Article
Cell Biology
Jianye Yang, Leilei Qin, Jiaxing Huang, Yuwan Li, Sha Xu, Hai Wang, Sizheng Zhu, Jiawei Wang, Bo Zhu, Feilong Li, Wei Huang, Xuan Gong, Ning Hu
Summary: Astragalus polysaccharide (APS) has demonstrated the ability to inhibit osteoclast formation and differentiation, regulate inflammatory osteolysis, and potentially become an effective treatment for disorders associated with osteoclasts.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Urology & Nephrology
Qi Zhang, Qiuhong Sun, Yan Tong, Xiao Bi, Lin Chen, Jianxin Lu, Wei Ding
Summary: This study confirmed the renoprotective effect of leonurine in attenuating cisplatin-induced AKI and explored the potential mechanisms associated with it.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Cell Biology
Yuzhen Li, Lang Shi, Fan Zhao, Yanwen Luo, Mingjiao Zhang, Xiongfei Wu, Jiefu Zhu
Summary: This study reveals the protective effect of PIM1 in cisplatin-induced AKI and suggests that the regulation of Drp1 activation might be the underlying mechanism.
CELLULAR SIGNALLING
(2024)
Article
Biochemistry & Molecular Biology
Peipei Zhang, Hao Lu, Yuan Wu, Danbo Lu, Chenguang Li, Xiangdong Yang, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: Doxorubicin (DOX) can lead to mitochondrial dysfunction and heart failure. COX5A, an important regulator of mitochondrial energy metabolism, plays a protective role in DOX-induced cardiomyopathy. The expression of COX5A is decreased in patients with dilated cardiomyopathy and after DOX treatment. Overexpression of COX5A improves cardiac function, glucose uptake, mitochondrial morphology, COX activity, and ATP content in DOX-stimulated mice. COX5A protects against oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis via the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Jianping Chen, Tugui Fan, Jiarui Li, Rui Li, Xiaofei Liu, Bing Wu, Jialong Gao, Ying Liu, Hao Dong, Saiyi Zhong
Summary: This study examined the protective effects of curcumin/cyclodextrin polymer inclusion complex (CUR/CDP) on ethanol-induced liver injury in mice. The results showed that CUR/CDP at high dose had a stronger protective effect than silymarin and CUR by enhancing the activities of antioxidant enzymes and suppressing DNA damage.
FOOD SCIENCE & NUTRITION
(2023)
Article
Immunology
Hailong Li, Ruotong Zhang, Yayue Hu, Jinhe Li, Ying Yang, Dan Wu, Xiaoting Gu, Fubo Zhang, Honggang Zhou, Cheng Yang
Summary: This study explores the effect and mechanism of axitinib on liver fibrosis using a CCl4-induced hepatic fibrosis mouse model and a TGF-β1-induced hepatic stellate cell model. The results show that axitinib can alleviate liver tissue damage, inhibit enzyme production, collagen and hydroxyproline deposition, and protein expression associated with liver fibrosis. Axitinib also inhibits the expression of CTGF and α-SMA in hepatic stellate cells. Further studies reveal that axitinib inhibits HSCs activation by enhancing mitochondrial complex activity, thus mitigating the progression of liver fibrosis. This study highlights the strong potential of axitinib in the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Saeed Mehrzadi, Mehdi Goudarzi, Iman Fatemi, Zahra Basir, Alireza Malayeri, Hamidreza Khalili
Summary: The study demonstrated that CHR could alleviate the nephrotoxic effects of SA through antioxidative stress and anti-inflammatory mechanisms.
Article
Endocrinology & Metabolism
Jay Kumar, Ghulam Mohammad, Kumari Alka, Renu A. Kowluru
Summary: Mitochondrial dysfunction plays a critical role in the development of diabetic retinopathy. Hyperglycemia downregulates the mtDNA-encoded LncRNA cytochrome B (LncCytB) in retinal endothelial cells, leading to impaired mtDNA packaging and increased vulnerability to damage.
Article
Biochemistry & Molecular Biology
Jian Sun, Jinjin Pan, Qinlong Liu, Jizhong Cheng, Qing Tang, Yuke Ji, Ke Cheng, Rui Wang, Liang Liu, Dingyou Wang, Na Wu, Xu Zheng, Junxia Li, Xueyan Zhang, Zhilong Zhu, Yanchun Ding, Feng Zheng, Jia Li, Ying Zhang, Yuhui Yuan
Summary: This study found that melatonin can prevent aristolochic acid-induced acute kidney injury by attenuating mitochondrial damage, providing a potential therapeutic method for renal AA toxicity.
BIOMOLECULES & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Anke Schumann, Marion Brutsche, Monique Havermans, Sarah C. Gruenert, Stefan Koelker, Olaf Gross, Luciana Hannibal, Ute Spiekerkoetter
Summary: Methylmalonic aciduria (MMA-uria) is a condition caused by a lack of the enzyme methylmalonyl-CoA mutase (MUT) in mitochondria. It affects energy generation from certain amino acids, fatty acids, and cholesterol. Chronic kidney disease (CKD) is a known complication of MMA-uria. Research has shown that MMA-uria cells have increased creatinine levels and decreased antioxidant defense. Mitochondrial homeostasis is disrupted, with changes in metabolites and impaired energy generation from fatty acid oxidation. Potentially toxic metabolite methylcitrate is increased under high protein and isoleucine/valine conditions. Mitophagy is disabled, while autophagy is active, especially under high protein and isoleucine/valine conditions. Mitochondrial dynamics shift towards fission and the stress-resistance protein Sirtuin1 is down-regulated. Overall, these findings highlight the role of protein toxicity and provide insight into how accumulating toxic organic acids may contribute to CKD in MMA-uria.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Mingfei Guo, Jiarong Gao, Lei Jiang, Yaji Dai
Summary: Diabetic nephropathy is a chronic inflammatory complication of diabetes characterized by hyperglycemia, albuminuria, and edema. Astragalus polysaccharide, extracted from Astragalus membranaceus, has been used for the treatment of diabetes mellitus. This study aimed to investigate the molecular mechanism of Astragalus polysaccharide on diabetic nephropathy. The results demonstrated that Astragalus polysaccharide effectively reduced fasting blood glucose levels, improved kidney function, and alleviated renal pathological damage in diabetic nephropathy models.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Min Cai, Keqi Gao, Haichan Huang, Xinyue He, Di Jiang, Weihua Jin, Weihong Zhong
Summary: A new sulfated polysaccharide (SP7) with kidney protective activity was purified from Laminarina japonica. SP7 showed inhibitory effects on oxidative kidney damage and ferroptosis, suggesting its potential in protecting kidney health.
PROCESS BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Javier Donate-Correa, Beatriz Martin-Carro, Jorge B. Cannata-Andia, Carmen Mora-Fernandez, Juan F. Navarro-Gonzalez
Summary: Reducing oxidative stress is crucial in preventing cellular senescence and aging. In kidney disease, targeting oxidative stress, mitochondrial dysfunction, and cellular senescence in kidney cells could be significant for controlling disease progression. This review focuses on the mechanisms linking oxidative stress damage and mitochondrial dysfunction in kidney disease, with a special emphasis on the role of the anti-aging Klotho protein and its modulation of signaling pathways involving known antioxidant systems and mitochondrial function regulators. Klotho is proposed as a promising therapeutic target in combating oxidative stress, mitochondria abnormalities, and cellular senescence in kidney disease patients.
Review
Medicine, Research & Experimental
Anjali Srivastava, Bhawna Tomar, Divyansh Sharma, Srikanta Kumar Rath
Summary: Chronic kidney disease (CKD) permanently changes the function and structure of the kidney over time and is often characterized by glomerular filtration defect or proteinuria lasting longer than three months. Mitochondrial dysfunction is a common response to CKD damage, leading to altered mitochondrial shape, increased oxidative stress, and decreased biogenesis and ATP generation. This article summarizes the recent advancements in understanding the involvement of mitochondrial remodeling in CKD and emphasizes the importance of understanding mitochondrial biology for developing effective treatment options.
