Review
Pharmacology & Pharmacy
Dany Perocheau, Loukia Touramanidou, Sonam Gurung, Paul Gissen, Julien Baruteau
Summary: Exosomes, a subset of extracellular vesicles, play a crucial role in cell-cell communication and have shown promising potential as diagnostic biomarkers and therapeutic carriers. Their reduced immunogenicity and ability to cross physiological barriers make them an appealing option for clinical application.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Juliette Schoenberg, Juergen Borlak
Summary: The study evaluated the quantification of blood-borne miRNAs and found that in the assessment of miRNAs related to hepatic impairment, the internal control showed high variability and some diagnostic miRNAs lacked accuracy.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Computer Science, Theory & Methods
Kelsey Harley, Rodney Cooper
Summary: The importance of integrity in information security has been traditionally underestimated but is crucial for our well-being. This review discusses information integrity through formal information flow models and the data modification view, as well as its relationship to data quality. While integrity protection is advancing, there is still a lack of standardization in terminology and application.
ACM COMPUTING SURVEYS
(2021)
Review
Biochemistry & Molecular Biology
Wided Najahi-Missaoui, Robert D. Arnold, Brian S. Cummings
Summary: The field of nanotechnology has rapidly grown over the past two decades, leading to the emergence of nanoparticles as promising tools in various applications. However, questions about the toxicity and safety of nanoparticles remain unanswered, despite efforts to understand them. Several approaches to minimize and prevent nanoparticle toxicity have been identified through research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Mauricio Flores Carvalho, Yuri L. Boteon, James V. Guarrera, Pranjal R. Modi, Laura Llado, Georg Lurje, Mureo Kasahara, Philipp Dutkowski, Andrea Schlegel
Summary: This article discusses the challenges of implementing machine perfusion of solid organs in practice, including the roles of clinical practitioners, hospitals, regulatory bodies, and industry stakeholders worldwide. It emphasizes the need for strong collaboration between these stakeholders and presents integrated roadmaps to achieve wider implementation. The importance of research development, clear regulatory pathways, and flexible reimbursement schemes is highlighted, along with potential solutions to address relevant hurdles. The article provides an overview of the current landscape of liver perfusion and underscores the role of clinical, regulatory, and financial stakeholders globally.
Review
Biochemistry & Molecular Biology
Elisa Arrigo, Stefano Comita, Pasquale Pagliaro, Claudia Penna, Daniele Mancardi
Summary: Ischemia is a potential mechanism in various pathological conditions, and understanding the intracellular events during and after blood restriction is crucial for improving clinical outcomes. Gasotransmitters, such as nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO), have been shown to have cytoprotective effects in experiments and are being tested in clinical trials for ischemia/reperfusion injury treatment. This review aims to assess the current development of therapeutic applications for NO, H2S, and CO and their potential clinical scenarios.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Maha AlSendi, David O'Reilly, Youssef H. Zeidan, Catherine M. Kelly
Summary: Patients with metastatic breast cancer have seen significant improvements in survival recently. Treatment decisions for oligometastatic breast cancer vary widely due to lack of trials and disease heterogeneity. Research is ongoing to better understand the biology and treatment options for oligometastatic breast cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Aoife Reilly, Lucia Chehade, Rashmi Kothary
Summary: Spinal Muscular Atrophy (SMA) is a severe neuromuscular disease caused by the loss or deletion of the survival motor neuron 1 gene (SMN1). Significant advancements have been made in SMA therapeutics, improving the outcomes for patients. However, challenges and limitations still exist, necessitating further research for the best outcomes.
Review
Immunology
Benedict T. Bloom, Mary-Jessimine Bushell
Summary: Drug abuse is a global public health problem. Immunotherapy, particularly vaccines, has been studied as a treatment option for drug abuse. However, efficacy data do not support the use of vaccines for treating nicotine and cocaine abuse. Clinical trials are still needed to determine the effectiveness of vaccines against opioid abuse. Current treatments have limitations, highlighting the need for novel treatment strategies.
Article
Engineering, Electrical & Electronic
Rajeev Bansal
Summary: If the world were to self-destruct, the last sound we would hear would be an expert saying, "It can't be done."
IEEE MICROWAVE MAGAZINE
(2023)
Review
Clinical Neurology
Marie Dagonnier, Geoffrey A. Donnan, Stephen M. Davis, Helen M. Dewey, David W. Howells
Summary: Blood biomarkers have the potential to expedite diagnosis and increase eligibility for reperfusion therapies in acute stroke, but further research is needed to determine the optimal timing for early measurement.
FRONTIERS IN NEUROLOGY
(2021)
Editorial Material
Cell Biology
Jake Atkinson, Eva Bezak, Ivan Kempson
Summary: DNA double-strand breaks play a fundamental role in cell biology, but there is a lack of a reliable assay for quantitatively visualizing DSBs. Relying on proxy detection methods can lead to misinterpretation of conventional assays, highlighting the need for the development of more accurate DSB detection methods.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Business
Fara Azmat, Ameeta Jain, Bhavani Sridharan
Summary: The effectiveness of PRME in transforming management education to RME and developing responsible future leaders has been debated. This study analyzes how the introduction of SDGs has influenced the progress of RME across B-schools using Habermas's theory. Multiple stakeholders' perspectives from different countries are considered to understand the challenges and opportunities for embedding SDGs for RME. A four-step framework is proposed for B-schools to effectively integrate SDGs. This research has important implications for academics, B-schools, and policymakers to improve policy and practice in higher education and contribute to the PRME/SDG discourse.
JOURNAL OF BUSINESS RESEARCH
(2023)
Article
Development Studies
Son Nghiem, Bach Tran, Clifford Afoakwah, Joshua Byrnes, Paul Scuffham
Summary: The history of humankind has witnessed a continuous improvement in living standards, but economic development has also had negative impacts on the environment and health. Technological progress is believed to help achieve a balance between health, income, and the environment. The study found evidence of convergence in emissions of carbon monoxide and nitrogen oxides, and emphasized the importance of improving human capital for the synergy between health, clean environment, and positive economic growth.
Editorial Material
Medicine, General & Internal
Lucy Perrem, Felix Ratjen
Summary: This study found that cross-species immune responses may take weeks or months to affect renal function after transplantation, indicating that the immune reaction in kidney transplantation is a long-term process. Additionally, the study also found that the transcriptional activation of immunity primarily occurs in innate immune cells rather than lymphocytes.
