Article
Engineering, Electrical & Electronic
Kjeld Laursen, Milad Zamani, Yasser Rezaeiyan, Seyedsina Hosseini, Tanmay Mondal, Brian Corbett, Abdel Mouttalib Ouagazzal, Marianne Amalric, Farshad Moradi
Summary: This article presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation, which is highly efficient and miniaturized.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Review
Chemistry, Multidisciplinary
Ziyuan Che, Sarah O'Donovan, Xiao Xiao, Xiao Wan, Guorui Chen, Xun Zhao, Yihao Zhou, Junyi Yin, Jun Chen
Summary: Triboelectric nanogenerators (TENGs) have gained significant attention in the bioengineering community for their potential applications in healthcare. Recent research has focused on implantable TENGs (I-TENGs) for self-powered cardiovascular healthcare, including monitoring devices, therapeutic devices, and power sources for pacemakers. This review provides an overview of the progress and long-term expectations of these implantable TENG devices, including biocompatibility and utilization strategies.
Article
Multidisciplinary Sciences
Yilin Yang, Xiaoping Hu, Yuxin Liu, Bin Ouyang, Jiaxi Zhang, Huawei Jin, Zhenhua Yu, Ruiwei Liu, Zhe Li, Lelun Jiang, Xudong Lin, Bingzhe Xu
Summary: A promising alternative for treating brain tumors has been developed by creating an implantable ultrasound-powered tumor treating device (UP-TTD) that disrupts cancer cell division without harming normal neurons. In vitro and in vivo experiments demonstrate significant therapeutic effects, with inhibition of tumor cell growth rate and reduction of cancer area. The UP-TTD is wireless, compact, lightweight, and can be adjusted without increasing its size or adding circuits.
Article
Materials Science, Multidisciplinary
Sebin Devasia, S. Shaji, D. A. Avellaneda, J. A. Aguilar Martinez, B. Krishnan
Summary: In this research, lead-free, all-inorganic, Cs3Bi2I9 perovskite-inspired films were developed using ultrasonic spray deposition at different substrate temperatures. These films demonstrate promising photodetection properties without any external bias or power consumption. The film's structural, morphological, optical, and electrical characteristics were analyzed in detail, and highly crystalline films with well-packed grains were obtained at temperatures below 325 degrees C. The Cs3Bi2I9 films showed direct band gaps of 1.8-2.1 eV and absorption coefficients of about 10^4 cm(-1). Photocurrent in the nanoampere range was observed in all the films under illumination. The films also remained chemically stable even after rapid thermal processing up to 500 degrees C. Additionally, self-powered photodetection using Ag/FTO/Cs3Bi2I9/C-Ag heterostructure was demonstrated under different illuminations, with the highest responsivity and detectivity obtained for the Cs3Bi2I9-based photodetector being 0.0051 mAW(-1) and 5.93 x 108 Jones (405 nm, 50 mW), respectively. The spray-deposited Cs3Bi2I9 films show great potential for self-powered devices, particularly in blue light detectors.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Review
Engineering, Biomedical
Kuntal Kumar Das, Bikramjit Basu, Pralay Maiti, Ashutosh Kumar Dubey
Summary: Piezoelectric nanogenerators (PENGs) hold great promise in personalized healthcare, providing self-powered sensors, drug delivery systems, and tissue regeneration. This comprehensive review examines the recent advancements in synthetic and nature-inspired piezoelectric materials for PENGs and discusses the potential of these materials and data science approaches to enhance personalized healthcare devices.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Physical
Manhui Zheng, Xuechuan Wang, Ouyang Yue, Zhongxue Bai, Boqiang Cui, Xinhua Liu
Summary: Currently, there is a growing emphasis on all-around disease prevention and health care due to improvements in living standards. Self-powered implantable tissue batteries integrated with electrochemical materials play a crucial role in disease prevention, diagnosis, treatment, postoperative therapy, and healthcare applications. In this review, the concept of self-powered tissue batteries (SPTBs) is introduced, highlighting their potential in tissue repair promotion and their advantages in terms of biocompatibility and electrical stimulation therapy. The review comprehensively discusses the electrochemical materials used in various types of SPTBs, their applications in disease prevention, diagnosis, precision therapy, and personalized health monitoring, as well as potential mechanisms for tissue repair promotion. It also addresses the challenges and provides recommendations for future research.
