Review
Oncology
Stefano Fogli, Giulia Gianfilippo, Federico Cucchiara, Marzia Del Re, Laura Valerio, Rossella Elisei, Romano Danesi
Summary: Lenvatinib is a non-selective tyrosine kinase inhibitor that is most effective in patients with thyroid cancer. The drug is well tolerated and common adverse reactions can be managed by dose adjustment. Monitoring of blood pressure and cardiac function may be required during treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Pavan K. Yadav, Ravi Saklani, Amrendra K. Tiwari, Saurabh Verma, Divya Chauhan, Pooja Yadav, a Rafquat Rana, Navodayam Kalleti, Jiaur R. Gayen, Srikanta K. Rath, Madhav N. Mugale, Kalyan Mitra, Manish K. Chourasia
Summary: This study co-encapsulated Paclitaxel and Baicalein in a nanoemulsion for breast cancer treatment. The optimized synergistic ratio was determined through cytotoxicity assessment, and the nanoemulsion was characterized using Quality by Design approach. The results showed that the nanoemulsion had significant anticancer effects in cell experiments and animal models, indicating its potential as a therapeutic approach for breast cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Hindu Kalluru, Surulivel Rajan Mallayasamy, Satish Srinivas Kondaveeti, Vinodhini Chandrasekhar, Mangathayaru Kalachaveedu
Summary: This study investigates the impact of turmeric on the pharmacokinetics of paclitaxel in breast cancer patients. The results show that turmeric does not significantly affect the pharmacokinetic parameters of paclitaxel. Therefore, turmeric can be safely combined with paclitaxel at the recommended dose.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Annalisa Schirizzi, Marialessandra Contino, Livianna Carrieri, Chiara Riganti, Giampiero De Leonardis, Maria Principia Scavo, Maria Grazia Perrone, Morena Miciaccia, Joanna Kopecka, Maria Grazia Refolo, Claudio Lotesoriere, Nicoletta Depalo, Federica Rizzi, Gianluigi Giannelli, Caterina Messa, Rosalba D'Alessandro
Summary: This study aimed to investigate the molecular processes underlying PTX-mediated resistance in gastric cancer cells. The key features of PTX-resistant cells were found to be the overexpression of pro-angiogenic factors and the elevated level of TUB beta III and P-glycoprotein. The findings also highlighted the effectiveness of Ramucirumab and Elacridar in treating resistant cells.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
V. Manjusha, M. R. Rajeev, T. S. Anirudhan
Summary: Safe delivery of hydrophobic drugs to the tumor site is a challenging task for the scientific community. In this study, iron oxide nanoparticles coated chitosan with [2-(methacryloyloxy) ethyl] trimethyl ammonium chloride (METAC) (CS-IONPs-METAC-PTX) were developed as a drug carrier for hydrophobic drug delivery. The drug carrier exhibited excellent therapeutic efficacy and selectivity when tested in cell lines, demonstrating its potential for PTX delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Lamya S. Alnaim, Hind M. Almalki, Afrah M. Almutairi, Heba J. Salamah
Summary: The prevalence of drug-drug interactions (DDIs) in cancer patients is high, especially due to the multiple medications they receive. Factors such as the number of drugs, type of treatment, and length of stay in hospital contribute to the occurrence of DDIs.
Article
Pharmacology & Pharmacy
Mahendra Kumar Prajapati, Rohan Pai, Pradeep Vavia
Summary: The study aimed to develop a liposomal system with folate modification to enhance the selectivity of anticancer drugs towards ovarian tumor cells and reduce toxicity to healthy cells. Results showed that the optimized liposome significantly reduced tumor volume and weight, and improved survival rate.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Food Science & Technology
Zvonimir Petric, Irena Zuntar, Predrag Putnik, Danijela Bursac Kovacevic
Summary: Fruit juices contain phytochemicals which can interfere with drug metabolism enzymes, leading to food-drug interactions that affect drug effects and toxicity. These interactions typically affect pharmacokinetic parameters, but predicting them accurately is challenging due to limited study subjects and individual variability.
Article
Pharmacology & Pharmacy
Ruben A. G. van Eerden, Leni van Doorn, Femke M. de Man, Niels Heersche, Michail Doukas, Thierry P. P. van den Bosch, Esther Oomen-de Hoop, Peter de Bruijn, Sander Bins, Eman Ibrahim, Suzan Nikkessen, Lena E. Friberg, Stijn L. W. Koolen, Manon C. W. Spaander, Ron H. J. Mathijssen
Summary: This study investigated the expression of ABCB1 and intratumoral pharmacokinetics of paclitaxel in esophageal cancer patients, finding that ABCB1 expression was significantly higher in tumor tissue compared to normal esophageal tissue. Differences in ABCB1 expression and tumor histological types may partly explain why tumors respond differently to systemic treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanjun Cui, Ying Li, Caihui Guo, Yajing Li, Yinling Ma, Zhanjun Dong
Summary: This study investigated the pharmacokinetic drug interactions between canagliflozin and sorafenib or lenvatinib and found significant changes in the plasma concentrations and apparent clearance of these drugs. These findings provide a reference for the use of canagliflozin, sorafenib and lenvatinib in patients with HCC and T2DM.
Review
Chemistry, Medicinal
Jie Li, Shuting Wang, Fengjie Tian, Shuang-Qing Zhang, Hongtao Jin
Summary: As the use of herbs increases worldwide, there are more reports of interactions between herbs and drugs. The complex active components of herbs inevitably affect the pharmacokinetics of chemical drugs in vivo. The expression of drug transporters is closely related to the absorption, distribution, metabolism, and excretion of drugs. When herbs inhibit or induce the expression of transporters, it can result in changes in substrate pharmacokinetics, affecting the efficacy and toxicity of drugs. This article summarizes the tissue distribution and physiological functions of drug transporters, analyzes the effects of herbs on drug transporters, and discusses the possible mechanisms of herb-drug interactions, providing ideas and references for safe clinical drug use.
Article
Genetics & Heredity
Seung Tae Kim, Jason K. Sa, Sung Yong Oh, Kyung Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Jeeyun Lee
Summary: The study identified a subset of GC patients with distinct clinical response to ramucirumab therapy through prospective molecular characterization. The results demonstrate the feasibility of personalized therapeutic opportunities in gastric cancer.
Article
Medicine, General & Internal
Min Joo Yang, Young Jin Choi, Hyo Jeong Kim, Do Young Kim, Young Mi Seol
Summary: The combination of ramucirumab and paclitaxel chemotherapy is effective and safe for hemodialysis patients with metastatic gastric cancer, and dose adjustment is not necessary.
Article
Chemistry, Medicinal
Moon Hee Lee, Seok-Kyu Yoon, Hyungsub Kim, Yong-Soon Cho, Sungpil Han, Shi Hyang Lee, Kyun-Seop Bae, Jina Jung, Sung Hee Hong, Hyeong-Seok Lim
Summary: This study aimed to examine the pharmacokinetic interactions between bazedoxifene and cholecalciferol and the tolerability of their combined administration in healthy male subjects. The results showed that this combined therapy was well tolerated at the dose levels used in the study, and there was a mild degree of pharmacokinetic interaction.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Oncology
Hon Lyn Tan, Guowei Kim, Christopher John Charles, Renee R. Li, Clarisse J. M. Jang, Asim Shabbir, Koy Min Chue, Chia Hui Tai, Raghav Sundar, Boon Cher Goh, Glenn Kunnath Bonney, Wen Donq Looi, Esther S. H. Cheow, Jimmy B. Y. So, Lingzhi Wang, Wei Peng Yong
Summary: The study evaluated the pharmacokinetics, peritoneal tissue drug concentration, penetration, and short-term safety of PIPAC using solvent-based paclitaxel in swine, showing linear pharmacokinetics and lower systemic exposure compared to IV administration. PIPAC paclitaxel demonstrated concentration at the peritoneal surface with estimated 2 mm penetration. Overall, PIPAC paclitaxel at 15mg/m(2) showed favorable toxicity profile, with dose-dependent neutropenia being the most significant adverse event.
