Article
Radiology, Nuclear Medicine & Medical Imaging
Dimitri N. Graf, Anne Thallinger, Veronika Zubler, Reto Sutter
Summary: This study found that intraarticular steroid injections have a lower rate of severe complications compared to previous smaller studies, but the rate of complications in women is disproportionately higher than in men.
Article
Engineering, Environmental
Jung Hun Kim, Quanzhe Liu, Uk-Jae Lee, Arun Kumar Rajendran, Minjoon Cho, Sivashanmugam Amirthalingam, Tae Hoon Kang, Beom Seok Kim, Gyeong-Guk Park, Byung-Gee Kim, Jae Hyup Lee, Nathaniel S. Hwang
Summary: Core decompression is a common surgery for early-stage osteonecrosis of the femoral head. However, there is a lack of bone scaffolds that can reduce oxidative stress and inflammation. We introduce an antioxidant-coated bone scaffold that has shown successful bone regeneration and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Bing Xu, Zeyu Luo, Duan Wang, Zeyu Huang, Zongke Zhou, Haoyang Wang
Summary: In this study, a nanocellulose-collagen-nano hydroxyapatite organic-inorganic hybrid aerogel loaded with stromal cell derived factor-1 and sclerostin monoclonal antibody was synthesized and investigated for its ability to repair steroid-induced osteonecrosis. The scaffold demonstrated good elastic modulus, appropriate pore structure, and sustained release of the loaded substances. In vitro and in vivo studies showed promising osteogenesis and tissue repair results.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Yusuke Osawa, Yasuhiko Takegami, Daisaku Kato, Masanori Okamoto, Hiroki Iida, Shiro Imagama
Summary: This study aimed to investigate the process of hip function and secondary osteoarthritis changes in ONFH patients undergoing conservative treatment. The results showed that hip joint function improved in patients with collapse cessation <3 mm after conservative treatment.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Materials Science, Biomaterials
Xinguang Wang, Qirui Guo, Yizhen He, Xiao Geng, Cheng Wang, Yang Li, Zijian Li, Caimei Wang, Dong Qiu, Hua Tian
Summary: In this study, a pH neutral bioactive glass was successfully coated on 3D-printed porous Ti6Al4V scaffolds, promoting osseointegration and bone ingrowth. In vitro and in vivo experiments showed that the coated scaffolds had better biocompatibility and osteogenic capabilities, validating the effectiveness of the coating method.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Engineering, Multidisciplinary
Zhewen Liu, Mei Zhang, Zihang Wang, Yilong Wang, Wenying Dong, Wendi Ma, Shanshan Zhao, Dahui Sun
Summary: By integrating the modified CSMA/POSS bioactive microporous surface with PEEK scaffolds, enhanced protein adsorption and bone formation can be achieved, showing promising potential for improving osseointegration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Orthopedics
Fangjun Xiao, Tengfei Wei, Huan Xiao, Wei He, Qiushi Wei
Summary: This study found that the level of 4-Hydroxynonenal (4-HNE) is negatively associated with the staging of steroid-induced osteonecrosis of the femoral head (SIONFH). Lower levels of 4-HNE may serve as a critical biomarker for the progression of SIONFH.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Bo Liu, Feng Gao, Xiaofei Xiu, Tao Wu, Zeming Liu, Bingshi Zhang, Sikai Liu, Yongtai Han
Summary: This study demonstrates that denosumab has a positive effect in preventing femoral head collapse in patients with steroid-induced ONFH. It can improve the Harris hip score, relieve bone marrow edema, increase bone mineral density in the femoral head, and reduce the progression of osteosclerosis. Additionally, the protective mechanism of denosumab may be associated with the inhibition of osteoclasts and their autophagy.