Article
Acoustics
Emanuele Perra, Nick Hayward, Kenneth P. H. Pritzker, Heikki J. Nieminen
Summary: Ultrasonic cavitation has significant applications in influencing matter on a micro-scale, such as tissue or drug vehicles. This study demonstrates the cavitation phenomena near ultrasonically actuated needles through simulations and experiments. These findings are crucial for developing new methods and technologies.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Biophysics
Jinmo Jeong, Jieun Jung, Dongwuk Jung, Juho Kim, Hunpyo Ju, Tae Kim, Jongho Lee
Summary: Optogenetics is a cutting-edge tool in neuroscience that demonstrates causal relationships by manipulating specific neuronal populations and observing behavioral phenotypes, but the tethering system used to deliver light can constrain natural animal behaviors and experimental design.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Shuncheng Yao, Minjia Zheng, Zhuo Wang, Yunchao Zhao, Shaobo Wang, Zhirong Liu, Zhou Li, Yunqian Guan, Zhong Lin Wang, Linlin Li
Summary: This article reports on a self-powered, wirelessly controlled gas therapy system for intracranial neuroglioma treatment. The system utilizes a self-powered triboelectric nanogenerator and an implantable nitric oxide releasing device. The efficacy of the system is validated in mouse breast cancer models and rat glioblastoma multiforme.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Feifan Sheng, Bo Zhang, Yihan Zhang, Yanyan Li, Renwei Cheng, Chuanhui Wei, Chuan Ning, Kai Dong, Zhong Lin Wang
Summary: Implantable sensor OFS-TENG based on organogel/silicone fiber-helical structure has been developed for power-free and sutureable ligament strain monitoring. It shows high stability, ultrastretchability, and the ability to monitor knee ligament stretch and muscle stress in real-time, providing a solution for real-time diagnosis of muscle and ligament injuries.
Article
Multidisciplinary Sciences
Zhuo Liu, Yang Zhou, Xuecheng Qu, Lingling Xu, Yang Zou, Yizhu Shan, Jiawei Shao, Chan Wang, Ying Liu, Jiangtao Xue, Dongjie Jiang, Yubo Fan, Zhou Li, Haifeng Ye
Summary: The study proposes a self-powered optogenetic system for implantable blood glucose control. This system can harvest energy from body movement and effectively regulate blood glucose homeostasis in treating diabetes.
Article
Multidisciplinary Sciences
Guang Yao, Lei Kang, Cuicui Li, Sihong Chen, Qian Wang, Junzhe Yang, Yin Long, Jun Li, Kangning Zhao, Weina Xu, Weibo Cai, Yuan Lin, Xudong Wang
Summary: The study introduced a self-powered implantable fracture therapy device, which can accelerate bone fracture healing, improve bone density, and flexural strength. The device is characterized by self-responsiveness, battery-free operation, and no surgical removal after biomedical intervention.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Acoustics
Emanuele Perra, Nick Hayward, Kenneth P. H. Pritzker, Heikki J. Nieminen
Summary: The study demonstrates the potential of using an ultrasonically actuated medical needle to overcome some limitations of high-intensity focused ultrasound (HIFU) by translating nanoparticles and fluids through nonlinear phenomena. Simulation and experimental results show that ultrasound can increase the volume covered by the delivered agent in the liver, potentially improving the safety and efficacy of drug therapies.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Chemistry, Physical
Lele Gong, Ningning Xuan, Guangxiang Gu, Peng Lv, Ningning Huang, Chunhui Song, Mingli Zheng, Jingjing Wang, Peng Cui, Guangqin Gu, Yu Jia, Gang Cheng, Zuliang Du
Summary: In this research, an advanced integrated system driven by a unidirectional current rotational freestanding triboelectric-layer mode Pulsed-TENG was developed, which simultaneously produced green hydrogen at the cathode and value-added formic acid at the anode. After optimizing the power management, the green hydrogen production rate was increased by 1.68 times, and stable and efficient production of formic acid was achieved. This study provides an effective method for the simultaneous and rapid production of high-purity green hydrogen and value-added formic acid using clean energy sources.
Article
Gastroenterology & Hepatology
Hyung Sun Kim, Woojin Kim, Itaru Endo, Jin-Young Jang, Hongbeom Kim, Ki Byung Song, Dae Wook Hwang, Chang Moo Kang, Ho Kyoung Hwang, Sang-Jae Park, Sung-Sik Han, Yoo-Seok Yoon, Jae Do Yang, Ryosuke Amano, Sadaaki Yamazoe, Hiroaki Yanagimoto, Tetsuo Ajiki, Masayuki Ohtsuka, Daisuke Suzuki, Dong-Shik Lee, Yuji Kitahata, Koji Amaya, Jun Sakata, Hyung Il Seo, Junichiro Yamauchi, Yasuhiro Yabushita, Takayuki Tanaka, Naoki Sakurai, Teijiro Hirashita, Akihiko Horiguchi, Michiaki Unno, Dong Do You, Yo-ichi Yamashita, Shogo Kobayashi, Yusuke Kyoden, Takao Ide, Hiroaki Nagano, Masafumi Nakamura, Hiroki Yamaue, Masakazu Yamamoto, Joon Seong Park
Summary: In this study, a nomogram was developed and validated to predict the overall survival and recurrence-free survival of patients with ampulla of Vater cancer. The nomogram can aid clinicians in treatment decision-making and prognosis prediction in AOV cancer patients.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Hyung S. Kim, Ho-Seong Han, Woojin Kim, Changsoo Kim, Jin-Young Jang, Wooil Kwon, Jin S. Heo, Sang H. Shin, Ho K. Hwang, Joon S. Park
Summary: This study examined the clinical characteristics and survival rate of young age pancreatic cancer patients after curative resection using the KOTUS-BP Database. The results showed that although young patients were diagnosed at more advanced stages, the overall survival rate was similar in both the young age and standard groups after receiving adjuvant treatment.
Article
Pharmacology & Pharmacy
Da Eun Lee, Hyeon Woong Kang, So Yi Kim, Myeong Jin Kim, Jae Woong Jeong, Woosol Chris Hong, Sungsoon Fang, Hyung Sun Kim, Yun Sun Lee, Hyo Jung Kim, Joon Seong Park
Summary: This study demonstrates that the combination of ivermectin and gemcitabine effectively suppresses pancreatic cancer by inhibiting cell proliferation and inducing cell apoptosis through cell cycle arrest and mitochondrial dysfunction. In vivo experiments also support the tumor-inhibiting effect of this combination treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Sai Teja Reddy Gidde, Sayemul Islam, Albert Kim, Parsaoran Hutapea
Summary: The aim of this study is to propose a mosquito-inspired design of a surgical needle that can reduce the insertion force and tissue deformation, which cause target inaccuracy during percutaneous procedures. By mimicking the geometrical shapes of mosquito proboscis, a bioinspired needle was developed and tested to determine optimized needle shapes. The results showed that using the bioinspired design decreased the needle insertion force by 60% and reduced tissue deformation by 48%. This finding is significant for improving needle-based medical procedures.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2023)
Article
Engineering, Biomedical
Sayemul Islam, Rebecca C. Huggins, Abdulaziz N. A. E. Almeseri, Michael Domic, Seung Hyun Song, Brian D. Polizzotti, Albert Kim
Summary: This paper presents a totally implantable oxygen generator (TIOG) for localized and controlled oxygen delivery. The TIOG system can be remotely operated and delivers oxygen through electrolysis with a precisely controlled electrical signal. In vitro experiments demonstrate that the TIOG can deliver oxygen at a specific rate and suppress chlorine generation. The longevity of the TIOG system enables long-term ambulatory oxygen therapy.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Jiwon Cha, Hyungseok Cho, Jae-Seung Chung, Joon Seong Park, Ki-Ho Han
Summary: Circulating tumor cells (CTCs) exhibit antigenic heterogeneity between epithelial and mesenchymal phenotypes. This study demonstrates a more efficient CTC isolation method using both EpCAM and vimentin antibodies, combined with a lateral magnetophoretic microseparator. The results show that combining antibodies significantly improves CTC isolation efficiency, with different antibody choices being more effective for specific cancer types and stages.
