Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models

Correlation between SFRP1 expression and clinicopathological parameters in patients with triple-negative breast cancer

(2019) Sarah Alexandra Schäfer et al.   Future Oncology

Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study

(2019) Su Young Jung et al.   INVESTIGATIONAL NEW DRUGS

Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice

(2018) Jessica I Grill et al.   CARCINOGENESIS

Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion

(2018) Ting Shao et al.   Cell Death & Disease

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

(2018) Gwen Lomberk et al.   Nature Communications

Association of TGF-β responsive signature with anti-tumor effect of vactosertib, a potent, oral TGF-β receptor type I (TGFBRI) inhibitor in patients with advanced solid tumors.

(2018) Vicki Leigh Keedy et al.   JOURNAL OF CLINICAL ONCOLOGY

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

(2018) Kohei Miyazono et al.   Frontiers of Medicine

A genetic roadmap of pancreatic cancer: still evolving

(2017) Faiyaz Notta et al.   GUT

Early detection of pancreatic cancer: Where are we now and where are we going?

(2017) Bin Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation

(2017) Jessica I. Grill et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TGF-β in pancreatic cancer initiation and progression: two sides of the same coin

(2017) Wei Shen et al.   Cell and Bioscience

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

(2017) Sunjida Ahmed et al.   Journal of Clinical Medicine

BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia

(2016) Cora Hallas et al.   BMC CANCER

SFRP1 repression in prostate cancer is triggered by two different epigenetic mechanisms

(2016) Pilar García-Tobilla et al.   GENE

Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer

(2016) Thi My Hien Nguyen et al.   GYNECOLOGIC ONCOLOGY

Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial

(2016) Andrea Wang-Gillam et al.   LANCET

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78

(2015) J. M. Kang et al.   CANCER RESEARCH

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis

(2014) J. Y. Son et al.   MOLECULAR CANCER THERAPEUTICS

A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer

(2013) A H Ko et al.   BRITISH JOURNAL OF CANCER

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

(2013) Jeong-Hwan Yoon et al.   EMBO Molecular Medicine

Tumor Suppressor Role of theCL2/DRO1/CCDC80Gene in Thyroid Carcinogenesis

(2013) Angelo Ferraro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Transcriptional repression of the tumor suppressor DRO1 by AIB1

(2011) Juan Ferragud et al.   FEBS LETTERS

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen

(2010) Caiyun Liu et al.   BMC CANCER

Bidirectional Modulation of Adipogenesis by the Secreted Protein Ccdc80/DRO1/URB

(2009) Frédéric Tremblay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

LY2109761, a novel transforming growth factor   receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

(2008) D. Melisi et al.   MOLECULAR CANCER THERAPEUTICS