LRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT)

A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel

(2019) Kevin Strange et al.   JOURNAL OF GENERAL PHYSIOLOGY

Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo

(2018) Raymond Wong et al.   ACTA PHARMACOLOGICA SINICA

Structure of a volume-regulated anion channel of the LRRC8 family

(2018) Dawid Deneka et al.   NATURE

Cell Volume-Activated and Volume-Correlated Anion Channels in Mammalian Cells: Their Biophysical, Molecular, and Pharmacological Properties

(2018) Yasunobu Okada et al.   PHARMACOLOGICAL REVIEWS

Selective transport of neurotransmitters and –modulators by distinct volume-regulated LRRC8 anion channels

(2017) Darius Lutter et al.   JOURNAL OF CELL SCIENCE

Swelling-induced chloride current in glioblastoma proliferation, migration, and invasion

(2017) Raymond Wong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Subunit-dependent oxidative stress sensitivity of LRRC8 volume-regulated anion channels

(2017) Antonella Gradogna et al.   JOURNAL OF PHYSIOLOGY-LONDON

Volume-sensitive outwardly rectifying chloride channel blockers protect against high glucose-induced apoptosis of cardiomyocytes via autophagy activation

(2017) Lin Wang et al.   Scientific Reports

Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes

(2016) Héctor Gaitán-Peñas et al.   BIOPHYSICAL JOURNAL

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength

(2016) Ruhma Syeda et al.   CELL

LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis

(2016) Hyehun Choi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR)

(2016) Stine F. Pedersen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status

(2016) Yuan Chi et al.   Redox Biology

The identification of a volume-regulated anion channel: an amazing Odyssey

(2015) S. F. Pedersen et al.   Acta Physiologica

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

(2015) R. Planells-Cases et al.   EMBO JOURNAL

Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules

(2015) Xuhui Tong et al.   JOURNAL OF GENERAL PHYSIOLOGY

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-rich Repeat-containing Protein 8D

(2014) Clarissa C. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt

(2014) M Shen et al.   Cell Death & Disease

DCPIB, a potent volume-regulated anion channel antagonist, Attenuates microglia-mediated inflammatory response and neuronal injury following focal cerebral ischemia

(2013) Qingdong Han et al.   BRAIN RESEARCH

Volume-Sensitive Anion Channels Mediate Osmosensitive Glutathione Release from Rat Thymocytes

(2013) Ravshan Z. Sabirov et al.   PLoS One

Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity

(2013) I Rubera et al.   Cell Death & Disease

Neuroprotective effects of volume-regulated anion channel blocker DCPIB on neonatal hypoxic-ischemic injury

(2012) Ammar Alibrahim et al.   ACTA PHARMACOLOGICA SINICA

CFTR Is Involved in the Fine Tuning of Intracellular Redox Status

(2012) Christophe Duranton et al.   AMERICAN JOURNAL OF PATHOLOGY

LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication

(2012) Federico Abascal et al.   BIOESSAYS

TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition

(2012) C. E. Hills et al.   DIABETOLOGIA

Does NAD(P)H oxidase-derived H2O2 participate in hypotonicity-induced insulin release by activating VRAC in β-cells?

(2011) R. Crutzen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endothelin signalling regulates volume-sensitive Cl− current via NADPH oxidase and mitochondrial reactive oxygen species

(2010) Wu Deng et al.   CARDIOVASCULAR RESEARCH

Glutathione Transport Is a Unique Function of the ATP-binding Cassette Protein ABCG2

(2010) Heather M. Brechbuhl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra

(2008) Yonghua Zhang et al.   EXPERIMENTAL NEUROLOGY