Article
Materials Science, Multidisciplinary
Sayemul Islam, Eungyoul Oh, Chaerin Jun, Jungkwun Kim, Won Seok Chang, Seunghyun Song, Albert Kim
Summary: This paper presents a new ultrasonic powering scheme that uses three-dimensional polyhedral shapes as receivers. The experimental results show that receivers with polyhedral shapes have higher power density and efficiency compared to traditional diced PZT receivers. This innovative scheme provides a revolutionary solution for implantable biomedical devices.
ACS MATERIALS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Woosol Chris Hong, Da Eun Lee, Hyeon Woong Kang, Myeong Jin Kim, Minsoo Kim, Ju Hyun Kim, Sungsoon Fang, Hyo Jung Kim, Joon Seong Park
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer and the role of CD74 in PDAC is not well understood. Silencing CD74 in the pancreatic cancer cell line Capan-1 led to reduced cell proliferation, migration, invasion, increased apoptosis, and decreased expression and secretion of S100A8 and S100A9. The study suggests that CD74 may serve as a potential diagnostic biomarker and therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Yun Sun Lee, Hyung Sun Kim, Hyo Jung Kim, Hyeon Woong Kang, Da Eun Lee, Myeong Jin Kim, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Joon Seong Park
Summary: LOXL2 plays a significant role in drug resistance and EMT regulation in pancreatic cancer, and its inhibition reduces cancer stemness by regulating MAPK signaling activity. The activation of glucose metabolism and regulation of NF-kappa B signaling contribute to LOXL2 induction and cancer progression in gemcitabine-resistant pancreatic cancer.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cell Biology
Myeong Jin Kim, Hyung Sun Kim, Hyeon Woong Kang, Da Eun Lee, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Hyo Jung Kim, Joon Seong Park
Summary: Pancreatic cancer patients often have poor outcomes with gemcitabine treatment due to chemoresistance. This study identified SLC38A5 as a potential therapeutic target for gemcitabine-resistant pancreatic cancer. Inhibition of SLC38A5 decreased cell proliferation and migration, triggered ferroptosis signaling pathway, and restored gemcitabine sensitivity in animal models. These findings suggest SLC38A5 could be a novel target for overcoming gemcitabine resistance in pancreatic cancer therapy.
Article
Chemistry, Multidisciplinary
Sophia Selvarajan, Hyunji Shim, Eunjeong Byun, Albert Kim, Seung Hyun Song
Summary: This study presents an acousto-nanodevice that can oxidize redox proteins under ultrasonic irradiation. By using surface-engineered barium titanate (BTO) nanoparticles with a gold half-coating, the nanodevice is capable of modulating the redox proteins and enabling unidirectional electron transfer. This new class of ultrasonically powered nano-sized protein redox agents has the potential to be a highly selective modulator for biological processes with deeper treatment sites.
Article
Oncology
Sung Ill Jang, Ji Hae Nahm, See Young Lee, Jae Hee Cho, Min-Young Do, Joon Seong Park, Hye Sun Lee, Juyeon Yang, Jiwon Kong, Seunghwan Jung, Sunghoon Kim, Dong Ki Lee
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related deaths, but there is a lack of effective prognostic markers. This study found that expression of MARS1 is significantly increased in PDAC and high expression is associated with poor prognosis in patients.
Article
Biochemical Research Methods
Atul Dhall, Jun Ying Tan, Min Jun Oh, Sayemul Islam, Jungkwun Kim, Albert Kim, Geelsu Hwang
Summary: The dental implant-on-a-chip model is a novel microfluidic model that integrates dental implant biomaterials with gingival cells for studying host-material-pathogen interactions in peri-implant diseases. The model successfully replicates the morphology of keratinocytes and fibroblasts in the vicinity of dental implant biomaterials, and demonstrates the potential of photobiomodulation therapy in protecting epithelial cells from bacterial challenges.