Article
Biotechnology & Applied Microbiology
Jing Huang, Zhenlin Gu, Yingying Xu, Lei Jiang, Weiguo Zhu, Wanwei Wang
Summary: The study found that CHI3L1 is overexpressed in esophageal cancer tissues and positively correlated with tumor size, as well as with increased expression of macrophage signature genes in the tumor tissues. Additionally, CHI3L1 overexpression may promote macrophage recruitment in esophageal tumor tissues.
Article
Medicine, Research & Experimental
Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen
Summary: The study revealed that Carfilzomib effectively converted M2 macrophages into M1-like macrophages, reshaped the tumor microenvironment, and synergized with PD-1 inhibitors to treat autochthonous lung cancers.
EMBO MOLECULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Alireza Najafi, Maryam Keykhaee, Hossein Khorramdelazad, Mohammad Yahya Karimi, Leila Nejatbakhsh Samimi, Nazanin Aghamohamadi, Milad Karimi, Reza Falak, Mehdi Khoobi
Summary: The tumor microenvironment (TME) plays a critical role in tumor progression and resistance to treatment. Tumor-associated macrophages (TAMs) and hypoxia are important factors in the TME. Catalase and catalase-mimicking compounds can reduce hypoxia and promote TAM polarization, showing potential in cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Jian Yang, Yongzheng Li, Zhaowei Sun, Hanxiang Zhan
Summary: This review summarizes recent advances in understanding the origin, distribution, and polarization of macrophages in pancreatic cancer, as well as their role in carcinogenesis and development, and potential therapeutic value. Macrophages play a crucial role in creating an immunosuppressive tumor microenvironment, ultimately facilitating tumor initiation and progression in pancreatic cancer.
Review
Multidisciplinary Sciences
Martha Lopez-Yrigoyen, Luca Cassetta, Jeffrey W. Pollard
Summary: Tumorigenesis is influenced by interactions between cancer cells and the tumor microenvironment. Tumor-associated macrophages play a crucial role in tumor development, with the potential to both promote antitumor responses and exhibit immunosuppressive protumor phenotypes. Targeting TAMs has become a strategy in cancer therapy, with a focus on reprogramming TAMs to support antitumor immune responses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Oncology
Nisha Kumari, Seung Hong Choi
Summary: Cancer immunotherapy has had limited success, but nanoparticles have emerged as crucial tools in targeting tumor-associated macrophages (TAMs) and improving therapy outcomes. Current strategies include restricting TAMs survival, inhibiting TAMs recruitment, and repolarizing tumor-supportive TAMs to an antitumor phenotype.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Yuanyuan An, Qing Yang
Summary: Ovarian cancer is influenced significantly by the tumor microenvironment, where macrophages play a crucial role in regulating the progression of the disease. Targeted therapy focusing on macrophages shows promise in treating ovarian cancer, despite facing challenges. Interactions between macrophages and other immune cells within the microenvironment also impact the development of ovarian cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Song Liao, Jianxiong Li, Song Gao, Yuchen Han, Xinli Han, Yanan Wu, Jingyou Bi, Meng Xu, Wenzhi Bi
Summary: Tumor progression is driven by intrinsic malignant behaviors and interactions with the tumor microenvironment (TME). Targeting immunomodulatory stromal cells in the TME, such as cancer-associated fibroblasts and tumor-associated macrophages, could be a potential therapeutic strategy. This study investigated the effect of sulfatinib, a multi-targeted tyrosine kinase inhibitor, on the treatment of osteosarcoma.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Oncology
Ewa Cendrowicz, Zuzanna Sas, Edwin Bremer, Tomasz P. Rygiel
Summary: Tumor-Associated Macrophages (TAMs) play a crucial role in tumor development and are potential targets for cancer therapy due to their influence on immunity and tumor microenvironment.
