Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Review
Oncology
N. V. Vani, R. Madhanagopal, R. Swaminathan, T. S. Ganesan
Summary: The recent increase in HR-HPV-associated oral and oropharyngeal cancers is an important issue due to their distinct clinical and molecular characteristics. The natural history of oral HPV is still unclear, with a global prevalence ranging from 0.67% to 35% in healthy individuals and 31%-38.5% in head and neck cancer. The persistence rate of oral HR-HPV infection is globally 5.5%-12.8%. In India, HR-HPV-associated HNC accounts for 26% with an active infection in 8%-15% of these tumors. The expression of p16 as an HPV marker in HNC lacks concordance. Treatment de-escalation is not possible due to a lack of evidence despite improved outcomes in HPV-associated oropharyngeal cancers. A better understanding of the oncogenic role of HR-HPV in HNC is crucial for developing novel therapeutic approaches and implementing preventive strategies, which can have a significant public health impact.
Article
Oncology
Erin T. Wong, Shao Hui Huang, Brian O'Sullivan, Vincent Persaud, Jie Su, John Waldron, David P. Goldstein, John de Almeida, Jolie Ringash, John Kim, Andrew Hope, Scott Bratman, John Cho, Meredith Giuliani, Ali Hosni, Anna Spreafico, Aaron Hansen, Li Tong, Wei Xu, Eugene Yu
Summary: The study on surveillance imaging utilization pattern of head and neck revealed that imaging surveillance reduces the need for neck dissection, but routine surveillance without clinical symptoms/signs may not effectively identify locoregional failure or toxicity. For radiologic residual LNs, if two consecutive follow-up scans demonstrate stable/regressing features, clinical surveillance without further imaging appears to be safe.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Otorhinolaryngology
Cara Sauder, Mara Kapsner-Smith, Carolyn Baylor, Kathryn Yorkston, Neal Futran, Tanya Eadie
Summary: This study demonstrated that pretreatment communication predicts quality of life and is negatively impacted in some patients with oral and oropharyngeal head and neck cancers. Factors influencing QOL included tumor site, T stage, p16 status, perceived depression, swallowing, and communicative participation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Agnieszka M. Frydrych, Richard Parsons, Omar Kujan
Summary: The study found that ONS use is common among patients with head and neck cancer and is associated with the development of caries. Larger studies are needed to determine the reasons for caries development and the impact of ONS use on oral health.
Article
Oncology
Jason Tasoulas, Douglas R. Farquhar, Siddharth Sheth, Trevor Hackman, Wendell G. Yarbrough, Chris B. Agala, Alzina Koric, Luca Giraldi, Eleonora Fabianova, Jolanta Lissowska, Beata Swiatkowska, Marta Vilensky, Victor Wunsch-Filho, Marcos Brasilino de Carvalho, Rossana Veronica Mendoza Lopez, Ivana Holcatova, Diego Serraino, Jerry Polesel, Cristina Canova, Lorenzo Richiardi, Jose P. Zevallos, Andy Ness, Miranda Pring, Steve J. Thomas, Tom Dudding, Yuan-Chin Amy Lee, Mia Hashibe, Paolo Boffetta, Andrew F. Olshan, Kimon Divaris, Antonio L. Amelio
Summary: Good oral health, as defined by maintaining natural teeth and frequent dental visits, appears to be associated with improved overall survival among head and neck squamous cell carcinoma patients.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Alex Whitmarsh, Miranda Pring, Steve J. Thomas, Andrea Waylen, Andy R. Ness, Tom Dudding, Michael Pawlita, Nicole Brenner, Tim Waterboer, Lea Schroeder
Summary: The study found that patients with HPV-positive oropharyngeal cancer have better survival rates, especially among younger patients. The HPV antibody pattern may affect survival, while the antibody level does not show a significant difference.
Article
Oncology
Alex Whitmarsh, Miranda Pring, Steve J. Thomas, Andrea Waylen, Andy R. Ness, Tom Dudding, Michael Pawlita, Nicole Brenner, Tim Waterboer, Lea Schroeder
Summary: Patients with HPV-driven oropharyngeal cancer generally experience better survival rates, with younger patients showing a more significant advantage in survival. The HPV antibody pattern may also influence survival, independent of antibody levels.
Article
Multidisciplinary Sciences
Rex H. Lee, Ritu Roy, Hua Li, Aaron Hechmer, Tian Ran Zhu, Adila Izgutdina, Adam B. Olshen, Daniel E. Johnson, Jennifer R. Grandis
Summary: Currently, there are no clinical strategies utilizing tumor gene expression to inform therapeutic selection for patients with head and neck squamous cell carcinoma (HNSCC). Patient-derived xenografts (PDXs) are translationally relevant preclinical models for human tumors; however, the overall transcriptomic concordance of HNSCC PDXs with primary human HNSCC, especially in HPV+ disease, is understudied. This study characterized 64 HNSCC PDXs at the transcriptomic level and found that PDXs can recapitulate HNSCC molecular subtypes and provide a resource for the discovery of predictive biomarkers for treatment selection in HNSCC.
Article
Otorhinolaryngology
Anna C. H. Willemsen, Walmari Pilz, Ann Hoeben, Frank J. P. Hoebers, Annemie M. W. J. Schols, Laura W. J. Baijens
Summary: This study investigates the relationship between cancer cachexia and oropharyngeal dysphagia in patients with head and neck cancer. The findings suggest that cachexia independently predicts the presence of patient-reported dysphagia.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Ricklie Julian, Malvi Savani, Julie E. Bauman
Summary: HPV-positive head and neck squamous cell carcinoma (HNSCC) differs from HPV-negative HNSCC in molecular, pathological, and clinical features, showing a better response to immunotherapy. Numerous clinical trials are underway to further refine the application of immunotherapy specifically for HPV-positive HNSCC.
Review
Biochemistry & Molecular Biology
Giuseppe Riva, Camilla Albano, Francesca Gugliesi, Selina Pasquero, Sergio Fernando Castillo Pacheco, Giancarlo Pecorari, Santo Landolfo, Matteo Biolatti, Valentina Dell'Oste
Summary: The APOBEC proteins play a significant role in HPV-positive HNSCC, with their expression depending on HPV infection status and their activity playing a major role in mutagenesis in HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Brittney L. Dickey, Bradley Sirak, Laura Martin-Gomez, Richard R. Reich, Martha Abrahamsen, Kimberly Isaacs-Soriano, Christine H. Chung, Anna R. Giuliano
Summary: Background rates of oropharyngeal cancer associated with alcohol & tobacco use have decreased, while HPV associated OPC has increased among men in the US. Salivary SLPI was not significantly associated with OPC risk but was associated with higher odds of an incomplete treatment response. Additionally, oral SLPI was associated with tonsillectomy among cases and with HPV in the oral gargle among controls.
Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Article
Computer Science, Information Systems
Naman Dhariwal, Rithvik Hariprasad, L. Mohana Sundari
Summary: This paper investigates the correlation between lifestyle factors such as smoking and human papilloma virus and head and neck cancers, and predicts the mortality rate using machine learning and deep learning models. The gradient boosting algorithm achieves the highest accuracy, and the duration of follow-up is found to be the most influential factor in mortality prediction.
Article
Dentistry, Oral Surgery & Medicine
Jacqueline M. Burgette, Shelly X. Wu, Kimon Divaris
Summary: This study aimed to understand caregivers' experiences and factors influencing their children's use of dental services in the Galapagos Islands. The findings revealed that participants preferred care provided by pediatric dentists and recognized the important role of school-based dental care programs.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tracie L. Shing, John S. Preisser, Daniela Sotres-Alvarez, Kimon Divaris, James D. Beck
Summary: This study characterized site-level disease patterns and correlations in periodontal disease, finding that posterior sites had the highest odds of CAL >= 3 mm and PD >= 4 mm, while interproximal sites had higher odds of PD >= 4 mm but lower odds of CAL >= 3 mm. Mexicans had the lowest odds of CAL >= 3 mm among Hispanic/Latino backgrounds, and differences were observed in PD >= 4 mm odds among different Hispanic/Latino groups. Site-level proportions and pairwise correlations of PD were generally smaller than CAL.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alexander Gormley, Simon Haworth, Miguel Simancas-Pallares, Pernilla Lif Holgerson, Anders Esberg, Poojan Shrestha, Kimon Divaris, Ingegerd Johansson
Summary: The study found that different subtypes of early childhood caries (ECC) can predict subsequent caries experience. This suggests that developing and validating an ECC classification can help identify high-risk individuals for developing new caries lesions during childhood and adolescence.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Oncology
Tarik Gheit, Richard Muwonge, Eric Lucas, Luisa Galati, Devasena Anantharaman, Sandrine McKay-Chopin, Sylla G. Malvi, Kasturi Jayant, Smita Joshi, Pulikkottil O. Esmy, M. Radhakrishna Pillai, Partha Basu, Rengaswamy Sankaranarayanan, Massimo Tommasino
Summary: This study compared the prevalence of oral HPV infections in women vaccinated with different doses of HPV vaccine and found that three doses of the vaccine were more effective in preventing oral HPV infection compared to a single dose.
Article
Environmental Sciences
Kaitlin E. Jones, Miguel A. Simancas-Pallares, Jeannie Ginnis, Poojan Shrestha, Kimon Divaris
Summary: This study aimed to examine the association between guardians' self-reported oral health and their children's oral health among preschool-age children in North Carolina. The findings showed a strong association between guardians' self-reported oral health and their children's oral health, with ethnicity, education level, and dental home playing potential modifying roles in this association.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Dentistry, Oral Surgery & Medicine
J. S. Preisser, T. Shing, B. F. Qaqish, K. Divaris, J. Beck
Summary: Multiple imputation of measures for nonselected tooth sites can reduce bias in periodontitis estimates. The results show that multiple imputation provides less biased estimates of periodontitis prevalence and extent compared to direct application of full-mouth case definitions to partial-mouth samples.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Yupeng Liu, Lydia Zhong, Sidharth Puram, Angela L. Mazul
Summary: This study examined the survival rates of patients with oral cavity cancer (OCC) and laryngeal cancer based on race, ethnicity, and neighborhood socioeconomic status (nSES). The results showed that higher nSES was associated with better survival rates for non-Hispanic White, non-Hispanic Black, and Asian patients with OCC and laryngeal cancer. However, non-Hispanic Black patients had worse survival rates than non-Hispanic White patients, and Asian patients had better survival rates than other races within the high nSES group. These findings highlight the importance of considering intersectionality in discussions of health equity.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Stephanie Companioni, Tung Nguyen, Kimon Divaris, John Christensen
Summary: This study provides evidence for tooth selection criteria in autotransplantation by examining root width and crown-root angle of candidate donor teeth. The results indicate that mandibular premolars are the most compatible for replacing maxillary central incisors, while mandibular central incisors are the most compatible for replacing maxillary lateral incisors. This information can be considered in addition to existing tooth selection criteria for autotransplantation.
DENTAL TRAUMATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Joshua A. Raisin, Martha Ann Keels, Michael W. Roberts, Kimon Divaris, Nina Jain, Deanna W. Adkins
Summary: Although health disparities and barriers to medical care are well documented, there is a lack of research on the experiences and expectations of transgender and gender nonbinary (TGNB) people regarding oral health care. This study examines the factors related to gender identity that influence TGNB individuals' experiences in the dental setting, subjective oral health, and avoidance of oral health care. The findings highlight discrepancies between TGNB patients' expectations and actual experiences, suggesting a need for improvement in the dental care provided to this population.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Hunyong Cho, Zhi Ren, Kimon Divaris, Jeffrey Roach, Bridget M. Lin, Chuwen Liu, M. Andrea Azcarate-Peril, Miguel A. Simancas-Pallares, Poojan Shrestha, Alena Orlenko, Jeannie Ginnis, Kari E. North, Andrea G. Ferreira Zandona, Apoena Aguiar Ribeiro, Di Wu, Hyun Koo
Summary: In this study, the authors found that Selenomonas sputigena interacts with Streptococcus mutans in the supragingival biofilm, forming a honeycomb-like multicellular-superstructure, and promoting the development of childhood dental caries.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Emily Z. Z. Yan, Benjamin M. M. Wahle, Sean T. T. Massa, Paul Zolkind, Randal C. C. Paniello, Patrik Pipkorn, Ryan S. S. Jackson, Jason T. T. Rich, Sidharth V. V. Puram, Angela L. L. Mazul
Summary: This study aimed to understand the impact of human papillomavirus (HPV) on race and socioeconomic status (SES) disparities in oropharyngeal squamous cell carcinoma (OPSCC) patients. The results showed that Black patients had lower overall survival rates than patients of other races in both HPV-positive and HPV-negative OPSCC. Higher SES was associated with improved survival in all patients. Low SES Black patients had significantly worse survival than low SES patients of other races.
Article
Microbiology
Bridget M. M. Lin, Hunyong Cho, Chuwen Liu, Jeff Roach, Apoena Aguiar Ribeiro, Kimon Divaris, Di Wu
Summary: Integration of multi-omics data is crucial for understanding human health and disease processes. This paper introduces a new network and module analysis method that addresses the limitations of current methods in integrating microbiome and metabolome data. The method, BZINB-iMMPath, improves the accuracy of correlation-based modeling and allows for efficient testing of correlations between healthy and diseased groups.
Article
Biochemical Research Methods
Hunyong Cho, Yixiang Qu, Chuwen Liu, Boyang Tang, Ruiqi Lyu, Bridget M. Lin, Jeffrey Roach, M. Andrea Azcarate-Peril, Apoena Aguiar Ribeiro, Michael Love, Kimon Divaris, Di Wu
Summary: Understanding the function of the human microbiome is important, but statistical methods for metatranscriptomics are still in their early stages. A comprehensive evaluation of 10 differential analysis methods was conducted to address this gap. The logistic-beta (LB) test showed the highest sensitivity and controlled type I error well, while the MAST test had inflated type I error. The LB and log-normal (LN) tests successfully identified genes associated with childhood dental disease in a study.
BRIEFINGS IN BIOINFORMATICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
L. M. Silva, K. Divaris, T. H. Bugge, N. M. Moutsopoulos
Summary: The hemostatic and inflammatory systems cooperate to maintain homeostasis at mucosal barrier sites. Fibrin plays a crucial role in this process and acts as an immune regulator, influencing mucosal homeostasis, wound healing, and inflammation. Recent studies have revealed the role of fibrin-neutrophil activation in regulating mucosal and periodontal homeostasis. Individuals with congenital plasminogen deficiency, a genetic defect affecting fibrinolysis, are predisposed to severe periodontitis in childhood, highlighting the importance of fibrin in periodontal health. Genomic studies have also identified polymorphisms in the PLG gene, encoding plasminogen, as associated with periodontal disease, suggesting PLG variants as potential risk indicators.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Stephanie Companioni, Tung Nguyen, Kimon Divaris, John Christensen
Summary: This study provides evidence of the compatibility of root width and crown-root angles for tooth autotransplantation. Mandibular premolars are the most suitable teeth for replacing maxillary central incisors, while mandibular central incisors are the most compatible for replacing maxillary lateral incisors. These findings are important for surgical planning and esthetics.
DENTAL TRAUMATOLOGY
(2023)
