Review
Biochemistry & Molecular Biology
Enrique A. Castellon, Sebastian Indo, Hector R. Contreras
Summary: This article explores the presence and role of cancer stem cells (CSCs) and the Epithelial-Mesenchymal transition (EMT) in prostate cancer (PCa), and finds that the stemness-mesenchymal axis is a critical process related to relapse, metastasis, and resistance. Manipulating the stemness-EMT axis genes on the androgen receptor (AR) may shed light on the effect of this axis on metastasis and castration resistance in PCa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter Ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin, Aristidis Moustakas
Summary: TGF beta promotes sternness and invasiveness in breast cancer cells by inducing epithelial-mesenchymal transition (EMT) and metastatic colonization by inducing mesenchymal-epithelial transition (MET). However, whether TGF beta can promote both sternness and invasiveness simultaneously via EMT remains unclear.
MOLECULAR ONCOLOGY
(2022)
Review
Oncology
Evan M. McCabe, Theodore P. Rasmussen
Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Pelin Balcik-Ercin, Laure Cayrefourcq, Rama Soundararajan, Sendurai A. Mani, Catherine Alix-Panabieres
Summary: Metastasis is a complex and not fully understood process in cancer, where circulating tumor cells (CTCs) play a crucial role. CTCs possess a unique ability to transition between epithelial and mesenchymal states, known as epithelial-to-mesenchymal plasticity (EMP), which aids in their metastatic potential. This study focuses on the EMP phenotype of colon CTC lines, showing that these cells have minimal mesenchymal features but exhibit an increase in mesenchymal-epithelial transition (MET) markers, suggesting a quick reversion to the epithelial state for successful metastasis.
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Oncology
Heming Long, Hongmei Chen, Jun Yan, Haiyan Cheng
Summary: Emodin, a small molecular drug derived from natural plants, exhibits antitumor effects on ovarian cancer cells by inducing cytotoxicity, inhibiting proliferation, reducing migration and invasion abilities through the inhibition of epithelial-mesenchymal transition, and decreasing stemness of tumor cells.
Review
Biochemistry & Molecular Biology
Rahul Advani, Sara Luzzi, Emma Scott, Caroline Dalgliesh, Joachim Weischenfeldt, Jennifer Munkley, David J. Elliott
Summary: This article discusses the expression of splicing regulators ESRP1 and ESRP2 in aggressively proliferating primary prostate tumors as markers of disease progression. It suggests that ESRP1 and ESRP2 act as lineage survival oncogenes in prostate cancer and highlights the need to identify the gene expression targets controlled by these regulators to develop targeted therapies.
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Oncology
Jinrong He, Shanshan Chen, Tong Yu, Weiqun Chen, Jin Huang, Caixia Peng, Yu Ding
Summary: The study found that Harmine can suppress epithelial-mesenchymal transition and metastasis of breast cancer cells by regulating TAZ. The results of this study suggest that HM has the potential to be used as a drug for breast cancer treatment and chemoprevention.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Oncology
Pinaki Banerjee, Prachi Kapse, Shehnaz Siddique, Moumita Kundu, Jasoda Choudhari, Varshasnata Mohanty, Diksha Malhotra, Suresh W. Gosavi, Rajesh N. Gacche, Gopal C. Kundu
Summary: Prostate cancer is a heterogeneous disease involving multiple cell types, with tumor heterogeneity resulting from genomic instability and sub-clone differentiation. Prostate cancer stem cells (PCSCs), a small subset of cells with tumor-initiating and stem-like properties, play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs, methods for their isolation and enrichment, as well as cellular and metabolic signaling pathways involved in their induction and maintenance, and potential therapeutic targeting.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Oncology
Bingfeng Luo, Yuan Yuan, Yifei Zhu, Songwu Liang, Runan Dong, Jian Hou, Ping Li, Yaping Xing, Zhenquan Lu, Richard Lo, Guan-Ming Kuang
Summary: miRNA-145-5p was found to negatively regulate EMT, inhibit Pca bone metastasis, and promote apoptosis. It may serve as a potential target for treating Pca with bone metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qi Chen, Meng Gu, Zhi-kang Cai, Hu Zhao, Shi-cheng Sun, Chong Liu, Ming Zhan, Yan-bo Chen, Zhong Wang
Summary: CD44 serves as a marker of cancer stem cells in many tumors, with alternative splicing generating various isoforms. This study reveals a novel mechanism where TGF-beta 1 induces CD44 alternative splicing, promoting epithelial-to-mesenchymal transition and stemness in prostate cancer cells. The findings demonstrate the important roles of CD44 isoforms and TGF-beta 1 in tumor progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rodrigo A. Acuna, Manuel Varas-Godoy, Diego Herrera-Sepulveda, Mauricio A. Retamal
Summary: Connexins are a family of proteins that play a crucial role in cellular communication, but certain types may have pro-tumorigenic effects. Research has shown that Cx46 can modulate the characteristics of cancer stem cells and epithelial-to-mesenchymal transition in breast cancer cells, potentially influencing future cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Wei-Kun Shi, Yun-Hao Li, Xue-Shan Bai, Guo-Le Lin
Summary: This study used bioinformatics to search for genes associated with the prognosis of colorectal cancer (CRC), and identified several genes that may be important for CRC prognosis. Further experiments confirmed the role of one of these genes, CDKN2A, in colorectal cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Urology & Nephrology
Lianmin Luo, Shankun Zhao, Jiamin Wang, Yangzhou Liu, Zhiguo Zhu, Qian Xiang, ZhiGang Zhao
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2020)
Article
Oncology
Zhigang Zhao, Ermao Li, Lianmin Luo, Shankun Zhao, Luhao Liu, Jiamin Wang, Ran Kang, Jintai Luo
MOLECULAR CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Zhiguo Zhu, Yaoan Wen, Chunxiang Xuan, Qingping Chen, Qian Xiang, Jiamin Wang, Yangzhou Liu, Lianmin Luo, Shankun Zhao, Yihan Deng, Zhigang Zhao
Review
Urology & Nephrology
Shankun Zhao, Xiaolan Wang, Xie Qiang, Hui Wang, Jian He, Maolei Shen, Changjun Zheng, Ran Kang
JOURNAL OF SEXUAL MEDICINE
(2020)
Review
Urology & Nephrology
Yin Pan, Qiang Xie, Zhuoni Zhang, Yuechu Dai, Lizhong Lin, Mingming Quan, Xiaowei Guo, Maolei Shen, Shankun Zhao
JOURNAL OF SEXUAL MEDICINE
(2020)
Article
Andrology
Hui Wang, Xin Li, Ping Zhang, Shixiong Liu, Qiang Xie, Shankun Zhao
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2020)
Review
Medicine, Research & Experimental
Maolei Shen, Qinzhang Wang, Shuaijun Xu, Guang Chen, Hao Xu, Xin Li, Shankun Zhao
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Urology & Nephrology
Jiamin Wang, Lianmin Luo, Shankun Zhao, Yangzhou Liu, Zhiguo Zhu, Zhigang Zhao
INTERNATIONAL BRAZ J UROL
(2020)
Review
Biochemistry & Molecular Biology
Shankun Zhao, Weizhou Wu, Xuezheng Lin, Maolei Shen, Zhenyu Yang, Sicong Yu, Yu Luo
Summary: This review summarizes the evidence on the role of autophagy in the protective effect of dexmedetomidine (DEX) against vital organ injuries. Most studies indicate that autophagy modulation is inhibited under DEX treatment, but a few studies suggest an increase in autophagy levels after DEX administration. Autophagy is involved in the protective effect of DEX through mechanisms such as antiapoptotic properties, inhibition of inflammatory response, removal of damaged mitochondria, and reduction of oxidative stress.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Shankun Zhao, Weizhou Wu, Zufu Jiang, Fuqin Tang, Lingzhi Ding, Weifang Xu, Libin Ruan
Summary: ARID1A variations play an important role in colorectal cancer, functioning as a tumor suppressor and a prognostic factor. This review summarizes the clinical implications and molecular pathogenesis of ARID1A variations in CRC.
MOLECULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Weifang Xu Xu, Weizhou Wu, Suqing Yang, Tingting Chen, Xiao Teng, Danping Gao, Shankun Zhao
Summary: This study provides evidence that women who underwent hysterectomy without oophorectomies are at a higher risk of osteoporosis and bone fractures than the general population. Early interventions for these susceptible women may help to delay or reduce the risk of osteoporosis and bone fractures.
OSTEOPOROSIS INTERNATIONAL
(2022)
Correction
Endocrinology & Metabolism
W. Xu, W. Wu, S. Yang, T. Chen, X. Teng, D. Gao, S. Zhao
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Cell Biology
Xiaojiao Lin, Weizhou Wu, Yukang Ying, Jun Luo, Xuhui Xu, Linxia Zheng, Weili Wu, Suqing Yang, Shankun Zhao
Summary: This comprehensive review summarizes the current evidence on the association between miR-31 and oral squamous cell carcinoma (OSCC). Most studies demonstrate that miR-31 acts as an oncogenic factor in the tumorigenesis and progression of OSCC. Significantly upregulated expression of miR-31 is found in plasma, saliva, and tumor tissue of OSCC. miR-31 plays an essential role in OSCC development by forming a complex network with its targeted genes and signaling cascades. miR-31 may serve as a potential diagnostic, prognostic, and predictive biomarker for OSCC.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Shankun Zhao, Weizhou Wu, Jian Liao, Xinsheng Zhang, Maolei Shen, Xin Li, Qi Lin, Chaoliang Cao
Summary: Coenzyme Q10 (CoQ10) has been found to have a significant protective effect against acute kidney injury (AKI), exerting its renal protective role through its antiperoxidative, anti-apoptotic, and anti-inflammatory potential. CoQ10 may be a potential strategy in the treatment of AKI.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cell Biology
Zhiguo Zhu, Lianmin Luo, Qian Xiang, Jiamin Wang, Yangzhou Liu, Yihan Deng, Zhigang Zhao
CELL DEATH & DISEASE
(2020)