Article
Medicine, Research & Experimental
Jing Zhu, Zhejun Chen, LiTing Zhu, ZeHui Meng, GenCheng Wu, ZhanZhuang Tian
Article
Medicine, Research & Experimental
Jing Zhu, Zhejun Chen, Jinxing Tian, Zehui Meng, Mingda Ju, Gencheng Wu, Zhanzhuang Tian
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2017)
Article
Neurosciences
Jing Zhu, Zhejun Chen, Zehui Meng, Minda Ju, Mizhen Zhang, Gencheng Wu, Haidong Guo, Zhanzhuang Tian
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Oncology
Wen Cai, Zaoyu Wang, Biao Cai, Yichu Yuan, Wen Kong, Jin Zhang, Yonghui Chen, Qiang Liu, Yiran Huang, Jiwei Huang, Wei Xue
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2020)
Letter
Oncology
Wen Cai, Biao Cai, Juan Zhou, Yonghui Chen, Jin Zhang, Yiran Huang, Wei Xue, Jiwei Huang
CANCER COMMUNICATIONS
(2019)
Article
Oncology
Minyan Zhu, Zhejun Chen, Yuehan Wei, Yanhong Yuan, Liang Ying, Hang Zhou, Xiajing Che, Min Fang Zhang, Zhaohui Ni, Ming Zhang, Shan Mou
Summary: This study aimed to evaluate the predictive value of urinary KIM-1 and other biomarkers for the long-term prognosis of kidney transplantation patients. Results showed that uKIM-1 on the first day post transplantation can predict short-term graft function and is a potent biomarker for the long-term prognosis of graft function.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shaowei Xie, Wenshe Sun, Chunfu Zhang, Baijun Dong, Jingxing Yang, Mengfei Hou, Liqin Xiong, Biao Cai, Xuesong Liu, Wei Xue
Summary: The flexible manipulation of cancer cell fate through exogenous stimulation-induced metabolic reprogramming can effectively handle therapy resistance and sensitize tumors to ferroptosis. The proposed heat-triggered tumor-specific ferroptosis strategy utilizing nanoformulation showed promising antitumor effects by inducing oxidative damage and targeting key pro-ferroptotic factors. This work provides insights and strategies for heat-triggered ferroptosis in situ, offering a potential alternative to direct ferroptosis inducers with reduced side effects.
Article
Cell Biology
Zhejun Chen, Ting Zhang, Kaiqiong Mao, Xinghua Shao, Yao Xu, Minyan Zhu, Hang Zhou, Qin Wang, Zhenyuan Li, YuanYuan Xie, Xiaodong Yuan, Liang Ying, Ming Zhang, Jiajia Hu, Shan Mou
Summary: By utilizing single-cell RNA sequencing technology, the study investigated the cellular gene expression profiles of glomerulonephritis and revealed the heterogeneity of kidney diseases, uncovering novel findings related to various renal diseases.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Biao Cai, Mengfei Hou, Shijun Zhang, Zhixiang Xin, Jiwei Huang, Jingxing Yang, Yueming Wang, Xingyun Cai, Shaowei Xie, Chunfu Zhang, Yiran Huang
Summary: The study utilized a phase change material to encapsulate iron oxide nanoparticles and a UPR modulator for enhanced cancer therapy. The theranostic platform showed excellent tumor-targeting properties and effective photothermal-enhanced tumor inhibition both in vitro and in vivo. By inducing ER stress and apoptosis in cancer cells through redox imbalance, the strategy offers novel directions for treating therapy-resistant cancers.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Ting Zhang, Chenbo Ding, Huifang Chen, Jun Zhao, Zhejun Chen, Baiwen Chen, Kaiqiong Mao, Yajuan Hao, Manolis Roulis, Hao Xu, Yuval Kluger, Qiang Zou, Youqiong Ye, Meixiao Zhan, Richard A. Flavell, Hua-Bing Li
Summary: Colonic mucosal barrier dysfunction is a major cause of inflammatory bowel disease (IBD), and m(6)A modification plays a crucial role in maintaining the homeostatic self-renewal of colonic stem cells.
Article
Oncology
Minyan Zhu, Zhenhua Zhang, Zhejun Chen, Yao Xu, Jiajin Wu, Xiajing Che, Liang Ying, Xinghua Shao, Lumin Tang, Wenyan Zhou, Minfang Zhang, Ming Zhang, Shan Mou
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)