Article
Biophysics
Yi Pan, Xinlin Wei, Xiaodong Guo, Hui Wang, Haiyun Song, Canping Pan, Naifeng Xu
Summary: A dual-model colorimetric/fluorescent immune probe based on Au-Ag NCs and PEI-Au NPs was successfully constructed for rapid and ultrasensitive detection of DICO, with improved sensitivity in ic-ELISA method and a quantitative LOD in LFIA method. The fluorescence signal significantly enhanced the detection sensitivity in ic-ELISA method with a LOD of 0.62 ng/mL, while the fluorescence model detection in LFIA method achieved a quantitative LOD at the level of 1.59 ng/mL.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Analytical
Brij Mohan, Sandeep Kumar, Vineet Kumar, Tianhui Jiao, Harish Kumar Sharma, Quansheng Chen
Summary: Early detection of severe diseases like cancer is essential for public health and safety. Metal-organic frameworks (MOFs) with excellent electrochemiluminescence (ECL) properties have gained significant attention for sensing cancer biomarkers.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Shuai Zhang, Feilong Rong, Chuanpan Guo, Fenghe Duan, Linghao He, Minghua Wang, Zhihong Zhang, Mengmeng Kang, Miao Du
Summary: Metal-organic frameworks (MOFs) have emerged as promising porous crystalline materials with various applications due to their large surface areas, tunable pore scales, and good adsorption capabilities. They have been utilized for developing highly sensitive and selective biosensors, particularly for early cancer diagnosis and treatment monitoring, by anchoring diverse probes for construction of electrochemical biosensors.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Zhenyu Han, Chunyan Xia, Bao'an Ning, Zehua Xu, Xiao Liu, Hu Zuo, Lingchao Cai, Tieqiang Sun, Ying Liu
Summary: We developed a dual signal read-out enzyme-linked immunosorbent assay method for sensitive detection of Norfloxacin. The method utilizes a bifunctional ligand and enzymatic signal amplification system to achieve detection. It was successfully applied to detect veterinary drug residues in commercially available milk.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Ping Zhou, Shaohua Gong, Bo Liu, Mingwan Shi, Fei Lu, Na Li, Bo Tang
Summary: This dual-colorimetric miRNA detection kit is able to simultaneously detect two miRNAs with high sensitivity and selectivity, achieving lung cancer diagnosis using clinical serum samples in a short time. The data can be easily read by the naked eye, allowing for quick differentiation between patients and healthy individuals.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Jianguo Chang, Nailong Gao, Peng Dai, Ziming Zhu, Hui You, Wei Han, Lu Li
Summary: The study introduces a fluorescence immunoassay method based on co-coupling for detecting AFP. By immobilizing antibodies through co-coupling of phenylboronic acid and Protein A, the immunoassay achieves oriented antibody fixation. The recorded fluorescence intensity is proportional to AFP concentration after immunoreaction, demonstrating high sensitivity, specificity, and reliability.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Brij Mohan, Diksha Dhiman, Qiming Virender, Masood Mehak, Gurjaspreet Priyanka, Qiming Sun, Masood Jan, Gurjaspreet Singh, Neera Raghav
Summary: Metal-organic frameworks (MOFs) are widely used for the detection of cancer biomarkers due to their permanent porosity and tunable pore size. This review focuses on the electrochemical detection of cancer biomarkers using MOFs. The importance of tunable porosity and surface areas in MOFs for sensor development is discussed. The applications of MOF biosensors in detecting target cancer biomarkers are also highlighted, along with the challenges and future directions in this field.
