Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?

Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson’s disease

(2019) Liang Zhu et al.   Cell Death & Disease

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

Prenatal exposure to oxidative phosphorylation xenobiotics and late-onset Parkinson disease

(2018) Eldris Iglesias et al.   AGEING RESEARCH REVIEWS

Parkinson's disease genetic risk in a midbrain neuronal cell line

(2018) Steven E. Pierce et al.   NEUROBIOLOGY OF DISEASE

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

(2018) Nicolas Giguère et al.   Frontiers in Neurology

Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson’s disease etiology

(2016) Simon G. Coetzee et al.   Scientific Reports

The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication

(2016) Irum Javaid Siddiqui et al.   Scientific Reports

How to make a midbrain dopaminergic neuron

(2015) E. Arenas et al.   DEVELOPMENT

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients

(2015) R. Fernandez-Santiago et al.   EMBO Molecular Medicine

Genetic control of midbrain dopaminergic neuron development

(2015) Sandra Blaess et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The intriguing complexities of mammalian gene regulation: How to link enhancers to regulated genes. Are we there yet?

(2014) Bence Daniel et al.   FEBS LETTERS

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

(2013) Pablo Garcia-Reitboeck et al.   EXPERIMENTAL NEUROLOGY

Interactions of Wnt/ -Catenin Signaling and Sonic Hedgehog Regulate the Neurogenesis of Ventral Midbrain Dopamine Neurons

(2013) M. Tang et al.   JOURNAL OF NEUROSCIENCE

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(2012) Guang-Hui Liu et al.   NATURE

Effects of Two Commonly Found Strains of Influenza A Virus on Developing Dopaminergic Neurons, in Relation to the Pathophysiology of Schizophrenia

(2012) Fernando Landreau et al.   PLoS One

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Neuroprotective Upregulation of Endogenous Alpha-Synuclein Precedes Ubiquitination in Cultured Dopaminergic Neurons

(2010) R. E. J. Musgrove et al.   NEUROTOXICITY RESEARCH

Gene–environment interactions in Parkinson's disease and other forms of parkinsonism

(2010) Jeffery M. Vance et al.   NEUROTOXICOLOGY

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

(2009) Wei Lin et al.   DEVELOPMENTAL BIOLOGY

Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon

(2009) Tomoya Nakatani et al.   DEVELOPMENTAL BIOLOGY

Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease

(2009) Dietrich Haubenberger et al.   NEUROBIOLOGY OF AGING

Morphometry of the human substantia nigra in ageing and Parkinson’s disease

(2008) Gay Rudow et al.   ACTA NEUROPATHOLOGICA

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

(2008) D. Omodei et al.   DEVELOPMENT