Drug metabolism by flavin-containing monooxygenases of human and mouse

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans

(2016) Filippo Fiorentini et al.   ACS Chemical Biology

Individual differences inin vitroandin vivometabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3

(2016) Maho Okubo et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

What is the contribution of human FMO3 in the N -oxygenation of selected therapeutic drugs and drugs of abuse?

(2016) Lea Wagmann et al.   TOXICOLOGY LETTERS

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

(2015) Sandra G. Gonzalez Malagon et al.   BIOCHEMICAL PHARMACOLOGY

In vitrometabolism of an estrogen-related receptor γ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s

(2015) Jeongmin Joo et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers

(2015) Makiko Shimizu et al.   Drug Metabolism and Pharmacokinetics

Effect of various diets on the expression of phase-I drug-metabolizing enzymes in livers of mice

(2015) Ying Guo et al.   XENOBIOTICA

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance

(2014) Sunil Veeravalli et al.   BIOCHEMICAL PHARMACOLOGY

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

(2014) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers

(2014) Li-Ping Zhou et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Clinical utility gene card for: Trimethylaminuria – update 2014

(2014) Elizabeth A Shephard et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities

(2013) Hiroshi Yamazaki et al.   BIOCHEMICAL PHARMACOLOGY

An LC–MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model

(2013) X. Jin et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors

(2013) Gianluca Catucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacogenetics of olanzapine metabolism

(2013) Mao Mao Söderberg et al.   PHARMACOGENOMICS

Metabolomics reveals the metabolic map of procainamide in humans and mice

(2012) Fei Li et al.   BIOCHEMICAL PHARMACOLOGY

Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety

(2012) Gang Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale

(2012) Steven P. Hanlon et al.   CHEMICAL COMMUNICATIONS

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

(2012) A. Joseph Bloom et al.   Pharmacogenetics and Genomics

Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients

(2012) M M Söderberg et al.   PHARMACOGENOMICS JOURNAL

In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine

(2011) Jiang Ping Luo et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

(2011) A. Potega et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

(2010) J. Yu et al.   DRUG METABOLISM AND DISPOSITION

A Baeyer-Villiger Oxidation Specifically Catalyzed by Human Flavin-Containing Monooxygenase 5

(2010) W. G. Lai et al.   DRUG METABOLISM AND DISPOSITION

A rapid and sensitive CE method with field-enhanced sample injection and in-capillary derivatization for selenomethionine metabolism catalyzed by flavin-containing monooxygenases

(2010) Xin Hai et al.   ELECTROPHORESIS

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism

(2010) Elizabeth A Shephard et al.   Expert Opinion on Drug Metabolism & Toxicology

Inter-individual Variation in Flavin-containing Monooxygenase 3 in Livers from Japanese: Correlation with Hepatic Transcription Factors

(2009) Satomi Nagashima et al.   Drug Metabolism and Pharmacokinetics

Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms

(2009) Xin Hai et al.   ELECTROPHORESIS

Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine

(2009) Diana Hernandez et al.   Pharmacogenetics and Genomics

Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide

(2008) A. A. Francois et al.   DRUG METABOLISM AND DISPOSITION

Aryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse Liver

(2008) T. Celius et al.   DRUG METABOLISM AND DISPOSITION

Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics

(2008) L. Wang et al.   DRUG METABOLISM AND DISPOSITION

Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes

(2008) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

Role of flavin-containing monooxgenase in drug development

(2008) John R Cashman   Expert Opinion on Drug Metabolism & Toxicology

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

(2008) Krishna R. Veeramah et al.   Pharmacogenetics and Genomics

Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes

(2008) Marilyn C. Henderson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Flavin-containing monooxygenases: mutations, disease and drug response

(2008) I PHILLIPS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms

(2007) Lisbeth K. Siddens et al.   BIOCHEMICAL PHARMACOLOGY