ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity

ARID1A promotes genomic stability through protecting telomere cohesion

(2019) Bo Zhao et al.   Nature Communications

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

(2018) Pol Margalef et al.   CELL

ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination

(2018) Szilvia Juhász et al.   MOLECULAR CELL

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

(2018) Jacqueline A. Brosnan-Cashman et al.   PLoS One

PHF11 promotes DSB resection, ATR signaling, and HR

(2017) Yi Gong et al.   GENES & DEVELOPMENT

Systematic analysis of telomere length and somatic alterations in 31 cancer types

(2017) Floris P Barthel et al.   NATURE GENETICS

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATRX is a regulator of therapy induced senescence in human cells

(2017) Marta Kovatcheva et al.   Nature Communications

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication

(2016) Fani‐Marlen Roumelioti et al.   EMBO REPORTS

Noncanonical views of homology-directed DNA repair

(2016) Priyanka Verma et al.   GENES & DEVELOPMENT

The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends

(2016) Camille Gelot et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining

(2016) Ylli Doksani et al.   Cell Reports

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

(2015) Mahesh Ramamoorthy et al.   CANCER CELL

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas

(2015) Jen-Chieh Lee et al.   MODERN PATHOLOGY

Genetic Inactivation ofATRXLeads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells

(2015) Rita Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

(2015) Grzegorz Sarek et al.   MOLECULAR CELL

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATRX represses alternative lengthening of telomeres

(2015) Christine E. Napier et al.   Oncotarget

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

(2015) Yuchen Jiao et al.   Oncotarget

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

(2015) Kasthuri Kannan et al.   Oncotarget

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets

(2014) Kavitha Sarma et al.   CELL

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

(2014) David Clynes et al.   PLoS One

Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress

(2013) Justin Wai-Chung Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span

(2013) L. Ashley Watson et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair

(2013) X. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

ATRX-mediated chromatin association of histone variant macroH2A1 regulates  -globin expression

(2012) K. Ratnakumar et al.   GENES & DEVELOPMENT

Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma

(2012) Nai-Kong V. Cheung   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Compromised genomic integrity impedes muscle growth after Atrx inactivation

(2012) Michael S. Huh et al.   JOURNAL OF CLINICAL INVESTIGATION

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres

(2012) Kylie Bower et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

(2011) Sebastian Eustermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATRX Partners with Cohesin and MeCP2 and Contributes to Developmental Silencing of Imprinted Genes in the Brain

(2010) Kristin D. Kernohan et al.   DEVELOPMENTAL CELL

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

Genome-wide Reinforcement of Cohesin Binding at Pre-existing Cohesin Sites in Response to Ionizing Radiation in Human Cells

(2010) Beom-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomeric recombination induced by dysfunctional telomeres

(2010) Marie Eve Brault et al.   MOLECULAR BIOLOGY OF THE CELL

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cohesin Is Limiting for the Suppression of DNA Damage–Induced Recombination between Homologous Chromosomes

(2010) Shay Covo et al.   PLoS Genetics

Cohesin: Its Roles and Mechanisms

(2009) Kim Nasmyth et al.   Annual Review of Genetics

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells

(2009) Silvia Canudas et al.   JOURNAL OF CELL BIOLOGY

Telomere Protection by TPP1 Is Mediated by POT1a and POT1b

(2009) T. Kibe et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Short Telomeres Initiate Telomere Recombination in Primary and Tumor Cells

(2009) Tammy A. Morrish et al.   PLoS Genetics

Loss of ATRX leads to chromosome cohesion and congression defects

(2008) Kieran Ritchie et al.   JOURNAL OF CELL BIOLOGY

Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells

(2008) A. Nabetani et al.   MOLECULAR AND CELLULAR BIOLOGY