Article
Geriatrics & Gerontology
Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Michelle M. Adams
Summary: Using the zebrafish model, research found that dietary restriction can increase healthspan and slow down the effects of aging on cells and synapses. Aging reduces certain protein levels, while different dietary regimens have varying effects.
NEUROBIOLOGY OF AGING
(2021)
Article
Genetics & Heredity
Begun Erbaba, Duygu Macaroglu, N. Ilgim Ardic-Avci, Ayca Arslan-Ergul, Michelle M. Adams
Summary: Overfeeding and obesity increase the risk for brain aging and neurodegenerative diseases, while caloric restriction has effects on extending lifespan and health-span. The study on zebrafish found that overfeeding led to downregulation of the stem cell marker Sox2, while caloric restriction may prolong lifespan by reinforcing the stem cell pool and downregulating inflammation.
Review
Biochemistry & Molecular Biology
Aleksandra Mladenovic Djordjevic, Natasa Loncarevic-Vasiljkovic, Efstathios S. Gonos
Summary: It is well established that lifestyle and dietary habits have a significant impact on life span, aging rate, and age-related diseases. Dietary restriction and healthy dietary patterns have been linked to increased survival and longevity, with the ability to modify oxidative stress levels. However, the debate regarding the role of dietary restriction as a golden standard for prolonging life span and ameliorating aging effects continues.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Medicine, General & Internal
Froylan Albarran-Tamayo, Blanca Murillo-Ortiz, Roberto Gonzalez Amaro, Sergio Lopez Briones
Summary: In aged men, telomere length shortening and reduced T cell proliferation are not related to the capacity of IL-2 production and CD25 expression on T lymphocytes.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Cell Biology
Fei Yin, Yang Zhou, Dongli Xie, Jianchen Hu, Xiaogang Luo
Summary: This study synthesizes multiple research evidence and concludes that exposure to nanomaterials is associated with telomere attrition, cell senescence, and increased mortality in model animals.
AGEING RESEARCH REVIEWS
(2023)
Review
Food Science & Technology
Sepideh Aminzadeh-Gohari, Barbara Kofler, Chiara Herzog
Summary: There is increasing evidence that dietary restriction can extend both lifespan and healthspan, and this is achieved through molecular mechanisms such as removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Hye-Yeon Lee, Bora Lee, Eun-Ji Lee, Kyung-Jin Min
Summary: Dietary restriction (DR) is a widely accepted strategy to increase lifespan and stress resistance in eukaryotic organisms. This study investigated the effects of parental DR on the fitness of their offspring and found that the offspring displayed increased body weight, stress resistance, and lifespan. However, the development and fecundity of the offspring were not affected. Interestingly, parental DR led to a reduction in the feeding rate of their offspring. These findings suggest that the effects of DR can extend to the offspring and should be considered in studies on aging.
Review
Cell Biology
Begun Erbaba, Ayca Arslan-Ergul, Michelle M. Adams
Summary: Caloric restriction is a non-genetic intervention that extends lifespan and healthspan by promoting cell survival, reducing cell proliferation, inducing stem cell quiescence, and preserving stem cell reserve for extreme needs. This protective mechanism induced by diet may involve downregulation of crucial cell cycle-related transcription activators and could offer new targets for treatments against neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Nutrition & Dietetics
Mario Vailati-Riboni, Laurie Rund, Maria Elisa Caetano-Silva, Noah T. Hutchinson, Selena S. Wang, Katiria Soto-Diaz, Jeffrey A. Woods, Andrew J. Steelman, Rodney W. Johnson
Summary: With increasing age, microglia shift towards a pro-inflammatory phenotype, but increasing dietary fiber intake may prevent or reverse this dysregulation. Inulin supplementation can increase the levels of SCFAs in the cecum and restore microglial gene expression and TNF-α secretion to a more youthful state.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Hui Duan, Jinwei Li, Leilei Yu, Liuping Fan
Summary: Dietary restriction can delay aging by regulating nutrient-sensing pathways and gut microbiota. However, the effects of DR regimens on longevity remain controversial, with some studies suggesting that intermittent fasting influences longevity, while others suggest that restricted-carbohydrate or -protein diets determine health and longevity. Individual differences and DR-related factors play a significant role in explaining the controversial effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biology
Hiroshi Nishida, Morihiro Okada, Lynna Yang, Tomomi Takano, Sho Tabata, Tomoyoshi Soga, Diana M. Ho, Jongkyeong Chung, Yasuhiro Minami, Sa Kan Yoo
Summary: The study reveals that Src drives cell proliferation and death through parallel MAPK pathways in an obligatorily coupled manner. Reduction of dietary methionine can uncouple the connection between cell proliferation and death, suppressing tumorigenesis and tumor-induced lethality.
Article
Cell Biology
Natasha A. Grande de Franca, Yves Rolland, Sophie Guyonnet, Philipe de Souto Barreto
Summary: The hallmarks of aging are a set of interconnected mechanisms that can be influenced by lifestyle factors, such as dietary strategies. This review aimed to summarize the evidence on the impact of dietary restriction or specific dietary patterns on these hallmarks. Dietary restriction has been shown to modulate genomic instability, proteostasis, nutrient sensing, cellular senescence, and intercellular communication. Limited evidence exists on the role of dietary patterns, with studies mainly focusing on the Mediterranean Diet, plant-based diets, and the ketogenic diet. It is crucial to determine the effects of nutritional strategies on lifespan and healthspan considering feasibility, long-term adherence, and potential side effects.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Smilja Todorovic, Valentina Simeunovic, Milica Prvulovic, Tamara Dakic, Tanja Jevdjovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovic
Summary: Insulin plays a key role in peripheral glucose regulation, but also affects brain function and cognitive performance. Dietary restriction has been shown to delay neurodegenerative processes associated with aging, but the timing and duration of the restriction may be important factors in its effectiveness.
Article
Cell Biology
Carlos Gonzalez-Blanco, Patricia Marques, Jesus Burillo, Beatriz Jimenez, Gema Garcia, Manuel Benito, Carlos Guillen
Summary: Hutchinson-Gilford Progeria Syndrome is a rare disease characterized by accelerated aging and other pathological changes due to the accumulation of abnormal protein progerin in the nucleus. Recent studies have found that improving the proliferative capacity of cells can help reduce the toxicity of prelamin A protein and slow down the aging process.
Article
Multidisciplinary Sciences
Beryl Laplace-Builhe, Audrey Barthelaix, Said Assou, Candice Bohaud, Marine Pratlong, Dany Severac, Gautier Tejedor, Patricia Luz-Crawford, Mai Nguyen-Chi, Marc Mathieu, Christian Jorgensen, Farida Djouad
Summary: This study utilized single-cell RNA sequencing to characterize the cells involved in blastema formation and fin regeneration in zebrafish, highlighting the role of neural crest cells in orchestrating regeneration through the NRG1/ErbB axis. The presence of foxd3-positive neural crest-derived cells was identified to be crucial in regulating macrophage recruitment and polarization during blastema formation and caudal fin regeneration. The findings underscore the critical function of the NRG1/ErbB pathway in controlling the communication between macrophages and neural crest-derived cells during fish fin regeneration.
NATURE COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Begun Erbaba, Ozge Pelin Burhan, Naz Serifoglu, Bihter Muratoglu, Fatma Kahveci, Michelle M. Adams, Ayca Arslan-Ergul
NEUROBIOLOGY OF AGING
(2020)
Article
Geriatrics & Gerontology
Aysenur Karaduman, Elif Tugce Karoglu-Eravsar, Utku Kaya, Alaz Aydin, Michelle M. Adams, Hulusi Kafaligonul
Summary: Understanding the principles underlying age-related changes in motion perception is crucial for improving the quality of life and health of older adults. The study found that age and genotype had no significant main effects, but there was a significant three-way interaction between contrast level, age, and genotype in optomotor responses. These findings suggest a complex relationship between visual motion characteristics and the cholinergic system during neural aging.
NEUROBIOLOGY OF AGING
(2021)
Review
Cell Biology
Begun Erbaba, Ayca Arslan-Ergul, Michelle M. Adams
Summary: Caloric restriction is a non-genetic intervention that extends lifespan and healthspan by promoting cell survival, reducing cell proliferation, inducing stem cell quiescence, and preserving stem cell reserve for extreme needs. This protective mechanism induced by diet may involve downregulation of crucial cell cycle-related transcription activators and could offer new targets for treatments against neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Geriatrics & Gerontology
Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Michelle M. Adams
Summary: This study aimed to investigate the effects of environmental enrichment on cognitive function and synaptic dynamics in aging animals. Results indicated that environmental enrichment can increase brain volume in aged animals and prevent declines in synaptic proteins, glutamate receptor subunits, and neuronal markers.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Geriatrics & Gerontology
Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Michelle M. Adams
Summary: Using the zebrafish model, research found that dietary restriction can increase healthspan and slow down the effects of aging on cells and synapses. Aging reduces certain protein levels, while different dietary regimens have varying effects.
NEUROBIOLOGY OF AGING
(2021)
Editorial Material
Neurosciences
Dilara Halim, Fen-Biao Gao
TRANSLATIONAL NEURODEGENERATION
(2022)
Article
Genetics & Heredity
Begun Erbaba, Duygu Macaroglu, N. Ilgim Ardic-Avci, Ayca Arslan-Ergul, Michelle M. Adams
Summary: Overfeeding and obesity increase the risk for brain aging and neurodegenerative diseases, while caloric restriction has effects on extending lifespan and health-span. The study on zebrafish found that overfeeding led to downregulation of the stem cell marker Sox2, while caloric restriction may prolong lifespan by reinforcing the stem cell pool and downregulating inflammation.
Article
Genetics & Heredity
Naz Serifoglu, Begun Erbaba, Michelle M. Adams, Ayca Arslan-Ergul
Summary: Telomerase reactivation is common in most cancers. This study focused on investigating the DNA methylation status of proximal and distal TERT promoter, and found a hypomethylation site in the distal tert promoter that is associated with aging and shortened telomeres. Through site-directed mutagenesis and silencing of DNMT3B, the critical role of GC spots and DNMT3B in regulating telomerase expression and senescence was revealed. The study also proposed a model for the efficacy of two chemotherapeutic drugs on gliomas based on the criticality of the distal TERT promoter.
JOURNAL OF NEUROGENETICS
(2022)
Review
Genetics & Heredity
Dilara O. Halim, Mary Munson, Fen-Biao Gao
Summary: Exocytosis is a vital process that mediates the delivery of materials to the cell surface or the release of cargoes to the extracellular space. The exocyst, an octameric protein complex, plays a crucial role in controlling the assembly of SNARE complex for vesicle fusion and tethering secretory vesicles to the plasma membrane. Dysfunction in exocyst has been linked to various cellular functions and human diseases, particularly neurodevelopmental disorders and ciliopathies. This review summarizes the mutations and variants in exocyst subunits associated with disease, as well as the implications of exocyst dysfunction in other disorders.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
