Review
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: The meta-analysis showed no significant association between the ACE I/D polymorphism and lung cancer risk, and subgroup analysis by ethnicity did not yield significant results.
Article
Medicine, General & Internal
Cecilia Calabrese, Anna Annunziata, Antonietta Coppola, Pia Clara Pafundi, Salvatore Guarino, Valentina Di Spirito, Valeria Maddaloni, Nicola Pepe, Giuseppe Fiorentino
Summary: Recent studies suggest a high risk of thromboembolism in patients with severe COVID-19 pneumonia, with a potential link to ACE gene polymorphisms. In this pilot study, researchers found a significant difference in ACE I/D polymorphisms between COVID-19 patients with and without pulmonary embolism, indicating a possible genetic susceptibility to thromboembolism in COVID-19.
FRONTIERS IN MEDICINE
(2021)
Correction
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: An amendment to this paper has been published and can be accessed via the original article.
Article
Virology
Anna Papadopoulou, Paraskevi C. Fragkou, Eirini Maratou, Dimitra Dimopoulou, Antonis Kominakis, Ioanna Kokkinopoulou, Christos Kroupis, Athina Nikolaidou, Georgios Antonakos, Vasiliki Papaevangelou, Apostolos Armaganidis, Argirios Tsantes, Eftychia Polyzogopoulou, Sotirios Tsiodras, Anastasia Antoniadou, Paraskevi Moutsatsou
Summary: Accumulated data suggests a role of the renin-angiotensin system in COVID-19 pathogenesis, with the ACE insertion/deletion polymorphism potentially increasing the risk for severe disease. A retrospective study found that COVID-19 patients with the DD genotype and D allele carriers had a higher risk of developing severe disease, associated with lower ACE activity. This highlights the need for further research on ACE genotype-based therapies in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Oncology
Silvia Selene Moreno-Guerrero, Arturo Ramirez-Pacheco, Luz Maria Rocha-Ramirez, Gabriela Hernandez-Pliego, Pilar Eguia-Aguilar, Maria Argelia Escobar-Sanchez, Alfonso Reyes-Lopez, Luis Enrique Juarez-Villegas, Juan Jose Luis Sienra-Monge
Summary: Neuroblastoma (NB) is a heterogeneous disease with varying characteristics, and genetic variants of cytokines such as IL-6 and IL-8 may influence tumor progression and metastasis. Elevated levels of IL-6 and IL-8 could potentially serve as biomarkers for predicting poor outcomes in NB patients. The study suggests that genetic polymorphisms and serum levels of IL-6 and IL-8 play a significant role in the prognosis of NB patients, particularly in Mexican children.
Article
Medical Laboratory Technology
Jaroslav A. Hubacek, Ladislav Dusek, Ondrej Majek, Vaclav Adamek, Tereza Cervinkova, Dana Dlouha, Vera Adamkova
Summary: This study found that ACE I/D polymorphism has the potential to predict the severity of COVID-19, with I/I homozygotes being at increased risk of symptomatic COVID-19.
CLINICA CHIMICA ACTA
(2021)
Article
Public, Environmental & Occupational Health
Rangaprasad Sarangarajan, Robert Winn, Michael A. Kiebish, Chas Bountra, Elder Granger, Niven R. Narain
Summary: The study suggests a correlation between ACE insertion/deletion polymorphism and COVID-19 infections and comorbidities, with higher frequency of ACE D allele in European, Asian, African, and American populations. ACE DD polymorphism may lead to inflammation, organ damage, and increased risk of COVID-19 infection.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2021)
Review
Cell Biology
Himanshu Rai, Roisin Colleran, Salvatore Cassese, Michael Joner, Adnan Kastrati, Robert A. Byrne
Summary: The meta-analysis showed a significant association between IL6 -174 G/C polymorphism and CAD, driven mainly by Asian and Asian Indian ancestral subgroups. Upregulation of plasma IL-6 levels in the 'C' allele carriers appears to contribute to this association. Further research is needed, particularly among Asian and Asian Indian ancestral groups.
INFLAMMATION RESEARCH
(2021)
Review
Pathology
Simone Gusmao Ramos, Bruna Amanda da Cruz Rattis, Giulia Ottaviani, Mara Rubia Nunes Celes, Eliane Pedra Dias
Summary: COVID-19, caused by SARS-CoV-2, produces extensive damage to the body and affects important organ systems, leading to changes in microcirculation and injury mechanisms in different organs. The research provides a new assessment of COVID-19, exploring it as a transient molecular disease, and offers new insights for a rational treatment strategy.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Genetics & Heredity
Arezoo Faridzadeh, Mahmoud Mahmoudi, Sara Ghaffarpour, Mohammad Saber Zamani, Akram Hoseinzadeh, Mohammad Mehdi Naghizadeh, Tooba Ghazanfari
Summary: This study aimed to evaluate the association of ACE1 and ACE2 gene polymorphisms with the severity of COVID-19. The findings suggest that the ACE1 DD genotype is inversely correlated with intubation risk and mortality in COVID-19 patients. Additionally, the ACE2 rs1978124 CT and TT genotypes have a positive role in susceptibility to COVID-19 in females, but a protective effect against the severity of the disease.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Prishni Gupta, Eli Mohapatra, Suprava Patel, Lisie L. Patnayak, Rachita Nanda, Seema Shah, Jessy Abraham, Ajoy Behera, Atul Jindal
Summary: This study aimed to analyze the effect of I/D mutation in the ACE gene on COVID-19 patients and their healthy contacts. Through PCR analysis, it was found that the wild 'D' allele was dominant in the population. The mutant 'I' allele was observed more in the controls than in the cases, and there was a significant association. The study concluded that the wild 'D' allele increased the risk of being affected by COVID-19, while the 'I' allele had a protective effect.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
T. Turan, A. Pekel, Z. C. Duvan, A. Gonenc
Summary: The study found that UI patients had significantly higher serum INHB levels compared with controls, decreased serum ACE levels, and no significant difference in serum AMH levels. Analysis showed that the DD genotype of ACE insertion/deletion polymorphism may be associated with a higher risk for UI. Further studies with larger populations are needed to confirm these findings.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
T. Turan, A. Pekel, Z. C. Duvan, A. Gonenc
Summary: The study found that serum INHB levels were significantly higher in unexplained infertility patients, and the DD genotype may be a high-risk factor for infertility, although the association was not significant. Further studies are needed to confirm these findings.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Immunology
Jusi Wang, Tingyu Chen, Weifeng Tang, Mingqiang Kang, Shuchen Chen
Summary: The study found that the rs2227282 (C > G) and rs2243283 (C > G) loci in the IL4 gene play protective roles in the development of ESCC, reducing the risk for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Guillaume Butler-Laporte, Tomoko Nakanishi, Vincent Mooser, Alessandra Renieri, Sara Amitrano, Sirui Zhou, Yiheng Chen, Vincenzo Forgetta, J. Brent Richards
Summary: Mendelian randomization using genetic determinants of serum-ACE levels found no association between genetically decreased ACE levels and susceptibility to, or severity of, COVID-19, suggesting that individuals taking ACE inhibitors should not discontinue therapy during the pandemic.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)