Article
Oncology
Leonie K. de Klerk, Anuj K. Patel, Sarah Derks, Eirini Pectasides, Jeremy Augustin, Mohamed Uduman, Nihal Raman, Fahire G. Akarca, Nadine J. McCleary, James M. Cleary, Douglas A. Rubinson, Jeffrey W. Clark, Bridget Fitzpatrick, Lauren K. Brais, Megan E. Cavanaugh, Amanda J. Rode, Melissa G. Jean, Patrick H. Lizotte, Matthew J. Nazzaro, Mariano Severgnini, Hui Zheng, Charles S. Fuchs, Peter C. Enzinger, Adam J. Bass
Summary: This study indicates that single-agent pembrolizumab has limited efficacy in patients with esophageal cancer, but circulating CXCL10 at baseline appears to be a robust predictor of response. Upregulation of other T cell exhaustion markers in PD-L1-positive patients suggests that immunotherapy combinations may hold promise in refractory esophageal cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Rachel V. Brady, Douglas H. Thamm
Summary: Macrophages, ancient immune cells, play diverse roles in development, homeostasis, tissue repair, inflammation, and immunity. In cancer, most tumor-associated immune cells are macrophages, with both anti-tumor and pro-tumorigenic properties. Manipulating macrophages as a therapeutic strategy against cancer has been of interest since the 1970s. Companion dogs serve as a valuable comparative immuno-oncology model, and data from clinical trials in humans and dogs can contribute to scientific advancements for both species. This review provides an overview of macrophages in general and focuses on their role as a therapeutic strategy against cancer in humans and companion dogs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Hyosuk Kim, Hyun-Ju Park, Hyo Won Chang, Ji Hyun Back, Su Jin Lee, Yae Eun Park, Eun Hye Kim, Yeonsun Hong, Gijung Kwak, Ick Chan Kwon, Ji Eun Lee, Yoon Se Lee, Sang Yoon Kim, Yoosoo Yang, Sun Hwa Kim
Summary: The highly immunosuppressive tumor microenvironment with protumoral immune cells accelerates malignant transformation and treatment resistance. Tumor-associated macrophages (TAMs), as the predominant immune cells in tumors, play a crucial role in regulating the immunosuppressive tumor microenvironment. This study explores an exosome-guided direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages, potentially enhancing antitumor immunity.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Quratulain Babar, Ayesha Saeed, Tanveer A. Tabish, Mohsin Sarwar, Nanasaheb D. Thorat
Summary: The tumor microenvironment (TME) consists of cellular and stromal components, including tumor cells, immune cells, mesenchymal cells, cancer-associated fibroblasts, and extracellular matrix. Targeting TME has emerged as a potential strategy for cancer treatment due to its crucial role in tumor initiation, proliferation, invasion, metastasis, and response to therapy. Various therapies, such as cold atmospheric plasma, oncolytic viral therapy, bacterial therapy, nano-vaccines, and repurposed pharmaceuticals, along with combination therapy, antiangiogenic drugs, and immunotherapies, are being explored for their effectiveness in targeting TME.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Chen Li, Jiagui Song, Zhengyang Guo, Yueqing Gong, Tengrui Zhang, Jiaqi Huang, Rui Cheng, Xiaotong Yu, Yanfang Li, Li Chen, Xiaojuan Ma, Yan Sun, Yan Wang, Lixiang Xue
Summary: This study investigates the role of EZH2 inhibitors in modulating macrophage polarization in the tumor microenvironment of colorectal cancer. The two different EZH2 inhibitors, EPZ6438 and GSK126, were compared. The findings suggest that EZH2 inhibitors not only suppress CRC cell proliferation directly, but also regulate macrophage polarization to exert a tumor suppressive effect.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Masataka Fujikawa, Yu-ichiro Koma, Masayoshi Hosono, Naoki Urakawa, Kohei Tanigawa, Masaki Shimizu, Takayuki Kodama, Hiroki Sakamoto, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: The overexpression of CCL1 in TAM-like macrophages promotes ESCC progression by enhancing cell motility, while the expression of CCR8 receptor on ESCC cell surface also plays a significant role. These interactions suggest novel therapeutic targets for treating ESCC.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Hiroki Sakamoto, Yu-ichiro Koma, Nobuhide Higashino, Takayuki Kodama, Kohei Tanigawa, Masaki Shimizu, Masataka Fujikawa, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: The study reveals that PAI-1 derived from cancer-associated fibroblasts promotes invasion of esophageal squamous cell carcinoma cells and migration of macrophages through LRP1. High expression of PAI-1 and/or LRP1 is associated with poor prognosis in ESCC patients, suggesting PAI-1/LRP1 axis could be a potential target for cancer therapy.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Mizuho Nishio, Mari Nishio, Naoe Jimbo, Kazuaki Nakane
Summary: The study aimed to develop a CAD system for automatic classification of histopathological images of lung tissues. Two datasets were used for developing and validating CAD, and it was found that HI was more useful than conventional texture analysis for the CAD systems.
Review
Cell Biology
Manabu Shigeoka, Yu-ichiro Koma, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki
Summary: This review highlights the significance of macrophages in oral carcinogenesis and proposes studying the alteration of macrophage infiltrating compartments as a novel approach for gaining insights into cancer prevention and early detection.
Article
Oncology
Masaki Shimizu, Yu-ichiro Koma, Hiroki Sakamoto, Shuichi Tsukamoto, Yu Kitamura, Satoshi Urakami, Kohei Tanigawa, Takayuki Kodama, Nobuhide Higashino, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: In this study, we found that MT2A plays a crucial role in the progression of ESCC, affecting the migration and invasiveness of tumor cells in CAF-like cells and cancer cells. MT2A and IGFBP2 may serve as potential novel therapeutic targets in ESCC.
Article
Gastroenterology & Hepatology
Kei Matsumoto, Shinwa Tanaka, Takashi Toyonaga, Nobuaki Ikezawa, Mari Nishio, Masanao Uraoka, Tomoatsu Yoshihara, Hiroya Sakaguchi, Hirofumi Abe, Tetsuya Yoshizaki, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Hiroshi Yokozaki, Yuzo Kodama
Summary: This study found that patients in the Billroth II group with remnant gastric cancer at the anastomotic site had larger lesions with severe remnant gastritis compared to those in the non-Billroth II group. Endoscopic submucosal dissection in Billroth II patients involved longer operative times and a higher frequency of bleeding episodes.
CLINICAL ENDOSCOPY
(2022)
Article
Pathology
Kohei Tanigawa, Shuichi Tsukamoto, Yu-ichiro Koma, Yu Kitamura, Satoshi Urakami, Masaki Shimizu, Masataka Fujikawa, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: Direct co-culture of esophageal squamous cell carcinoma (ESCC) cells and macrophages enhances the migration and invasion abilities of ESCC cells and promotes ESCC progression through the Akt and p38 MAPK signaling pathways. The expression and release of S100A8/A9 are significantly increased in co-cultured ESCC cells and play a crucial role in this process.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Kazuyoshi Yanagihara, Yuki Iino, Hiroshi Yokozaki, Takanori Kubo, Tatsuya Oda, Takashi Kubo, Masayuki Komatsu, Hiroki Sasaki, Hitoshi Ichikawa, Takeshi Kuwata, Toshio Seyama, Atsushi Ochiai
Summary: This study successfully established 13 matched patient-derived tumor models of PDA, including PDX, PDCL, and CDX. By comparing the histological and molecular alterations in these model systems, researchers found that PDX tumors had similar molecular alterations to PDCL and CDX tumors, while OI tumors showed specific immunohistochemical profiles. These patient-derived tumor models provide useful tools for monitoring responses to antineoplastic agents and studying the biology of PDA.
Article
Oncology
Yu Kitamura, Yu-ichiro Koma, Kohei Tanigawa, Shuichi Tsukamoto, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: High infiltration of tumor-associated macrophages (TAMs) is correlated with poor prognosis of esophageal squamous cell carcinoma (ESCC). In this study, direct co-culture of ESCC cells with macrophages induced interleukin 7 receptor (IL-7R) expression. Overexpression of IL-7R promoted ESCC cell survival and growth via the activation of the Akt and Erk1/2 signaling pathways. The IL-7/IL-7R axis also contributed to ESCC cell migration via the Akt and Erk1/2 signaling pathways. ESCC patients with high IL-7R expression in cancer nests exhibited poor disease-free survival.
Article
Oncology
Shuichi Tsukamoto, Yu-ichiro Koma, Yu Kitamura, Kohei Tanigawa, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Masayoshi Hosono, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki
Summary: Tumor-associated macrophages (TAMs) play a role in the progression of esophageal squamous cell carcinoma (ESCC). A direct co-culture system was used to study the interaction between ESCC cells and TAMs, revealing that matrix metalloproteinase 9 (MMP9) expression in ESCC cells was induced by direct co-culture with TAMs. MMP9 was associated with ESCC cell migration and invasion, and its expression was controlled by the Stat3 signaling pathway. Immunohistochemical analyses showed that MMP9 expression in cancer cells at the invasive front was related to high infiltration of M2-like TAMs and worse survival of patients. However, MMP9 expression in cancer stroma was not associated with any clinicopathological factors or patient prognoses.
Article
Oncology
Satoshi Urakami, Yu-ichiro Koma, Shuichi Tsukamoto, Yuki Azumi, Shoji Miyako, Yu Kitamura, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hirofumi Abe, Yu Usami, Yuzo Kodama, Hiroshi Yokozaki
Summary: M2 macrophages contribute to the progression of oesophageal squamous cell carcinoma (ESCC) by promoting the proliferation and migration of Het-1A cells. This phenomenon is mediated by the mTOR-p70S6K signaling pathway activated by hypersecreted YKL-40 and OPN. YKL-40 and OPN also promote M2 polarization, proliferation, and migration of macrophages.
JOURNAL OF PATHOLOGY
(2023)
Article
Genetics & Heredity
Shihori Tanabe, Eger Boonstra, Taehun Hong, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Hiroshi Yokozaki, Edward J. Perkins, Hiroki Sasaki
Summary: This study analyzed the molecular networks of anti-cancer drugs such as cisplatin, carboplatin, oxaliplatin, and arsenic trioxide in various types of cancer to reveal the mechanism of drug resistance. The study also highlighted the significance of tumor microenvironment in the treatment of drug-resistant cancer.
Article
Surgery
Takeo Kimoto, Norio Kohno, Akiko Okamoto, Kyosuke Ota, Takafumi Tani, Takeshi Kondo, Mari Nishio
Summary: This case report presented a rare occurrence of breast cancer metastasis to the inguinal lymph nodes in a patient who had undergone multiple surgeries. The progression of the inguinal lymph node metastases was closely correlated with that of the primary breast cancer, with one potential cause being attributed to extensive previous abdominal operations.
SURGICAL CASE REPORTS
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
