Article
Biochemistry & Molecular Biology
Tommi Vatanen, Qi Yan Ang, Lea Siegwald, Shafiqul Alam Sarker, Caroline Le Roy, Stephane Duboux, Omar Delannoy-Bruno, Catherine Ngom-Bru, Claire L. Boulange, Martin Strazar, Julian Avila-Pacheco, Amy Deik, Kerry Pierce, Kevin Bullock, Courtney Dennis, Shamima Sultana, Sharika Sayed, Mahbubar Rahman, Tahmeed Ahmed, Monica Modesto, Paola Mattarelli, Clary B. Clish, Hera Vlamakis, Damian R. Plichta, Olga Sakwinska, Ramnik J. Xavier
Summary: This study investigated the gut microbiome and metabolome of 222 young children in Dhaka, Bangladesh during the first two years of life. It found that a specific Bifidobacterium longum clade expanded after the introduction of solid foods and had enzymes for utilizing both breast milk and solid food substrates. The clade was prevalent in Bangladesh, present globally (at lower prevalence), and correlated with other gut taxa and metabolites, indicating its important role in gut ecology.
Article
Pediatrics
Micaela C. Morgado, Monica Sousa, Claudia Marques, Andre B. Coelho, Julio A. Costa, Andre Seabra
Summary: This study examines the gut microbiota composition in overweight and obese school children and assesses the effects of a 12-week multidisciplinary intervention. The intervention, which combined recreational football and nutritional education, resulted in a significant decrease in Bifidobacterium and Roseburia abundance. Additionally, the abundance of Roseburia was negatively correlated with physical activity while Prevotella copri was positively correlated with physical activity and protein intake.
Article
Microbiology
Xiaolei Ma, Emily Brinker, Emily C. Graff, Wenqi Cao, Amanda L. Gross, Aime K. Johnson, Chao Zhang, Douglas R. Martin, Xu Wang
Summary: Obesity in domestic cats is a growing health problem that increases the risk of various diseases and decreases lifespan. This study found a significant reduction in microbial diversity in the gut microbiota of obese cats, suggesting potential dysbiosis. Additionally, several specific bacterial species showed increased abundance in the microbiome of obese cats, which may serve as indicators of obesity.
MICROBIOLOGY SPECTRUM
(2022)
Article
Gastroenterology & Hepatology
Baskar Balakrishnan, Vaithinathan Selvaraju, Jun Chen, Priscilla Ayine, Lu Yang, Jeganathan Ramesh Babu, Thangiah Geetha, Veena Taneja
Summary: This study aimed to investigate the differences in gut and oral microbial communities in obese African American and European American children, indicating a specific association between ethnicity and microbial profiles.
Article
Biotechnology & Applied Microbiology
Ping Li, Jiyang Jiang, Yifei Li, Yue Lan, Fan Yang, Jiao Wang, Yuxin Xie, Fei Xiong, Jinhui Wu, Hanmin Liu, Zhenxin Fan
Summary: The study observed significant differences in the gut microbiome of obese children compared to controls, with the bacterial pathogen Campylobacter rectus significantly more abundant in obese children. Functional annotation of microbial genes indicated the presence of gut inflammation in obese children, while the gut microbiomes of overweight children were in a transitional state between obese and control children. Additionally, Trichuris trichiura was found to be significantly more abundant in the guts of obese Mexican children compared to obese Chinese children, highlighting differences in gut microbial composition between populations.
Article
Biochemistry & Molecular Biology
Apostolos Galaris, Dionysios Fanidis, Elli-Anna Stylianaki, Vaggelis Harokopos, Alexandra-Styliani Kalantzi, Panagiotis Moulos, Antigone S. Dimas, Pantelis Hatzis, Vassilis Aidinis
Summary: The microbiome is important for tissue homeostasis in health and disease. Dysbiosis of the gut microbiome is related to autoimmune and metabolic diseases, while high-fat diets and obesity affect microbiome diversity and complexity, thus modulating pathophysiology. Obesity increases microbial complexity in the gut, liver, and lung, with the lungs showing the most significant changes in microbial diversity.
Article
Nutrition & Dietetics
Junying Zhao, Wei Yi, Bin Liu, Yaohua Dai, Tiemin Jiang, Shuxing Chen, Jianwu Wang, Baowen Feng, Weicang Qiao, Yanpin Liu, Huihuang Zhou, Jianying He, Juncai Hou, Lijun Chen
Summary: This study shows that breastfed infants have a higher abundance of Bifidobacterium in their gut microbiota compared to formula-fed infants. The microbiome shifts in stool were associated with changes in urine metabolites. Key components of MFGM were significantly positively correlated with Bifidobacterium in stool samples, and stimulated its growth rate in vitro.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Andrology
Makoto Matsushita, Kazutoshi Fujita, Daisuke Motooka, Koji Hatano, Junya Hata, Mitsuhisa Nishimoto, Eri Banno, Kentaro Takezawa, Shinichiro Fukuhara, Hiroshi Kiuchi, Yue Pan, Toshifumi Takao, Akira Tsujimura, Shinichi Yachida, Shota Nakamura, Wataru Obara, Hirotsugu Uemura, Norio Nonomura
Summary: This study examined the relationship between gut microbiota and testosterone levels in elderly Japanese men. The results showed that certain bacteria belonging to the Firmicutes phylum were associated with higher levels of testosterone. This suggests that the gut microbiota may affect testosterone metabolism in elderly males.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Medicine, General & Internal
Emilia Sawicka-Smiarowska, Kinga Bondarczuk, Witold Bauer, Magdalena Niemira, Anna Szalkowska, Justyna Raczkowska, Miroslaw Kwasniewski, Ewa Tarasiuk, Marlena Dubatowka, Magda Lapinska, Malgorzata Szpakowicz, Zofia Stachurska, Anna Szpakowicz, Pawel Sowa, Andrzej Raczkowski, Marcin Kondraciuk, Magdalena Gierej, Joanna Motyka, Jacek Jamiolkowski, Mateusz Bondarczuk, Malgorzata Chlabicz, Jolanta Bucko, Marcin Kozuch, Slawomir Dobrzycki, Jerzy Bychowski, Wlodzimierz Jerzy Musial, Adrian Godlewski, Michal Ciborowski, Attila Gyenesei, Adam Kretowski, Karol Adam Kaminski
Summary: Despite knowledge of classical coronary artery disease (CAD) risk factors, the morbidity and mortality associated with this disease remain high. New factors that may affect the development of CAD, such as the gut microbiome, are extensively investigated. CAD is associated with altered gut microbiome composition and function, including changes in Firmicutes/Bacteroidetes ratio and alpha-beta biodiversity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ruxandra Florentina Ionescu, Robert Mihai Enache, Sanda Maria Cretoiu, Bogdan Severus Gaspar
Summary: This article summarizes the recent findings on the correlation between gestational diabetes mellitus (GDM) and dysbiosis, as well as the prevention and treatment methods. The most common changes in the microbiome of GDM patients are an increase in Firmicutes phylum or a decrease in Bacteroidetes and Actinobacteria phyla. Gut dysbiosis persists postpartum and affects the development of newborns. Probiotic supplementation and regular physical activity have strong evidence in controlling blood glucose levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ting Ma, Zeyu Wu, Jing Lin, Chao Shan, Aisaiti Abasijiang, Jin Zhao
Summary: This study analyzed the oral and gut microbiota of obese and normal weight children aged 3-5 years using long-range DNA sequencing. The results showed significant differences in the microbial community structure between obesity and controls, as well as specific oral and gut microbial genera in children with obesity. The study highlights the importance of understanding the relationship between childhood obesity and microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Devesha H. Kulkarni, Brigida Rusconi, Alexandria N. Floyd, Elisabeth L. Joyce, Khushi B. Talati, Hrishi Kousik, Dereck Alleyne, Dalia L. Harris, Lorena Garnica, Ryan Mcdonough, Shay S. Bidani, Hrishikesh S. Kulkarni, Elizabeth P. Newberry, Keely G. Mcdonald, Rodney D. Newberry
Summary: Obesity and the metabolic syndrome are complex disorders influenced by various factors including genetics, diet, activity, inflammation, and gut microbes. This study aimed to investigate the specific role of gut microbiota in driving obesity and inflammation, independent of diet and genetics. The findings demonstrate that the gut microbiota from obese individuals alone can cause weight gain and inflammation.
Article
Microbiology
Chongkai Zhai, Ji-Seon Ahn, Md Minarul Islam, Enkhchimeg Lkhagva, Hea-Jong Chung, Seong-Tshool Hong
Summary: This study analyzes the effects of gut microbiome on host phenotype by replacing the original gut microbiome with a new one within the same individual. The results show that different gut microbiomes have different effects on weight gain, and weight gain is negatively correlated with the Firmicutes/Bacteroidetes ratio.
Article
Psychiatry
Li-ya Pan, Yuan-yue Zhou, Xue Zhang, Hai-yin Jiang
Summary: This study investigated the longitudinal changes in the microbiome during treatment with atypical antipsychotics and found that the baseline composition of the gut microbiome was associated with the risk of weight gain associated with antipsychotic medication.
PSYCHIATRY RESEARCH
(2022)
Article
Microbiology
Lucia A. Mendez-Garcia, Nallely Bueno-Hernandez, Miguel A. Cid-Soto, Karen L. De Leon, Viridiana M. Mendoza-Martinez, Aranza J. Espinosa-Flores, Miguel Carrero-Aguirre, Marcela Esquivel-Velazquez, Mireya Leon-Hernandez, Rebeca Viurcos-Sanabria, Alejandra Ruiz-Barranco, Julian M. Cota-Arce, Angelica Alvarez-Lee, Marco A. De Leon-Nava, Guillermo Melendez, Galileo Escobedo
Summary: Sucralose consumption alters microbiome and carbohydrate metabolism in mouse models, but there are no conclusive studies in humans. In this open-label clinical trial, volunteers drinking sucralose for ten weeks showed changes in gut microbiota abundance and insulin and glucose levels.
