Polarized lung inflammation and tie2/angiopoietin-mediated endothelial dysfunction during severe orientia tsutsugamushi infection

Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection

(2019) Brandon Trent et al.   Frontiers in Microbiology

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

(2018) Chiraz Atri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulated Th1 Immune and Vascular Responses in Scrub Typhus Pathogenesis

(2018) Lynn Soong   JOURNAL OF IMMUNOLOGY

Experimental murine acute lung injury induces increase of pulmonary TIE2-expressing macrophages

(2018) Heidi Ehrentraut et al.   Journal of Inflammation-London

A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses

(2018) Chan-Ki Min et al.   Frontiers in Immunology

The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation

(2017) Samir M. Parikh   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nitric oxide enhanced the growth of an obligated intracellular bacterium Orientia tsutsugamushi in murine macrophages

(2017) Motohiko Ogawa et al.   MICROBIAL PATHOGENESIS

Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice

(2017) Lynn Soong et al.   PLoS Neglected Tropical Diseases

Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection

(2017) Nicole L. Mendell et al.   PLoS Neglected Tropical Diseases

Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

(2017) Guang Xu et al.   PLoS Neglected Tropical Diseases

Diversification of Orientia tsutsugamushi genotypes by intragenic recombination and their potential expansion in endemic areas

(2017) Gwanghun Kim et al.   PLoS Neglected Tropical Diseases

Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis

(2017) Francesca R. Bertani et al.   Scientific Reports

Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells

(2016) Benjamin D. Singer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors

(2016) Supranee Phanthanawiboon et al.   PLoS One

Gene control of tyrosine kinaseTIE2and vascular manifestations of infections

(2016) Chandra C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

(2016) Sarah J. Higgins et al.   Science Translational Medicine

IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice

(2016) Thomas R. Shelite et al.   PLoS Neglected Tropical Diseases

An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

(2016) Lynn Soong et al.   PLoS Neglected Tropical Diseases

Protective and Pathogenic Roles of CD8+ T Lymphocytes in Murine Orientia tsutsugamushi Infection

(2016) Matthias Hauptmann et al.   PLoS Neglected Tropical Diseases

Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells

(2016) Pedro Curto et al.   Frontiers in Cellular and Infection Microbiology

Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1

(2016) Jens E. V. Petersen et al.   Scientific Reports

M2 Polarization of Human Macrophages Favors Survival of the Intracellular Pathogen Chlamydia pneumoniae

(2015) Tanja Buchacher et al.   PLoS One

Diverse macrophage populations mediate acute lung inflammation and resolution

(2014) Neil R. Aggarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung-Targeted RNA Interference Against Angiopoietin-2 Ameliorates Multiple Organ Dysfunction and Death in Sepsis

(2014) Thomas Stiehl et al.   CRITICAL CARE MEDICINE

Increased endothelial and macrophage markers are associated with disease severity and mortality in scrub typhus

(2014) Kari Otterdal et al.   JOURNAL OF INFECTION

Strong Type 1, but Impaired Type 2, Immune Responses Contribute to Orientia tsutsugamushi-Induced Pathology in Mice

(2014) Lynn Soong et al.   PLoS Neglected Tropical Diseases

Cytokine Network in Scrub Typhus: High Levels of Interleukin-8 Are Associated with Disease Severity and Mortality

(2014) Elisabeth Astrup et al.   PLoS Neglected Tropical Diseases

Dissemination of Orientia tsutsugamushi and Inflammatory Responses in a Murine Model of Scrub Typhus

(2014) Christian A. Keller et al.   PLoS Neglected Tropical Diseases

A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

(2014) Thomas R. Shelite et al.   PLoS Neglected Tropical Diseases

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

(2013) Alexander V. Misharin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Unresolved Problems Related to Scrub Typhus: A Seriously Neglected Life-Threatening Disease

(2013) Daniel H. Paris et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Scrub typhus in South India: clinical and laboratory manifestations, genetic variability, and outcome

(2013) George M. Varghese et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

An Intradermal Inoculation Model of Scrub Typhus in Swiss CD-1 Mice Demonstrates More Rapid Dissemination of Virulent Strains of Orientia tsutsugamushi

(2013) Piyanate Sunyakumthorn et al.   PLoS One

Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil

(2013) Chunyun Liu et al.   PLoS One

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

(2013) B. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

(2013) Wei Ying et al.   Jove-Journal of Visualized Experiments

Variable clinical responses of a scrub typhus outbred mouse model to feeding by Orientia tsutsugamushi infected mites

(2012) Woradee Lurchachaiwong et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

Active Escape of Orientia tsutsugamushi from Cellular Autophagy

(2012) Youngho Ko et al.   INFECTION AND IMMUNITY

Orientia tsutsugamushi, the causative agent of scrub typhus, induces an inflammatory program in human macrophages

(2012) Wiwit Tantibhedhyangkul et al.   MICROBIAL PATHOGENESIS

Orientia tsutsugamushi in Human Scrub Typhus Eschars Shows Tropism for Dendritic Cells and Monocytes Rather than Endothelium

(2012) Daniel H. Paris et al.   PLoS Neglected Tropical Diseases

Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis

(2011) Sascha David et al.   CYTOKINE

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

(2011) Marie Jeansson et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Orientia tsutsugamushi Stimulates an Original Gene Expression Program in Monocytes: Relationship with Gene Expression in Patients with Scrub Typhus

(2011) Wiwit Tantibhedhyangkul et al.   PLoS Neglected Tropical Diseases

Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation

(2010) Sebastien P. Tabruyn et al.   AMERICAN JOURNAL OF PATHOLOGY

Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway

(2010) Kyung-Ah Cho et al.   MICROBIAL PATHOGENESIS

A serosurvey of Orientia tsutsugamushi from patients with scrub typhus

(2009) D.M. Kim et al.   CLINICAL MICROBIOLOGY AND INFECTION

Differential patterns of endothelial and leucocyte activation in typhus-like illnesses in Laos and Thailand

(2008) D. H. Paris et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pulmonary pathology in patients associated with scrub typhus

(2008) Yung-Hsiang Hsu et al.   PATHOLOGY