeneration

(2019) Sihan Lin et al.   Advanced Science

The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway

(2019) Chu-Chih Hung et al.   Acta Biomaterialia

Magnesium alloy based interference screw developed for ACL reconstruction attenuates peri-tunnel bone loss in rabbits

(2018) Jiali Wang et al.   BIOMATERIALS

An innovative Mg/Ti hybrid fixation system developed for fracture fixation and healing enhancement at load-bearing skeletal site

(2018) Li Tian et al.   BIOMATERIALS

Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration

(2018) Alessandra Marrella et al.   Materials Today

Current status and outlook on the clinical translation of biodegradable metals

(2018) Hyung-Seop Han et al.   Materials Today

High Magnesium Corrosion Rate has an Effect on Osteoclast and Mesenchymal Stem Cell Role During Bone Remodelling

(2018) Diana Maradze et al.   Scientific Reports

Hybrid fracture fixation systems developed for orthopaedic applications: A general review

(2018) Li Tian et al.   Journal of Orthopaedic Translation

Comparison of a resorbable magnesium implant in small and large growing-animal models

(2018) N.G. Grün et al.   Acta Biomaterialia

Corrigendum to ‘An innovative Mg/Ti hybrid fixation system developed for fracture fixation and healing enhancement at load-bearing skeletal site’ [Biomaterials (2018) 173–183]

(2018) Li Tian et al.   BIOMATERIALS

Current development of biodegradable polymeric materials for biomedical applications

(2018) Richard Song et al.   Drug Design Development and Therapy

Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration

(2018) Ryan C. Ransom et al.   NATURE

The effect of surface mechanical attrition treatment on texture evolution and mechanical properties of AZ31 magnesium alloy

(2018) Jinhua Peng et al.   MATERIALS CHARACTERIZATION

Study of corrosion in biocompatible metals for implants: A review

(2017) N.S. Manam et al.   JOURNAL OF ALLOYS AND COMPOUNDS

Enhancement of bone regeneration with the accordion technique via HIF-1α/VEGF activation in a rat distraction osteogenesis model

(2017) Jia Xu et al.   Journal of Tissue Engineering and Regenerative Medicine

Macrophage phagocytosis of biomedical Mg alloy degradation products prepared by electrochemical method

(2017) Jian Zhang et al.   Materials Science & Engineering C-Materials for Biological Applications

The deformation behavior of AZ31 Mg alloy with surface mechanical attrition treatment

(2017) Xiangchen Meng et al.   MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING

Dual-phase nanostructuring as a route to high-strength magnesium alloys

(2017) Ge Wu et al.   NATURE

Biodegradable Magnesium Screws Accelerate Fibrous Tissue Mineralization at the Tendon-Bone Insertion in Anterior Cruciate Ligament Reconstruction Model of Rabbit

(2017) Jiali Wang et al.   Scientific Reports

Angiogenesis Assays for the Evaluation of Angiogenic Properties of Orthopaedic Biomaterials - A General Review

(2017) Wai Ching Liu et al.   Advanced Healthcare Materials

Atypical femoral fractures related to bisphosphonate treatment

(2017) A. Koh et al.   Bone & Joint Journal

Bone biomaterials and interactions with stem cells

(2017) Chengde Gao et al.   Bone Research

Biomechanical comparison of pure magnesium interference screw and polylactic acid polymer interference screw in anterior cruciate ligament reconstruction—A cadaveric experimental study

(2017) Bin Song et al.   Journal of Orthopaedic Translation

In vitro and in vivo responses of macrophages to magnesium-doped titanium

(2017) Bin Li et al.   Scientific Reports

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

(2016) Katharina Jähn et al.   Acta Biomaterialia

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

(2016) Di Tie et al.   Acta Biomaterialia

Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head

(2016) Dewei Zhao et al.   BIOMATERIALS

Magnesium from bioresorbable implants: Distribution and impact on the nano- and mineral structure of bone

(2016) T.A. Grünewald et al.   BIOMATERIALS

High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF

(2016) Pengfei Cheng et al.   BIOMATERIALS

The association of race/ethnicity and risk of atypical femur fracture among older women receiving oral bisphosphonate therapy

(2016) Joan C. Lo et al.   BONE

Fracture healing in osteoporotic bone

(2016) Wing Hoi Cheung et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Incidence of Atypical Femur Fractures in Cancer Patients: The MD Anderson Cancer Center Experience

(2016) Beatrice J Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Magnesium ring device to restore function of a transected anterior cruciate ligament in the goat stifle joint

(2016) Kathryn F. Farraro et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A comparative study of zinc, magnesium, strontium-incorporated hydroxyapatite-coated titanium implants for osseointegration of osteopenic rats

(2016) Zhou-Shan Tao et al.   Materials Science & Engineering C-Materials for Biological Applications

Examination of a biodegradable magnesium screw for the reconstruction of the anterior cruciate ligament: A pilot in vivo study in rabbits

