Review
Environmental Sciences
Saurav Kumar, Tapas Paul, S. P. Shukla, Kundan Kumar, Sutanu Karmakar, Kuntal Krishna Bera, Chandra Bhushan Kumar
Summary: Triclosan (TCS), an emergent pollutant, is raising global concern due to its toxic effects on organisms and aquatic ecosystems. Thorough research on identifying potential biomarkers for assessing chronic effects of TCS is crucial for addressing ecological impacts and monitoring in the future. Subcellular biomarkers such as oxidative stress, lipid peroxidation, neurotoxicity, and metabolic enzymes can be used to evaluate the cytotoxic effect of TCS in future investigations.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Ziga Tkalec, Tina Kosjek, Janja Snoj Tratnik, Anja Stajnko, Agneta Annika Runkel, Marianthi Sykiotou, Darja Mazej, Milena Horvat
Summary: The study in Slovenian children and adolescents revealed exposure to a wide range of different endocrine disrupting chemicals, with variations in levels based on age, gender, and location. Associations were found between exposure levels and factors such as dietary habits, use of food packaging, and personal care products. Additionally, a genetic polymorphism in UGT2B15 gene was linked to levels of methyl and ethyl paraben, indicating a potential biomarker for susceptibility to adverse effects caused by exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Ziga Jakopin
Summary: Parabens are common endocrine-disrupting chemicals, but there is limited understanding of the endocrine-disrupting potential of their halogenated counterparts, posing a challenge for regulatory decision making. Research suggests that halogenated parabens may have more pronounced endocrine-disrupting activities than parent compounds.
Article
Environmental Sciences
Thilomi Samarakoon, Takeshi Fujino
Summary: The toxicity of triclosan (TCS) on the freshwater cladoceran Moina macrocopa was investigated. The results showed that TCS had minimal acute toxicity but significantly affected the growth, reproduction, and population-growth-related characteristics of M. macrocopa even at low concentrations. Furthermore, high concentrations of TCS could induce oxidative stress and DNA alterations.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Engineering, Environmental
Jiefeng Liang, Xiaoxi Yang, Qian S. Liu, Zhendong Sun, Zhihua Ren, Xiaoyun Wang, Qing Zhang, Xiaomin Ren, Xiuchang Liu, Qunfang Zhou, Guibin Jiang
Summary: This study investigated the developmental toxicity of parabens on zebrafish embryos and larvae, with butyl paraben showing the highest toxicity. Paraben exposure led to mortality, decreased hatching rate, reduced body length, lowered heart rate, and malformation. The study also found that paraben exposure disrupted thyroid hormone levels and gene expression in the hypothalamic-pituitary-thyroid axis, indicating their potential thyroid endocrine disruption effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Mai Homburg, Ase Krogh Rasmussen, Louise Ramhoj, Ulla Feldt-Rasmussen
Summary: This study investigated the influence of triclosan on the human thyroid system through a systematic literature review of human studies. The results showed mixed associations between triclosan and thyroid hormones, with some studies finding negative associations and others finding no associations or opposite associations. The limited measurement timepoints and low concentrations of triclosan used in intervention studies influenced the quality of the dataset. Further larger studies with more continuous and elaborate outcome measurements are needed to determine whether triclosan at current exposure levels adversely affects the human thyroid hormone system.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Infectious Diseases
Maria Stefania Sinicropi, Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda, Michele Pellegrino, Carmela Saturnino, Pasquale Longo, Stefano Aquaro
Summary: Triclosan (TCS) is a widely used broad-spectrum antimicrobial agent in personal care products. Its toxicity to mammals and the adverse effects of long-term exposure are still unclear. Recent reports suggest its potential use in cancer treatment and cutaneous leishmaniasis.
Article
Environmental Sciences
Samarasinghe Vidane Arachchige Chamila Samarasinghe, Kannan Krishnan, Robert John Aitken, Ravi Naidu, Mallavarapu Megharaj
Summary: The study found that methyl-, propyl-, and butyl parabens do not negatively affect the survival, growth, and reproduction of Eisenia fetida up to a concentration of 1000 mg Kg(-1), and that these compounds exhibit low persistence in soil, with over 90% disappearing within three days. Moreover, microbial activity in frozen soil was found to only degrade 16-54% of parabens, indicating rapid degradation of these compounds in terrestrial environments and minimal threat to species like Eisenia fetida. This study represents the first report on the toxicity of parabens to earthworms.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Medicine, Legal
L. Svobodova, K. Kejlova, M. Rucki, J. Chrz, P. Kubincova, M. Dvorakova, H. Kolarova, D. Jirova
Summary: This study confirmed the safety of using the allowed parabens in the highest recommended concentrations in cosmetics or pharmaceuticals, based on testing their toxicological properties using novel in vitro methods.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Evelyn Siqueira Caixeta, Joao Vitor Meza Bravo, Boscolli Barbosa Pereira
Summary: Several studies have shown that effluent discharges can contaminate waterways. However, the impact of chemical pollutants on sediment, especially from an ecotoxicological perspective, is not well understood. This study compared water-sediment samples from high-anthropogenic urban areas and low-anthropogenic peri-urban areas. The results suggest chronic toxicity effects in the samples collected from the high-anthropogenic urban area, while no acute toxicity was observed in both areas.
Review
Biochemistry & Molecular Biology
Ag-Anne P. M. de Menezes, Rai P. S. Aguiar, Jose V. O. Santos, Chandan Sarkar, Muhammad T. Islam, Antonio L. Braga, Mohammad M. Hasan, Felipe C. C. da Silva, Javad Sharifi-Rad, Abhijit Dey, Daniela Calina, Ana A. C. Melo-Cavalcante, Joao M. C. Sousa
Summary: This study conducted a systematic review on the anti-proliferative activity of CIT in cancer, finding that it intervenes in important mediators and cell signaling pathways, inducing cell death, reducing DNA repair capacity, and exerting cytotoxic and genotoxic effects in cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
Zvonimir Petric, Julia Ruzic, Irena Zuntar
Summary: The effects of paraben toxicity, particularly its endocrine-disruption properties, have been a subject of research for decades. However, there is still debate on the hazards it may pose to human health. Current studies suggest that methyl-, ethyl-, and propylparaben are safe for use in cosmetics and pharmaceuticals within recommended doses, but alternatives would need rigorous testing for toxicity and safety.
ACTA PHARMACEUTICA
(2021)
Review
Environmental Sciences
Ivana Durovcova, Stanislav Kyzek, Jana Fabova, Jana Makukova, Eliska Galova, Andrea Sevcovicova
Summary: This review aims to summarize the genotoxic effects of BPA on organisms across all taxa. BPA can induce DNA damage through multiple mechanisms and has adverse effects on organisms in various ecosystems.
ENVIRONMENTAL POLLUTION
(2022)
Review
Environmental Sciences
Hafiz Ubaid Ur Rahman, Waqas Asghar, Wahab Nazir, Mansur Abdullah Sandhu, Anwaar Ahmed, Nauman Khalid
Summary: Chlorpyrifos (CPF) is a broad-spectrum chlorinated organophosphate pesticide used for controlling insects and pathogens, but its toxicity can lead to neurological dysfunctions, endocrine disruption, and other serious health complications.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Duo Zhang, Jinqiu Xiao, Qinru Xiao, Yining Chen, Xiangyu Li, Quanzhi Zheng, Jiaojiao Ma, Jiayi Xu, Jinfeng Fu, Junchun Shen, Lehan Xiao, Shaoyou Lu
Summary: This study investigated the levels of common preservatives and antimicrobials in major infant food sources in southern China and found potential health risks associated with the intake of certain additives. It is recommended that breastfeeding women reduce their consumption of personal care products and processed food, especially during the first month after delivery.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemical Research Methods
Luis A. P. Silva, Stefano Campagnolo, Sara R. R. Fernandes, Sara S. S. Marques, Luisa Barreiros, Benedita Sampaio-Maia, Marcela A. Segundo
Summary: A rapid and sensitive HPLC method with fluorescence detection was developed for simultaneous quantification of protein-bound uremic toxins in human plasma. The method showed good accuracy and precision, and was successfully applied to analyze plasma samples from control subjects and CKD patients.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Sara R. Fernandes, Andreia N. Meireles, Sara S. Marques, Luis Silva, Luisa Barreiros, Benedita Sampaio-Maia, Manuel Miro, Marcela A. Segundo
Summary: This review addresses the monitoring and evaluation of protein-bound uremic retention solutes in biological fluids, such as indole-3-acetic acid, indoxyl sulfate, p-cresol, and p-cresol sulfate, which have been associated with the development of kidney, cardiovascular, and bone toxicities. The review discusses conventional and advanced sample treatment procedures and chromatographic analytical methods for quantification of these compounds, with a particular focus on plasma, serum, and urine samples. There is a trend towards using liquid chromatography-tandem mass spectrometry for analysis, requiring protein precipitation, solid-phase extraction, and/or dilution prior to sample analysis. Miniaturized methods using microplate devices are recommended for sustainability.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Spectroscopy
Rafael C. Castro, David S. M. Ribeiro, Joao L. M. Santos, Claudia Nunes, Salette Reis, Ricardo N. M. J. Pascoa
Summary: A fast, simple, and reliable method for determination of metformin was developed by coupling surface-enhanced Raman spectroscopy (SERS) with chemometric methods. The method utilized a portable Raman spectrometer and citrate stabilized gold nanoparticles (AuNPs) as substrate, resulting in improved sensitivity. Principal component analysis (PCA) and partial least squares (PLS) regression were used for data analysis. Optimization of the PLS model led to RMSECV and R2CV values of 0.42 mg/L and 0.94, respectively. Validation of the optimized PLS regression model with commercial pharmaceutical samples yielded good results in terms of R2P (0.97), RE (4.54%), and analytical sensitivity (2.13 mg/L).
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Sara S. Marques, Ines I. Ramos, Carla Silva, Luisa Barreiros, Maria R. Domingues, Marcela A. . Segundo
Summary: The concentration of nanoparticles (NPs) is crucial for the development and quality control of nanocarriers. This study proposes a miniaturized automated method to measure NPs concentration, which is fast, simple, and suitable for research and quality control operations. The method utilizes the measurement of light scattering caused by NPs passing through an optical path, achieving accurate and efficient quantification of NPs concentration.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Filipa A. Soares, Pedro Costa, Celia T. Sousa, Miguel Horta, Catarina Pereira-Leite, Catarina Leal Seabra, Sofia A. Costa Lima, Salette Reis, Claudia Nunes
Summary: This study aims to develop and optimize the production of PEGylated magnetoliposomes (MLPs@PEG) by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs) within fusogenic liposomes. The optimized MLPs@PEG has a mean size of 182 nm, polydispersity index (PDI) of 0.19, and SPIONs encapsulation efficiency (%EE) around 76%. Cytocompatibility assays demonstrate that the MLPs@PEG exhibits no toxicity in fibroblasts and no hemolytic effect at safe lipid and iron concentrations.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Biochemistry & Molecular Biology
Filipa Serrasqueiro, Ana Isabel Barbosa, Sofia A. Costa Lima, Salette Reis
Summary: Understanding the impact of carbohydrate-targeting mannose receptors on macrophages is crucial for improving carrier design. Functionalized fucoidan/chitosan nanoparticles with mannose and mannan were characterized and shown to activate macrophages towards an M1-polarized state, indicating their potential therapeutic use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Llucia Garcia-Moll, Alexandra Sixto, Enrique Javier Carrasco-Correa, Manuel Miro
Summary: For the first time, low force stereolithography is used to fabricate chemiluminescence flow-through cells, which outperform those produced through milling, blowing, or alternative 3D printing methods. Different cross-section geometries and customized gaskets and reactors are critically evaluated to enhance the analytical performance of the cells. A five-side polygon cell with Y-type confluence is found to be the most efficient in terms of reagent mixing and photon capture.
