Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway

Is metformin poised for a second career as an antimicrobial?

(2018) Faiza Malik et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegans

(2017) Yi Xiao et al.   Innate Immunity

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

(2016) Lianfeng Wu et al.   CELL

Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner

(2016) Xiou Cao et al.   CURRENT BIOLOGY

Metformin prevents the effects ofPseudomonas aeruginosaon airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth

(2016) Wishwanath R. A. Patkee et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin protects against infection-induced myocardial dysfunction

(2016) Theodora Tzanavari et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection

(2016) Ahmad A. Othman et al.   PARASITOLOGY INTERNATIONAL

Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis

(2015) Rohit Vashisht et al.   Journal of Translational Medicine

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

A pilot study of add-on oral hypoglycemic agents in treatment-naïve genotype-1 chronic hepatitis C patients receiving peginterferon alfa-2b plus ribavirin

(2014) Ching-Sheng Hsu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

(2014) Marcella Facchini et al.   Jove-Journal of Visualized Experiments

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway

(2013) Jian-Wu Yu et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells

(2013) Y.-H. Xun et al.   JOURNAL OF VIRAL HEPATITIS

Metformin reduces airway glucose permeability and hyperglycaemia-inducedStaphylococcus aureusload independently of effects on blood glucose

(2013) James P Garnett et al.   THORAX

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

(2012) Valentina Grossi et al.   CANCER BIOLOGY & THERAPY

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome

(2011) Kathleen Fitch et al.   AIDS

Understanding the benefit of metformin use in cancer treatment

(2011) Ryan JO Dowling et al.   BMC Medicine

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Neuronal GPCR Controls Innate Immunity by Regulating Noncanonical Unfolded Protein Response Genes

(2011) J. Sun et al.   SCIENCE

Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

(2010) Daniel A. Kane et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced neuronal RNAi in C. elegans using SID-1

(2010) Andrea Calixto et al.   NATURE METHODS

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Immunomodulatory Properties of Antibiotics

(2010) R. Nau et al.   Current Molecular Pharmacology

Protein Kinase D Is an Essential Regulator of C. elegans Innate Immunity

(2009) Min Ren et al.   IMMUNITY

Nucleolar Proteins Suppress Caenorhabditis elegans Innate Immunity by Inhibiting p53/CEP-1

(2009) Laura E. Fuhrman et al.   PLoS Genetics

Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans

(2008) D. Kim   Disease Models & Mechanisms