Article
Microbiology
Gregory J. Golden, Alejandro Gomez Toledo, Alex Marki, James T. Sorrentino, Claire Morris, Raquel J. Riley, Charlotte Spliid, Qiongyu Chen, Ingrid Cornax, Nathan E. Lewis, Nissi Varki, Dzung Le, Johan Malmstrom, Christofer Karlsson, Klaus Ley, Victor Nizet, Jeffrey D. Esko
Summary: Hepatic failure is a significant risk factor for poor outcomes in septic patients. Modifying endothelial heparan sulfate can reduce neutrophil trafficking to the liver, thereby reducing liver damage caused by sepsis.
Article
Immunology
Mengqin Yuan, Lichao Yao, Ping Chen, Zheng Wang, Pingji Liu, Zhiyu Xiong, Xue Hu, Lanjuan Li, Yingan Jiang
Summary: hUC-MSCs inhibit HSC activation through the miR-148a-5p/SLIT3 pathway, thus alleviating LF. High-throughput RNA-Seq analysis identified potential genes involved in the therapeutic effects of hUC-MSCs. miR-148a-5p delivered by hUC-MSCs via exosomes suppressed the activated phenotype of LX2 cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alvin Wen Choong Chua, Dianyang Guo, Jia Chi Tan, Frances Ting Wei Lim, Chee Tian Ong, Jeyakumar Masilamani, Tony Kiat Hon Lim, William Ying Khee Hwang, Ivor Jiun Lim, Jinmiao Chen, Toan Thang Phan, Xiubo Fan
Summary: This study investigated the therapeutic efficacy and working mechanisms of human umbilical cord lining mesenchymal stromal cells (CL-MSCs) in lupus-prone mice. The results showed that CL-MSCs improved the survival and kidney function of mice by reducing lupus nephritis activity and chronicity, and lymphocyte infiltration. Additionally, CL-MSCs reduced urinary albumin-to-creatinine ratio and the production of anti-dsDNA and isotype antibodies. Mechanistically, CL-MSCs suppressed splenic neutrophils and monocytes/macrophages, reduced proinflammatory cytokines, and modulated immunomodulatory pathways. These findings highlight the potential of CL-MSCs as a novel therapy for systemic lupus erythematosus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Lichao Yao, Xue Hu, Mengqin Yuan, Pingji Liu, Qiuling Zhang, Zheng Wang, Ping Chen, Zhiyu Xiong, Lun Wu, Kai Dai, Yingan Jiang
Summary: This study revealed that human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) alleviate liver cirrhosis in mice through the Hippo/YAP/Id1 pathway and macrophage-dependent mechanisms, providing a theoretical basis for their potential use as a therapeutic strategy for patients with liver cirrhosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Fei Yin, Li-Cui Mao, Qi-Qi Cai, Wen-Hua Jiang
Summary: Studies have shown that HGF-transfected hUCMSCs can decrease cell viability of HSCs-T6, promote apoptosis, inhibit activation, and reduce the expression of Collagen I, Collagen III, TGF-beta 1, Smad2, and Smad3, possibly through inhibiting the TGF-beta 1/Smads signaling pathway. These findings suggest that HGF-transfected hUCMSCs may be a novel therapeutic approach for treating LF.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Immunology
Hongwu Wang, Junlin Luo, Aijia Li, Xing Su, Chuiqin Fang, Lichun Xie, Yi Wu, Feiqiu Wen, Yufeng Liu, Tianyou Wang, Yong Zhong, Lian Ma
Summary: The study conducted proteomic and phosphorylated proteomic analysis of lung tissue of juvenile septic rats after HUMSCs intervention, revealing potential therapeutic targets of HUMSCs in alleviating lung injury. Results highlighted the significance of ECM receptor interaction pathway and tight junction pathway in immune inflammatory reaction.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yuming Peng, Qiang Yin, Miaoxian Yuan, Lijian Chen, Xinyi Shen, Weixin Xie, Jinqiao Liu
Summary: This review summarizes the role of hepatic stellate cells (HSCs) in liver ischemia-reperfusion injury (IRI). The functional roles and molecular mechanisms of HSCs in IRI have been extensively studied, and their regulation in liver repair and regeneration after IRI is discussed. Future research needs to address unanswered questions regarding the contributions of HSCs to IRI in the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Rui Chen, Yingjun Xie, Xuan Zhong, Fei Chen, Yu Gong, Na Wang, Ding Wang
Summary: The study showed that amniotic fluid-derived mesenchymal stem cells (AF-MSCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) have different therapeutic effects in treating CLP-induced sepsis in rats, exerting varied effects on different tissues affected by sepsis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Cell Biology
Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Xiang Hu, Qin Xu
Summary: The study evaluated the effects of intravenous injection of hUC-MSCs on reproduction and development in rats, finding no significant adverse effects within a certain dosage range, but high doses may lead to mortality in pregnant female rats, highlighting the importance of cautious use.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Chuan He, Chao Yang, Qiang Zeng, Zhigang Liu, Fangfang Wang, Qiang Chen, Ting Liu
Summary: Umbilical cord-derived MSCs cultured in different media showed the general characteristics of MSCs. HGF, ANG-1, and TGF-beta 1 secretion by MSCs in the MCL was higher than in the other media, while PGE2 secretion was lower in the MCL. MSCs in the MCL inhibited IFN-gamma and TNF-alpha more effectively. MSC treatment promoted recovery of peripheral blood cells, increased Treg ratio and VEGF level, and significantly improved bone marrow.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Lijun Kong, Xiangxiang Xu, Hewei Zhang, Yi Zhou, Hongjian Huang, Bicheng Chen, Zhenxu Zhou
Summary: The study demonstrated that HUCMSCs inhibited the secretion of inflammatory cytokines, activation of pancreatic stellate cells, and apoptosis of acinar cells in treating CP. Furthermore, HUCMSCs noticeably suppressed the AKT-mTOR-S6K1 pathway in pancreatic tissue.
Review
Cell Biology
Huagui Huang, Xin Liu, Jinzuo Wang, Moran Suo, Jing Zhang, Tianze Sun, Wentao Zhang, Zhonghai Li
Summary: Intervertebral disc degeneration is a complex and not yet fully understood cause of low back pain. In recent years, mesenchymal stem cells derived from the fetal umbilical cord have shown promising results in regenerating intervertebral discs. These cells have excellent characteristics and can potentially replace the commonly used sources of mesenchymal stem cells. However, the survival of umbilical cord mesenchymal stem cells within the disc is crucial for their regenerative capacity, and biomaterial scaffolds have shown potential in aiding their survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chanbin Lee, Minju Kim, Jinsol Han, Myunghee Yoon, Youngmi Jung
Summary: Liver fibrosis is a common feature of chronic liver disease and regulating HSC activation is crucial for its treatment. MSCs interact directly with immune cells, HSCs, and hepatocytes to secrete modulators and reduce liver fibrosis. Both MSC itself and MSC modulators have shown anti-fibrotic functions, but the underlying mechanism is yet to be established.
Article
Otorhinolaryngology
Seong Hoon Bae, Sang Hyun Kwak, Jee Eun Yoo, Kyu Min Kim, Young Min Hyun, Jae Young Choi, Jinsei Jung
Summary: Resident macrophages in spiral ligaments of the cochlea predominantly locate in areas away from the stria vascularis, and this distribution pattern remains consistent even under inflammatory conditions.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2021)
Article
Clinical Neurology
Joohyun Park, Jong Youl Kim, Yu Rim Kim, Meiying Huang, Ji Young Chang, A. Young Sim, Hosung Jung, Won Taek Lee, Young-Min Hyun, Jong Eun Lee
Summary: After ischemic stroke, CCR2(high)CX3CR1(low) monocytes recruited to the injured brain are cytokine-dependently converted into CCR2(low)CX3CR1(high) macrophages, attenuating neuroinflammation. The regulation of monocyte-switching is crucial in ischemic stroke, and the adaptation of monocytes in a locally inflamed milieu is vital in alleviating the effects of stroke through innate immunity.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Medicine, General & Internal
Hyun Soo Park, Hayan Kwon, Ja-Young Kwon, Yun Ji Jung, Hyun-Joo Seol, Won Joon Seong, Hyun Mi Kim, Han-Sung Hwang, Ji-Hee Sung, Soo-young Oh
Summary: This study aimed to analyze the changes in elastographic parameters in the cervix before and after delivery, comparing women with spontaneous labor and labor induction. The research found that as gestation progressed, cervical length decreased, with significant differences in most elastographic parameters between the two groups and some parameters increasing significantly with gestational age.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Hee-Sun Kim, Kyu-Min Lee, Sung Won Han, Geum Joon Cho, Han-Sung Hwang
Summary: This study found an association between pre-pregnancy body mass index and sensorineural hearing loss during pregnancy. However, SSNHL during pregnancy did not increase the risk during delivery or cause adverse perinatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Immunology
Seunghwan Son, Sung-Hyun Yoon, Byeong Jun Chae, Inhwa Hwang, Do-Wan Shim, Young Ho Choe, Young-Min Hyun, Je-Wook Yu
Summary: Neutrophils can prolong inflammasome response via mitochondria-dependent resistance to NLRP3 desensitization and function as major interleukin-1 beta-secreting cells in DAMP-rich inflammatory region. This resistance allows inflammasome-activated neutrophils to avoid pyroptosis, leading to sustained inflammasome response and interleukin-1 beta secretion. The unique mitochondrial characteristics in neutrophils, such as the lack of SARM1 expression, contribute to their resistance to NLRP3 desensitization and prolonged inflammasome activation potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hyeji Jung, Hyojeong Lee, Dongwook Kim, Eunji Cheong, Young-Min Hyun, Je-Wook Yu, Ji Won Um
Summary: This study found that mild neuroinflammation induces regionally different microglial activation, which leads to the production of proinflammatory cytokines. These observations provide insight into the potential development of region-specific neuroinflammation-associated brain pathologies through microglial activation.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biology
Jeong Ha Wie, Se Jin Lee, Sae Kyung Choi, Yun Sung Jo, Han Sung Hwang, Mi Hye Park, Yeon Hee Kim, Jae Eun Shin, Ki Cheol Kil, Su Mi Kim, Bong Suk Choi, Hanul Hong, Hyun-Joo Seol, Hye-Sung Won, Hyun Sun Ko, Sunghun Na
Summary: This study developed an automated machine learning model to predict emergent cesarean section before onset of labor in term nulliparous women. Nine different machine learning methods were applied and compared, with logistic regression showing the best predictive performance. The model identified several significant variables for prediction of emergent cesarean section.
Article
Pharmacology & Pharmacy
Eun-Jeong Jang, Young-Ju Kim, Han-Sung Hwang, Jeong Yee, Hye-Sun Gwak
Summary: This study found significant associations between single nucleotide polymorphisms in GNAS and RGS2 genes and ritodrine-induced adverse events. A risk scoring system was developed to identify high-risk patients.
Article
Cell Biology
Soi Jeong, Bora Kim, Da Jeong Byun, Sunmin Jin, Bo Seung Seo, Mi Hwa Shin, Ah Young Leem, Jai Jun Choung, Moo Suk Park, Young-Min Hyun
Summary: This study assessed the effectiveness of lysophosphatidylcholine (LPC) as a treatment for acute lung inflammation caused by sepsis. The researchers found that LPC can alleviate inflammation and reduce the infiltration of neutrophils into the lungs, leading to improved lung function. These findings provide evidence for the potential therapeutic application of LPC treatment for sepsis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Minjeong Nam, Mina Hur, Hanah Kim, Gun-Hyuk Lee, Mikyoung Park, Han-Sung Kwon, Han-Sung Hwang, In-Sook Sohn
Summary: This study established reference intervals for presepsin, KL-6, and SP-A levels and evaluated the influence of neonatal and maternal factors on these levels in umbilical cord blood. The levels showed non-parametric distributions and no significant differences were found based on the analyzed factors. The study also found a slight increase in KL-6 levels with gestational age.
Article
Obstetrics & Gynecology
Hyungwoo Lee, Seung-Woo Yang, Yeji Kim, Hyunju Shin, Yong-Soo Seo, Min Jeong Oh, Sangbum Choi, Geum Joon Cho, Han-Sung Hwang
Summary: In this large cohort study, a history of pregnancy-induced hypertension was found to increase the risk of central serous chorioretinopathy, diabetic retinopathy, retinal vein occlusion, and hypertensive retinopathy in the long-term postpartum stage. These findings highlight the importance of understanding the relationship between pregnancy-induced hypertension and ocular diseases.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Medicine, Research & Experimental
Sung Yong Ahn, Chris Hyunchul Jo
Summary: This study investigated the role and mechanism of Axin2 in breast cancer progression. It was found that Axin2, despite being previously identified as a tumor suppressor, exhibits oncogenic effects by mediating Snail1-induced EMT in breast cancer cells. Knockdown of Axin2 decreased cell proliferation, attenuated tumorigenic potential, and altered expression of EMT markers. These findings suggest that Axin2 may be a potential therapeutic target for breast cancer treatment.
Article
Biochemistry & Molecular Biology
Byung-Ho Jin, Jiwon Woo, Mirae Lee, Seockmo Ku, Hyung Seok Moon, Seung Jun Ryu, Young-Min Hyun, Jeong-Yoon Park, Sung Uk Kuh, Yong Eun Cho
Summary: Recent developments in tissue clearing methods allow three-dimensional analysis of biological structures, providing a greater understanding of spatial relationships. However, maintaining structural integrity and preventing tissue expansion/shrinkage in hard bone tissues remains a challenge.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Hee Ja Kim, Kyungwon Yang, Kiyoon Kim, Ye-Ji Lee, Sieun Lee, Sung Yong Ahn, Young-Ho Ahn, Jihee Lee Kang
Summary: The interaction between apoptotic cancer cells and CAFs can inhibit migration and invasion of cancer cells and CAFs, thereby preventing cancer progression and metastasis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Da Jeong Byun, Young Min Kim, Young-Min Hyun
Summary: Intravital imaging via two-photon microscopy is an effective tool for observing biological events in live animals. The technique allows for the visualization of cell-to-cell interactions in the brain and provides insights into the formation and function of neutrophil extracellular traps (NETs) in inflammation. This method is valuable for studying inflammation and the resolution process.
LABORATORY ANIMAL RESEARCH
(2022)