Dephosphorylation of the Retinoblastoma protein (Rb) inhibits cancer cell EMT via Zeb

Meeting Report Europhosphatase 2015: Phosphatases as Drug Targets in Cancer

(2016) Elmer Hoekstra et al.   CANCER RESEARCH

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

(2015) Richard S Finn et al.   LANCET ONCOLOGY

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax

(2014) Lisa A Antonucci et al.   CELL CYCLE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

(2014) M. S. Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Inductions of the ZEB1 Transcription Factor Caused by Mutation of Rb and Then Ras Proteins Are Required for Tumor Initiation and Progression

(2013) Yongqing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ZEB1 Transcription Factor Acts in a Negative Feedback Loop with miR200 Downstream of Ras and Rb1 to Regulate Bmi1 Expression

(2013) Yongqing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PNUTS Functions as a Proto-Oncogene by Sequestering PTEN

(2012) S. Kavela et al.   CANCER RESEARCH

Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition

(2012) Brandon Lentine et al.   CELL CYCLE

PP1 and PP2A phosphatases - cooperating partners in modulating retinoblastoma protein activation

(2012) Victoria Kolupaeva et al.   FEBS Journal

Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer

(2012) Yoshimi Arima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E-Cadherin Is Transcriptionally Activated via Suppression of ZEB1 Transcriptional Repressor by Small RNA-Mediated Gene Silencing

(2011) Minami Mazda et al.   PLoS One

Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis

(2010) Gabriel De Leon et al.   CANCER BIOLOGY & THERAPY

SMAD6 Contributes to Patient Survival in Non-Small Cell Lung Cancer and Its Knockdown Reestablishes TGF-  Homeostasis in Lung Cancer Cells

(2008) H.-S. Jeon et al.   CANCER RESEARCH

Rb Depletion Results in Deregulation of E-Cadherin and Induction of Cellular Phenotypic Changes that Are Characteristic of the Epithelial-to-Mesenchymal Transition

(2008) Y. Arima et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL