Article
Chemistry, Multidisciplinary
Hongbo Wu, Yingjie Xu, Ruyan Xie, Mingyu Tang, Lihua Chen, Fengyu Qu, Changhong Guo, Fang Chai
Summary: This study presents a fluorescent probe based on Au nanoclusters for tracing dopamine. The probe exhibits high specificity and sensitivity for dopamine detection through an on-off strategy, and can be used for real-time detection with the assistance of a smartphone. Additionally, the probe allows for detection of dopamine in serum and living cells.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biophysics
Tingting Bai, Luhai Wang, Meng Wang, Yefei Zhu, Wenhan Li, Zhirui Guo, Yu Zhang
Summary: A convenient method for preparing metal nanoparticles with high peroxidase activity and visible-light plasmonic property has been developed, which can be directly applied in industrial production and achieve ultrasensitive colorimetric detection in lateral flow immunoassay.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Miao-Miao Yin, Wen-Qi Chen, Yan-Jun Hu, Yi Liu, Feng-Lei Jiang
Summary: Deep-red thiolated Ag@Au nanoclusters with a quantum yield of approximately 18% were prepared rapidly in aqueous solutions. The effects of pH and silver ions were demonstrated, and surface modification resulted in nanoclusters with a quantum yield of approximately 38%, the highest value reported for water-soluble red Au nanoclusters. These findings will greatly facilitate their applications in sensing, bioimaging, etc.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Ditta Ungor, Istvan Szilagyi, Edit Csapo
Summary: The study presents a simple one-pot preparation protocol for the synthesis of AMP-Au/Ag NCs, which show potential applications as biosensors and in rapid testing. Detailed analysis revealed the detection limit and dynamic range of the NCs as folate sensors, and proposed a mechanism for the fluorescence quenching process.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Arpad Turcsanyi, Ditta Ungor, Marek Wojnicki, Edit Csapo
Summary: Fabrication protocol of BSA- and LYZ-stabilized Au/Ag NCs was optimized by adjusting the protein/metal ion ratios, metal concentration, pH, and incubation time. The incorporation of silver into the gold core significantly enhanced the fluorescence properties of the nanoclusters. The stability of the bimetallic NCs during interaction with biocolloids was much higher compared to monometallic derivatives, indicating their potential as fluorescent reporters in biomedical applications.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Analytical
Mingliang Xue, Wei Mao, Jisen Chen, Fenfen Zheng, Wenhui Chen, Wei Shen, Sheng Tang
Summary: Gold and silver nanomaterials have been widely used in glucose determination due to their specific properties, with advantages of simple operation, low cost, and easy observation in colorimetric methods. Various synthesis methods and strategies for colorimetric determination of glucose using gold or silver nanomaterials are discussed, along with challenges and prospects for their application in glucose detection.
Article
Biotechnology & Applied Microbiology
Zhongli Lei, Jie Zhou, Miao Liang, Yan Xiao, Zhihong Liu
Summary: In this study, glutathione stabilized alloy Au/Ag NCs were synthesized for the fluorescence detection of PPi and PPase based on a Zn2+-regulated AIE strategy. This method offers a simple procedure, high sensitivity and stability, and low toxicity. Additionally, the AIE behaviors of the Au/Ag NCs were studied, providing fundamental understanding of the AIE properties of water-soluble alloy NCs and potential for further applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Ji Zheng, Jia-Nan Wang, Ting Wang, Kun Wu, Rong-Jia Wei, Weigang Lu, Dan Li
Summary: A series of Ag/Au clusters with high-energy phosphorescence have been synthesized, showing tunable luminescence color through the modulation of substituents. These heterometallic clusters exhibit over 23-fold boost in phosphorescence quantum yield compared to their homometallic Ag(I) analogues.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Deepika Sharma, Nishima Wangoo, Rohit K. Sharma
Summary: This work presents a simple, cost-effective, and highly sensitive method for detecting ethyl parathion using bimetallic BSA@AuAg nanoclusters. The synthesized biosensor is capable of detecting ethyl parathion in the picomolar range, with a detection limit of 2.40 pM. Real sample analysis demonstrates the reproducibility and robustness of the synthesized nanoprobe, showing specificity towards ethyl parathion compared to other pesticides.
