Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

(2019) Marilia Rita Pinzone et al.   Nature Communications

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy

(2019) Kevin B. Einkauf et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

(2019) Andrew Musick et al.   Frontiers in Microbiology

No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication

(2019) G. Bozzi et al.   Science Advances

Impact of Different Antiretroviral Strategies on Total HIV-DNA Level in Virologically Suppressed HIV-1 Infected Patients

(2018) Isabella Bon et al.   CURRENT HIV RESEARCH

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption

(2018) D. Brenda Salantes et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Short-Term Antiretroviral Therapy Interruption on Levels of Integrated HIV DNA

(2018) Zachary Strongin et al.   JOURNAL OF VIROLOGY

Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA

(2018) Jana Ferdin et al.   PLoS One

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

(2018) Zheng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Digital PCR as a tool to measure HIV persistence

(2018) Sofie Rutsaert et al.   Retrovirology

HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

(2018) Steven A. Yukl et al.   Science Translational Medicine

Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals

(2018) Katherine E. Clarridge et al.   PLoS Pathogens

Quantitation of Integrated HIV Provirus by Pulsed-Field Gel Electrophoresis and Droplet Digital PCR

(2018) Steven M. Lada et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Comparative analysis and generation of a robust HIV-1 DNA quantification assay

(2018) Jordan Thomas et al.   JOURNAL OF VIROLOGICAL METHODS

The role of integration and clonal expansion in HIV infection: live long and prosper

(2018) Elizabeth M. Anderson et al.   Retrovirology

A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

(2018) Daniel B. Reeves et al.   Nature Communications

No evidence of HIV replication in children on antiretroviral therapy

(2017) Gert U. Van Zyl et al.   JOURNAL OF CLINICAL INVESTIGATION

Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents

(2017) David M. Margolis et al.   JOURNAL OF INFECTIOUS DISEASES

Defining total-body AIDS-virus burden with implications for curative strategies

(2017) Jacob D Estes et al.   NATURE MEDICINE

Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

(2017) Ann Wiegand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV integration sites in latently infected cell lines: evidence of ongoing replication

(2017) Jori Symons et al.   Retrovirology

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4 + T Cells from Effectively Treated Participants

(2017) Bonnie Hiener et al.   Cell Reports

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

(2017) John K. Bui et al.   PLoS Pathogens

Multiple Origins of Virus Persistence during Natural Control of HIV Infection

(2016) Eli A. Boritz et al.   CELL

Novel Assays for Measurement of Total Cell-Associated HIV-1 DNA and RNA

(2016) Feiyu Hong et al.   JOURNAL OF CLINICAL MICROBIOLOGY

HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay

(2016) Sara Sunshine et al.   JOURNAL OF VIROLOGY

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy

(2016) Hiromi Imamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonally expanded CD4+T cells can produce infectious HIV-1 in vivo

(2016) Francesco R. Simonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrovirus Integration Database (RID): a public database for retroviral insertion sites into host genomes

(2016) Wei Shao et al.   Retrovirology

Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy

(2016) Birgit Grund et al.   PLoS One

HIV-1 Integration Landscape during Latent and Active Infection

(2015) Lillian B. Cohn et al.   CELL

Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies

(2015) Amanda M. Crooks et al.   JOURNAL OF INFECTIOUS DISEASES

Towards an HIV-1 cure: measuring the latent reservoir

(2015) Katherine M. Bruner et al.   TRENDS IN MICROBIOLOGY

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

(2015) Alessandra Ruggiero et al.   EBioMedicine

HIV-1 DNA Decay Dynamics in Blood During More Than a Decade of Suppressive Antiretroviral Therapy

(2014) Guillaume J. Besson et al.   CLINICAL INFECTIOUS DISEASES

Comparison of Droplet Digital PCR and Seminested Real-Time PCR for Quantification of Cell-Associated HIV-1 RNA

(2014) Maja Kiselinova et al.   PLoS One

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

(2014) T. A. Wagner et al.   SCIENCE

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

(2014) F. Maldarelli et al.   SCIENCE

Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy

(2014) Mary F. Kearney et al.   PLoS Pathogens

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

HIV Populations Are Large and Accumulate High Genetic Diversity in a Nonlinear Fashion

(2013) F. Maldarelli et al.   JOURNAL OF VIROLOGY

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

(2013) Matthew C. Strain et al.   PLoS One

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Early Antiretroviral Therapy During Primary HIV-1 Infection Results in a Transient Reduction of the Viral Setpoint upon Treatment Interruption

(2011) Viktor von Wyl et al.   PLoS One

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

(2011) Ravi P Subramanian et al.   Retrovirology

Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells

(2011) Alberto Bosque et al.   PLoS Pathogens

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics

LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)

(2008) Avettand-Fènoël Véronique et al.   JOURNAL OF MEDICAL VIROLOGY

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

(2008) S. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV rebounds from latently infected cells, rather than from continuing low-level replication

(2008) B. Joos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA