Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes

Antibody Responses to Influenza A/H1N1pdm09 Virus After Pandemic and Seasonal Influenza Vaccination in Healthcare Workers: A 5-Year Follow-up Study

(2018) Mai-Chi Trieu et al.   CLINICAL INFECTIOUS DISEASES

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Metformin and Autoimmunity: A “New Deal” of an Old Drug

(2018) Francesco Ursini et al.   Frontiers in Immunology

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization

(2018) Chidchamai Kewcharoenwong et al.   Frontiers in Immunology

The double burden of diabetes and global infection in low and middle-income countries

(2018) Susanna Dunachie et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

(2017) Jonatan Ersching et al.   IMMUNITY

Boosting of post-exposure human T-cell and B-cell recall responsesin vivobyBurkholderia pseudomallei-related proteins

(2017) Arnone Nithichanon et al.   IMMUNOLOGY

Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

(2017) Bradley S. Barrett et al.   Retrovirology

Benefits of flu vaccination for persons with diabetes mellitus: A review

(2017) M. Goeijenbier et al.   VACCINE

Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?

(2017) Katina D. Hulme et al.   Frontiers in Microbiology

NETosis before and after Hyperglycemic Control in Type 2 Diabetes Mellitus Patients

(2017) Agostina Carestia et al.   PLoS One

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

Diabetes Care: “Taking It to the Limit One More Time”

(2016) William T. Cefalu et al.   DIABETES CARE

Whole-Virion Influenza Vaccine Recalls an Early Burst of High-Affinity Memory B Cell Response through TLR Signaling

(2016) Taishi Onodera et al.   JOURNAL OF IMMUNOLOGY

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

(2016) Piero Dalle Pezze et al.   Nature Communications

mTOR Regulation of Lymphoid Cells in Immunity to Pathogens

(2016) Rachael Keating et al.   Frontiers in Immunology

Glibenclamide impairs responses of neutrophils against Burkholderia pseudomallei by reduction of intracellular glutathione

(2016) Chidchamai Kewcharoenwong et al.   Scientific Reports

Long-Term Immunogenicity and Safety of a Conventional Influenza Vaccine in Patients with Type 2 Diabetes

(2015) Yu Bin Seo et al.   Clinical and Vaccine Immunology

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

(2015) Helder I. Nakaya et al.   IMMUNITY

The antibody response to influenza vaccination is not impaired in type 2 diabetics

(2015) Patricia A. Sheridan et al.   VACCINE

Peering into the Crystal Ball: Influenza Pandemics and Vaccine Efficacy

(2014) Matthew S. Miller et al.   CELL

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Immunogenicity of influenza A(H1N1)pdm09 vaccine in patients with diabetes mellitus

(2014) Yumi Egawa et al.   Human Vaccines & Immunotherapeutics

B Cell-Specific Deficiencies in mTOR Limit Humoral Immune Responses

(2013) S. Zhang et al.   JOURNAL OF IMMUNOLOGY

B Cell-Intrinsic TLR7 Signaling Is Required for Optimal B Cell Responses during Chronic Viral Infection

(2013) J. M. Clingan et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells

(2013) Keqin Yan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

(2013) Rachael Keating et al.   NATURE IMMUNOLOGY

Updates of mTOR Inhibitors

(2012) Hongyu Zhou et al.   Anti-Cancer Agents in Medicinal Chemistry

HI responses induced by seasonal influenza vaccination are associated with clinical protection and with seroprotection against non-homologous strains

(2012) Willem Luytjes et al.   VACCINE

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Toll-like Receptor 7 Controls the Anti-Retroviral Germinal Center Response

(2011) Edward P. Browne   PLoS Pathogens

Advances in the vaccination of the elderly against influenza: role of a high-dose vaccine

(2010) Seth J Sullivan et al.   Expert Review of Vaccines

Systems Vaccinology

(2010) Bali Pulendran et al.   IMMUNITY

Interferon-α and -β in kidney inflammation

(2010) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Plasmacytoid Dendritic Cells Delineate Immunogenicity of Influenza Vaccine Subtypes

(2010) S. Koyama et al.   Science Translational Medicine

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets

(2009) Grace L. Chen et al.   VIROLOGY

The Pathology of Influenza Virus Infections

(2008) Jeffery K. Taubenberger et al.   Annual Review of Pathology-Mechanisms of Disease

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE

RAPping production of type I interferon in pDCs through mTOR

(2008) Mauro Costa-Mattioli et al.   NATURE IMMUNOLOGY

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

Role of the Akt pathway in mRNA translation of interferon-stimulated genes

(2008) S. Kaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA