Moderate Nrf2 Activation by Genetic Disruption of Keap1 Has Sex-Specific Effects on Bone Mass in Mice

Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo

(2018) Eiki Yoshida et al.   GENES TO CELLS

Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis

(2017) Eiko Sakai et al.   FASEB JOURNAL

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

(2017) Takafumi Suzuki et al.   Nature Communications

Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age

(2017) Gretel Gisela Pellegrini et al.   PLoS One

Deletion of Nrf2 reduces skeletal mechanical properties and decreases load-driven bone formation

(2015) Yong-Xin Sun et al.   BONE

Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling

(2015) Angelika F. Winkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Nrf2 Deficiency on Bone Microarchitecture in an Experimental Model of Osteoporosis

(2014) Lidia Ibáñez et al.   Oxidative Medicine and Cellular Longevity

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling

(2013) Hiroyuki Kanzaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species

(2011) Hongkang Zhou et al.   BONE

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

(2009) Sylvia A. Vetrone et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca2+- and ATP-dependent in MC3T3-E1 osteoblasts

(2007) Dawei Liu et al.   BONE