(2016) Julia Diekmann et al.   Materials Science & Engineering C-Materials for Biological Applications

Osteoimmunomodulation for the development of advanced bone biomaterials

(2016) Zetao Chen et al.   Materials Today

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

(2016) Yifeng Zhang et al.   NATURE MEDICINE

Neuronal origin of osteogenic effects of magnesium

(2016) David Holmes   Nature Reviews Endocrinology

Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy

(2016) Jee-Wook Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation

(2016) Meng Wang et al.   Biomaterials Science

Review of various treatment options and potential therapies for osteonecrosis of the femoral head

(2016) Huijuan Cao et al.   Journal of Orthopaedic Translation

Atypical femoral fractures and current management

(2016) Nianye Zheng et al.   Journal of Orthopaedic Translation

The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats

(2016) Deni Noviana et al.   Journal of Orthopaedic Translation

Magnesium inference screw supports early graft incorporation with inhibition of graft degradation in anterior cruciate ligament reconstruction

(2016) Pengfei Cheng et al.   Scientific Reports

Biodegradable Magnesium (Mg) Implantation Does Not Impose Related Metabolic Disorders in Rats with Chronic Renal Failure

(2016) Jiali Wang et al.   Scientific Reports

In vivo study of magnesium plate and screw degradation and bone fracture healing

(2015) Amy Chaya et al.   Acta Biomaterialia

Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials

(2015) Jiali Wang et al.   Acta Biomaterialia

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

(2015) Christina Rössig et al.   Acta Biomaterialia

Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture

(2015) Lili Wu et al.   Acta Biomaterialia

In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model

(2015) Pei Han et al.   BIOMATERIALS

Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits

(2015) Ling Qin et al.   BIOMATERIALS

Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism

(2015) Jing Zhang et al.   BIOMATERIALS

Biodegradable magnesium screws and vascularized iliac grafting for displaced femoral neck fracture in young adults

(2015) Xiaobing Yu et al.   BMC MUSCULOSKELETAL DISORDERS

Management of hypertrophic nonunion with failure of internal fixation by distraction osteogenesis

(2015) Jia Xu et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Effect of osteoporosis medications on fracture healing

(2015) V. Hegde et al.   OSTEOPOROSIS INTERNATIONAL

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Animal Models for Evaluation of Bone Implants and Devices

(2015) L. M. Wancket   VETERINARY PATHOLOGY

Metal implant removal: benefits and drawbacks – a patient survey

(2015) Georg Reith et al.   BMC Surgery

The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep

(2015) Ulrich Thormann et al.   Biomed Research International

Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation

(2014) Sayuri Yoshizawa et al.   Acta Biomaterialia

Magnesium alloys as a biomaterial for degradable craniofacial screws

(2014) Sarah E. Henderson et al.   Acta Biomaterialia

Osteoimmunomodulatory properties of magnesium scaffolds coated with β-tricalcium phosphate

(2014) Zetao Chen et al.   BIOMATERIALS

The effect of metallic magnesium degradation products on osteoclast-induced osteolysis and attenuation of NF-κB and NFATc1 signaling

(2014) Zanjing Zhai et al.   BIOMATERIALS

TRPM7 regulates proliferation and polarisation of macrophages

(2014) T. Schilling et al.   JOURNAL OF CELL SCIENCE

Biodegradable metals

(2014) Y.F. Zheng et al.   MATERIALS SCIENCE & ENGINEERING R-REPORTS

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Risk of Atypical Femoral Fracture during and after Bisphosphonate Use

(2014) Jörg Schilcher et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vitro and in vivo evaluation of biodegradable, open-porous scaffolds made of sintered magnesium W4 short fibres

(2013) K. Bobe et al.   Acta Biomaterialia

Loss of mechanical properties in vivo and bone–implant interface strength of AZ31B magnesium alloy screws with Si-containing coating

(2013) Lili Tan et al.   Acta Biomaterialia

Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: short term results of the first prospective, randomized, controlled clinical pilot study

(2013) Henning Windhagen et al.   Biomedical Engineering Online

Corrosion of ultra-high-purity Mg in 3.5% NaCl solution saturated with Mg(OH)2

(2013) Fuyong Cao et al.   CORROSION SCIENCE

Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral Research

(2013) Elizabeth Shane et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Magnesium deficiency results in an increased formation of osteoclasts

(2013) Marina M. Belluci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cytotoxicity studies of AZ31D alloy and the effects of carbon dioxide on its biodegradation behavior in vitro

(2013) Jiali Wang et al.   Materials Science & Engineering C-Materials for Biological Applications

Effect of surface mechanical attrition treatment on biodegradable Mg–1Ca alloy

(2013) N. Li et al.   Materials Science & Engineering C-Materials for Biological Applications