MICROCHEMICAL JOURNAL
(2023)
Article
Oncology
Ya-Xian Wu, Shan Xing, Yu Wang, Bo-Yu Tian, Meng Wu, Xue-Ping Wang, Qi Huang, Xia He, Shu-Lin Chen, Xiao-Hui Li, Mu-Sheng Zeng, Wan-Li Liu
Summary: A highly sensitive method for detecting serum interleukin-15 (sIL-15) levels was developed to select nasopharyngeal carcinoma (NPC) patients who would benefit most or least from immune checkpoint inhibitors (ICIs)-based treatments. Lower sIL-15 levels were associated with poorer progression-free survival, indicating the potential of sIL-15 as a predictive biomarker for personalized immunotherapy in NPC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Food Science & Technology
Yiheng Shi, Yuhan Sun, Xiaowei Qu, Lei Zhou, Zhouli Wang, Zhenpeng Gao, Zhongqiu Hu, Tianli Yue, Yahong Yuan
Summary: In this study, a highly specific monoclonal antibody was developed to detect A. acidoterrestris with great potential for preventing spoilage in the fruit juice industry. The immunoassay platform demonstrated rapid, sensitive, and selective detection capabilities, making it a robust tool for industry applications.
Article
Chemistry, Multidisciplinary
Jin-jin Tian, Dian-dian Deng, Long Wang, Zhao Chen, Shouzhi Pu
Summary: A tetraphenylethene-modified rhodanine derivative was designed and synthesized, exhibiting excellent fluorescence properties and multiple applications such as aggregation-induced emission enhancement, solvatochromic fluorescence effect, reversible mechanochromic fluorescence behavior, and sensitive detection of Hg2+.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yu-Long Li, Fa-Ting Xie, Cao Yao, Gui-Qun Zhang, Yan Guan, Yun-Hui Yang, Jian-Mei Yang, Rong Hu
Summary: In this study, a ratiometric electrochemical aptasensor based on a DNA tetrahedral nanomaterial and a zirconium metal-organic framework was developed for the detection of Ochratoxin A (OTA). The sensor exhibited high specificity for OTA and a good linear range, allowing for the effective detection of OTA in corn kernel samples.
Article
Chemistry, Inorganic & Nuclear
Huizhi Yang, Yuxin Xie, Xingjuan Zhong, Lei Li
Summary: Three crystalline network compounds, ZrLimi-X, were synthesized via solvothermal methods using a four-connecting ligand and imidazole-derived chromophore. These materials possess a scu topology with a large surface area and porosity. ZrLimi-X exhibits excellent thermal and chemical stability in both acidic and alkaline aqueous solutions. The three MOFs show good carbon dioxide adsorption capacity and interesting fluorescence properties. The changes in fluorescence maximum emission and fluorescent lifetime of the ligand or MOFs caused by the stepwise methylation of imidazole show an opposite trend, indicating a reduction in conjugation due to the methylation of imidazole.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Spectroscopy
Xuhua Zhao, Xiaochun Dai, Suya Zhao, Xiaohua Cui, Tao Gong, Zhiling Song, Hongmin Meng, Xiaobing Zhang, Baofeng Yu
Summary: Aptamers, as short single-stranded RNA or DNA molecules that can recognize targets with high affinity and specificity, have unique advantages such as easy chemical synthesis, high stability, low molecular weight, and lack of immunogenicity. Utilizing aptamers in fluorescent sensors provides exciting opportunities for sensitive detection and quantification of analytes, particularly in the field of cancer biomarker detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Jinjie Hou, Pei Jia, Kairong Yang, Tong Bu, Shuang Zhao, Longwen Li, Li Wang
Summary: A facile, effective, and highly selective Cu2+ probe was constructed using ZTM metal-organic framework for detection. The introduction of FITC and design of a ratiometric fluorescent probe, as well as the development of a pronounced colorimetric sensor, were highlighted in the study.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Hongxia Zhao, Chao Qi, Xuewu Yan, Jinyan Ji, Zhifang Chai, Shuao Wang, Tao Zheng
Summary: The material for managing and monitoring waste made from the waste itself is an excellent example of cyclic utilization, which could reduce issues and be more sustainable. The researchers synthesized a three-dimensional porous uranyl phosphonate MOF (UPF-105) through a hydrothermal method. UPF-105 exhibited stability in aqueous solution within the pH range of 1-11 and maintained crystallinity below 215 degrees C. The uncoordinated phosphonate groups in the channels of UPF-105 acted as functional anchors for selectively capturing uranyl ions, with a maximum uranium adsorption capacity of 170.23 mg g(-1). The fluorescence of UPF-105 made it a good candidate for a uranyl ion sensor in uranium-contaminated solutions with concentrations in the range of 5-90 ppm.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)