Structural Diversity, Characterization and Toxicology of Microcystins

The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium

(2019) Shishido et al.   Marine Drugs

Comprehensive multi-technique approach reveals the high diversity of microcystins in field collections and an associated isolate of Microcystis aeruginosa from a Turkish lake

(2019) Mete Yilmaz et al.   TOXICON

The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review

(2019) Du et al.   Toxins

Novel Microcystins from Planktothrix prolifica NIVA-CYA 544 Identified by LC-MS/MS, Functional Group Derivatization and 15N-labeling

(2019) Vittoria Mallia et al.   Marine Drugs

A Data-Independent Methodology for the Structural Characterization of Microcystins and Anabaenopeptins Leading to the Identification of Four New Congeners

(2019) Audrey Roy-Lachapelle et al.   Toxins

Dhb Microcystins Discovered in USA Using an Online Concentration LC–MS/MS Platform

(2019) Johnna A. Birbeck et al.   Toxins

Microcystin-RR: Occurrence, content in water and food and toxicological studies. A review

(2018) Leticia Díez-Quijada et al.   ENVIRONMENTAL RESEARCH

An overview of the accumulation of microcystins in aquatic ecosystems

(2018) Thanh-Luu Pham et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

The biosynthesis of 15 N-labeled microcystins and the comparative MS/MS fragmentation of natural abundance and their 15 N-labeled congeners using LC-MS/MS

(2018) Allison K. Stewart et al.   TOXICON

Toxic Cyanobacteria in Svalbard: Chemical Diversity of Microcystins Detected Using a Liquid Chromatography Mass Spectrometry Precursor Ion Screening Method

(2018) Julia Kleinteich et al.   Toxins

Analysis of free and metabolized microcystins in samples following a bird mortality event

(2018) Amanda J. Foss et al.   HARMFUL ALGAE

Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme

(2018) Ganesan Senthil Kumar et al.   Science Advances

Occurrence and toxicity of microcystin congeners other than MC-LR and MC-RR: A review

(2018) Leticia Díez-Quijada et al.   FOOD AND CHEMICAL TOXICOLOGY

Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water

(2017) et al.   Marine Drugs

Current research scenario for microcystins biodegradation – A review on fundamental knowledge, application prospects and challenges

(2017) Jieming Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Modulation of microcystin congener abundance following nitrogen depletion of a Microcystis batch culture

(2016) Jonathan Puddick et al.   AQUATIC ECOLOGY

Conjugation of Microcystins with Thiols Is Reversible: Base-Catalyzed Deconjugation for Chemical Analysis

(2016) Christopher O. Miles et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toxicological Perspective on Climate Change: Aquatic Toxins

(2016) Luis M. Botana   CHEMICAL RESEARCH IN TOXICOLOGY

Regioselective Cleavage of Thioether Linkages in Microcystin Conjugates

(2016) Ivan Zemskov et al.   CHEMISTRY-A EUROPEAN JOURNAL

High diversity of microcystins in a Microcystis bloom from an Algerian lake

(2016) Ratiba Bouhaddada et al.   ENVIRONMENTAL POLLUTION

The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria

(2016) Leanne A. Pearson et al.   HARMFUL ALGAE

An overview of cyanobacterial bloom occurrences and research in Africa over the last decade

(2016) L.L. Ndlela et al.   HARMFUL ALGAE

How rising CO 2 and global warming may stimulate harmful cyanobacterial blooms

(2016) Petra M. Visser et al.   HARMFUL ALGAE

Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans

(2016) Emily Chen et al.   mBio

Feasibility study on production of a matrix reference material for cyanobacterial toxins

(2015) Christie Hollingdale et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Sensitive biosensor based on recombinant PP1α for microcystin detection

(2015) Gaëlle Catanante et al.   BIOSENSORS & BIOELECTRONICS

Combined LC–MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle

(2015) Roberta Teta et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

An integrated strategy for rapid and accurate determination of free and cell-bound microcystins and related peptides in natural blooms by liquid chromatography–electrospray-high resolution mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry using both positive and negative ionization modes

(2015) Cintia Flores et al.   JOURNAL OF CHROMATOGRAPHY A

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria

(2015) Elke Dittmann et al.   TRENDS IN MICROBIOLOGY

UV-B Exposure Affects the Biosynthesis of Microcystin in Toxic Microcystis aeruginosa Cells and Its Degradation in the Extracellular Space