Article
Chemistry, Multidisciplinary
Xuejuan Zou, Shuping He, Xi Kang, Shuang Chen, Haizhu Yu, Shan Jin, Didier Astruc, Manzhou Zhu
Summary: Two novel nanoclusters, M1Ag21 (M = Au/Ag), were synthesized and characterized using dppf as an activating ligand. These nanoclusters, supported on activated carbon, demonstrated efficient catalytic activity for the oxygen reduction reaction in alkaline solutions. The catalytic activities were attributed to the ensemble synergy effect between the M-13 kernel and dppf ligand in M1Ag21, as verified by density functional theory calculations.
Article
Chemistry, Physical
Ye Liu, Zhi Li, Xiao-He Liu, Nicola Pinna, Yu Wang
Summary: In this study, atomically precise AuxAg25-x nanoclusters (NCs) were used for photocatalytic hydrogen evolution. The incorporation of Au atoms into Ag25 NCs narrowed the HOMO-LUMO gaps and created an interstitial Au-Ag microenvironment, promoting photogenerated charge carrier utilization and optimizing reaction dynamics.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Analytical
Yu-Syuan Lin, Li-Wei Chuang, Bo-Yi Wu, Yi-Hui Lin, Huan-Tsung Chang
Summary: A GSH-assisted approach using a polymer template was used to prepare stable and fluorescent gold nanoclusters. The polymer PDDA was found to be more suitable for the preparation of Au NCs compared to PSS. These nanoclusters demonstrated high sensitivity and selectivity for sulfide ions.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Yu Ouyang, Pu Zhang, Hadar Manis-Levy, Yossi Paltiel, Itamar Willner
Summary: The study introduces a method to control the optical properties of Au NPs or CdSe/ZnS QDs through their dynamic aggregation/deaggregation, achieved by nucleic acid-modified pairs and biocatalytic reactions. It leads to the dynamic recovery of the original NP or QDs modules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Roman Tumskiy, Boris Khlebtsov, Anastasiia Tumskaia, Stella Evstigneeva, Evgeniya Antoshkina, Andrey Zakharevich, Nikolai G. Khlebtsov
Summary: This paper reports a simple synthesis of water-soluble glutathione-capped silver nanoclusters (GSH-Ag NCs), which showed enhanced antibacterial activity. The synthesized GSH-Ag NCs were found to be a pure composition without any impurities. The antibacterial activity of the chelated silver in the nanoclusters was significantly higher compared to free silver ions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yiyang Zeng, Yuanyuan Dong, Junli Chen, Xinwen Xu, Fuli Zhang, Hongling Liu
Summary: Counterfeiting is a global issue that poses threats to human health and economic security. This study presents a novel approach to apply bimetallic nanoclusters to textile materials for anti-counterfeiting purposes. The optimized Au-Ag nanoclusters exhibited strong orange-red fluorescence and high zeta potential values, which were then used to create anti-counterfeiting films. A cyclic fluorescent color chart and a microstructure model were developed to demonstrate the potential of this method in textile anti-counterfeiting.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Ziyan Chen, Lizeng Cheng, Yichen He, Xinlin Wei
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Biochemistry & Molecular Biology
Lizeng Cheng, Liang Chen, Qiongqiong Yang, Yuanfeng Wang, Xinlin Wei
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Review
Biochemistry & Molecular Biology
Lizeng Cheng, Yuanfeng Wang, Xiangxiang He, Xinlin Wei
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Biochemistry & Molecular Biology
Jiangxiong Zhu, Ziyan Chen, Liang Chen, Chuang Yu, Hongxin Wang, Xinlin Wei, Yuanfeng Wang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Chemistry, Applied
Ziyan Chen, Yan Zhao, Mengke Zhang, Xiufang Yang, Pengxiang Yue, Dikang Tang, Xinlin Wei
CARBOHYDRATE POLYMERS
(2020)
Article
Agriculture, Multidisciplinary
Lizeng Cheng, Qiongqiong Yang, Ziyan Chen, Jiarong Zhang, Qiong Chen, Yuanfeng Wang, Xinlin Wei
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Food Science & Technology
Yi Pan, Dingwen Fei, Pinhe Liu, Xiaodong Guo, Lanlan Peng, Yuanfeng Wang, Naifeng Xu, Xinlin Wei
Summary: A SERS-based LFA strip was developed for ultrasensitive detection of chloramphenicol antibiotics in aquatic products, demonstrating favorable sensitivity and stability.
FOOD ANALYTICAL METHODS
(2021)
Review
Agriculture, Multidisciplinary
Jia Xu, Yang Wei, Yi Huang, Xinlin Wei
Summary: Nonalcoholic fatty liver disease (NAFLD), a common chronic liver disease, is influenced by environmental, genetic, and metabolic factors. Current treatments for NAFLD, such as diet and exercise interventions, have limited efficacy due to the complexity of the disease. Drug therapy is also associated with serious side effects. Developing high-efficiency natural supplements, such as tea, is a sustainable strategy for the prevention and treatment of NAFLD. This review explores the potential effects of tea active compounds, such as catechins and flavonoids, on NAFLD and proposes future directions for research and application.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Li Wang, Yi Pan, Zhengwu Wang, Yuanfeng Wang, Xinlin Wei
Summary: A novel fluorescence nanoprobe based on an enzyme-mediated silver nanoparticle-modified metal organic framework was developed for rapid detection of organophosphorus pesticides (OPPs). The nanoprobe showed good correlation with the concentration of fenitrothion, an OPP, and exhibited excellent anti-interference ability and stability. This method provides a universal platform for screening enzyme inhibitors to detect OPPs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Agriculture, Multidisciplinary
Zi Han, Yi Pan, Shouhui Chen, Xinlin Wei
Summary: A new time-resolved fluorescent immunosensor based on FRET was developed for the rapid detection of cadmium ion. The immunosensor showed a quick response time of 30 minutes, a detection limit of 0.29 ng/mL, and a linear range of 1-500 ng/mL. The accuracy of the immunosensor for cadmium ion detection was further validated through testing tea samples, exhibiting satisfactory recovery rates. This method provides a good model for the rapid and high-throughput detection of heavy metals.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Kang Wei, Yang Wei, Yuanfeng Wang, Xinlin Wei
Summary: The potential biological function of tea and its active components on colitis has attracted attention. In this study, the effects of different tea active ingredients on dextran sulfate sodium (DSS)-induced colitis in mice were compared. Tea polyphenols (TPPs) showed the greatest effect on colitis, followed by tea polysaccharides (TPS) and theabrownin (TB), while theanine (TA) had no obvious alleviative effect. TPP, TPS, and TB regulated gut microbiota, increased short-chain fatty acids (SCFAs), and enhanced intestinal barrier function. TPP and TPS also regulated the activation of Nrf2/ARE and the TLR4/MyD88/NF-kappa B P65 pathway to alleviate colitis. Additionally, TPP demonstrated the greatest antiapoptosis and mitochondrial function protective capability among the tea ingredients.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Li Wang, Yi Pan, Zhengwu Wang, Yuanfeng Wang, Xinlin Wei
Summary: In this study, a novel fluorescence nanoprobe was developed for rapid detection of organophosphorus pesticides (OPPs). The nanoprobe showed good sensitivity and anti-interference ability. This work provides a new method for OPP detection and a universal platform for screening other enzyme inhibitors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)