Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review

Emended description of Gardnerella vaginalis and description of Gardnerella leopoldii sp. nov., Gardnerella piotii sp. nov. and Gardnerella swidsinskii sp. nov., with delineation of 13 genomic species within the genus Gardnerella

(2019) Mario Vaneechoutte et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Humoral and T cell-mediated immune response against trichomoniasis

(2018) M. Nemati et al.   PARASITE IMMUNOLOGY

A Comprehensive in Silico Analysis of Regulatory SNPs of Human CLEC7A Gene and Its Validation as Genotypic and Phenotypic Disease Marker in Recurrent Vulvovaginal Infections

(2018) Namarta Kalia et al.   Frontiers in Cellular and Infection Microbiology

Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections

(2018) Noa Ziklo et al.   Frontiers in Cellular and Infection Microbiology

2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge

(2018) Jackie Sherrard et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Vulvovaginal candidiasis: histologic lesions are primarily polymicrobial and invasive and do not contain biofilms

(2018) Alexander Swidsinski et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

SNPs in 3′-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels

(2018) Namarta Kalia et al.   IMMUNOBIOLOGY

Double-stranded RNA viral infection of Trichomonas vaginalis (TVV1) in Iranian isolates

(2017) Khadijeh Khanaliha et al.   MICROBIAL PATHOGENESIS

The 50 kDa metalloproteinase TvMP50 is a zinc-mediated Trichomonas vaginalis virulence factor

(2017) Jonathan Puente-Rivera et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition

(2017) A C Hearps et al.   Mucosal Immunology

Gardnerella vaginalis diversity and ecology in relation to vaginal symptoms

(2017) John J. Schellenberg et al.   RESEARCH IN MICROBIOLOGY

Trichomonas vaginalis infection in symbiosis with Trichomonasvirus and Mycoplasma

(2017) Raina Fichorova et al.   RESEARCH IN MICROBIOLOGY

A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa

(2017) Vicky Jespers et al.   Scientific Reports

Genetic and Phenotypic Screening of Mannose-Binding Lectin in Relation to Risk of Recurrent Vulvovaginal Infections in Women of North India: A Prospective Cohort Study

(2017) Namarta Kalia et al.   Frontiers in Microbiology

Vaginal Lactobacillus Inhibits HIV-1 Replication in Human Tissues Ex Vivo

(2017) Rogers A. Ñahui Palomino et al.   Frontiers in Microbiology

Vaginal Candida spp. genomes from women with vulvovaginal candidiasis

(2017) L. Latéy Bradford et al.   Pathogens and Disease

The presence of the putative Gardnerella vaginalis sialidase A gene in vaginal specimens is associated with bacterial vaginosis biofilm

(2017) Liselotte Hardy et al.   PLoS One

Influence of 120 kDa Pyruvate:Ferredoxin Oxidoreductase on Pathogenicity of Trichomonas vaginalis

(2016) Hyun-Ouk Song   KOREAN JOURNAL OF PARASITOLOGY

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

Gardnerella vaginalis Subgroups Defined by cpn60 Sequencing and Sialidase Activity in Isolates from Canada, Belgium and Kenya

(2016) John J. Schellenberg et al.   PLoS One

Leukocyte Lysis and Cytokine Induction by the Human Sexually Transmitted Parasite Trichomonas vaginalis

(2016) Frances Mercer et al.   PLoS Neglected Tropical Diseases

Symbiotic Association with Mycoplasma hominis Can Influence Growth Rate, ATP Production, Cytolysis and Inflammatory Response of Trichomonas vaginalis

(2016) Valentina Margarita et al.   Frontiers in Microbiology

Sequestration of host-CD59 as potential immune evasion strategy of Trichomonas vaginalis

(2015) Alexandra Ibáñez-Escribano et al.   ACTA TROPICA

L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation

(2015) Waldemar Wagner et al.   Cell Communication and Signaling

Biofilms: An Underappreciated Mechanism of Treatment Failure and Recurrence in Vaginal Infections: Table 1.

