Article
Instruments & Instrumentation
Anvay Ukidve, Katharina Cu, Ninad Kumbhojkar, Joerg Lahann, Samir Mitragotri
Summary: This review focuses on efforts to overcome tumor-associated biological barriers and enhance the potency of immunotherapy, including understanding barriers that limit drug entry into tumors, in vitro techniques for investigating transport processes, and delivery strategies to overcome these barriers. The aim is to provide a framework for the rational development of technologies for improved solid tumor immunotherapy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Maria Joao Ramalho, Joana Angelica Loureiro, Manuel A. N. Coelho, Maria Carmo Pereira
Summary: This review provides an overview and discussion on the recent advances concerning the strategies to target the transferrin receptor in the treatment of GBM, as well as their benefits and limitations.
Editorial Material
Chemistry, Physical
Satish G. Jadhav, Steven F. Dowdy
Summary: Ionizable phospholipids have been developed to improve the delivery of mRNA and sgRNA for gene editing by selectively targeting organs and destabilizing endosomal membranes.
Review
Oncology
Mirna Lechpammer, Rohan Rao, Sanjit Shah, Mona Mirheydari, Debanjan Bhattacharya, Abigail Koehler, Donatien Kamdem Toukam, Kevin J. Haworth, Daniel Pomeranz Krummel, Soma Sengupta
Summary: Glioblastoma is a highly aggressive brain tumor with limited treatment options. Immunotherapy, which stimulates the immune system to attack tumor cells, is a promising approach. However, there are challenges such as tumor heterogeneity, the blood-brain barrier, and the lack of specific targets. New technologies like microbubble-enhanced focused ultrasound are being developed to overcome these barriers.
Review
Chemistry, Multidisciplinary
Jianlei Xie, Yingwei Wang, Wonseok Choi, Paramesh Jangili, Yanqi Ge, Yunjie Xu, Jianlong Kang, Liping Liu, Bin Zhang, Zhongjian Xie, Jun He, Ni Xie, Guohui Nie, Han Zhang, Jong Seung Kim
Summary: Photodynamic therapy (PDT) has shown great potential in tumor treatment due to its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability. However, the clinical application of PDT is restricted by various factors such as traditional photosensitizer limitations, light penetration issues, tumor resistance, and pain induction. Recent advancements in using nanomaterials as photosensitizers or carriers, combined with optimized therapy strategies, have shown promising results in overcoming these barriers and improving the effectiveness of PDT in cancer treatment.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Medicine, Research & Experimental
Manish Muhuri, Yukiko Maeda, Hong Ma, Sanjay Ram, Katherine A. Fitzgerald, W. L. Phillip, Guangping Gao
Summary: Research has shown that host immune responses against rAAVs have hindered the progress of gene therapy. Both the innate and adaptive arms of the immune system play a role in this response.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, Research & Experimental
Saikat Ghosh, Pie Huda, Nicholas L. Fletcher, Christopher B. Howard, Bradley Walsh, Douglas Campbell, Mark B. Pinkham, Kristofer J. Thurecht
Summary: Glioblastoma is the most aggressive form of primary brain cancer, and the current conventional treatments still face challenges. Targeted therapies enabled through antibody engineering show promise in overcoming treatment obstacles and improving patient survival rates. In addition, alternative routes that bypass the natural barriers of the brain could be used to administer anti-glioblastoma biologics.
MOLECULAR PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Qianqian Lu, Hongyue Yu, Tiancong Zhao, Guanjia Zhu, Xiaomin Li
Summary: In recent years, researchers have made significant progress in developing nanomedicines with transformable physicochemical properties, which enable responsive switching of size, shape, surface charge, and other parameters. These properties allow the nanomedicines to overcome biological barriers and achieve maximum delivery efficiency. This review summarizes recent developments in this field, including the analysis of biological dilemmas, the design and synthesis of nanomaterials with transformable properties, and the discussion of other switchable physicochemical parameters. The prospects and challenges for nanomedicines with these properties are also highlighted.
Article
Instruments & Instrumentation
Yuan Rui, Jordan J. Green
Summary: Glioblastoma remains one of the most deadly forms of primary adult tumors, with little improvement in prognosis over the past two decades. Cancer immunotherapy shows promise in treating glioblastoma, but faces unique challenges in drug delivery due to the blood-brain barrier and immune privileged status of the central nervous system. Recent advances in biomaterial-based strategies for cancer immunotherapy may offer potential solutions for effective treatment of glioblastoma.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Changyong Gao, Yong Wang, Zihan Ye, Zhihua Lin, Xing Ma, Qiang He
Summary: Self-propelled micro- and nanomotors have great potential in biomedical applications, but challenges such as overcoming biological barriers and in vivo navigation still need to be addressed. With continued attention and innovation, it is believed that they will improve targeted drug delivery efficiency in the future.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Xiufeng Ju, Tongtong Miao, Haiyan Chen, Jiang Ni, Liang Han
Summary: Mfsd2a plays a crucial role in regulating the transcytosis and permeability of the blood-brain barrier. Strategies involving priming nanoparticles and drug-loaded nanoparticles have shown promising results in enhancing BBB crossing efficiency and brain accumulation of therapeutics for breast cancer brain metastases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Instruments & Instrumentation
Shann S. Yu, Jeffrey A. Hubbell, Melody A. Swartz
Summary: Immunotherapies aim to treat diseases by modulating immune cell activity, but transport barriers may hinder delivery and retention at diseased sites. Overcoming these barriers by exploiting immunobiology to engineer molecular and cellular approaches is crucial. Integrating expertise from pathologists, clinicians, immunologists, biophysicists, immunoengineers and more is essential for impactful and practical solutions across various diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Instruments & Instrumentation
Olivia M. Turk, Ryan C. Woodall, Margarita Gutova, Christine E. Brown, Russell C. Rockne, Jennifer M. Munson
Summary: Cell-based therapies to the brain show promise for treating various brain disorders, but must overcome multiple physiological barriers. The blood-brain barrier has long been a major challenge for drug delivery, while other barriers may present specific challenges or opportunities for therapeutic delivery. Ongoing clinical trials using cell-based therapies to treat diseases, particularly cancers, have shown potential in treating some of the deadliest illnesses.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Nanoscience & Nanotechnology
Lara M. Molle, Cameron H. Smyth, Daniel Yuen, Angus P. R. Johnston
Summary: Nucleic acid therapeutics have the potential to treat genetic disorders, infectious diseases, and cancer, but their full potential is hindered by inefficient delivery. Current research focuses on overcoming the barriers to efficient nucleic acid delivery using nanoparticles.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Terence Tieu, Yingkai Wei, Anna Cifuentes-Rius, Nicolas H. Voelcker
Summary: RNA interference and siRNA therapeutics have brought new hope for many difficult-to-treat diseases. Nanoparticles have been utilized to overcome barriers in siRNA delivery, resulting in numerous promising preclinical successes.
ADVANCED THERAPEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Jean-Michel Rabanel, Jimmy Faivre, Soudeh F. Tehrani, Augustine Lalloz, Patrice Hildgen, Xavier Banquy
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Polymer Science
Igor Elkin, Jean-Michel Rabanel, Patrice Hildgen
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2015)
Article
Polymer Science
Gwenaelle Pound-Lana, Jean-Michel Rabanel, Patrice Hildgen, Vanessa Carla Furtado Mosqueira
EUROPEAN POLYMER JOURNAL
(2017)
Article
Multidisciplinary Sciences
Pierre-Luc Latreille, Vahid Adibnia, Antone Nour, Jean-Michel Rabanel, Augustine Lalloz, Jochen Arlt, Wilson C. K. Poon, Patrice Hildgen, Vincent A. Martinez, Xavier Banquyf
NATURE COMMUNICATIONS
(2019)
Review
Chemistry, Multidisciplinary
Jean-Michel Rabanel, Philippe Delbreil, Xavier Banquy, Davide Brambilla, Charles Ramassamy
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Chemistry, Multidisciplinary
Jean-Michel Rabanel, Pierre-Alexandre Piec, Sarra Landri, Shunmoogum A. Patten, Charles Ramassamy
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Engineering, Biomedical
Jean -Michel Rabanel, Jimmy Faivre, Charlotte Zaouter, Shunmoogum A. Patten, Xavier Banquy, Charles Ramassamy
Summary: Zwitterion polymers have been proposed as a promising alternative to PEG for coating drug nanocarriers, with studies showing significant differences in cellular uptake, blood-brain barrier penetration, protein interactions, and biodistribution when compared to PEG-coated nanoparticles. This highlights the critical role of surface chemistry in determining the fate of nanoparticles and emphasizes the need for further research in this area.
