Article
Clinical Neurology
Alon Kalron, Ibtisam Mahameed, Israela Weiss, Dror Rosengarten, Gingy Ronen Balmor, Moshe Heching, Mordechai Reuven Kramer
Summary: The study compared the effectiveness of a combined aerobic and strength training program with flexibility alone in ambulatory ALS patients and found that the combined training program significantly improved respiratory function, mobility, and wellbeing compared to flexibility training alone.
JOURNAL OF NEUROLOGY
(2021)
Review
Rehabilitation
Masoud Rahmati, Fatemeh Malakoutinia
Summary: This study evaluated the effects of aerobic, resistance, and combined exercise training in ALS patients through systematic review and meta-analysis, finding positive impacts on functional ability, quality of life, and Vo2peak. However, the safety and effectiveness of exercise therapy in ALS patients remains unclear, necessitating further high-quality research.
Article
Medicine, General & Internal
Thomas H. Julian, Nicholas Glascow, A. Dylan Fisher Barry, Tobias Moll, Calum Harvey, Yann C. Klimentidis, Michelle Newell, Sai Zhang, Michael P. Snyder, Johnathan Cooper-Knock, Pamela J. Shaw
Summary: The study suggests a positive causal relationship between frequent and strenuous leisure-time exercise and ALS, but only in individuals with specific risk genotypes. It is shown that exercise can activate ALS risk genes, particularly the G4C2 repeat expansion of C9ORF72 which may predispose to exercise-induced ALS.
Article
Physiology
Ji He, Jiayu Fu, Wei Zhao, Chuan Ren, Ping Liu, Lu Chen, Dan Li, Lequn Zhou, Lu Tang, Xiangyi Liu, Shan Ye, Xiaolu Liu, Yan Ma, Yixuan Zhang, Xinran Ma, Linjing Zhang, Gaoqi Zhang, Nan Li, Dongsheng Fan
Summary: This study evaluated the clinical value of cardiopulmonary exercise testing (CPET) in amyotrophic lateral sclerosis (ALS). The results showed that ALS patients had significantly decreased exercise capacity, and the peak oxygen consumption (VO2 peak) and peak heart rate (HR peak) were closely correlated with disease severity and predicted a worse prognosis.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elisa Duranti, Chiara Villa
Summary: ALS is a fatal disease characterized by the loss of motor neurons, leading to muscle damage and paralysis. Muscle research plays a crucial role in understanding the molecular mechanisms and developing treatments for this disease.
Review
Clinical Neurology
Baohua Zhou, Jiajun Wei, Yanli Zhang, Yue Liu, Shuhui Shan, Shan Ye, Baohua Li, Dongsheng Fan, Yongmei Luo
Summary: The study aimed to evaluate the effect of more intensive exercise training on the functional ability of patients with amyotrophic lateral sclerosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Tomoya Hirai, Kazuhiro Fujiyoshi, Satoru Yamada, Takuya Matsumoto, Junko Kikuchi, Kohki Ishida, Miwa Ishida, Minako Yamaoka-Tojo, Takayuki Inomata, Kyo Shigeta, Taiki Tojo
Summary: This study found that the AGEs score was associated with HbA1c, isometric knee extension strength (IKES), and 6 min walking distance (6MWD) in patients with cardiovascular disease (CVD). The AGEs score may be a useful indicator for evaluating both glycemic control and physical functions.
Article
Clinical Neurology
Virginia Kudritzki, Ileana M. Howard
Summary: The Veterans Health Administration (VHA) has been a leader in implementing telehealth technologies for rehabilitation and expanding non-traditional patient encounters. ALS is a progressive neurodegenerative disease that affects veterans at a higher rate and has limited access to specialized care. Exercise interventions delivered through telehealth have shown promise in maintaining or restoring function for ALS patients. This review proposes a framework for telehealth delivery of exercise interventions and discusses the evidence supporting telehealth-based exercise for neuromuscular disorders.
FRONTIERS IN NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Stefano Cacciatore, Matteo Tosato, Francesco Landi, Emanuele Marzetti
Summary: Previous studies have shown that regular aerobic training and adherence to a Mediterranean diet can lower the prevalence of sarcopenia in older adults. However, the effect of their combination on sarcopenia indices is unknown.
Article
Geriatrics & Gerontology
Jan Spaas, Richie P. Goulding, Charly Keytsman, Lena Fonteyn, Jack van Horssen, Richard T. Jaspers, Bert O. Eijnde, Rob C. I. Wust
Summary: Patients with multiple sclerosis (MS) have lower exercise tolerance due to reduced skeletal muscle oxidative phenotype. However, skeletal muscle mitochondria seem resistant to the effects of exercise training, suggesting that other physiological systems may be driving the improvements in exercise capacity following exercise training in MS.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cardiac & Cardiovascular Systems
Tim Kambic, Nejc Sarabon, Mitja Lainscak, Vedran Hadzic
Summary: This study investigated the effects of high load resistance training (HL-RT) and low load resistance training (LL-RT) combined with aerobic training (AT) compared to AT alone on body composition and physical performance in patients with coronary artery disease (CAD). The results showed that both HL-RT and LL-RT combined with AT resulted in similar improvements in physical performance, which were superior to AT alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Emily K. Plowman, Lauren T. Gray, Jennifer Chapin, Amber Anderson, Terrie Vasilopoulos, Clifton Gooch, Tuan Vu, James P. Wymer
Summary: This study aimed to evaluate the short-term and one-year effects of a 12-week respiratory strength training program on individuals with ALS. The results showed that the training program led to improvements in maximum expiratory pressure but had no significant effect on maximum inspiratory pressure, and some short-term and long-term outcomes were improved.
Article
Biochemistry & Molecular Biology
Debora Lanznaster, Clement Bruno, Jerome Bourgeais, Patrick Emond, Ilyess Zemmoura, Antoine Lefevre, Pascal Reynier, Sebastien Eymieux, Emmanuelle Blanchard, Patrick Vourc'h, Christian R. Andres, Salah Eddine Bakkouche, Olivier Herault, Luc Favard, Philippe Corcia, Helene Blasco
Summary: This study investigates the relationship between biomarkers, pathological alterations, and energetic metabolism dysfunction in the muscle of ALS patients. The findings suggest that there is a global dysfunction in the early-stage ALS patients' muscles. Novel metabolites have been identified as potential biomarkers for the diagnosis and prognosis of ALS patients.
Review
Environmental Sciences
Laura Ortega-Hombrados, Guadalupe Molina-Torres, Alejandro Galan-Mercant, Eduardo Sanchez-Guerrero, Manuel Gonzalez-Sanchez, Maria Ruiz-Munoz
Summary: The study found that therapeutic physical exercise can significantly improve the functional abilities of patients with amyotrophic lateral sclerosis (ALS) and help slow down the degeneration of muscles. Participants showed significant improvements in subjective perception and functional capacities in the short, medium and long terms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Clinical Neurology
Xiaoting Zheng, Shichan Wang, Jingxuan Huang, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Rui Huang, Chunyu Li, Huifang Shang
Summary: Vigorous physical activity, occupational-related activity, leisure time activity, unclassified PA, and professional athletes were associated with a higher risk of developing ALS, while sport-related activity showed no association with ALS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Marina Cattaneo, Pierre Jesus, Andrea Lizio, Philippe Fayemendy, Nicoletta Guanziroli, Ettore Corradi, Valeria Sansone, Letizia Leocani, Massimo Filippi, Nilo Riva, Philippe Corcia, Philippe Couratier, Christian Lunetta
Summary: The study revealed that 10% of ALS patients have hypometabolic state, while 40% have hypermetabolic state. Hypometabolism is associated with later need for gastrostomy, non-invasive ventilation and tracheostomy, and hypometabolic patients with ALS have significantly longer survival compared to normometabolic and hypermetabolic patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Bernardo Gialanella, Laura Comini, Paola Prometti
Summary: This study aimed to determine the importance of individual items in the Berg Balance Scale (BBS) in predicting functional improvement in patients with peripheral neuropathy (PN). The results showed that unsupported standing was the most important determinant of functional improvement, suggesting that the ability to stand without support is crucial for achieving higher levels of functional abilities in PN patients.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Nilo Riva, Francesco Gentile, Federica Cerri, Francesca Gallia, Paola Podini, Giorgia Dina, Yuri Matteo Falzone, Raffaella Fazio, Christian Lunetta, Andrea Calvo, Giancarlo Logroscino, Giuseppe Lauria, Massimo Corbo, Sandro Iannaccone, Adriano Chio, Alberto Lazzerini, Eduardo Nobile-Orazio, Massimo Filippi, Angelo Quattrini
Summary: This study aimed to define the TDP-43/pTDP-43 pathology and evaluate its potential as a tissue biomarker for amyotrophic lateral sclerosis (ALS) and non-ALS cases, by using diagnostic motor nerve biopsies from patients with lower motor neuron syndrome. The researchers found that pTDP-43 aggregates were present in the peripheral nervous system of ALS patients, even in cases with normal features at standard histopathological analysis, suggesting that pTDP-43 aggregation is an early event that may contribute to ALS pathogenesis.
Article
Otorhinolaryngology
Daniela Ginocchio, Aurora Ninfa, Nicole Pizzorni, Christian Lunetta, Valeria Ada Sansone, Antonio Schindler
Summary: The study successfully crossculturally translated and adapted the Dysphagia Handicap Index (DHI) into Italian (I-DHI) and demonstrated that I-DHI is a reliable and valid Health-related Quality of Life (HRQOL) questionnaire for Italian adults with oropharyngeal dysphagia (OD). The translation process followed standard procedures, participants were able to complete the questionnaire within 10 minutes, and the results showed good reliability, validity, and interpretability of I-DHI. This questionnaire can assist in evaluating the quality of life of OD patients.
Letter
Clinical Neurology
Philippe Corcia, Christian Lunetta, Philippe Couratier, Patrick Vourc'h, Marta Gromicho, Claude Desnuelle, Marie-Helene Soriani, Susana Pinto, Mamede de Carvalho
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Raffaele Pugliese, Riccardo Sala, Stefano Regondi, Benedetta Beltrami, Christian Lunetta
Summary: Amyotrophic lateral sclerosis (ALS) is an incurable disease characterized by the degeneration of motor neurons, leading to muscle weakness and paralysis. Multidisciplinary approaches and emerging technologies have been used to manage ALS, but there are still unresolved issues.
JOURNAL OF NEUROLOGY
(2022)
Correction
Genetics & Heredity
Wouter van Rheenen, Rick A. A. van der Spek, Mark K. Bakker, Joke J. F. A. van Vugt, Paul J. Hop, Ramona A. J. Zwamborn, Niek de Klein, Harm-Jan Westra, Olivier B. Bakker, Patrick Deelen, Gemma Shireby, Eilis Hannon, Matthieu Moisse, Denis Baird, Restuadi Restuadi, Egor Dolzhenko, Annelot M. Dekker, Klara Gawor, Henk-Jan Westeneng, Gijs H. P. Tazelaar, Kristel R. van Eijk, Maarten Kooyman, Ross P. Byrne, Mark Doherty, Mark Heverin, Ahmad Al Khleifat, Alfredo Iacoangeli, Aleksey Shatunov, Nicola Ticozzi, Johnathan Cooper-Knock, Bradley N. Smith, Marta Gromicho, Siddharthan Chandran, Suvankar Pal, Karen E. Morrison, Pamela J. Shaw, John Hardy, Richard W. Orrell, Michael Sendtner, Thomas Meyer, Nazli Basak, Anneke J. van der Kooi, Antonia Ratti, Isabella Fogh, Cinzia Gellera, Giuseppe Lauria, Stefania Corti, Cristina Cereda, Daisy Sproviero, Sandra D'Alfonso, Gianni Soraru, Gabriele Siciliano, Massimiliano Filosto, Alessandro Padovani, Adriano Chio, Andrea Calvo, Cristina Moglia, Maura Brunetti, Antonio Canosa, Maurizio Grassano, Ettore Beghi, Elisabetta Pupillo, Giancarlo Logroscino, Beatrice Nefussy, Alma Osmanovic, Angelica Nordin, Yossef Lerner, Michal Zabari, Marc Gotkine, Robert H. Baloh, Shaughn Bell, Patrick Vourc'h, Philippe Corcia, Philippe Couratier, Stephanie Millecamps, Vincent Meininger, Francois Salachas, Jesus S. Mora Pardina, Abdelilah Assialioui, Ricardo Rojas-Garcia, Patrick A. Dion, Jay P. Ross, Albert C. Ludolph, Jochen H. Weishaupt, David Brenner, Axel Freischmidt, Gilbert Bensimon, Alexis Brice, Alexandra Durr, Christine A. M. Payan, Safa Saker-Delye, Nicholas W. Wood, Simon Topp, Rosa Rademakers, Lukas Tittmann, Wolfgang Lieb, Andre Franke, Stephan Ripke, Alice Braun, Julia Kraft, David C. Whiteman, Catherine M. Olsen, Andre G. Uitterlinden, Albert Hofman, Marcella Rietschel, Sven Cichon, Markus M. Nothen, Philippe Amouyel, Giancarlo Comi, Nilo Riva, Christian Lunetta, Francesca Gerardi, Maria Sofia Cotelli, Fabrizio Rinaldi, Luca Chiveri, Maria Cristina Guaita, Patrizia Perrone, Mauro Ceroni, Luca Diamanti, Carlo Ferrarese, Lucio Tremolizzo, Maria Luisa Delodovici, Giorgio Bono, Umberto Manera, Rosario Vasta, Alessandro Bombaci, Federico Casale, Giuseppe Fuda, Paolina Salamone, Barbara Iazzolino, Laura Peotta, Paolo Cugnasco, Giovanni De Marco, Maria Claudia Torrieri, Francesca Palumbo, Salvatore Gallone, Marco Barberis, Luca Sbaiz, Salvatore Gentile, Alessandro Mauro, Letizia Mazzini, Fabiola De Marchi, Lucia Corrado, Sandra D'Alfonso, Antonio Bertolotto, Maurizio Gionco, Daniela Leotta, Enrico Odddenino, Daniele Imperiale, Roberto Cavallo, Pietro Pignatta, Marco De Mattei, Claudio Geda, Diego Maria Papurello, Graziano Gusmaroli, Cristoforo Comi, Carmelo Labate, Luigi Ruiz, Delfina Ferrandi, Eugenia Rota, Marco Aguggia, Nicoletta Di Vito, Piero Meineri, Paolo Ghiglione, Nicola Launaro, Michele Dotta, Alessia Di Sapio, Guido Giardini, Cinzia Tiloca, Silvia Peverelli, Franco Taroni, Viviana Pensato, Barbara Castellotti, Giacomo P. Comi, Roberto Del Bo, Mauro Ceroni, Stella Gagliardi, Lucia Corrado, Letizia Mazzini, Flavia Raggi, Costanza Simoncini, Annalisa Lo Gerfo, Maurizio Inghilleri, Alessandra Ferlini, Isabella L. Simone, Bruno Passarella, Vito Guerra, Stefano Zoccolella, Cecilia Nozzoli, Ciro Mundi, Maurizio Leone, Michele Zarrelli, Filippo Tamma, Francesco Valluzzi, Gianluigi Calabrese, Giovanni Boero, Augusto Rini, Bryan J. Traynor, Andrew B. Singleton, Miguel Mitne Neto, Ruben J. Cauchi, Roel A. Ophoff, Martina Wiedau-Pazos, Catherine Lomen-Hoerth, Vivianna M. van Deerlin, Julian Grosskreutz, Annekathrin Roediger, Nayana Gaur, Alexander Joerk, Tabea Barthel, Erik Theele, Benjamin Ilse, Beatrice Stubendorff, Otto W. Witte, Robert Steinbach, Christian A. Huebner, Caroline Graff, Lev Brylev, Vera Fominykh, Vera Demeshonok, Anastasia Ataulina, Boris Rogelj, Blaz Koritnik, Janez Zidar, Metka Ravnik-Glavac, Damjan Glavac, Zorica Stevic, Vivian Drory, Monica Povedano, Ian P. Blair, Matthew C. Kiernan, Beben Benyamin, Robert D. Henderson, Sarah Furlong, Susan Mathers, Pamela A. McCombe, Merrilee Needham, Shyuan T. Ngo, Garth A. Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Karen A. Mather, Perminder S. Sachdev, Anjali K. Henders, Leanne Wallace, Mamede de Carvalho, Susana Pinto, Susanne Petri, Markus Weber, Guy A. Rouleau, Vincenzo Silani, Charles J. Curtis, Gerome Breen, Jonathan D. Glass, Robert H. Brown, John E. Landers, Christopher E. Shaw, Peter M. Andersen, Ewout J. N. Groen, Michael A. van Es, R. Jeroen Pasterkamp, Dongsheng Fan, Fleur C. Garton, Allan F. McRae, George Davey Smith, Tom R. Gaunt, Michael A. Eberle, Jonathan Mill, Russell L. McLaughlin, Orla Hardiman, Kevin P. Kenna, Naomi R. Wray, Ellen Tsai, Heiko Runz, Lude Franke, Ammar Al-Chalabi, Philip Van Damme, Leonard H. van den Berg, Jan H. Veldink
Article
Clinical Neurology
Luca Diamanti, Paola Borrelli, Raffaele Dubbioso, Margherita Capasso, Claudia Morelli, Christian Lunetta, Antonio Petrucci, Gabriele Mora, Paolo Volanti, Maurizio Inghilleri, Lucio Tremolizzo, Jessica Mandrioli, Letizia Mazzini, Marcella Vedovello, Gabriele Siciliano, Massimiliano Filosto, Sabrina Mata, Cristina Montomoli
Summary: The DYALS questionnaire, adapted from the DYMUS questionnaire, is a reliable and easily manageable tool for screening dysphagia in ALS patients. It can be shared among all Italian ALS centers to collect uniform data for therapeutic strategies and clinical trials.
NEUROLOGICAL SCIENCES
(2022)
Article
Rehabilitation
Elena Carraro, Jacopo L. Casiraghi, Beatrice Bobba, Andrea Lizio, Carolina Cardella, Emilio Albamonte, Christian Lunetta, Susanna Pozzi, Valeria A. Sansone
Summary: This study evaluated the psychosocial well-being of patients with neuromuscular diseases who play wheelchair hockey versus those who do not. Wheelchair hockey players showed higher quality of life, physical self-efficacy scores, and perceived physical ability compared to non-players. No significant difference in coping strategies was found between the two groups.
Article
Clinical Neurology
Tessa Kliest, Ruben P. A. Van Eijk, Ammar Al-Chalabi, Alberto Albanese, Peter M. Andersen, Maria Del Mar Amador, Geir BrAthen, Veronique Brunaud-Danel, Lev Brylev, William Camu, Mamede De Carvalho, Cristina Cereda, Hakan Cetin, Delia Chaverri, Adriano Chio, Philippe Corcia, Philippe Couratier, Fabiola De Marchi, Claude Desnuelle, Michael A. Van Es, JesUs Esteban, Massimiliano Filosto, Alberto GarcIa Redondo, Julian Grosskreutz, Clemens O. Hanemann, Trygve Holmoy, Helle Hoyer, Caroline Ingre, Blaz Koritnik, Magdalena Kuzma-Kozakiewicz, Thomas Lambert, Peter N. Leigh, Christian Lunetta, Jessica Mandrioli, Christopher J. Mcdermott, Thomas Meyer, Jesus S. Mora, Susanne Petri, MOnica Povedano, Evy Reviers, Nilo Riva, Kit C. B. Roes, Miguel A. Rubio, FranCois Salachas, Stayko Sarafov, Gianni SorarU, Zorica Stevic, Kirsten Svenstrup, Anette Torvin Moller, Martin R. Turner, Philip Van Damme, Lucie A. G. Van Leeuwen, Luis Varona, Juan F. VAzquez Costa, Markus Weber, Orla Hardiman, Leonard H. Van den Berg
Summary: In Europe, conducting clinical studies on the effect of therapy in children with ALS is not feasible. Pediatric ALS has a very low prevalence and recruiting pediatric patients may involve lengthy periods, high costs, ethical/legal implications, challenges in trial design, and limited information.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Article
Clinical Neurology
Ettore Beghi, Elisabetta Pupillo, Elisa Bianchi, Valentina Bonetto, Silvia Luotti, Laura Pasetto, Caterina Bendotti, Massimo Tortarolo, Francesca Sironi, Laura Camporeale, Alexander V. Sherman, Sabrina Paganoni, Ada Scognamiglio, Fabiola De Marchi, Paolo Bongioanni, Renata Del Carratore, Claudia Caponnetto, Luca Diamanti, Daniele Martinelli, Andrea Calvo, Massimiliano Filosto, Alessandro Padovani, Stefano Cotti Piccinelli, Claudia Ricci, Stefania Dalla Giacoma, Nicoletta De Angelis, Maurizio Inghilleri, Rossella Spataro, Vincenzo La Bella, Giancarlo Logroscino, Christian Lunetta, Claudia Tarlarini, Jessica Mandrioli, Ilaria Martinelli, Cecilia Simonini, Elisabetta Zucchi, Maria Rosaria Monsurro, Dario Ricciardi, Francesca Trojsi, Nilo Riva, Massimo Filippi, Isabella Laura Simone, Gianni Soraru, Cristina Spera, Lucia Florio, Sonia Messina, Massimo Russo, Gabriele Siciliano, Amelia Conte, Maria Valeria Saddi, Nicola Carboni, Letizia Mazzini
Summary: This study is a clinical trial on the effects of RNS60 in ALS patients. The results indicate that RNS60 has positive effects on respiratory and bulbar function, suggesting further investigation is warranted.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Lucia Catherine Greco, Antonino La Tona, Federica Solca, Silvia Torre, Laura Carelli, Debora Pain, Alice Radici, Andrea Lizio, Jacopo Casiraghi, Federica Cerri, Agostino Brugnera, Angelo Compare, Susan Woolley, Jennifer Murphy, Lucio Tremolizzo, Ildebrando Appollonio, Federico Verde, Vincenzo Silani, Nicola Ticozzi, Christian Lunetta, Valeria Ada Sansone, Barbara Poletti
Summary: This study aimed to validate and provide reliability evidence for the Italian version of the ALS Cognitive Behavioral Screen (ALS-CBS) and test its diagnostic capabilities within an Italian ALS cohort. The results showed that the cognitive subscales of ALS-CBS were internally reliable and correlated with ECAS executive and fluency scores. The cognitive section of ALS-CBS accurately detected cognitive impairment and discriminated between ALS patients and healthy controls.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Federica Solca, Lucia Catherine Greco, Silvia Torre, Laura Carelli, Claudia Morelli, Alberto Doretti, Eleonora Colombo, Stefano Messina, Debora Pain, Alice Radici, Andrea Lizio, Jacopo Casiraghi, Federica Cerri, Susan Woolley, Jennifer Murphy, Lucio Tremolizzo, Ildebrando Appollonio, Federico Verde, Valeria Ada Sansone, Christian Lunetta, Vincenzo Silani, Nicola Ticozzi, Barbara Poletti
Summary: This study aimed to establish equivalent standards for estimating ECAS scores based on ALS-CBS(TM) scores in non-demented ALS patients. The results showed that ALS-CBS(TM) scores could predict ECAS scores accurately, and two methods were provided to estimate the corresponding ECAS scores based on ALS-CBS(TM) scores.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alex Berger, Matteo Locatelli, Ximena Arcila-Londono, Ghazala Hayat, Nicholas Olney, James Wymer, Kelly Gwathmey, Christian Lunetta, Terry Heiman-Patterson, Senda A. Ajroud-driss, Eric Macklin, Marie-Abele Bind, Kimberly Goslin, Tamela Stuchiner, Lauren Brown, Tracy Bazan, Tyler Regan, Ashley Adamo, Valerie Ferment, Carly Schroeder, Megan Somers, Georgios Manousakis, Kenneth Faulconer, Ervin Sinani, Julia Mirochnick, Hong V. Yu, Alexander Sherman, David Walk
Summary: To understand the full natural history of ALS, comprehensive data on a diverse range of ALS patients is needed. The ALS Natural History Consortium (ALS NHC) has built a comprehensive dataset reflective of the ALS population, which includes data from 9 ALS clinics. Compared to clinical trial data, the ALS NHC dataset has a higher diversity of diagnostic and demographic data.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Geriatrics & Gerontology
Bernardo Gialanella, Paola Prometti, Laura Comini, Vittoria Monguzzi, Raffaele Santoro
Summary: The study found that functional impairment at admission and age are important predictors of functional abilities at the end of rehabilitation in patients with peripheral neuropathy. Additional rehabilitation may be needed for older, more disabled patients to achieve higher functional levels.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)