ORTHOPAEDIC SURGERY
(2023)
Article
Orthopedics
Peng Peng, Mincong He, Weihua Fang, Mengqi Lai, Fangjun Xiao, Wei He, Huan Xiao, Qiushi Wei
Summary: Plasma 8-OHdG may serve as potential biomarkers for different stages of SIONFH. Higher plasma 8-OHdG levels were observed in SIONFH patients compared to healthy controls. The decrease in plasma 8-OHdG levels was associated with higher disease stages.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Tianye Lin, Kaishen Cai, Peng Yang, Shana WuRi, Weijian Chen, Pan Deng, Ziqi Li, Zhenqiu Chen, Wei He, Qingwen Zhang, Qiushi Wei
Summary: The study investigates the predictive effect of composite indices of femoral neck strength on femoral head collapse in steroid-associated osteonecrosis of the femoral head (ONFH) patients. The results suggest that the composite indices are more effective predictors of femoral head collapse compared to bone turnover markers.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Medicine, General & Internal
Lijun Shi, Xu Yang, Peixu Wang, Xiangwei Ma, Dan Li, Xinjie Wu, Fuqiang Gao, Wei Sun
Summary: The study found that ESWT, based on drug treatment, is an effective treatment method for nontraumatic ONFH, which can significantly relieve pain, restore function, and delay the injury of femoral head cartilage.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Orthopedics
Philippe Hernigou
Summary: This study proposes machine learning to analyze the risk factors of collapse in patients with non-traumatic hip osteonecrosis of the femoral head. The study demonstrates the prediction and ranking of factors for collapse using machine learning, and reveals that collapse in these patients is due to multiple risk factors.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Philippe Hernigou, Sophie Verrier, Yasuhiro Homma, Helene Rouard, Charles Henri Flouzat Lachaniette, Karadi Hari Sunil Kumar
Summary: This study aimed to predict the efficiency of cell therapy for hip osteonecrosis using artificial intelligence methods such as machine learning and artificial neural networks. The results showed that the machine learning algorithm for predicting ten year collapse-free survival had good accuracy. By developing a calculator for prognosis hip osteonecrosis cell therapy (PHOCT), this study provides a useful tool for clinical use.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Health Care Sciences & Services
Sion Glyn-Jones, Muhammad K. Javaid, David Beard, Julia Newton, Robert Kerslake, Callum McBryde, Tim Board, Susan J. Dutton, Melina Dritsaki, Vikas Khanduja, Magbor Akanni, Shaun Sexton, John Skinner, Nicholas Peckham, Ruth Knight, Ines Rombach, Loretta Davies, Vicki Barber
Summary: The MANTIS trial aimed to evaluate the clinical effectiveness and cost-effectiveness of alendronate in the treatment of avascular necrosis. However, the trial was limited by a low recruitment rate and difficulties in identifying the disease at an early stage. Future research should involve more research sites and a longer recruitment period, as well as the establishment of a database or registry for collecting data on avascular necrosis patients.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Orthopedics
Ming-Tao Wen, Xue-Zhen Liang, Di Luo, Jia-Cheng Li, Bo-Zhao Yan, Bo-Wen Lu, Yan-Bo Guo, Bo Xu, Gang Li
Summary: This study evaluates the biomechanical implications of the CJFH classification system and hip flexion angles on the necrotic area in ONFH. The findings suggest that the alteration in the mechanical environment of the necrotic area is the primary cause of the observed collapse in osteonecrosis of the femoral head.
ORTHOPAEDIC SURGERY
(2023)
Article
Polymer Science
Wenjie Wu, Zhong Lin Wang, Liqun Zhang
Summary: Dielectric elastomers (DEs) are special materials that deform in response to an electric field. The current main mechanism suggests that the deformations in DEs are induced by Maxwell stress. However, a new molecular mechanism based on entropy-dominated elasticity has been proposed recently, highlighting its importance in the process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Immunology
Cui Liu, Li Liu, Yanping Huang, Ruiming Shi, Yue Wu, Intan Hakimah Binti Ismail
Summary: This study aimed to explore the impacts of interleukin (IL)-33 in minimal change disease (MCD) and its potential mechanism. The findings demonstrated that IL-33 significantly alleviated kidney injury, inflammation, oxidative stress, and apoptosis in MCD rat models. Additionally, IL-33 reversed the reduced viability and increased oxidative stress and apoptosis in an in vitro ADM-induced podocyte injury model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Acoustics
Mandy Yuen-Man Chan, Yan To Ling, Xiang-Yan Chen, Suk-Tak Chan, Kenneth K. Kwong, Yong-Ping Zheng
Summary: This study measured the success rates of transcranial Doppler (TCD) scanning at different temporal windows in the elderly population. The results showed that the scanning success rates were influenced by gender, age, and physical attributes of the head. Male participants had higher success rates at all three window locations, while younger age and smaller tragus-to-tragus arc length were associated with higher success rates at specific locations. Based on the findings, the authors recommended using the middle temporal window (MTW) as the first location for TCD scanning in the elderly and suggested choosing the MTW and posterior temporal window (PTW) when scanning two temporal windows.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Niraj Singh Tharu, Monzurul Alam, Yan To Ling, Arnold Y. L. Wong, Yong-Ping Zheng
Summary: The aim of this study was to examine the effects of transcutaneous electrical spinal cord stimulation and conventional task-specific rehabilitation on trunk control and sitting stability in people with chronic tetraplegia secondary to a spinal cord injury. The results showed that the combination of stimulation and rehabilitation significantly improved the participants' reach distance and trunk control. The intervention also led to long-term sustainable recovery in independent trunk control and sitting balance.
Article
Neurosciences
Jinyu Zheng, Qiqi Ma, Wanying He, Yanping Huang, Ping Shi, Sujiao Li, Hongliu Yu
Summary: This study evaluated the effects of multiple VR interaction modalities on cerebral cortical activation using fNIRS, and found that the multi-sensory integration of visual, auditory, and haptic feedback leads to stronger cortical activation and cognitive control. Additionally, there is an interaction effect between visual and auditory feedback, which improves the level of cortical activation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Qian Liu, Yanping Huang, Qian Yang, Hong Peng, Jun Wang
Summary: This paper proposes a novel model for aspect-level sentiment analysis called ALS, which is based on the LSTM-SNP model. The ALS model utilizes the three gates of the LSTM-SNP model to capture sentiment features and integrates attention mechanism to compute the correlation between context and aspect words. Experimental results show that the ALS model has a simpler structure and achieves better performance compared to baseline models.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2023)
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Review
Chemistry, Analytical
Vaheh Nazari, Yong-Ping Zheng
Summary: This paper presents a critical review and comparison of recently published studies on human-machine interface and the use of sonomyography (SMG) for upper limb prosthesis control. The results show that ultrasound sensing can be used as a viable human-machine interface and various ultrasound modes, machine learning algorithms, and feature extraction methods can enhance the accuracy of controlling bionic hands.
Article
Oncology
Zhen Huang, Zhe Wu, Quan-qing Zou, Yu-jie Xie, Li-hui Li, Yan-ping Huang, Feng-ming Wu, Dong Huang, Yin-hua Pan, Jian-rong Yang
Summary: This study aimed to investigate the risk factors of non-sentinel lymph node metastasis in breast cancer patients with 1-2 sentinel lymph node macrometastases undergoing total mastectomy. The results showed that tumor size and ratio of sentinel lymph node macrometastases were independent risk factors for non-sentinel lymph node metastasis. The incidence of non-sentinel lymph node metastasis could be reduced to 17.1% for patients with tumor size ≤ 22 mm and ratio of sentinel lymph node macrometastases ≤ 0.33.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Niraj Singh Tharu, Timothy Tin-Yan Lee, Kelly Ka-Lee Lai, Ting-Er Lau, Chui-Yi Chan, Yong-Ping Zheng
Summary: The aim of this study was to compare the sagittal spinal alignment between individuals with chronic SCI and normal subjects, and to determine the effects of TSCS on thoracic kyphosis and lumbar lordosis to restore normal spinal alignment. A case series study was conducted, involving 12 individuals with SCI and 10 neurologically intact subjects. The results showed that individuals with SCI had a higher risk of spinal deformity, but TSCS treatment was able to reverse this by reducing the thoracic kyphosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Respiratory System
Bo Xiao, Liangxian Li, Dong Yao, Biwen Mo
Summary: Asthma is a complex and heterogeneous airway disease treated with hormones and biologics. Noncoding RNAs, especially microRNAs, have been found to be associated with pathological changes to airway smooth muscle cells (ASMCs) in asthmatic patients. This review highlights recent research into ncRNAs and their role in ASMC pathologies, providing potential insights for future diagnostic and treatment strategies.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Computer Science, Artificial Intelligence
Ye-Jiao Mao, Andy Yiu-Chau Tam, Queenie Tsung-Kwan Shea, Yong-Ping Zheng, James Chung-Wai Cheung
Summary: Falls in hospitals are a major problem, but physical and chemical restraints may be unethical and harmful. Therefore, a non-contract restraint-free tracking system is needed to identify and notify fall risks, with high sensitivity and robustness.
Article
Rheumatology
Nan-nan Liu, Yan-ping Huang, Yu-bao Shao, Xue-fei Fan, He-yan Sun, Tao-rong Wang, Tao Yao, Xiao-Yu Chen
Summary: This study found that the long-stranded non-coding RNA TUG1 is lowly expressed in osteoarthritic chondrocytes. Through database analysis and experimental validation, it was demonstrated that TUG1 inhibits chondrocyte apoptosis and inflammation by competitively binding miR-144-3p, deregulating the negative regulatory effect of miR-144-3p on DUSP1, promoting DUSP1 expression, and inhibiting the p38 MAPK signaling pathway. These findings provide an experimental and theoretical basis for genetic engineering tools to promote articular cartilage repair.
ARTHRITIS RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Gongpu Lan, Michael D. Twa, Chengjin Song, JinPing Feng, Yanping Huang, Jingjiang Xu, Jia Qin, Lin An, Xunbin Wei
Summary: Clinical measurement of corneal biomechanics has significant implications in the diagnosis, tracking, and evaluation of ocular diseases. Advancements in interdisciplinary collaborations and testing methods, both ex vivo and in vivo, have contributed to our understanding of corneal biomechanics. However, in vivo measurement remains a challenge and ongoing research is focused on developing accurate approaches. This review discusses existing and emerging methods, such as corneal applanation, Brillouin microscopy, elastography, and optical coherence elastography, along with their fundamental concepts, analytical methods, and clinical status.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
James F. Griffith, Cynthia T. P. Leung, Jeremiah C. H. Lee, Jason C. S. Leung, David K. W. Yeung, Patrick S. H. Yung
Summary: This study used a practical positional MRI protocol to evaluate tibiofemoral translation and rotation in normal and injured knees. The results showed that ACL tear knees exhibited increased tibial anterior translation and decreased external rotation compared to normal knees. Multidirectional malalignment was more common in ACL tear knees.
EUROPEAN RADIOLOGY
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