Article
Pharmacology & Pharmacy
Soudeh F. Tehrani, Jean-Michel Rabanel, Samuel Legeay, Jerome Cayon, Jeremie Riou, Patrick Saulnier, Sylvie Marleau, V. Gaelle Roullin, Patrice Hildgen, Guillaume Bastiat
Summary: Polymer nanoparticles (NPs) have been extensively studied as drug delivery systems, but their effects on inflammatory processes are not well understood. This study investigated the impact of PEG chain length coating on inflammatory gene expression and ROS generation in vascular endothelial cells. The results showed that PEGylated NPs caused mild and transient activation of inflammatory genes and did not trigger ROS generation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Philippe Delbreil, Jean-Michel Rabanel, Xavier Banquy, Davide Brambilla
Summary: Nanotechnology holds great promise in the treatment of Alzheimer's Disease, but faces numerous challenges including effective drug delivery and commercialization barriers.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Pierre-Luc Latreille, Jean-Michel Rabanel, Marine Le Goas, Sina Salimi, Jochen Arlt, Shunmoogum A. Patten, Charles Ramassamy, Patrice Hildgen, Vincent A. Martinez, Xavier Banquy
Summary: A new theoretical framework that utilizes differential dynamic microscopy (DDM) in fluorescence imaging mode is proposed for quantifying protein adsorption and aggregation on nanoparticles (NP). This methodology provides insights into the thermodynamic and kinetic properties of the protein corona (PC) in vitro and in vivo.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Marine Le Goas, Justine Saber, Sara Gonzalez Bolivar, Jean-Michel Rabanel, Jean-Marc Awogni, Daria C. Boffito, Xavier Banquy
Summary: Multiple inorganic nanoparticles are being developed for nanomedicine, and the organic ligands on their surface play a crucial role in their stability and biological fate. However, the stability of ligands has been little addressed in the literature. This review aims to provide an overview of this phenomenon, identify mechanisms promoting ligand instability, and discuss the biological fate of ligands.
Article
Materials Science, Multidisciplinary
Mateusz Olszewski, Duy Anh Pham, Sara Gonzalez Bolivar, Jean-Michel Rabanel, Michael Martinez, Krzysztof Matyjaszewski, Xavier Banquy
Summary: This paper reports the synthesis and characterization of water-soluble macromolecular bottlebrushes (MBs) with poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA) side chains. The PMSEA MBs exhibited tunable hydrodynamic lubrication properties and low cytotoxicity against different types of cells.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jean-Michel Rabanel, Marziye Mirbagheri, Mateusz Olszewski, Guojun Xie, Marine Le Goas, Pierre-Luc Latreille, Hermine Counil, Vincent Herve, Rummenigge Oliveira Silva, Charlotte Zaouter, Vahid Adibnia, Mariana Acevedo, Marc J. Servant, Vincent A. Martinez, Shunmoogum A. Patten, Krzysztof Matyjaszewski, Charles Ramassamy, Xavier Banquy
Summary: This study demonstrates that bottle-brush polymers can efficiently cross the blood-brain barrier and penetrate dense tissues such as the brain. They have a faster translocation rate compared to nanospheres of similar composition. The ability of bottle-brush polymers to escape the vasculature compartment and exhibit higher penetration in brain tissues makes them promising drug carriers in the field of nanomedicine.
Review
Chemistry, Multidisciplinary
Jean-Michel Rabanel, Vahid Adibnia, Soudeh F. Tehrani, Steven Sanche, Patrice Hildgen, Xavier Banquy, Charles Ramassamy