Article
Oncology
Martin H. Voss, Michael S. Gordon, Monica Mita, Brian Rini, Vicky Makker, Teresa Macarulla, David C. Smith, Andres Cervantes, Igor Puzanov, Roberto Pili, Ding Wang, Shadia Jalal, Shubham Pant, Manish R. Patel, Rachel L. Neuwirth, Aaron Enke, Yaping Shou, Farhad Sedarati, Douglas V. Faller, Howard A. Burris
BRITISH JOURNAL OF CANCER
(2020)
Article
Oncology
Samuel R. Denmeade, Hao Wang, Neeraj Agarwal, David C. Smith, Michael T. Schweizer, Mark N. Stein, Vasileios Assikis, Przemyslaw W. Twardowski, Thomas W. Flaig, Russell Z. Szmulewitz, Jeffrey M. Holzbeierlein, Ralph J. Hauke, Guru Sonpavde, Jorge A. Garcia, Arif Hussain, Oliver Sartor, Shifeng Mao, Harry Cao, Wei Fu, Ting Wang, Rehab Abdallah, Su Jin Lim, Vanessa Bolejack, Channing J. Paller, Michael A. Carducci, Mark C. Markowski, Mario A. Eisenberger, Emmanuel S. Antonarakis
Summary: Bipolar androgen therapy (BAT) shows meaningful clinical activity and safety in prostate cancer patients, suggesting it could be an effective treatment approach. The study results indicate that BAT can enhance sensitivity to enzalutamide, potentially improving survival in castration-resistant prostate cancer patients.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Erin F. Cobain, Yi-Mi Wu, Rashmi Chugh, Francis Worden, David C. Smith, Scott M. Schuetze, Mark M. Zalupski, Vaibhav Sahai, Ajjai Alva, Anne F. Schott, Megan E. V. Caram, Daniel F. Hayes, Elena M. Stoffel, Michelle F. Jacobs, Chandan Kumar-Sinha, Xuhong Cao, Rui Wang, David Lucas, Yu Ning, Erica Rabban, Janice Bell, Sandra Camelo-Piragua, Aaron M. Udager, Marcin Cieslik, Robert J. Lonigro, Lakshmi P. Kunju, Dan R. Robinson, Moshe Talpaz, Arul M. Chinnaiyan
Summary: The study aimed to determine the clinical benefit of NGS profiling in patients with advanced solid tumors. Results showed a high rate of potentially actionable genomic alterations in diverse cancers, recommending germline testing for all patients with advanced cancer. Additionally, the study highlighted the importance of comprehensive NGS profiling for rare cancers like carcinoma of unknown primary origin.
Article
Oncology
Jordi Rodon, Guillem Argiles, Roisin M. Connolly, Ulka Vaishampayan, Maja de Jonge, Elena Garralda, Marios Giannakis, David C. Smith, Jason R. Dobson, Margaret E. McLaughlin, Abdelkader Seroutou, Yan Ji, Jennifer Morawiak, Susan E. Moody, Filip Janku
Summary: The Phase 1 study evaluated the safety and efficacy of Porcupine inhibitor WNT974 in patients with advanced solid tumours. The recommended dose for expansion was 10 mg once-daily, with dysgeusia being the most common adverse event. The study suggested that WNT974 may influence immune cell recruitment to tumours and enhance checkpoint inhibitor activity.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
V Subbiah, N. O. Iannotti, M. Gutierrez, D. C. Smith, L. Feliz, C. F. Lihou, C. Tian, I. M. Silverman, T. Ji, M. Saleh
Summary: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of pemigatinib in the treatment of refractory advanced malignancies. The results showed that pemigatinib can effectively treat various tumors and is associated with FGFR fusions/rearrangements and mutations, with manageable adverse reactions. These findings are of great significance for the registrational study in cholangiocarcinoma and phase II/III trials in other tumor types.
ANNALS OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zachery R. Reichert, Tadas Kasputis, Srinivas Nallandhighal, Sophia M. Abusamra, Amy Kasputis, Saloni Haruray, Yugang Wang, Shamara Williams, Udit Singhal, Ajjai Alva, Frank C. Cackowski, Megan E. V. Caram, Phillip L. Palmbos, Sarah E. Yentz, David C. Smith, Joshi J. Alumkal, Todd M. Morgan
Summary: The biological heterogeneity of metastatic prostate cancer affects personalized therapeutic approaches. A liquid biopsy approach can identify blood-based prognostic biomarkers for predicting disease progression and treatment response in patients with metastatic hormone-sensitive prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Oncology
Zachery R. Reichert, Michael Edward Devitt, Joshi J. Alumkal, David C. Smith, Megan Veresh Caram, Philip Palmbos, Ulka N. Vaishampayan, Ajjai Shivaram Alva, Thomas Braun, Sarah Elizabeth Yentz, Phoebe A. Tsao, Robert Dreicer, Frank Cameron Cackowski, Neel Shah, Emma Dean, Simon Smith, Elisabeth I. Heath
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Irene Tsung, Edward Green, Phillip Lee Palmbos, Zachery R. Reichert, Ulka N. Vaishampayan, David C. Smith, Megan Veresh Caram, Sarah Elizabeth Yentz, Stephanie Daignault-Newton, Zachery Sloan, Laura Hurley, Ajjai Shivaram Alva
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Steven B. Goldenthal, Melissa A. Reimers, Udit Singhal, Mark Farha, Rohit Mehra, Morand Piert, Jeffrey J. Tosoian, Parth K. Modi, Nicole Curci, James Peabody, Eduardo Kleer, David C. Smith, Todd M. Morgan
Summary: This study reports five cases of peritoneal carcinomatosis following robotic-assisted radical prostatectomy (RARP), which occurred relatively late and may be related to the preoperative pathological stage. The use of next-generation imaging modalities, such as PSMA PET, can help identify metastases. Further research and classification are needed to improve the understanding and management of this atypical presentation.
