Functional analysis of Rossmann-like domains reveals convergent evolution of topology and reaction pathways

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches

(2018) Zengrui Wu et al.   PHARMACOLOGICAL RESEARCH

Functional and evolutionary analysis of viral proteins containing a Rossmann-like fold

(2018) Kirill E. Medvedev et al.   PROTEIN SCIENCE

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

RadicalS-Adenosylmethionine Enzymes in Human Health and Disease

(2016) Bradley J. Landgraf et al.   Annual Review of Biochemistry

Crystal structure of SP-PTP, a low molecular weight protein tyrosine phosphatase from Streptococcus pyogenes

(2016) Bonsu Ku et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

One step beyond a ribosome: The ancient anaerobic core

(2016) Filipa L. Sousa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Allosteric sites: remote control in regulation of protein activity

(2016) Enrico Guarnera et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Dali server update

(2016) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

ECOD: new developments in the evolutionary classification of domains

(2016) R. Dustin Schaeffer et al.   NUCLEIC ACIDS RESEARCH

CATH: an expanded resource to predict protein function through structure and sequence

(2016) Natalie L. Dawson et al.   NUCLEIC ACIDS RESEARCH

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

ClassyFire: automated chemical classification with a comprehensive, computable taxonomy

(2016) Yannick Djoumbou Feunang et al.   Journal of Cheminformatics

New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases

(2016) Louise Lassalle et al.   Scientific Reports

An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

(2016) Paola Laurino et al.   PLOS BIOLOGY

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Manual classification strategies in the ECOD database

(2015) Hua Cheng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mysteries of Metals in Metalloenzymes

(2014) Crystal E. Valdez et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery

(2014) Nunziata Maio et al.   Cell Metabolism

The robustness and innovability of protein folds

(2014) Ágnes Tóth-Petróczy et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Natural History of Biocatalytic Mechanisms

(2014) Neetika Nath et al.   PLoS Computational Biology

ECOD: An Evolutionary Classification of Protein Domains

(2014) Hua Cheng et al.   PLoS Computational Biology

tRNA synthetase: tRNA aminoacylation and beyond

(2014) Yan Ling Joy Pang et al.   Wiley Interdisciplinary Reviews-RNA

Evolution of vitamin B2biosynthesis: eubacterial RibG and fungal Rib2 deaminases

(2013) Sheng-Chia Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

NMR-based analysis of protein–ligand interactions

(2013) Olivier Cala et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Structural Basis for a Bispecific NADP+and CoA Binding Site in an Archaeal Malonyl-Coenzyme A Reductase

(2013) Ulrike Demmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Hydrolysis and Polymorphism of Methotrexate Polyglutamate by Zebrafish γ-Glutamyl Hydrolase

(2013) Phimonphan Chuankhayan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The reductionist paradox: are the laws of chemistry and physics sufficient for the discovery of new drugs?

(2011) Gerald M. Maggiora   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Small Cofactors May Assist Protein Emergence from RNA World: Clues from RNA-Protein Complexes

(2011) Liang Shen et al.   PLoS One

Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis

(2010) L Aravind et al.   Biology Direct

Crystal structure of a transfer-ribonucleoprotein particle that promotes asparagine formation

(2010) Mickaël Blaise et al.   EMBO JOURNAL

The Structures and Physicochemical Properties of Organic Cofactors in Biocatalysis

(2010) Julia D. Fischer et al.   JOURNAL OF MOLECULAR BIOLOGY

SIMCOMP/SUBCOMP: chemical structure search servers for network analyses

(2010) M. Hattori et al.   NUCLEIC ACIDS RESEARCH

Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate

(2009) Pei-Ming Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

(2009) Suk-Kyeong Jung et al.   FASEB JOURNAL

Crystal Structure of the Hexameric Catabolic Ornithine Transcarbamylase from Lactobacillus hilgardii: Structural Insights into the Oligomeric Assembly and Metal Binding

(2009) Blanca de las Rivas et al.   JOURNAL OF MOLECULAR BIOLOGY

Metalloproteins and metal sensing

(2009) Kevin J. Waldron et al.   NATURE

Natural history of the E1-like superfamily: Implication for adenylation, sulfur transfer, and ubiquitin conjugation

(2008) A. Maxwell Burroughs et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Designed Protein-Protein Association

(2008) D. Grueninger et al.   SCIENCE