(2015) Christina A. Muzny et al.   CLINICAL INFECTIOUS DISEASES

Trichomonas vaginalis origins, molecular pathobiology and clinical considerations

(2015) Robert P. Hirt et al.   CURRENT OPINION IN INFECTIOUS DISEASES

The role of infection in miscarriage

(2015) Sevi Giakoumelou et al.   HUMAN REPRODUCTION UPDATE

Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells

(2015) Lindi Masson et al.   IMMUNOLOGY

α-Amylase in Vaginal Fluid

(2015) Dimitrios Nasioudis et al.   Reproductive Sciences

Vaginal Microbiota of Adolescent Girls Prior to the Onset of Menarche Resemble Those of Reproductive-Age Women

(2015) Roxana J. Hickey et al.   mBio

Metabolic Signatures of Bacterial Vaginosis

(2015) Sujatha Srinivasan et al.   mBio

Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus -Dominant Microbiota

(2015) Kenetta L. Nunn et al.   mBio

Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface

(2015) David L Moyes et al.   Virulence

The Cytolytic Activity of Vaginolysin Strictly Depends on Cholesterol and Is Potentiated by Human CD59

(2015) Milda Zilnyte et al.   Toxins

Selecting Anti-Microbial Treatment of Aerobic Vaginitis

(2015) Gilbert G. G. Donders et al.   Current Infectious Disease Reports

Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health

(2015) Mariya I. Petrova et al.   Frontiers in Physiology

Unravelling the Bacterial Vaginosis-Associated Biofilm: A Multiplex Gardnerella vaginalis and Atopobium vaginae Fluorescence In Situ Hybridization Assay Using Peptide Nucleic Acid Probes

(2015) Liselotte Hardy et al.   PLoS One

Mucosal Integrity Factors Are Perturbed during Bacterial Vaginosis: A Proteomic Analysis

(2014) Kelly Arnold et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Bacteriocin production and gene sequencing analysis from vaginal Lactobacillus strains

(2014) Galina Stoyancheva et al.   ARCHIVES OF MICROBIOLOGY

Recurrent vulvovaginitis

(2014) Anna M. Powell et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Desquamative inflammatory vaginitis

(2014) Orna Reichman et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Differential expression of lactic acid isomers, extracellular matrix metalloproteinase inducer, and matrix metalloproteinase-8 in vaginal fluid from women with vaginal disorders

(2014) J Beghini et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Genetic and phenotypic intra-species variation inCandida albicans

(2014) Matthew P. Hirakawa et al.   GENOME RESEARCH

Human α-amylase Present in Lower-Genital-Tract Mucosal Fluid Processes Glycogen to Support Vaginal Colonization by Lactobacillus

(2014) Gregory T. Spear et al.   JOURNAL OF INFECTIOUS DISEASES

Lactobacilli Inactivate Chlamydia trachomatis through Lactic Acid but Not H2O2

(2014) Zheng Gong et al.   PLoS One

An Emerging Mycoplasma Associated with Trichomoniasis, Vaginal Infection and Disease

(2014) Jennifer M. Fettweis et al.   PLoS One

Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms

(2014) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Influence of Bacterial Presence on Biofilm Formation ofCandida albicans

(2014) Su Jung Park et al.   YONSEI MEDICAL JOURNAL

The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages

(2014) N. Uwamahoro et al.   mBio

Characterisation of the vaginal Lactobacillus microbiota associated with preterm delivery

(2014) Ljubomir Petricevic et al.   Scientific Reports

Theaflavin-3,3′-Digallate and Lactic Acid Combinations Reduce Herpes Simplex Virus Infectivity

(2013) Charles E. Isaacs et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Striking a balance: fungal commensalism versus pathogenesis

(2013) Iliyan D Iliev et al.   CURRENT OPINION IN MICROBIOLOGY

Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis

(2013) N. van Oostrum et al.   HUMAN REPRODUCTION

Fungal Morphogenetic Pathways Are Required for the Hallmark Inflammatory Response during Candida albicans Vaginitis

(2013) Brian M. Peters et al.   INFECTION AND IMMUNITY

Degradation, Foraging, and Depletion of Mucus Sialoglycans by the Vagina-adaptedActinobacterium Gardnerella vaginalis

(2013) Warren G. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Vaginal Microbiota That Includes an Unknown Mycoplasma-Like Organism Is Associated With Trichomonas vaginalis Infection

(2013) David H. Martin et al.   JOURNAL OF INFECTIOUS DISEASES

Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy

(2013) Rebecca M. Brotman et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Characterization of the Vaginal Micro- and Mycobiome in Asymptomatic Reproductive-Age Estonian Women

(2013) Tiina Drell et al.   PLoS One

Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

(2013) Deirdre E. O’Hanlon et al.   PLoS One

Diverse Vaginal Microbiomes in Reproductive-Age Women with Vulvovaginal Candidiasis

(2013) Mu-Biao Liu et al.   PLoS One

Influence of infection during pregnancy on fetal development

(2013) Kristina M Adams Waldorf et al.   REPRODUCTION

Association Between Trichomonas vaginalis and Vaginal Bacterial Community Composition Among Reproductive-Age Women

(2013) Rebecca M. Brotman et al.   SEXUALLY TRANSMITTED DISEASES

The adherence ofTrichomonas vaginalisto host ectocervical cells is influenced by lactobacilli

(2013) Niha Phukan et al.   SEXUALLY TRANSMITTED INFECTIONS

The Villain Team-Up or howTrichomonas vaginalisand bacterial vaginosis alter innate immunity in concert

(2013) Raina N Fichorova et al.   SEXUALLY TRANSMITTED INFECTIONS

Influence of Vaginal Bacteria and D- and L-Lactic Acid Isomers on Vaginal Extracellular Matrix Metalloproteinase Inducer: Implications for Protection against Upper Genital Tract Infections

(2013) S. S. Witkin et al.   mBio

Candida albicanspathogenicity mechanisms

(2013) François L. Mayer et al.   Virulence

Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis

(2013) Jacques Ravel et al.   Microbiome

Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis

(2013) Jean M Macklaim et al.   Microbiome

A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans

(2012) Clarissa J. Nobile et al.   CELL

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

(2012) Iuliana V. Ene et al.   CELLULAR MICROBIOLOGY

Growth of Candida albicans Cells on the Physiologically Relevant Carbon Source Lactate Affects Their Recognition and Phagocytosis by Immune Cells

(2012) Iuliana V. Ene et al.   INFECTION AND IMMUNITY

Comparative Genomic Analyses of 17 Clinical Isolates of Gardnerella vaginalis Provide Evidence of Multiple Genetically Isolated Clades Consistent with Subspeciation into Genovars

(2012) A. Ahmed et al.   JOURNAL OF BACTERIOLOGY

Increased Diversity of Fungal Flora in the Vagina of Patients with Recurrent Vaginal Candidiasis and Allergic Rhinitis

(2012) Renyong Guo et al.   MICROBIAL ECOLOGY

Endobiont Viruses Sensed by the Human Host – Beyond Conventional Antiparasitic Therapy

(2012) Raina N. Fichorova et al.   PLoS One

Temporal Dynamics of the Human Vaginal Microbiota

(2012) P. Gajer et al.   Science Translational Medicine

The Microbiota of the Vagina and Its Influence on Women’s Health and Disease

(2011) David H. Martin   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Bacterial Vaginosis, Gonorrhea, and Chlamydial Infection Among Women Attending a Sexually Transmitted Disease Clinic: A Longitudinal Analysis of Possible Causal Links

(2011) Maria F. Gallo et al.   ANNALS OF EPIDEMIOLOGY

Group A streptococcal vaginitis: an unrecognized cause of vaginal symptoms in adult women

(2011) Hans Verstraelen et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

The vaginal microbiome: new information about genital tract flora using molecular based techniques

(2011) RF Lamont et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide

(2011) Deirdre E O'Hanlon et al.   BMC INFECTIOUS DISEASES

Assessment of in vitro biofilm formation by Candida species isolates from vulvovaginal candidiasis and ultrastructural characteristics

(2011) Luciene C.F. Paiva et al.   MICRON

Influence of Lactic Acid on Endogenous and Viral RNA-Induced Immune Mediator Production by Vaginal Epithelial Cells

(2011) Hannah Mossop et al.   OBSTETRICS AND GYNECOLOGY

From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells

(2011) Betty Wächtler et al.   PLoS One

The Fungal Pathogen Candida albicans Autoinduces Hyphal Morphogenesis by Raising Extracellular pH

(2011) S. Vylkova et al.   mBio

Infectious Causes of Stillbirth: A Clinical Perspective

(2010) ELIZABETH M. MCCLURE et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide

(2010) Steven S. Witkin et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-γ) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen

(2010) Darab Ghadimi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Candida albicans forms biofilms on the vaginal mucosa

(2010) M. M. Harriott et al.   MICROBIOLOGY-SGM

Medically important bacterial–fungal interactions

(2010) Anton Y. Peleg et al.   NATURE REVIEWS MICROBIOLOGY

Genetic control of Candida albicans biofilm development

(2010) Jonathan S. Finkel et al.   NATURE REVIEWS MICROBIOLOGY

Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial Vaginosis

(2010) Sujatha Srinivasan et al.   PLoS One

Vaginal microbiome of reproductive-age women

(2010) J. Ravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dispersion as an Important Step in the Candida albicans Biofilm Developmental Cycle

(2010) Priya Uppuluri et al.   PLoS Pathogens

Host Cell Invasion and Virulence Mediated by Candida albicans Ssa1

(2010) Jianing N. Sun et al.   PLoS Pathogens

How human pathogenic fungi sense and adapt to pH: the link to virulence

(2009) Dana A Davis   CURRENT OPINION IN MICROBIOLOGY

The vaginal bacterial communities of Japanese women resemble those of women in other racial groups

(2009) Xia Zhou et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Vaginal Microbiota of Women with Frequent Vulvovaginal Candidiasis

(2009) X. Zhou et al.   INFECTION AND IMMUNITY

Prospective Study of Vaginal Bacterial Flora and Other Risk Factors for Vulvovaginal Candidiasis

(2009) R. Scott McClelland et al.   JOURNAL OF INFECTIOUS DISEASES

Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus

(2009) S. K. Lai et al.   JOURNAL OF VIROLOGY

Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis-associated anaerobes

(2009) J. L. Patterson et al.   MICROBIOLOGY-SGM

Iron availability and infection

(2008) Eugene D. Weinberg   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Early Repeated Infections withTrichomonas vaginalisamong HIV‐Positive and HIV‐Negative Women

(2008) Patricia Kissinger et al.   CLINICAL INFECTIOUS DISEASES

Complementary Adhesin Function in C. albicans Biofilm Formation

(2008) Clarissa J. Nobile et al.   CURRENT BIOLOGY

Trichomonas vaginalis: The adhesins AP51 and AP65 bind heme and hemoglobin

(2008) Shahed Ardalan et al.   EXPERIMENTAL PARASITOLOGY

Loss of heterozygosity in commensal isolates of the asexual diploid yeast Candida albicans

(2008) Dorothée Diogo et al.   FUNGAL GENETICS AND BIOLOGY

Inhibition of Neisseria gonorrhoeae Epithelial Cell Interactions by Vaginal Lactobacillus Species

(2008) R. R. Spurbeck et al.   INFECTION AND IMMUNITY

Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions

(2008) Grazyna J. Sosinska et al.   MICROBIOLOGY-SGM

Candida albicanscell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance

(2008) Ingrid E. Frohner et al.   MOLECULAR MICROBIOLOGY

Molecular mechanisms of mechanosensing and their roles in fungal contact sensing

(2008) Carol A. Kumamoto   NATURE REVIEWS MICROBIOLOGY