Steroid-Associated Hip Joint Collapse in Bipedal Emus

(2013) Li-Zhen Zheng et al.   PLoS One

The Inhibition of Subchondral Bone Lesions Significantly Reversed the Weight-Bearing Deficit and the Overexpression of CGRP in DRG Neurons, GFAP and Iba-1 in the Spinal Dorsal Horn in the Monosodium Iodoacetate Induced Model of Osteoarthritis Pain

(2013) Degang Yu et al.   PLoS One

Macrophages as potential targets for zoledronic acid outside the skeleton—evidence from in vitro and in vivo models

(2013) T. L. Rogers et al.   CELLULAR ONCOLOGY

Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions

(2013) Sara Castiglioni et al.   Nutrients

Biodegradability engineering of biodegradable Mg alloys: Tailoring the electrochemical properties and microstructure of constituent phases

(2013) Pil-Ryung Cha et al.   Scientific Reports

In vitro and in vivo studies on a Mg–Sr binary alloy system developed as a new kind of biodegradable metal

(2012) X.N. Gu et al.   Acta Biomaterialia

Fast escape of hydrogen from gas cavities around corroding magnesium implants

(2012) Julia Kuhlmann et al.   Acta Biomaterialia

Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant

(2012) Dina Dziuba et al.   Acta Biomaterialia

The in vitro degradation process and biocompatibility of a ZK60 magnesium alloy with a forsterite-containing micro-arc oxidation coating

(2012) Xiao Lin et al.   Acta Biomaterialia

Hydrogen water consumption prevents osteopenia in ovariectomized rats

(2012) Ji-Dong Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Optimal Intensity Shock Wave Promotes the Adhesion and Migration of Rat Osteoblasts via Integrin β1-mediated Expression of Phosphorylated Focal Adhesion Kinase

(2012) Jian-kun Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: A general review

(2012) Jiali Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

Magnesium alloys for temporary implants in osteosynthesis: In vivo studies of their degradation and interaction with bone

(2011) Tanja Kraus et al.   Acta Biomaterialia

Corrosion of high purity Mg, Mg2Zn0.2Mn, ZE41 and AZ91 in Hank’s solution at 37°C

(2011) Nor Ishida Zainal Abidin et al.   CORROSION SCIENCE

Biomedical applications of biodegradable polymers

(2011) Bret D. Ulery et al.   JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS

Tumour macrophages as potential targets of bisphosphonates

(2011) Thea L Rogers et al.   Journal of Translational Medicine

Atypical Femoral Fractures and Bone Turnover

(2011) Sophie A. Jamal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bone lengthening (distraction osteogenesis): a literature review

(2011) F. Sailhan   OSTEOPOROSIS INTERNATIONAL

The history of biodegradable magnesium implants: A review☆

(2010) Frank Witte   Acta Biomaterialia

XPS Studies of Magnesium Surfaces after Exposure to Dulbecco's Modified Eagle Medium, Hank's Buffered Salt Solution, and Simulated Body Fluid

(2010) Di Tie et al.   ADVANCED ENGINEERING MATERIALS

Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials

(2010) Haruhisa Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microstructure, biocorrosion and cytotoxicity evaluations of rapid solidified Mg–3Ca alloy ribbons as a biodegradable material

(2010) X N Gu et al.   Biomedical Materials

Lipopolysaccharide induces calcitonin gene-related peptide in the RAW264.7 macrophage cell line

(2010) Weiya Ma et al.   IMMUNOLOGY

The Effects of Risedronate and Exercise on Osteoporotic Lumbar Rat Vertebrae and Their Sensory Innervation

(2010) Sumihisa Orita et al.   SPINE

TRPM7 is essential for Mg2+ homeostasis in mammals

(2010) Lillia V. Ryazanova et al.   Nature Communications

A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants

(2009) Hoi Man Wong et al.   BIOMATERIALS

Metal-related artifacts in instrumented spine. Techniques for reducing artifacts in CT and MRI: state of the art

(2009) P. Stradiotti et al.   EUROPEAN SPINE JOURNAL

The influence of osteoporosis in femoral fracture healing time

(2009) Vassilios S. Nikolaou et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Tibial tunnel widening after bioresorbable poly-lactide calcium carbonate interference screw usage in ACL reconstruction

(2009) Casper Foldager et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Revolutionizing biodegradable metals

(2009) Yeoheung Yun et al.   Materials Today

MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants

(2009) Bruno Zberg et al.   NATURE MATERIALS

Biomaterials in orthopaedics

(2008) M Navarro et al.   Journal of the Royal Society Interface

Effect of inorganic salts, amino acids and proteins on the degradation of pure magnesium in vitro

(2008) Akiko Yamamoto et al.   Materials Science & Engineering C-Materials for Biological Applications

Erratum to “Changes of microstructure and mineralized tissue in the middle and late phase of osteoporotic fracture healing in rats” [Bone 41 (2007) 631–638]

(2007) Ying-jie Hao et al.   BONE