Article
Oncology
Suzanne L. Topalian, Mario Sznol, David F. McDermott, Harriet M. Kluger, Richard D. Carvajal, William H. Sharfman, Julie R. Brahmer, Donald P. Lawrence, Michael B. Atkins, John D. Powderly, Philip D. Leming, Evan J. Lipson, Igor Puzanov, David C. Smith, Janis M. Taube, Jon M. Wigginton, Georgia D. Kollia, Ashok Gupta, Drew M. Pardoll, Jeffrey A. Sosman, F. Stephen Hodi
Summary: PD-1 blockade therapy can effectively reduce tumors and improve survival rates in patients with advanced melanoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
James J. J. Harding, Christiane Jungels, Jean-Pascal Machiels, David C. C. Smith, Chris Walker, Tao Ji, Ping Jiang, Xin Li, Ekaterine Asatiani, Eric Van Cutsem, Ghassan K. K. Abou-Alfa
Summary: This study investigated the safety, tolerability, and maximum tolerated dose of INCB062079, an oral selective FGFR4 inhibitor, in patients with advanced solid tumors. The results showed that the drug demonstrated a manageable safety profile and inhibited tumor growth at appropriate doses. However, the study was terminated prematurely due to difficulties in patient recruitment.
Article
Oncology
Allison J. Schepers, David C. Smith, Rachel L. McDevitt
Summary: This study describes the development and implementation of a protocol for complete outpatient administration of TIP chemotherapy. Evaluation of patients receiving outpatient TIP treatment showed that 77% of chemotherapy cycles were administered in the outpatient setting, resulting in a savings of 50 inpatient bed days in one year. No patients experienced dose reduction or delay in chemotherapy or acute toxicities during outpatient TIP treatment.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Oncology
Andrew L. Coveler, David C. Smith, Tycel Phillips, Brendan D. Curti, Sanjay Goel, Amitkumar N. Mehta, Timothy M. Kuzel, Svetomir N. Markovic, Olivier Rixe, David L. Bajor, Thomas F. Gajewski, Martin Gutierrez, Hun Ju Lee, Ajay K. Gopal, Paolo Caimi, Elisabeth Heath, John A. Thompson, Sahar Ansari, Celine Jacquemont, Ariel Topletz-Erickson, Peigen Zhou, Michael W. Schmitt, Juneko E. Grilley-Olson
Summary: SEA-CD40, an investigational antibody that activates CD40, demonstrated tolerability and potent immune activation in patients with solid tumors and lymphoma, showing evidence of antitumor activity. Further evaluation of SEA-CD40 as a component of combination therapy is warranted.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Meeting Abstract
Oncology
Zachery R. Reichert, Ulka N. Vaishampayan, Megan Veresh Caram, Joshi J. Alumkal, Ajjai Shivaram Alva, Philip Palmbos, Sarah Elizabeth Yentz, David C. Smith, Jason W. D. Hearn, Robert Timothy Dess, William C. Jackson
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Haley Neff-LaFord, Juneko E. Grilley-Olson, David C. Smith, Brendan Curti, Sanjay Goel, Timothy M. Kuzel, Svetomir N. Markovic, Olivier Rixe, David L. Bajor, Thomas F. Gajewski, Martin Gutierrez, Elisabeth I. Heath, John Thompson, Sahar Ansari, Shyra Gardai, Celine Jacquemont, Michael Schmitt, Andrew L. Coveler