(2015) Zhen Yang et al.   Toxins

Further Characterization of Glycine-Containing Microcystins from the McMurdo Dry Valleys of Antarctica

(2015) Jonathan Puddick et al.   Toxins

Microcystin Production and Regulation under Nutrient Stress Conditions in Toxic Microcystis Strains

(2014) Juliana S. M. Pimentel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Stoichiometric regulation of phytoplankton toxins

(2014) Dedmer B. Van de Waal et al.   ECOLOGY LETTERS

Sulfide Oxidations for LC-MS Analysis of Methionine-Containing Microcystins in Dolichospermum flos-aquae NIVA-CYA 656

(2014) Christopher O. Miles et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of storage, processing and proteolytic digestion on microcystin-LR concentration in edible clams

(2014) Marisa Freitas et al.   FOOD AND CHEMICAL TOXICOLOGY

High Levels of Structural Diversity Observed in Microcystins from Microcystis CAWBG11 and Characterization of Six New Microcystin Congeners

(2014) Jonathan Puddick et al.   Marine Drugs

Nitrogen Forms Influence Microcystin Concentration and Composition via Changes in Cyanobacterial Community Structure

(2014) Marie-Eve Monchamp et al.   PLoS One

Selectivity and Potency of Microcystin Congeners against OATP1B1 and OATP1B3 Expressing Cancer Cells

(2014) Timo H. J. Niedermeyer et al.   PLoS One

On the isobaric space of 25-hydroxyvitamin D in human serum: potential for interferences in liquid chromatography/tandem mass spectrometry, systematic errors and accuracy issues

(2014) Yulin Qi et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Nitrogen availability increases the toxin quota of a harmful cyanobacterium, Microcystis aeruginosa

(2014) Geoffrey P. Horst et al.   WATER RESEARCH

Convergent evolution of [D-Leucine1] microcystin-LR in taxonomically disparate cyanobacteria

(2013) Tânia Shishido et al.   BMC EVOLUTIONARY BIOLOGY

Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation

(2013) Nathan Wlodarchak et al.   CELL RESEARCH

Potent toxins in Arctic environments – Presence of saxitoxins and an unusual microcystin variant in Arctic freshwater ecosystems

(2013) Julia Kleinteich et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Genetic Basis for O-Acetylation of the Microcystin Toxin in Cyanobacteria

(2013) David P. Fewer et al.   CHEMISTRY & BIOLOGY

Cyanobacterial toxins: Modes of actions, fate in aquatic and soil ecosystems, phytotoxicity and bioaccumulation in agricultural crops

(2013) Sylvain Corbel et al.   CHEMOSPHERE

LC-MS Analysis with Thiol Derivatization to Differentiate [Dhb7]- from [Mdha7]-Microcystins: Analysis of Cyanobacterial Blooms, Planktothrix Cultures and European Crayfish from Lake Steinsfjorden, Norway

(2013) Christopher O. Miles et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The interaction between climate warming and eutrophication to promote cyanobacteria is dependent on trophic state and varies among taxa

(2013) Anna Rigosi et al.   LIMNOLOGY AND OCEANOGRAPHY

Diversity of cyanobacteria and cyanotoxins in Hartbeespoort Dam, South Africa

(2013) Andreas Ballot et al.   MARINE AND FRESHWATER RESEARCH

Structural Characterization of New Microcystins Containing Tryptophan and Oxidized Tryptophan Residues

(2013) Jonathan Puddick et al.   Marine Drugs

Isolation and structure determination of two new hydrophobic microcystins from Microcystis sp. (CAWBG11)

(2013) Jonathan Puddick et al.   Phytochemistry Letters

The conjugation of microcystin-RR by human recombinant GSTs and hepatic cytosol

(2013) Franca M. Buratti et al.   TOXICOLOGY LETTERS

Identification of microcystins in a Lake Victoria cyanobacterial bloom using LC–MS with thiol derivatization

(2013) Christopher O. Miles et al.   TOXICON

Microcystin production revisited: conjugate formation makes a major contribution

(2012) Sven Meissner et al.   ENVIRONMENTAL MICROBIOLOGY

Thiol Derivatization for LC-MS Identification of Microcystins in Complex Matrices

(2012) Christopher O. Miles et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Use of a Generalized Additive Model to Investigate Key Abiotic Factors Affecting Microcystin Cellular Quotas in Heavy Bloom Areas of Lake Taihu

(2012) Min Tao et al.   PLoS One

Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis

(2012) U. Kaasalainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human and rat hepatocyte toxicity and protein phosphatase 1 and 2A inhibitory activity of naturally occurring desmethyl-microcystins and nodularins

(2012) Helena Ufelmann et al.   TOXICOLOGY

The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins

(2011) Susana R. Pereira et al.   CRITICAL REVIEWS IN TOXICOLOGY

Microcystin production by Microcystis aeruginosa: Direct regulation by multiple environmental factors

(2011) Sabine Jähnichen et al.   HARMFUL ALGAE

Morphological, genetic, chemical and ecophysiological characterisation of two Microcystis aeruginosa isolates from the Vistula Lagoon, southern Baltic

(2011) Hanna Mazur-Marzec et al.   OCEANOLOGIA

Increasing Oxygen Radicals and Water Temperature Select for Toxic Microcystis sp

(2011) Claudia Dziallas et al.   PLoS One

Dissociation of deprotonated microcystin variants by collision-induced dissociation following electrospray ionization

(2011) Felipe Augusto Dörr et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Possible mechanism for the foodweb transfer of covalently bound microcystins

(2010) Juliette L. Smith et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Identification of microcystins from three collection strains of Microcystis aeruginosa

(2010) Francisca F. del Campo et al.   ENVIRONMENTAL POLLUTION

Subcellular distribution of glutathione and cysteine in cyanobacteria

(2010) Bernd Zechmann et al.   PROTOPLASMA

The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: A comparison of primary human hepatocytes and OATP-transfected HEK293 cells

(2010) A. Fischer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Spatial isolation favours the divergence in microcystin net production by Microcystis in Ugandan freshwater lakes

(2010) William Okello et al.   WATER RESEARCH

Non-autonomous transposable elements associated with inactivation of microcystin gene clusters in strains of the genus Anabaena isolated from the Baltic Sea

(2010) David P. Fewer et al.   Environmental Microbiology Reports

The ecological stoichiometry of toxins produced by harmful cyanobacteria: an experimental test of the carbon-nutrient balance hypothesis

(2009) Dedmer B. Van de Waal et al.   ECOLOGY LETTERS

Occurrence of microcystin-producing cyanobacteria in Ugandan freshwater habitats

(2009) William Okello et al.   ENVIRONMENTAL TOXICOLOGY

Structure and Function of the PP2A-Shugoshin Interaction

(2009) Zheng Xu et al.   MOLECULAR CELL

Microcystin Production in the Tripartite CyanolichenPeltigera leucophlebia

(2009) Ulla Kaasalainen et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Liquid chromatography coupled to quadruple time-of-flight tandem mass spectrometry for microcystin analysis in freshwaters: method performances and characterisation of a novel variant of microcystin-RR

(2009) Pasquale Ferranti et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

The effect of structural variation in 21 microcystins on their inhibition of PP2A and the effect of replacing cys269 with glycine

(2009) Tsuyoshi Ikehara et al.   TOXICON

NIES certified reference material for microcystins, hepatotoxic cyclic peptide toxins from cyanobacterial blooms in eutrophic water bodies

(2008) Tomoharu Sano et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Widespread Distribution and Identification of Eight Novel Microcystins in Antarctic Cyanobacterial Mats

(2008) S. A. Wood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Iron availability affects mcyD expression and microcystin-LR synthesis in Microcystis aeruginosa PCC7806

(2008) Emma Sevilla et al.   ENVIRONMENTAL MICROBIOLOGY

Amino acid availability determines the ratio of microcystin variants in the cyanobacterium Planktothrix agardhii

(2008) Linda Tonk et al.   FEMS MICROBIOLOGY ECOLOGY

Stability of toxigenic Microcystis blooms

(2008) Satya Prakash et al.   HARMFUL ALGAE

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

(2008) Matthew S. Kelker et al.   JOURNAL OF MOLECULAR BIOLOGY

Isolation and Structure Determination of Two Microcystins and Sequence Comparison of the McyABC Adenylation Domains inPlanktothrixSpecies

(2008) Guntram Christiansen et al.   JOURNAL OF NATURAL PRODUCTS

The mosaic structure of the mcyABC operon in Microcystis

(2008) A. Tooming-Klunderud et al.   MICROBIOLOGY-SGM

Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of the genus Anabaena (Cyanobacteria)

(2008) D. P. Fewer et al.   MICROBIOLOGY-SGM

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL

Simultaneous determination of microcystin-LR and its glutathione conjugate in fish tissues by liquid chromatography–tandem mass spectrometry

(2007) Ming Dai et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES