Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

(2019) Robert A. Feldman et al.   VACCINE

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

(2018) Norbert Pardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Maternal antibody inhibition of recombinant Newcastle disease virus vectored vaccine in a primary or booster avian influenza vaccination program of broiler chickens

(2018) Kateri Bertran et al.   VACCINE

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

(2018) Norbert Pardi et al.   Nature Communications

Antigen Acquisition Enables Newly Arriving B Cells To Enter Ongoing Immunization-Induced Germinal Centers

(2017) Jackson S. Turner et al.   JOURNAL OF IMMUNOLOGY

Maternal immunisation: collaborating with mother nature

(2017) Arnaud Marchant et al.   LANCET INFECTIOUS DISEASES

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Maternal Immunization

(2017) Saad B. Omer   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis

(2017) Roger Baxter et al.   PEDIATRICS

Transfer of maternal immunity and programming of the newborn immune system

(2017) Madeleine F. Jennewein et al.   Seminars in Immunopathology

What Is Wrong with Pertussis Vaccine Immunity?

(2017) Nicolas Burdin et al.   Cold Spring Harbor Perspectives in Biology

Influenza vaccination during pregnancy for prevention of influenza confirmed illness in the infants: A systematic review and meta-analysis

(2017) Marta C. Nunes et al.   Human Vaccines & Immunotherapeutics

The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses

(2017) Merryn Voysey et al.   JAMA Pediatrics

Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells

(2017) Gustaf Lindgren et al.   Frontiers in Immunology

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Relative Contribution of Dengue IgG Antibodies Acquired during Gestation or Breastfeeding in Mediating Dengue Disease Enhancement and Protection in Type I Interferon Receptor-Deficient Mice

(2016) Pei Xuan Lee et al.   PLoS Neglected Tropical Diseases

TCR Signal Strength Alters T–DC Activation and Interaction Times and Directs the Outcome of Differentiation

(2016) Nicholas van Panhuys   Frontiers in Immunology

Comparison of the effectiveness of rHVT-H5, inactivated H5 and rHVT-H5 with inactivated H5 prime/boost vaccination regimes in commercial broiler chickens carrying MDAs against HPAI H5N1 clade 2.2.1 virus

(2015) Walid H. Kilany et al.   AVIAN PATHOLOGY

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination

(2015) Giuseppe Lofano et al.   JOURNAL OF IMMUNOLOGY

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

Maternal antibodies and infant immune responses to vaccines

(2015) Kathryn M. Edwards   VACCINE

A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus

(2015) Gregory M. Frank et al.   mBio

Long-term survival correlates with immunological responses in renal cell carcinoma patients treated with mRNA-based immunotherapy

(2015) Susanne M. Rittig et al.   OncoImmunology

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

(2015) Hubert Kübler et al.   Journal for ImmunoTherapy of Cancer

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

Influenza Vaccination of Pregnant Women and Protection of Their Infants

(2014) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hospitalizations for Severe Lower Respiratory Tract Infections

(2014) A. H. Greenbaum et al.   PEDIATRICS

Epidemiological evidence for herd immunity induced by acellular pertussis vaccines

(2014) M. Domenech de Celles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR signal quantity and quality in CD4+ T cell differentiation

(2014) Noah J. Tubo et al.   TRENDS IN IMMUNOLOGY

Transplacental rotavirus IgG interferes with immune response to live oral rotavirus vaccine ORV-116E in Indian infants

(2013) Mohan Babu Appaiahgari et al.   VACCINE

Pulmonary Infection with Influenza A Virus Induces Site-Specific Germinal Center and T Follicular Helper Cell Responses

(2012) Alexander W. Boyden et al.   PLoS One

Insights into the regulatory mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies

(2011) D. Kim et al.   BLOOD

Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes and Peyer's Patches in Cynomolgus Monkeys

(2011) Akiko MORIYAMA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Development of Newborn and Infant Vaccines

(2011) G. Sanchez-Schmitz et al.   Science Translational Medicine

Vaccination of neonates: Problem and issues

(2011) Douglas C. Hodgins et al.   VACCINE

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

(2010) Santiago F Gonzalez et al.   NATURE IMMUNOLOGY

DNA-mediated vaccination conferring protection against infectious bursal disease in broiler chickens in the presence of maternal antibody

(2010) Ming Kun Hsieh et al.   VACCINE

Mucosal priming of newborn mice with S. Typhi Ty21a expressing anthrax protective antigen (PA) followed by parenteral PA-boost induces B and T cell-mediated immunity that protects against infection bypassing maternal antibodies

(2010) Karina Ramirez et al.   VACCINE

Electroporation enhances immune responses and protection induced by a bovine viral diarrhea virus DNA vaccine in newborn calves with maternal antibodies

(2010) Sylvia van Drunen Littel-van den Hurk et al.   VACCINE

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Safety and Immunogenicity of Trivalent Inactivated Influenza Vaccine in Infants

(2008) Natasha B. Halasa et al.   JOURNAL OF INFECTIOUS DISEASES