Correction
Chemistry, Multidisciplinary
Ali Sahragard, Milos Dvorak, Enrique J. Carrasco-Correa, Pakorn Varanusupakul, Pavel Kuban, Manuel Miro
Article
Chemistry, Analytical
Maria Pau Garcia-Moll, Llucia Garcia-Moll, Enrique Javier Carrasco-Correa, Miquel Oliver, Ernesto Francisco Simo-Alfonso, Manuel Miro
Summary: This study proposes a novel biomimetic microextraction approach for estimating the effective intestinal permeability of pharmaceuticals. The experimental results show that this method can develop reliable prediction models for human jejunum permeability.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Fabio M. S. Costa, Andreia Granja, Rocio L. Perez, Isiah M. Warner, Salette Reis, Marieta L. C. Passos, M. Lucia M. F. S. Saraiva
Summary: Antimicrobial resistance is a global public health concern, and strategic therapies are needed to replace ineffective antibacterials. GUMBOS, a group of uniform materials based on organic salts, provide a promising alternative approach by combining antibacterials with adjuvants to treat infections caused by resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Nuria Fontanals, Eva Pocurull, Rosa Montes, Iria Gonzalez-Marino, Sergio Santana-Viera, Manuel Miro, Andreu Rico, Sara Rodriguez-Mozaz, Francesc Borrull, Jose Benito Quintana, Rosa Maria Marce
Summary: This study describes an analytical method based on solid-phase extraction and liquid chromatography coupled to tandem mass spectrometry to monitor the occurrence of a group of seventeen pharmaceuticals in wastewater. The results showed that all studied pharmaceuticals were found in all samples, with concentrations ranging from non-detectable to 10,393 ng/L, and the highest concentrations were for tramadol. Furthermore, the study also found that the pattern of pharmaceutical use was generally similar in all cities monitored.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Ali Sahragard, Pakorn Varanusupakul, Manuel Miro
Summary: This review critically examines the current state-of-the-art of nanomaterial-based electrochemical sensors in flow injection (NBES-FI) platforms for in-line determination of environmental pollutants from 2013 to mid-2023. The synergistic effects of FI platforms and nanomaterial-based modifiers, such as metal nanoparticles and carbon-based nanomaterials, are discussed in detail, focusing on minimizing electrode fouling, alleviating overpotential, and boosting overall figures of merit. The impact of experimental parameters, including electrode properties and design, synthesis routes of nanomaterials, and electrochemical detection techniques, on the analytical performance of NBES-FI is thoroughly evaluated. Current challenges and the need for real-world implementation of NBES-FI in environmental settings are outlined, along with perspectives on integrating NBES-FI with microextraction approaches and utilizing 3D printing technology for customized fluidic platforms.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Review
Oncology
Sara C. C. Freitas, Daniel Sanderson, Sofia Caspani, Ricardo Magalhaes, Belen Cortes-Llanos, Andreia Granja, Salette Reis, Joao Horta Belo, Jose Azevedo, Maria Victoria Gomez-Gaviro, Celia Tavares de Sousa
Summary: Colorectal cancer is the third most common cancer worldwide. Current treatment strategies have room for improvement, and nanotechnology using plasmonic nanoparticles shows promise in enhancing cancer therapeutics as photothermal therapy agents and radiosensitizers. Combining radio- and phototherapies to enhance their clinical application is of imperative importance.
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)