A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans

(2016) Filippo Fiorentini et al.   ACS Chemical Biology

Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity

(2016) Tatsuki Fukami et al.   BIOCHEMICAL PHARMACOLOGY

Drug metabolism by flavin-containing monooxygenases of human and mouse

(2016) Ian R. Phillips et al.   Expert Opinion on Drug Metabolism & Toxicology

JWH-018 ω -OH, a shared hydroxy metabolite of the two synthetic cannabinoids JWH-018 and AM-2201, undergoes oxidation by alcohol dehydrogenase and aldehyde dehydrogenase enzymes in vitro forming the carboxylic acid metabolite

(2016) Niels Bjerre Holm et al.   TOXICOLOGY LETTERS

A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development

(2015) Shingo Oda et al.   Drug Metabolism and Pharmacokinetics

Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes

(2014) Kaori Matsumoto et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Analytical power of LLE–HPLC–PDA–MS/MS in drug metabolism studies: Identification of new nabumetone metabolites

(2013) Milan Nobilis et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetonein vitro

(2012) Lucie Skarydova et al.   XENOBIOTICA

In Vitro Characterization of the Cytochrome P450 Isoforms Involved in the Metabolism of 6-Methoxy-2-napthylacetic Acid, an Active Metabolite of the Prodrug Nabumetone

(2011) Kaori Matsumoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Baeyer-Villiger Oxidation Specifically Catalyzed by Human Flavin-Containing Monooxygenase 5

(2010) W. G. Lai et al.   DRUG METABOLISM AND DISPOSITION

Identification of Novel Substrates for Human Cytochrome P450 2J2

(2009) C. A. Lee et al.   DRUG METABOLISM AND DISPOSITION

Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis

(2009) A. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes

(2009) M. Turpeinen et al.   DRUG METABOLISM AND DISPOSITION

Baeyer–Villiger monooxygenase-catalyzed kinetic resolution of racemic α-alkyl benzyl ketones: enzymatic synthesis of α-alkyl benzylketones and α-alkyl benzylesters

(2009) Cristina Rodríguez et al.   TETRAHEDRON-ASYMMETRY

Role of flavin-containing monooxgenase in drug development

(2008) John R Cashman   Expert Opinion on Drug Metabolism & Toxicology