Article
Oncology
Joanna Lee, Tasnia Ahmed, Andrea Maurichi, Lorenzo Di Guardo, Anna M. Stagno, Lydia Warburton, Amelia. M. Taylor, Elisabeth Livingstone, Saba Rehman, Adnan Khattak, Katharina C. Kahler, Vito Vanella, Victoria Atkinson, Michael Millward, Dirk Schadendorf, Douglas B. Johnson, Paolo A. Ascierto, Axel Hauschild, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies, Matteo S. Carlino
Summary: For patients with advanced melanoma, there is a risk of recurrence after discontinuation of targeted therapy, but retreatment with targeted therapy shows a high response rate.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Ming Ren, Lu Wang, Zi-Xu Gao, Xin-Yi Deng, Kang-Jie Shen, Yan-Lin Li, Yi-Teng Ding, Chuan-Yuan Wei, Jian-Ying Gu
Summary: This study revealed the mechanism of drug resistance in melanoma to vemurafenib, showing that resistant cells regulate their own proliferation, oxidative stress, and tumor stemness by activating specific pathways, providing new insights into acquiring drug resistance.
Article
Cardiac & Cardiovascular Systems
Johnathan Kent, Philip Erwin, Daniel Haraf, Chih-Yi Liao, Joseph Durham, Peter Angelos, Nishant Agrawal, Brandon Jackson Baird, Maria Lucia L. Madariaga
Summary: Laryngotracheal resection and reconstruction after dabrafenib/trametinib treatment has been shown to be safe and effective in locoregionally advanced BRAF v600e mutated anaplastic thyroid carcinoma. This treatment improves rates of microscopically margin-negative resection and durable locoregional control.
ANNALS OF THORACIC SURGERY
(2023)
Article
Oncology
Kevin Yao, Emily Zhou, Chao Cheng
Summary: In this study, a B-Raf signature score was defined using RNA-seq data, which could predict B-Raf mutation status and other aberrations. Patients dichotomized by the median B-Raf score showed more significant stratification compared to other metrics. High B-Raf score also predicted higher sensitivity to B-Raf inhibitors and drugs targeting other relevant oncogenic pathways.
Article
Biochemistry & Molecular Biology
Honey Bokharaie, Walter Kolch, Aleksandar Krstic
Summary: Alternative splicing plays an important role in cancer, and one common mechanism of vemurafenib resistance in malignant melanoma involves alternative splicing of the BRAF gene. Our study shows that alternative splicing in vemurafenib-resistant cells can affect cell motility and melanin synthesis. The results highlight the need for further investigation of aberrant alternative splicing in patients with melanoma.
Article
Medicine, General & Internal
Weiwei Han, Lin Niu, Lin Wang, Jixiang Liu, Huanying Li
Summary: This study revealed that high expression of BANCR in laryngeal squamous carcinoma tissues and cells contributes to decreased sensitivity to cisplatin and enhanced cell proliferation. Down-regulation of BANCR, on the other hand, reverses cisplatin resistance in resistant LSCC cell lines by reducing cell proliferation and increasing sensitivity to cisplatin.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Health Care Sciences & Services
Lindsay Angus, Martijn P. A. Starmans, Ana Rajicic, Arlette E. Odink, Mathilde Jalving, Wiro J. Niessen, Jacob J. Visser, Stefan Sleijfer, Stefan Klein, Astrid A. M. van der Veldt
Summary: Patients with BRAF-mt metastatic melanoma currently benefit significantly from treatment with BRAF inhibitors. However, this study found that the prediction of BRAF mutation status in melanoma lung metastases using radiomics features or visually scored LIDC criteria was not successful.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Medicinal
Mohamed M. Saleh, Tarek El-Moselhy, Eman El-Bastawissy, Mahmoud A. A. Ibrahim, Shaban R. M. Sayed, Mohamed-Elamir F. Hegazy, Thomas Efferth, Laila A. Jaragh-Alhadad, Peter A. Sidhom
Summary: The MAPK pathway plays a crucial role in cell survival, division, and proliferation through RTK activation and subsequent downstream signaling cascades. Anomalies in this pathway can lead to cancer development and drug resistance. In this study, 12 candidates were synthesized and assessed for anti-cancer activity, and compound 3h showed impressive potency against multiple keystones of the MAPK pathway, including mutated forms.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alessio Annovazzi, Virginia Ferraresi, Sandra Rea, Michelangelo Russillo, Davide Renna, Silvia Carpano, Rosa Sciuto
Summary: The study found that baseline TMTV and metabolic response may be useful prognostic indicators for PFS and OS in patients with advanced melanoma treated with BRAF/MEK inhibitors.
EUROPEAN RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gregory A. Babbitt, Miranda L. Lynch, Matthew McCoy, Ernest P. Fokoue, Andre O. Hudson
Summary: The oncogenic mutations in the kinase domain of the B-Raf protein are associated with cancers involving the MAPK pathway. The V600E mutation is a common MAPK activating mutation in B-Raf and is found in many types of cancer. Drug development targeting B-Raf has shifted towards ATP competitive inhibitors. The study shows that V600E and other mutations in the regulatory loops of B-Raf affect the functional dynamics and identifies sites of low mutational tolerance.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Oncology
Mohd Nazzary Mamat Yusof, Ewe Seng Ch'ng, Nawal Radhiah Abdul Rahman
Summary: This systematic review and meta-analysis aimed to determine the overall prevalence of BRAF V600E mutation in reported ameloblastoma cases and its association with patient demographic and clinicopathological features. The results showed a high prevalence of BRAF V600E mutation in ameloblastoma, especially in patients younger than 54 years old and in the mandible. These findings can be utilized to improve treatment options and find new biomarkers for the early detection of ameloblastoma.
Article
Biochemistry & Molecular Biology
Ylana Adami Franco, Manoel Oliveira de Moraes Jr, Larissa A. C. Carvalho, Wolfgang Dohle, Renaira Oliveira da Silva, Isabella Harumi Yonehara Noma, Keli Lima, Barry V. L. Potter, Joao A. Machado-Neto, Silvya Stuchi Maria-Engler
Summary: The sulfamoylated derivative of endogenous estradiol, STX140, shows superior potential as a therapeutic agent for melanoma treatment. It inhibits cell proliferation, induces cell cycle arrest and apoptosis, reduces migration and clonogenic potential, and inhibits invasion in melanoma cells. Furthermore, STX140 induces senescence features and activates the senescence machinery in melanoma cells. These findings suggest that STX140 may be a promising candidate for melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ryan C. Maloney, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
Summary: Oncogenic mutations in B-Raf, especially the V600E mutation, are common in cancer and are a major drug target. This study found that the V600E mutation destabilizes the inactive state while stabilizing the active state, providing insights for the development of new Raf inhibitors.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Martina Radic, Ignacija Vlasic, Maja Jazvinscak Jembrek, Andela Horvat, Ana Tadijan, Maja Sabol, Marko Duzevic, Maja Herak Bosnar, Neda Slade
Summary: Despite the advancements in melanoma treatment, many patients still develop resistance to drugs, such as the RAF inhibitor vemurafenib. In this study, researchers generated and examined two melanoma-derived cell lines with acquired resistance to vemurafenib. They found that the resistant cells displayed features of epithelial-mesenchymal transition (EMT) and exhibited a hybrid phenotype. Surprisingly, the resistant cells showed decreased migration ability but had a tendency for collective migration. Signaling pathway analysis revealed reactivation of MAPK and activation of the PI3K/AKT pathway in the vemurafenib-resistant cells. The acquired resistance also led to resistance to chemotherapy in the primary melanoma cells. Further investigation is needed to understand the negative regulators of NME proteins in vemurafenib resistance and their impact on PI3K/AKT signaling and melanoma cell characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Andrew Rankin, Adrienne Johnson, Alison Roos, Geoffrey Kannan, Jeffrey Knipstein, Nicholas Britt, Mark Rosenzweig, James Haberberger, Dean Pavlick, Eric Severson, Jo-Anne Vergilio, Rachel Squillace, Rachel Erlich, Pratheesh Sathyan, Stuart Cramer, David Kram, Jeffrey Ross, Vince Miller, Prasanth Reddy, Brian Alexander, Siraj M. Ali, Shakti Ramkissoon
Summary: This study examined the landscape of BRAF and RAF1 genomic alterations in pediatric cancers, highlighting patients with positive responses to BRAF inhibitors in brain tumors and emphasizing the importance of incorporating precision medicine into pediatric oncology.
Article
Allergy
Shuli Li, Pan Kang, Weigang Zhang, Zhe Jian, Qian Zhang, Xiuli Yi, Sen Guo, Weinan Guo, Qiong Shi, Bing Li, Yuanmin He, Pu Song, Ling Liu, Kai Li, Gang Wang, Tianwen Gao, Chunying Li
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Cell Biology
Lin Liu, Qiao Yue, Jingjing Ma, Yu Liu, Tao Zhao, Weinan Guo, Guannan Zhu, Sen Guo, Shiyu Wang, Tianwen Gao, Chunying Li, Qiong Shi
CELL DEATH & DISEASE
(2020)
Article
Cell Biology
Jinyuan Ma, Huina Wang, Sen Guo, Xiuli Yi, Tao Zhao, Yu Liu, Qiong Shi, Tianwen Gao, Chunying Li, Weinan Guo
CELL DEATH & DISEASE
(2020)
Article
Oncology
Weinan Guo, Jinyuan Ma, Sen Guo, Huina Wang, Sijia Wang, Qiong Shi, Lin Liu, Tao Zhao, Fengfan Yang, Shuyang Chen, Jianru Chen, Jianhong Zhao, Chen Yu, Xiuli Yi, Yuqi Yang, Jingjing Ma, Qingrong Ni, Guannan Zhu, Tianwen Gao, Chunying Li
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Cell Biology
Ji-Min Dai, Wei-Nan Guo, Yi-Zhou Tan, Kun-Wei Niu, Jia-Jia Zhang, Cheng-Li Liu, Xiang-Min Yang, Kai-Shan Tao, Zhi-Nan Chen, Jing-Yao Dai
Summary: Wogonin can alleviate septic liver injury by activating Nrf2 signaling, reducing oxidative stress, and inhibiting inflammatory response, showing potential as a therapeutic agent for sepsis-induced liver damage.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Qiong Shi, Lin Liu, Weigang Zhang, Yanhong Zhao, Yu Liu, Guannan Zhu, Weinan Guo, Tao Zhao, Jianhong Zhao, Lei Wang, Chunying Li, Tianwen Gao
Summary: The study indicates that systemic IFN-alpha 1b treatment is relatively safe and may prolong the survival of patients with unresectable metastatic melanoma. For patients who had not received adjuvant interferon therapy, the treatment effect was moderate.
Article
Dermatology
Sijia Wang, Xiuli Yi, Zhenjie Wu, Sen Guo, Wei Dai, Huina Wang, Qiong Shi, Kang Zeng, Weinan Guo, Chunying Li
Summary: CAMKK2 regulates the sensitivity of melanoma cells to ferroptosis by modulating the AMPK.NRF2 pathway, potentially playing a crucial role in melanoma treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Huina Wang, Xiuli Yi, Sen Guo, Sijia Wang, Jinyuan Ma, Tao Zhao, Qiong Shi, Yangzi Tian, Hao Wang, Lintao Jia, Tianwen Gao, Chunying Li, Weinan Guo
Summary: The XBP1-MARCH5-MFN2 axis in melanoma cells coordinates mitochondrial fission and mitophagy, promoting resistance to ER stress. Targeting mitochondrial quality control machinery could enhance the efficacy of ER stress inducing agents against cancer.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Jingjing Ma, Qiong Shi, Sen Guo, Peng Xu, Xiuli Yi, Yuqi Yang, Weigang Zhang, Yu Liu, Lin Liu, Qiao Yue, Tao Zhao, Tianwen Gao, Weinan Guo, Chunying Li
Summary: This study explored the expression profile and role of long non-coding RNAs (lncRNAs) in melanoma progression. Through microarray analysis, differentially-expressed lncRNAs in primary melanomas compared with nevus were identified. Bioinformatics analysis revealed the involvement of dysregulated lncRNAs in melanoma biology and immune response. CD27-AS1-208, a novel nuclear-localized lncRNA, was found to facilitate melanoma cell proliferation, invasion, and migration by interacting with STAT3. The up-regulation of CD27-AS1-208 was shown to contribute to melanoma progression by activating the STAT3 pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Qiong Shi, Lin Liu, Jianru Chen, Weigang Zhang, Weinan Guo, Xiao Wang, Huina Wang, Sen Guo, Qiao Yue, Jingjing Ma, Yu Liu, Guannan Zhu, Tao Zhao, Jianhong Zhao, Ying Liu, Tianwen Gao, Chunying Li
Summary: This study conducted genomic research on acral melanoma in Asian populations, identifying mutated genes associated with the disease and analyzing its pathogenesis and therapeutic targets. Additionally, it reconstructed the mutational processes of the samples and identified early mutational events. This study provides a foundation for the development of personalized strategies for treating acral melanoma in Asian populations.
CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Jianru Chen, Xinju Wang, Tingting Cui, Qingrong Ni, Qian Zhang, Daopei Zou, Kaiqiao He, Wei Wu, Jingjing Ma, Yinghan Wang, Weinan Guo, Chunying Li, Shuli Li
Summary: Tregs in vitiligo patients are functionally disturbed, exhibiting a Th1-like phenotype, reduced suppression on CD8(+)T cells, and higher chemotaxis. Vitiligo serum can induce Tregs from healthy controls to adopt a Th1-like phenotype and impaired suppression.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Immunology
Yuhan Chen, Xiuli Yi, Ningyue Sun, Weinan Guo, Chunying Li
Summary: This review introduces the epidemiology, clinical characteristics, and therapeutic innovations of melanoma, discusses the tumor microenvironment and functions of different types of infiltrating immune cells in melanoma, systematically summarizes the linkage between epigenetics and antitumor immunity in melanoma, and introduces the progress of clinical trials regarding epigenetics-based melanoma immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Weinan Guo, Zhenjie Wu, Jianru Chen, Sen Guo, Weiming You, Sijia Wang, Jinyuan Ma, Huina Wang, Xiangxu Wang, Hao Wang, Jingjing Ma, Yuqi Yang, Yangzi Tian, Qiong Shi, Tianwen Gao, Xiuli Yi, Chunying Li
Summary: The upregulation of miR-21-3p contributes to IFN-gamma-driven ferroptosis and synergizes with anti-PD-1 antibody. Nanoparticle delivery of miR-21-3p is a promising therapeutic approach to increase immunotherapy efficacy without obvious systemic side effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Weinan Guo, Huina Wang, Chunying Li
Summary: Melanoma, a lethal skin cancer, has limited therapeutic options. Innovations in targeting mutated driver genes and immune checkpoints have improved patient prognosis, but resistance and low response rates remain challenges in melanoma treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Medicine, Research & Experimental
Yu Liu, Jingjing Ma, Yuqi Yang, Lin Liu, Guannan Zhu, Xiaoxia Wang, Shiyu Wang, Weinan Guo, Qiao Yue, Tao Zhao, Chunying Li, Tianwen Gao, Qiong Shi
MEDICAL SCIENCE MONITOR
(2020)
