Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

Lack of selective resistance of influenza A virus in presence of host-targeted antiviral, UV-4B

(2019) Kelly L. Warfield et al.   Scientific Reports

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

(2018) José A. Martina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling

(2018) Christina M. McGuire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication

(2018) Julianna Han et al.   Cell Reports

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

(2018) Frederick G. Hayden et al.   NEW ENGLAND JOURNAL OF MEDICINE

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

(2017) Anna L Miles et al.   eLife

Observed oseltamivir resistance in seasonal influenza viruses in Europe interpretation and potential implications

(2017) A Nicoll et al.   Eurosurveillance

Lysosomal adaptation: How cells respond to lysosomotropic compounds

(2017) Shuyan Lu et al.   PLoS One

TMEM199 Deficiency Is a Disorder of Golgi Homeostasis Characterized by Elevated Aminotransferases, Alkaline Phosphatase, and Cholesterol and Abnormal Glycosylation

(2016) Jos C. Jansen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation

(2016) Jos C. Jansen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

(2016) Laura R. Rega et al.   KIDNEY INTERNATIONAL

A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence

(2016) Syed I.A. Bukhari et al.   MOLECULAR CELL

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

(2016) Ryan J Park et al.   NATURE GENETICS

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

(2015) Koen Vercauteren et al.   GUT

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

(2015) Christine Schuberth-Wagner et al.   IMMUNITY

KEGG as a reference resource for gene and protein annotation

(2015) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Mapping the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation

(2015) Maria Merkulova et al.   Scientific Reports

RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus

(2015) Jill M. Perreira et al.   Cell Reports

pH-Controlled Two-Step Uncoating of Influenza Virus

(2014) Sai Li et al.   BIOPHYSICAL JOURNAL

Stepwise Priming by Acidic pH and a High K+ Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration

(2014) S. Stauffer et al.   JOURNAL OF VIROLOGY

Variations in pH Sensitivity, Acid Stability, and Fusogenicity of Three Influenza Virus H3 Subtypes

(2014) Deirdre A. Costello et al.   JOURNAL OF VIROLOGY

Targeting the host immune response to fight infection

(2014) J. K. Baillie   SCIENCE

Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins

(2014) A.V. Vasin et al.   VIRUS RESEARCH

A comprehensive map of the influenza A virus replication cycle

(2013) Yukiko Matsuoka et al.   BMC Systems Biology

Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency

(2013) Nunzia Pastore et al.   EMBO Molecular Medicine

The pH of Activation of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Replication and Pathogenesis in Mice

(2013) H. Zaraket et al.   JOURNAL OF VIROLOGY

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockdown of specific host factors protects against influenza virus-induced cell death

(2013) A T Tran et al.   Cell Death & Disease

hLGDB: a database of human lysosomal genes and their regulation

(2013) Alessandro Brozzi et al.   Database-The Journal of Biological Databases and Curation

Global Mortality Estimates for the 2009 Influenza Pandemic from the GLaMOR Project: A Modeling Study

(2013) Lone Simonsen et al.   PLOS MEDICINE

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

Robust rank aggregation for gene list integration and meta-analysis

(2012) Raivo Kolde et al.   BIOINFORMATICS

Structural Changes in Influenza Virus at Low pH Characterized by Cryo-Electron Tomography

(2012) J. Fontana et al.   JOURNAL OF VIROLOGY

IFITM3 restricts the morbidity and mortality associated with influenza

(2012) Aaron R. Everitt et al.   NATURE

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Recognition of Cap Structure by Influenza B Virus RNA Polymerase Is Less Dependent on the Methyl Residue than Recognition by Influenza A Virus Polymerase

(2011) C. Wakai et al.   JOURNAL OF VIROLOGY

Uncovering the global host cell requirements for influenza virus replication via RNAi screening

(2011) Silke Stertz et al.   MICROBES AND INFECTION

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Cellular Networks Involved in the Influenza Virus Life Cycle

(2010) Tokiko Watanabe et al.   Cell Host & Microbe

Estimating the Burden of 2009 Pandemic Influenza A (H1N1) in the United States (April 2009-April 2010)

(2010) S. S. Shrestha et al.   CLINICAL INFECTIOUS DISEASES

Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase

(2010) François Bélanger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection

(2009) Sagi D. Shapira et al.   CELL

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza

(2009) Baoquan Sui et al.   VIROLOGY

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Influenza A Virus Neuraminidase Limits Viral Superinfection

(2008) I-C. Huang et al.   JOURNAL OF VIROLOGY

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE