Article
Chemistry, Medicinal
Kun-Ming Chen, Yuan-Wan Sun, Dongxiao Sun, Krishne Gowda, Shantu Amin, Karam El-Bayoumy
Summary: In this study, it was found that black raspberry extract (BRBE) enhances synthesis of glutathione (GSH) and inhibits DBP-induced DNA damage in human oral leukoplakia and squamous cell carcinoma cells. LC-MS/MS analysis showed increased levels of DBPDE-GSH conjugate and decreased DNA damage in cells treated with BRBE followed by DBPDE.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Biochemical Research Methods
Shiqi Zhang, Mengyang Xu, Xiaowei Sun, Xuyu Liu, Fouad Choueiry, Rui Xu, Haifei Shi, Jiangjiang Zhu
Summary: This study investigated the impact of black raspberry extract on the gut microbiota composition and metabolism using an in vitro human colonic model. The results showed that black raspberry intervention could modulate the composition and metabolism of gut microbiota, potentially affecting host metabolism and health.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Microbiology
Young-Ran Song, Chan-Mi Lee, Seon-Hye Lee, Sang-Ho Baik
Summary: PA-M76 demonstrated strong probiotic properties with high tolerance in GIT environments, broad antimicrobial activity, and effective immune response elicitation. Lactic acid fermentation of BRE by PA-M76 resulted in increased antioxidant activity, while not significantly affecting total anthocyanin and flavonoid content.
Article
Food Science & Technology
Yasmin A. Elkhawas, Mae Seleem, Marwa I. Shabayek, Taghreed A. Majrashi, Tarfah Al-Warhi, Wagdy M. Eldehna, Nada M. Mostafa
Summary: Black garlic aqueous-ethanol extract (BGE) has antioxidant and anti-inflammatory effects, showing significant improvement in biochemical parameters and enhanced cognition in a multiple sclerosis induced-rat model. Molecular docking study suggests BGE has good affinities to inducible nitric oxide synthase.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Ni Shi, Tong Chen
Summary: Esophageal cancer is a deadly malignancy, with esophageal squamous cell carcinoma and esophageal adenocarcinoma being the two main types. Tobacco and alcohol use, along with limited intake of fresh fruits and vegetables, contribute to the prevalence of esophageal cancer. A food-based approach can help prevent esophageal cancer by targeting multiple processes in carcinogenesis. Black raspberries and strawberries have been found to be potent inhibitors of esophageal cancer.
Article
Pharmacology & Pharmacy
Abeer Salama, Rania Elgohary, Mohamed M. Amin, Sahar Abd Elwahab
Summary: Protocatechuic acid has immunomodulatory effects on brain injury induced by cyclophosphamide through modulation of inflammasomes NLRP3 and SIRT1. It improves cognition and memory, reduces inflammation and oxidative stress, and protects neurons.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Abel Garcia-Barrientos, David Torres-Uresti, Francisco R. Castillo-Soria, Ulises Pineda-Rico, Jose Antonio Hoyo-Montano, Obed Perez-Cortes, Patricio Ordaz-Oliver
Summary: This research presents the design and implementation of a car's black box system using a Raspberry Pi microcomputer and an Internet of things module. The system can acquire and process various data, including video, audio, GPS data, alcohol concentration, speed, and temperature. In addition, a graphics user interface was developed to process the stored files, allowing authorities to access the data when needed.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Kun-Ming Chen, Yuan-Wan Sun, Nicolle M. Krebs, Dongxiao Sun, Jacek Krzeminski, Lisa Reinhart, Krishne Gowda, Shantu Amin, Susan Mallery, John P. Richie, Karam El-Bayoumy
Summary: This study found that the levels of DNA adducts derived from PAHs in cigarette smoke were significantly higher in smokers compared to non-smokers. These results support that PAHs in tobacco smoke can contribute to the development of oral cancer in humans.
Article
Multidisciplinary Sciences
Rentong Hu, Weerachai Chantana, Pornsiri Pitchakarn, Subhawat Subhawa, Bhanumas Chantarasuwan, Piya Temviriyanukul, Teera Chewonarin
Summary: This study investigated the preventive action of Ficus dubia latex extract (FDLE) on rat colorectal carcinogenesis and its mechanisms. The results showed that FDLE could reduce the level of MAM in rat colonic lumen and inhibit DNA methylation in colonic mucosal cells. Additionally, FDLE modulated inflammation and suppressed the growth of aberrant colonic mucosal cells, leading to the retardation of ACF multiplicity.
SCIENTIFIC REPORTS
(2022)
Article
Toxicology
Andrea Gerdemann, Benedikt Cramer, Gisela H. Degen, Jannik Veerkamp, Georgia Guenther, Wiebke Albrecht, Matthias Behrens, Melanie Esselen, Ahmed Ghallab, Jan G. Hengstler, Hans-Ulrich Humpf
Summary: This study analyzed the metabolites formed by mouse, rat, and human primary hepatocytes after treatment with different concentrations of Aflatoxin B-1 (AFB(1)). The results showed species-specific differences in the metabolism of AFB(1) and provided insights into the toxification and detoxification mechanisms of AFB(1).
ARCHIVES OF TOXICOLOGY
(2023)
Article
Toxicology
Andrea Gerdemann, Benedikt Cramer, Gisela H. Degen, Jannik Veerkamp, Georgia Guenther, Wiebke Albrecht, Matthias Behrens, Melanie Esselen, Ahmed Ghallab, Jan G. Hengstler, Hans-Ulrich Humpf
Summary: This study compared the metabolism of AFB(1) in mouse, rat, and human primary hepatocytes, revealing differences in toxification and detoxification mechanisms. Mouse hepatocytes exhibited the fastest metabolism, mainly forming aflatoxin P-1, while human cells produced higher levels of aflatoxin M-1. In addition to glutathione conjugation, phase I metabolism was found to play an important role in AFB(1) detoxification.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana H. Sales, Marina Kolbanovskiy, Nicholas E. Geacintov, Kun-Ming Chen, Yuan-Wan Sun, Karam El-Bayoumy
Summary: The study demonstrates that the consumption of a diet containing freeze-dried black raspberries (BRB) can inhibit DNA damage and carcinogenesis. The researchers tested the effects of BRB extracts (BRBE) on DNA repair capacity using the HeLa cell extract system and found that BRBE enhances nucleotide excision repair (NER) activity and increases the expression of important NER factors. These findings suggest that BRBE can improve the repair of bulky and non-bulky DNA lesions.
Article
Food Science & Technology
Natasa Nastic, Zorana Mutavski, Jelena Zivkovic, Rita Ambrus, Naiara Fernandez, Nebojsa Menkovic, Senka Vidovic
Summary: The aim of this study was to extract anthocyanin-enriched fractions from black raspberry pomace using ultrasound-assisted extraction and the Particles from Gas-Saturated Solutions process. The results showed that the amplitude of ultrasound had a significant effect on extraction yield and total phenolic content. The high-performance techniques used in this study allowed for the production of natural fractions with desirable characteristics for the development of nutraceuticals and food formulations.
Article
Chemistry, Multidisciplinary
Seung-Yeon Shin, Jeong-Eun Kwon, Seonyu Kim, Yeong-Geun Lee, Soojin Park, Se-Chan Kang
Summary: Alopecia is a chronic inflammatory skin disease. This study found that Lespedeza bicolor extract (LBE) can promote hair growth by enhancing cell proliferation and regenerating the hair cycle.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Yuxin Hao, Jing Yang, Jingyan Cui, Yanling Fan, Nana Li, Chunyu Wang, Yongping Liu, Yuemeng Dong
Summary: Raspberry extract, rich in anthocyanins and low in sugar, undergoes metabolic changes in vitro digestion, with the stability of phenolic compounds mainly influenced by pH and intestinal microbiota. During the gastric to intestinal and colonic fermentation stages, the phenolic compounds rapidly decrease in concentration.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Hematology
Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma
Article
Environmental Sciences
Yuan-Wan Sun, Wieslawa Kosinska, Joseph B. Guttenplan
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Chemistry, Medicinal
Joseph B. Guttenplan, Kun-Ming Chen, Yuan-Wan Sun, Nora A. E. Shalaby, Wieslawa Kosinska, Dhimant Desai, Krishne Gowda, Shantu Amin, Karam El-Bayoumy
CHEMICAL RESEARCH IN TOXICOLOGY
(2019)
Article
Medicine, Research & Experimental
Gulsum E. Muku, Ann Kusnadi, Guray Kuzu, Rachel Tanos, Iain A. Murray, Krishne Gowda, Shantu Amin, Gary H. Perdew
LABORATORY INVESTIGATION
(2020)
Article
Oncology
Saketh S. Dinavahi, Raghavendra Gowda, Krishne Gowda, Christopher G. Bazewicz, Venkat R. Chirasani, Madhu Babu Battu, Arthur Berg, Nikolay V. Dokholyan, Shantu Amin, Gavin P. Robertson
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Oncology
Kun-Ming Chen, Yuan-Wan Wan Sun, Yuka Imamura Kawasawa, Anna C. Salzberg, Junjia Zhu, Krishne Gowda, Cesar Aliaga, Shantu Amin, Hannah Atkins, Karam El-Bayoumy
CANCER PREVENTION RESEARCH
(2020)
Article
Chemistry, Medicinal
Saketh S. Dinavahi, Raghavendra Gowda, Christopher G. Bazewicz, Madhu Babu Battu, Jyh Ming Lin, Robert J. Chitren, Manoj K. Pandey, Shantu Amin, Gavin P. Robertson, Krishne Gowda
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Hematology
Chunhua Song, Zheng Ge, Yali Ding, Bi-Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M. Cury, Jose Andres Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat
Article
Gastroenterology & Hepatology
Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa M. Tindall, Penny M. Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew
Article
Biochemistry & Molecular Biology
Neil D. Christensen, Kun-Ming Chen, Jiafen Hu, Douglas B. Stairs, Yuan-Wan Sun, Cesar Aliaga, Karla K. Balogh, Hannah Atkins, Debra Shearer, Jingwei Li, Sarah A. Brendle, Krishne Gowda, Shantu Amin, Vonn Walter, Raphael Viscidi, Karam El-Bayoumy
Summary: The study found that mice infected with MmuPV1 and treated with the tobacco carcinogen DBP have a higher risk of developing squamous cell carcinoma in oral tissues, compared to mice treated with virus or carcinogen individually. Virally-infected epithelium exhibited strong levels of viral DNA/RNA and viral protein staining, while areas of SCC showed reduced viral DNA staining but strong RNA signals.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Multidisciplinary Sciences
Kun-Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan-Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy
Summary: The study found that 4-OXO-DHA is the preferred metabolite in future chemoprevention studies, with the ability to combat breast cancer through pathways such as activating PPAR-ɣ and 15-PGDH.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Yuan-Wan Sun, Kun-Ming Chen, Hannah Atkins, Cesar Aliaga, Terry Gordon, Joseph B. Guttenplan, Karam El-Bayoumy
Summary: The study found that PG/G without nicotine increased levels of oxidative damage biomarkers in the lungs and plasma of mice, and e-cigarettes can cause more severe lung injury than tobacco smoke. This research data contributes to a better understanding of the impact of e-cigarettes on pulmonary oxidative stress and inflammation.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Oncology
Kun-Ming Chen, Yuan-Wan Sun, Nicolle M. Krebs, Dongxiao Sun, Jacek Krzeminski, Lisa Reinhart, Krishne Gowda, Shantu Amin, Susan Mallery, John P. Richie, Karam El-Bayoumy
Summary: This study found that the levels of DNA adducts derived from PAHs in cigarette smoke were significantly higher in smokers compared to non-smokers. These results support that PAHs in tobacco smoke can contribute to the development of oral cancer in humans.
Article
Chemistry, Medicinal
Kun-Ming Chen, Yuan-Wan Sun, Dongxiao Sun, Krishne Gowda, Shantu Amin, Karam El-Bayoumy
Summary: In this study, it was found that black raspberry extract (BRBE) enhances synthesis of glutathione (GSH) and inhibits DBP-induced DNA damage in human oral leukoplakia and squamous cell carcinoma cells. LC-MS/MS analysis showed increased levels of DBPDE-GSH conjugate and decreased DNA damage in cells treated with BRBE followed by DBPDE.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew
Summary: A certain diet can enhance the activity of the aryl hydrocarbon receptor (AHR) in the intestinal tract, which is responsible for maintaining intestinal barrier homeostasis. This is possibly achieved through the role of certain dietary substrates as CYP1A1/1B1 substrates, which increase the half-life of potent AHR ligands. The gut bacterial metabolite urolithin A (UroA) has been identified as one of these substrates, and its intake can lead to increased AHR activity in key barrier tissues.
