Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice

Effect of Zoledronic Acid and Denosumab in Patients With Low Back Pain and Modic Change: A Proof-of-Principle Trial

(2018) Guoqi Cai et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prevention and treatment of low back pain: evidence, challenges, and promising directions

(2018) Nadine E Foster et al.   LANCET

What low back pain is and why we need to pay attention

(2018) Jan Hartvigsen et al.   LANCET

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

(2018) Shouan Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-specific low back pain

(2017) Chris Maher et al.   LANCET

Netrin-Mediated Axon Guidance to the CNS Midline Revisited

(2017) Randal A. Hand et al.   NEURON

Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

(2017) Qin Bian et al.   Bone Research

Pathobiology of Modic changes

(2016) Stefan Dudli et al.   EUROPEAN SPINE JOURNAL

Chronic low back pain in relation to Modic changes, bony endplate lesions, and disc degeneration in a prospective MRI study

(2016) Katariina Luoma et al.   EUROPEAN SPINE JOURNAL

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

Association between changes in lumbar Modic changes and low back symptoms over a two-year period

(2015) Jyri Järvinen et al.   BMC MUSCULOSKELETAL DISORDERS

CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development

(2015) Tao Tu et al.   CELL RESEARCH

Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis

(2015) Jae-Sung Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ISSLS Prize Winner

(2015) Juhani H. Määttä et al.   SPINE

Behavioral signs of axial low back pain and motor impairment correlate with the severity of intervertebral disc degeneration in a mouse model

(2015) Magali Millecamps et al.   Spine Journal

Pathomechanisms of discogenic low back pain in humans and animal models

(2015) Seiji Ohtori et al.   Spine Journal

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Type 1 Modic changes was a significant risk factor for 1-year outcome in sick-listed low back pain patients: a nested cohort study using magnetic resonance imaging of the lumbar spine

(2014) Ole Kudsk Jensen et al.   Spine Journal

Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc

(2013) Aaron J. Fields et al.   Spine Journal

Netrin-1 Attracts Axons through FAK-Dependent Mechanotransduction

(2012) S. W. Moore et al.   JOURNAL OF NEUROSCIENCE

Inflammation-induced decrease in voluntary wheel running in mice: A nonreflexive test for evaluating inflammatory pain and analgesia

(2012) Enrique J. Cobos et al.   PAIN

ISSLS Prize Winner

(2012) Yue Wang et al.   SPINE

Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis

(2012) Niklas Schuelert et al.   ARTHRITIS RESEARCH & THERAPY

Morphology of the human vertebral endplate

(2011) Azucena G. Rodriguez et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain

(2011) Jae-Sung Kim et al.   ARTHRITIS RESEARCH & THERAPY

Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?

(2010) José García-Cosamalón et al.   JOURNAL OF ANATOMY

Prostaglandin E2Promotes Nav1.8 Trafficking via Its Intracellular RRR Motif Through the Protein Kinase A Pathway

(2009) Chao Liu et al.   TRAFFIC

The Modic Vertebral Endplate and Marrow Changes: Pathologic Significance and Relation to Low Back Pain and Segmental Instability of the Lumbar Spine

(2008) R. Rahme et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

(2008) Tue Secher Jensen et al.   EUROPEAN SPINE JOURNAL

MF498 [N- -2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

(2008) P. Clark et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Monosynaptic convergence of C- and Aδ-afferent fibres from different segmental dorsal roots on to single substantia gelatinosa neurones in the rat spinal cord

(2008) Vitor Pinto et al.   JOURNAL OF PHYSIOLOGY-LONDON

Species and strain differences in rodent sciatic nerve anatomy: Implications for studies of neuropathic pain

(2008) Marcel Rigaud et al.   PAIN