The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant

Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs homo-dimeric complexes

(2019) Emmanouela Leandrou et al.   BIOCHEMICAL JOURNAL

Leucine‐rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre‐synaptic sites

(2019) Antonella Marte et al.   JOURNAL OF NEUROCHEMISTRY

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

(2018) Katherine Fletcher et al.   EMBO JOURNAL

Cryopreservation of Primary Mouse Neurons: The Benefit of Neurostore Cryoprotective Medium

(2018) Francesca Pischedda et al.   Frontiers in Cellular Neuroscience

A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway

(2018) Nasia Antoniou et al.   Scientific Reports

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1

(2018) Maria Perez Carrion et al.   Frontiers in Molecular Neuroscience

The role of LRRK2 in cell signalling

(2018) Kirsten Harvey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

(2017) Mattia Volta et al.   eLife

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions

(2017) Maria Dolores Perez Carrion et al.   Scientific Reports

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

(2017) Kushal Sejwal et al.   Scientific Reports

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

(2016) Elisa Belluzzi et al.   Molecular Neurodegeneration

Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

(2016) Giambattista Guaitoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 Regulates Voltage-Gated Calcium Channel Function

(2016) Cade Bedford et al.   Frontiers in Molecular Neuroscience

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening

(2015) Nicholas J. Lavalley et al.   HUMAN MOLECULAR GENETICS

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology

(2015) Pablo Porras et al.   PROTEOMICS

TIRFM and pH-sensitive GFP-probes to Evaluate Neurotransmitter Vesicle Dynamics in SH-SY5Y Neuroblastoma Cells: Cell Imaging and Data Analysis

(2015) Federica Daniele et al.   Jove-Journal of Visualized Experiments

Computational analysis of the LRRK2 interactome

(2015) Claudia Manzoni et al.   PeerJ

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

(2014) Dayne A. Beccano-Kelly et al.   HUMAN MOLECULAR GENETICS

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

(2014) G. Piccoli et al.   MOLECULAR AND CELLULAR BIOLOGY

The association between the LRRK2 G2385R variant and the risk of Parkinson’s disease: a meta-analysis based on 23 case–control studies

(2014) Cheng-long Xie et al.   NEUROLOGICAL SCIENCES

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

(2014) Dayne A. Beccano-Kelly et al.   Frontiers in Cellular Neuroscience

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

(2014) Maria D. Cirnaru et al.   Frontiers in Molecular Neuroscience

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

(2012) Iakov N. Rudenko et al.   BIOCHEMICAL JOURNAL

The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders

(2012) Koichi Wakabayashi et al.   MOLECULAR NEUROBIOLOGY

LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

(2012) Samer Matta et al.   NEURON

LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

(2011) G. Piccoli et al.   JOURNAL OF NEUROSCIENCE

Structure and function of WD40 domain proteins

(2011) Chao Xu et al.   Protein & Cell

Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking

(2010) M. Messa et al.   JOURNAL OF CELL SCIENCE

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Armadillo-repeat protein functions: questions for little creatures

(2010) Rita Tewari et al.   TRENDS IN CELL BIOLOGY

LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi-center pooled analysis

(2009) E.K. Tan et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS