Interferon α in cancer immunoediting: From elimination to escape

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

E3611—A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma

(2018) Ahmad A. Tarhini et al.   CLINICAL CANCER RESEARCH

Dichotomal functions of phosphorylated and unphosphorylated STAT1 in hepatocellular carcinoma

(2018) Buyun Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation

(2018) Elisabeth Müller et al.   Frontiers in Immunology

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells

(2016) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma

(2016) Francesco Sabbatino et al.   JNCI-Journal of the National Cancer Institute

VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors

(2016) D Grun et al.   ONCOGENE

Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma

(2016) Francesco Sabbatino et al.   JNCI-Journal of the National Cancer Institute

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Opposing effects of immunotherapy in melanoma using multisubtype interferon-alpha – can tumor immune escape after immunotherapy accelerate disease progression?

(2015) Örjan Strannegård et al.   OncoImmunology

Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular “pseudoinflammation” contributing to an aggressive phenotype

(2015) Hanno Niess et al.   Oncotarget

High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer

(2014) Piotr Tymoszuk et al.   BMC CANCER

ISG15 Is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells

(2014) B. Sainz et al.   CANCER RESEARCH

Regulation of the Interferon regulatory factor-8 (IRF-8) Tumor Suppressor Gene by the Signal Transducer and Activator of Transcription 5 (STAT5) Transcription Factor in Chronic Myeloid Leukemia

(2014) Jeremy D. Waight et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?

(2012) J DeGregori   ONCOGENE

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity

(2011) B. C. Burnette et al.   CANCER RESEARCH

Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival

(2011) Martha L. Slattery et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer

(2011) Sahar M.A. Mahmoud et al.   JOURNAL OF CLINICAL ONCOLOGY

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resistance to IFN- -Induced Apoptosis Is Linked to a Loss of STAT2

(2010) A. L. Romero-Weaver et al.   MOLECULAR CANCER RESEARCH

Combinations of DNA Methyltransferase and Histone Deacetylase Inhibitors Induce DNA Damage in Small Cell Lung Cancer Cells: Correlation of Resistance with IFN-Stimulated Gene Expression

(2010) Wioleta Luszczek et al.   MOLECULAR CANCER THERAPEUTICS

Type I interferons inhibit the generation of tumor-associated macrophages

(2009) Lance U’Ren et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interferon-α counteracts the angiogenic switch and reduces tumor cell proliferation in a spontaneous model of prostatic cancer

(2009) Luca Persano et al.   CARCINOGENESIS

Somatic evolutionary genomics: Mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration

(2009) S. A. Frank   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired interferon signaling is a common immune defect in human cancer

(2009) R. J. Critchley-Thorne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

(2009) H. Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon Regulatory Factors IRF5 and IRF7 Inhibit Growth and Induce Senescence in Immortal Li-Fraumeni Fibroblasts

(2008) Q. Li et al.   MOLECULAR CANCER RESEARCH

An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer

(2008) R. R. Weichselbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA